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Tissue Polypeptide Antigen (0):
Recent article
Tissue Polypeptide Antigen
Abstract
Cervical carcinoma is the most frequent disease of the reproductive organ and is the second most common cancer in women after breast cancer. As it is characterized by high mortality, new diagnostic methods are needed, for example tumor markers, enabling earlier diagnosis and rapid detection of recur...
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PMID: 19252468
PDF is available here.
PDF is available here.
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Abstract
Finding and development of new bladder cancer markers is still a very dynamic field. Because of the mass of all these markers it is impossible to report all of them. This paper reviews the role of bladder cancer markers in diagnosis and highlights the most important biomarkers studied and reported r...
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PMID: 18923360
PDF is available here.
PDF is available here.
Cancer Letters (263)1 2008
Abstract
We reported a prolonged clinical benefit and overall survival when first line conventional antiestrogen hormone therapy was started at the lead time and also when an immunotherapy schedule was added to the same conventional hormone treatment. Thirty-two of these last patients were considered (group...
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PMID: 18241981
PDF is available here.
PDF is available here.
Surgical Endoscopy (22)5 2008
Abstract
The temperature of carbon dioxide used for insufflation of the abdominal cavity affects peritoneal biology. Cooling of the peritoneum by unheated carbon dioxide causes increased peritoneal PAI-1 levels, important in peritoneal healing processes....
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PMID: 17943363
PDF is available here.
PDF is available here.
Cancer Letters (262)2 2008
Abstract
Elevation of TPA was associated with worse overall survival....
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PMID: 18226853
PDF is available here.
PDF is available here.
Abstract
We present an asymptomatic patient with isolated breast cancer cervical recurrence diagnosed by colposcopy after 11 years from primary disease. After a PubMed search and a review of current guidelines, no indication to follow-up examination regarding the cervix is present. The adoption of colposcopy...
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PMID: 18156985
PDF is available here.
PDF is available here.
Abstract
The analysis of the entire examined group in relation to the control population showed elevated concentrations of S-100B protein (0.47 ng/ml vs. 0.19 g/ml). The highest concentrations were in the severe stroke group (0.89 ng/ml). The assessment of TPA blood plasma concentrations showed higher ones i...
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PMID: 17984926
PDF is available here.
PDF is available here.
Abstract
The development of autoimmune diseases may be influenced by hormonal, immunomodulatory, and metabolic pathways. Prolactin (PRL), ferritin, vitamin D, and the tumor marker tissue polypeptide antigen (TPA) were measured in autoimmune diseases: systemic lupus erythematosus (SLE), systemic sclerosis (SS...
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PMID: 17785327
PDF is available here.
PDF is available here.
Abstract
Nippon rinsho. Japanese journal of clinical medicine (65 Suppl 6) 2007
Abstract
Przeglad lekarski (64)12 2007
Abstract
We have focused on the role of new tumour markers, especially cytokines (for example G-CSF, VEGF) and molecular markers of carcinogenesis (for example Bcl-2 and p53), in comparison to typical tumour markers useful in diagnostic of cervical cancer such as CA 125, SCC-Ag, TPA, TPS, CYFRA 21-1....
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PMID: 18595508
PDF is available here.
PDF is available here.
Anticancer Research (27)4A 2007
Abstract
One hundred and nine patients who underwent exploratory laparotomy without any surgical therapy between September 1999 and June 2005 were studied. For patients with a serum level of CEA, CA19-9 and CA72-4 that was higher than the calculated cut-off hazard ratios of early death were respectively 3-,...
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PMID: 17649789
PDF is available here.
PDF is available here.
Anticancer Research (27)4A 2007
Abstract
Tumor markers CA 125, TPA, TPS were significantly elevated in exudates, irrespective of the etiology, as a non-specific reaction in mesothelial cells. TK had a sensitivity of over 80% for all the types of cancer examined, while CA 15-3 had a sensitivity of over 90%. CONCLUSION: Significant positivit...
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PMID: 17649796
PDF is available here.
PDF is available here.
BMC Cancer (6)1 2006
Abstract
Distant metastases occurred 19 times in 18 (6.7%) of the 268 patients who were disease-free at the beginning of the study. MCA sensitivity with both cut-off values was higher than that of CEA or TPA or CA15.3 (68% vs 10%, 26%, 32% and 53% vs 16%, 42%, 32% respectively). With cut-off > or = 11 U/mL,...
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PMID: 17116247
PDF is available here.
PDF is available here.
Medical Oncology (23)4 2006
Abstract
All the tumor markers that were studied have significant limitations in the early diagnosis of cancer, but TPA-M and CYFRA 21-1 may have a role in monitoring the success of therapy and follow up of patients with SCCHN....
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PMID: 17303904
PDF is available here.
PDF is available here.
Abstract
These results indicate that determining the serum levels of CA 15-3, TPA, and TPS may be used to establish the stage of disease and it provides useful guidance both in deciding whether to treat surgically and in estimating the efficacy of neoadjuvant chemotherapy in patients with breast cancer....
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PMID: 16767053
PDF is available here.
PDF is available here.
Thrombosis Research (118)2 2006
Abstract
Anticancer Research (26)3B 2006
Abstract
The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis. CONCLUSION: Among the four markers, only TPA-M may play a role in monitoring the...
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PMID: 16821638
PDF is available here.
PDF is available here.
Abstract
A greater life expectancy has led to an increasing proportion of elderly patients. Increasing age is an important risk factor for cardiovascular disease, but the mechanism of risk is not well understood. Because thrombosis plays a key role in plaque development and the onset of acute coronary syndro...
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PMID: 16253598
PDF is available here.
PDF is available here.
Abstract
The results showed the sensitivity value for the group of 35 patients was 29.4%, but in clinical stage IV was 70%. TPA levels correlate with T classification and lymph node metastasis. In T4 tumors it was significantly higher than in T2 (p=0.047). TPA levels were significantly higher in patients wit...
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PMID: 16379315
PDF is available here.
PDF is available here.
Neuroscience Letters (384)3 2005
Abstract
We aimed to evaluate platelet activation and fibrinolyis in acute atherosclerotic ischemic stroke patients to clarify the relationship between them. Plasma P-selectin antigen, tissue plasminogen activator (tPA) antigen and activity, and plasminogen activator inhibitor-1 (PAI-1) activity were determi...
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PMID: 15916851
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Abstract
Serum AFP levels were elevated in patients with hepatocellular carcinoma in comparison with that in cholangiocarcinoma patients (P=0.037), but the difference was not significant (P=0.737). Serum TPS levels were significantly correlated with the tumor size (P=0.001), but not with the number of the tu...
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PMID: 15684008
PDF is available here.
PDF is available here.
Anticancer Research (25)1B 2005
Abstract
Pathological concentrations of TPA, HER-2/neu and uPAR are detectable in the serum and in urine of bladder cancer patients. The calculated diagnostic sensitivity for TPA in serum was 68.37%, for TPA in urine 33.3%, for HER-2/neu 86.7% and for uPAR 79.5%. Pathological levels of TPA in serum (p=0.001)...
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PMID: 15816639
PDF is available here.
PDF is available here.
Abstract
Using these doses and schedules of FOLFOX-4 appears to be a promising therapy in patients pre-treated with platinum compounds. More studies are required to assess the possible role of this regimen in the treatment of advanced bladder cancer....
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PMID: 15640506
PDF is available here.
PDF is available here.
Differentiation (72)7 2004
Abstract
We demonstrated that, besides being expressed in several adult tissues of non-muscle lineage, MyoR was expressed at a much earlier stage in mammalian development than had previously been reported, that is, as early as the blastocyst stage, well before skeletal muscle specification. We also found tha...
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PMID: 15554945
PDF is available here.
PDF is available here.
Clinical Biochemistry (37)7 2004
Abstract
Cytokeratins, belonging to the intermediate filament (IF) protein family, are particularly useful tools in oncology diagnostics. At present, more than 20 different cytokeratins have been identified, of which cytokeratins 8, 18, and 19 are the most abundant in simple epithelial cells. Upon release fr...
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PMID: 15234234
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (62 Suppl 6) 2004
Abstract
Genes to Cells (9)3 2004
Abstract
A STAT3 (signal transducer and activator of transcription 3)- and a MEK/Erk-mediated signal can be activated by cytokines, including IL-6 (interleukin-6), PDGF, and EGF. Recently, STAT3 and an ERK-signal were shown to co-operatively activate the c-fos gene. Activation of a truncated form of the IL-6...
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PMID: 15005710
PDF is available here.
PDF is available here.
Abstract
The ability of the tumour markers Cancer Antigen 15-3 (CA 15-3), Carcinoembryonic Antigen (CEA), and Tissue Polypeptide Antigen (TPA) to signal progression in breast cancer patients was investigated in this study. Marker interpretation considered the analytical variation, intra-individual biological...
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PMID: 14962712
PDF is available here.
PDF is available here.
Abstract
Maternal TPA levels were significantly greater among cases than controls (P=.005). Superoxide production by maternal neutrophils and donor neutrophils cultured with STBM from cases of preeclampsia was greater than controls (P values.006 and.019, respectively), and dose-response relationships were ob...
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PMID: 14749668
PDF is available here.
PDF is available here.
Casopis lekaru ceskych (143)3 2004
Abstract
As optimal combination of tumor markers during the follow up seem to be tricombination CA 15-3, CEA and TPA, but also the clinical relevance and cost effectiveness of these assessments have to be considered. For the tumor disease follow up only CA 15-3 has sufficient sensitivities (at 95% specificit...
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PMID: 15134036
PDF is available here.
PDF is available here.
Abstract
We conclude that opium smoking is associated with elevated serum CEA levels. Therefore, for management of opium users with neoplastic diseases, increased levels of serum CEA should be viewed with caution to avoid misdiagnosis....
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PMID: 15646837
PDF is available here.
PDF is available here.
Abstract
Our study demonstrates that the concentrations of tumor markers in BAL expressed in relation to total protein were more effective than if expressed in mL of BAL fluid collected....
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PMID: 15077929
PDF is available here.
PDF is available here.
Lung Cancer (41)3 2003
Abstract
This data indicates that serum assay of NSE is a useful marker also in NSCLC and a significant predictor of survival, independently of the other prognostic factors....
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PMID: 12928122
PDF is available here.
PDF is available here.
Abstract
The levels and positivity rate of serum TPS and CA153 in breast cancer group were significantly higher than those in the normal subjects group and benign lesion group (P<0.01), and became even higher as the malignancy progressed. High serum TPS level was detected in the cancer patients in stage I. S...
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PMID: 12919909
PDF is available here.
PDF is available here.
Abstract
In patients with bladder cancer, the TPA serum level correlated with initial tumor stage and grade, but it was not useful for detecting or monitoring relapses....
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PMID: 12893327
PDF is available here.
PDF is available here.
Minerva ginecologica (55)4 2003
Abstract
Many circulating markers are already in clinical practice and in experimental use for the diagnosis, therapeutic monitoring, and in the follow-up of ovarian cancer. The cancer antigen-125 (CA-125) has shown to be useful in epithelial ovarian cancer, but its specificity is too low for the test to be...
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PMID: 14581857
PDF is available here.
PDF is available here.
Abstract
In most of their traditional clinical applications the two serum tests are equivalent because of their virtual identity. We strongly recommend using a CK test in the evaluation of each NSCLC patient. The choice between TPA and CYFRA 21-1 can be based on nonclinical factors, such as the laboratory ex...
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PMID: 12907552
PDF is available here.
PDF is available here.
Abstract
Impaired fibrinolysis is considered a sensitive marker of endothelial dysfunction. Persistent endothelial dysfunction occurs in some patients following Kawasaki disease. The aim of the present study was to assess whether impaired fibrinolysis is present in long-term survivors of Kawasaki disease. Th...
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PMID: 12632029
PDF is available here.
PDF is available here.
Oncology Reports (10)2 2003
Abstract
We compared the prognostic value of routine pathology, cytokeratin-positive (CK+) cells in the bone marrow (BM) and serum tumour markers (TM) in patients with non-small cell lung cancer (NSCLC) at the time of diagnosis with regard to overall survival (OS) and time to progression (TTP). Eighty patien...
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PMID: 12579292
PDF is available here.
PDF is available here.
Tumor Biology (24)6 2003
Abstract
These data suggest that a short monitoring with the CEA-TPA-CA15.3 tumour marker panel is an important tool to confirm or exclude metastatic disease in those patients who are suspected to have metastases following common instrumental investigations, and it is particularly important to avoid false po...
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PMID: 15004486
PDF is available here.
PDF is available here.
Anticancer Research (23)2A 2003
Abstract
For superficial bladder cancer the mutation frequency in TP53 was 44.8%. We found elevated TPA levels in 45.5% in serum and 36.1% in urine. For invasive bladder cancer the mutation frequency in TP53 was 79.2%. Elevated TPA levels were found in 57.7% in serum and in 58.3% in urine. TPA has a sensitiv...
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PMID: 12820330
PDF is available here.
PDF is available here.
Anticancer Research (23)1B 2003
Abstract
We have studied three serum markers TPA, Hyaluronan and CA 125 in a limited material (11 patients) with the purpose of finding out if they might reflect treatment effect and/or indicate prognosis. The results in our material show that correspondence between initial TPA levels and survival seems to b...
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PMID: 12680141
PDF is available here.
PDF is available here.
British Journal of Cancer (87)10 2002
Abstract
Several substances mark the course of lung cancer and may reliably help the clinician in decision-making. This is the first clinical study specifically designed to compare tissue polypeptide antigen and CA 125 tumour associated antigen. Three hundred and eighty-four new lung cancer patients (309 mal...
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PMID: 12402150
PDF is available here.
PDF is available here.
Ginekologia polska (73)11 2002
Abstract
Color doppler technique is a useful tool in diagnosis of adnexal masses and has higher sensitivity and specificity compared with measurements of Ca125, TPA levels and single tumor features achieved during transvaginal ultrasound....
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PMID: 12722396
PDF is available here.
PDF is available here.
Hypertension Research (25)6 2002
Abstract
Accumulating data support an association between hypertension and impaired fibrinolytic potential abnormalities in endogenous fibrinolysis. The present study examined whether there was an association between essential hypertension and either a polymorphism in the gene coding for t-PA or the plasma c...
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PMID: 12484521
PDF is available here.
PDF is available here.
Abstract
In patients with ovarian carcinoma, TPS and CA125 concentrations were significantly higher in the place of their generation compared with the concentrations in blood circulation. sIL-2Ralpha values were higher in ascites compared with the values in corresponding sera, and its concentrations in sera...
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PMID: 12404282
PDF is available here.
PDF is available here.
Abstract
We showed a significant elevation of 2 markers about 4 months before death. It seems that establishing of values of Cyfra 21.1 and TPA in the patient's follow up may be useful in recognition of tumour relapse....
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PMID: 12557434
PDF is available here.
PDF is available here.
Abstract
We describe the clinical case of a 76 year old man with chronic hepatitis C infection related to liver disease who had suffered for several months from chronic runny but blood and mucus-free diarrhea, together with progressive weight loss and flushing of the face. Serological tests made on admission...
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PMID: 12355985
PDF is available here.
PDF is available here.
Annals of Oncology (13)9 2002
Abstract
Repeated measurements of CEA, VEGF and bFGF in serum are of limited value in monitoring chemotherapy in ACRC. TPS seems to be of greater interest, but does not predict exactly which patients are going to have a positive outcome of palliative chemotherapy....
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PMID: 12196369
PDF is available here.
PDF is available here.
Abstract
The current study demonstrated that the preoperative serum TPS level was a significant factor in predicting early recurrence of HCC after curative resection. Patients with high serum TPS levels warrant more aggressive treatment and close follow-up after they undergo tumor resection.
Copyright 2002 A...
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PMID: 12115324
PDF is available here.
PDF is available here.
Lung Cancer (36)3 2002
Abstract
With a cut-off value of 3.57 ng/ml, Cyfra 21-1 was an independent prognostic factor for survival in NSCLC-patients with complete resection. Further evaluation is needed, particularly in stage I/II disease. When the prognostic impact is confirmed with larger patient numbers this may contribute to the...
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PMID: 12009236
PDF is available here.
PDF is available here.
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (25)5 2002
Abstract
The serum TPS in patients with lung cancer (273 +/- 172) U/L was significantly higher than the with benign lesions [(115 +/- 97) U/L, P < 0.001]. TPS level was related to clinical TNM stages and histological grades. It was significantly higher with TNM III, IV stages than that with I and II stages (...
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PMID: 12133315
PDF is available here.
PDF is available here.
Orvosi Hetilap (143)12 2002
Abstract
Insulin-like growth factor-1 standard deviation score increased: baseline: -4.1 +/- 0.5; 3 months: -0.3 +/- 0.3; 6 months: 0.7 +/- 0.2; 12 months: -0.2 +/- 0.6, P < 0.001 vs. baseline. The mean value of all tumor markers remained within the normal range and there was no significant increase within t...
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PMID: 11963397
PDF is available here.
PDF is available here.
Pathology International (52)2 2002
Abstract
Esophageal squamous cell carcinoma in situ (SCCIS) with diffuse pagetoid features is a recently recognized rare variant of squamous cell carcinoma. A histopathological study of a specimen from a 70-year-old male Japanese patient is reported. The patient died of respiratory failure due to rapidly pro...
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PMID: 11940220
PDF is available here.
PDF is available here.
Abstract
The positive rates of CK19mRNA, CEA, NSE, and TPA in lung cancer group (49.5%, 65.9%, 67.0%, and 83.5%, respectively) were remarkably higher than in BLD group(24.2%, 9.0%, 15.2%, and 9.0%, respectively) and in healthy control group (10.0%, 4.0%, 8.0%, and 6.0%, respectively) (P < 0.01). The positive...
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PMID: 12479076
PDF is available here.
PDF is available here.
Abstract
In diagnosing uterine cancers, cells and tissue samples can be directly obtained from the lesion. Cytologic and histologic investigation is the best method for screening and early detection of primary uterine cancers. Tumor markers may be useful for monitoring the clinical course of therapy and earl...
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PMID: 11865645
PDF is available here.
PDF is available here.
Hepato-gastroenterology (49)46 2002
Abstract
Preoperative serum CA72-4 level is correlated with staging of disease, but is not an independent predictor for clinical recurrence of disease in patients with gastric cancers that undergo surgery....
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PMID: 12143226
PDF is available here.
PDF is available here.
Anticancer Research (22)3 2002
Abstract
Serum levels of serum tissue polypeptide specific antigen (TPS) were compared with levels of carcinoembryonic antigen (CEA) and CA 15.3 with regards to their clinical values in Chinese breast cancer patients. A total of 81 patients were recruited and followed-up prospectively for disease recurrence...
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PMID: 12168883
PDF is available here.
PDF is available here.