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Peptides (33):
- Tyrothricin
- Peptaibols
- Cholecystokinin
- Protein Sorting Signals
- Polygeline
- Oligopeptides
- Charybdotoxin
- Polylysine
- Polyglutamic Acid
- Myocardial Depressant Factor
- Lipopeptides
- Intercellular Signaling Peptides and Proteins
- Distamycins
- Diazepam Binding Inhibitor
- Aptamers, Peptide
- Antimicrobial Cationic Peptides
- Peptoids
- Peptide Fragments
- Fibrinopeptide B
- Fibrinopeptide A
- Disintegrins
- Salivary Proteins and Peptides
- Phosphopeptides
- Peptide Hormones
- Intracellular Signaling Peptides and Proteins
- Peptide Library
- Neuropeptides
- Edeine
- Proteinase Inhibitory Proteins, Secretory
- Opioid Peptides
- Glycopeptides
- Tissue Polypeptide Antigen
- Peptides, Cyclic
Recent article
Peptides
Abstract
Biologic scaffolds composed of extracellular matrix (ECM) have been used successfully in preclinical models and humans for constructive remodeling of functional, site-appropriate tissue after injury. The mechanisms underlying ECM-mediated constructive remodeling are not completely un...
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PMID: 21563860
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Molecular BioSystems (7)10 2011
Abstract
We report the development of high-throughput assays that quantify the binding of bromodomains to acetylated histone peptides. We have used these assays to screen for histone binding partners of as yet uncharacterized bromodomains, adding to current knowledge of the histone code and expanding the rep...
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PMID: 21804994
PDF is available here.
PDF is available here.
Journal of Proteomics (74)8 2011
Abstract
Membrane proteins are an interesting class of proteins because of their functional importance. Unfortunately their analysis is hampered by low abundance and poor solubility in aqueous media. Since shotgun methods are high-throughput and partly overcome these problems, they are prefer...
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PMID: 21334471
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We investigated the ability of this platform to discriminate between the "sputome" of patients with asthma and chronic obstructive pulmonary disease, and between these groups and those of healthy control subjects. Six m/z peaks emerged as potential diagnostic peptidic patterns able to differentiate...
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PMID: 21751363
PDF is available here.
PDF is available here.
Abstract
The Quantitative Assay Database (QuAD), http://proteome.moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification....
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PMID: 21656910
PDF is available here.
PDF is available here.
Abstract
We describe here the exosome-mediated release of small membrane vesicles containing the stem and cancer stem cell marker prominin-1 (CD133) during haematopoietic cell differentiation. Surprisingly, this contrasts with the budding mechanism underlying the release of this cholesterol-binding protein f...
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PMID: 21591261
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
We report an approach for the fabrication of fully biodegradable self-rolled tubes based on patterned polysuccinimide/polycaprolactone bilayers. These polymers are biocompatible, biodegradable, produced industrially, and are already approved for biomedical purposes. Both polycaprolactone and polysuc...
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PMID: 21524116
PDF is available here.
PDF is available here.
Chemmedchem (6)6 2011
Abstract
We report the design and discovery of a novel APJ antagonist. By using a bivalent ligand approach, we have designed compounds with two 'affinity' motifs and a short series of linker groups with different conformational and non-bonded interaction properties. One of these, cyclo(1-6)CRPRLC-KH-cyclo(9-...
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PMID: 21560248
PDF is available here.
PDF is available here.
Nature Protocols (6)6 2011
Abstract
This protocol provides a detailed procedure for the preparation of stapled α-helical peptides, which have proven their potential as useful molecular probes and as next-generation therapeutics. Two crucial features of this protocol are (i) the construction of peptide substrates conta...
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PMID: 21637196
PDF is available here.
PDF is available here.
Abstract
An effective method for peptide sequencing based on phosphorylation strategy and UPLC-MS/MS is proposed in this report. A phosphorylation reaction was carried out by mixing model peptide solution with phosphorylation solution. UPLC-MS/MS was used to analyze and characterize the phosp...
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PMID: 21482258
PDF is available here.
PDF is available here.
Abstract
We previously prepared a SREB2-overexpressing transgenic mouse for functional analysis but were unable to confirm SREB2 protein expression level by immunochemical or biochemical methods. In this article, we report mass spectrometric identification and relative quantitative analysis of SREB2 in the f...
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PMID: 21395347
PDF is available here.
PDF is available here.
Abstract
We have developed MassWiz, a novel empirical scoring function that gives appropriate weights to major ions, continuity of b-y ions, intensities, and the supporting neutral losses based on the instrument type. We tested MassWiz accuracy on 486,882 spectra from a standard mixture of 18 proteins genera...
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PMID: 21417338
PDF is available here.
PDF is available here.
Abstract
A new method for enhancing peptide ion identification in proteomics analyses using ion mobility data is presented. Ideally, direct comparisons of experimental drift times (t(D)) with a standard mobility database could be used to rank candidate peptide sequence assignments. Such a dat...
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PMID: 21417239
PDF is available here.
PDF is available here.
Abstract
We used an iTRAQ reference data on hepatocellular carcinoma (HCC) to design a two-stage functional analysis pipeline to widen and improve the proteome coverage and, subsequently, to unveil the molecular changes that occur during HCC progression in human tumorous tissue. The first involved functional...
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PMID: 21410269
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Microbodies are novel pharmacophoric entities which are derived from naturally occurring cystine-knot microproteins. They provide extremely stable scaffolds that can be engineered to high-affinity binding proteins. A peptide-grafting approach yielded specific ligands for human thrombopoietin recepto...
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PMID: 19377985
PDF is available here.
PDF is available here.
Integrative Biology (3)4 2011
Abstract
We recently reported that apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor growth and improve survival in a mouse model of ovarian cancer. The current study was designed to examine whether inhibition of angiogenesis is one of the mechanisms for the observed anti-tumorigenic effe...
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PMID: 21283904
PDF is available here.
PDF is available here.
Acta Physiologica (201)4 2011
Abstract
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For ins...
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PMID: 21392266
PDF is available here.
PDF is available here.
Acta Physiologica (201)4 2011
Abstract
Gastrin and cholecystokinin (CCK) are homologous hormone systems known to regulate gastric acid secretion, gallbladder emptying, and cell growth in the pancreas and stomach. They are, however, also involved in the development and secretory functions of pancreatic islet cells. For ins...
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PMID: 21392266
PDF is available here.
PDF is available here.
Abstract
We studied the biological and genetic characteristics of such cells in CRC cell lines and primary tumors. Three CRC cell lines were sorted in CD133 positive and negative fractions. The respective genetic aberration profiles were studied using array comparative genomic hybridization (aCGH) and expres...
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PMID: 21435437
PDF is available here.
PDF is available here.
Abstract
We report several proteins and peptides that exhibit heightened degradation sensitivity, for instance superoxide dismutase in liver, and peptidyl-prolyl cis-trans isomerase and insulin C-peptides in pancreas. Tissue sampling based on snap freezing produces a greater amount of degradation products an...
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PMID: 20110281
PDF is available here.
PDF is available here.
Molecular Therapy (19)3 2011
Abstract
We have used human hematopoietic stem cells (HSCs) to generate anti-HIV gene expressing iPSCs for HIV gene therapy. HSCs were dedifferentiated into continuously growing iPSC lines with four reprogramming factors and a combination anti-HIV lentiviral vector containing a CCR5 short hairpin RNA (shRNA)...
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PMID: 21119622
PDF is available here.
PDF is available here.
Organic Letters (13)3 2011
Abstract
With two β-mercaptoethyl groups on the N, a tertiary amide of structure 1 is always poised for intramolecular thioesterification however it flips about the C-N bond. It is shown that a peptide with such a C-terminal N,N-bis(2-mercaptoethyl)-amide (BMEA) can be used directly for nati...
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PMID: 21175148
PDF is available here.
PDF is available here.
Organic Letters (13)3 2011
Abstract
With two β-mercaptoethyl groups on the N, a tertiary amide of structure 1 is always poised for intramolecular thioesterification however it flips about the C-N bond. It is shown that a peptide with such a C-terminal N,N-bis(2-mercaptoethyl)-amide (BMEA) can be used directly for nati...
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PMID: 21175148
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (22)2 2011
Abstract
These results suggest that the Gal-PHEA-DOX conjugate has great potential for use in hepatocellular carcinoma chemotherapy because of its enhanced antitumor effect with reduced systemic toxicity including hepatotoxicity....
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PMID: 20966743
PDF is available here.
PDF is available here.
Anti-Cancer Drugs (22)2 2011
Abstract
Aberrantly activated signal transducer and activator of transcription 3 (Stat3) protein plays a master regulatory role in the progression and survival of human cancers through the upregulation of target protooncogenes. Numerous human cancers, including breast, ovarian, prostate, leukemia, lymphoma,...
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PMID: 21063201
PDF is available here.
PDF is available here.
Hospital practice (1995) (39)1 2011
Abstract
Aging is characterized by a progressive increase in the prevalence of type 2 diabetes mellitus (T2DM), which approaches 20% by age 70 years. Older patients with T2DM are a very heterogeneous group with multiple comorbidities, an increased risk of hypoglycemia, and a greater susceptib...
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PMID: 21441754
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the effect of exenatide on fat deposition and a metabolic profile in patients with metabolic syndrome.
An uncontrolled, open clinical study was carried out in 10 patients with metabolic syndrome and without pharmacological treatme...
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PMID: 20874425
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)2 2011
Abstract
An attractive strategy for bone tissue engineering is the use of extracellular matrix (ECM) analogous biomaterials capable of governing biological response based on synthetic cell-ECM interactions. In this study, peptide amphiphiles (PAs) were investigated as an ECM-mimicking biomate...
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PMID: 20728586
PDF is available here.
PDF is available here.
Abstract
CD133(+) cells in glioblastoma (GBM) display cancer stem cell-like properties and have been considered as the culprit of tumor recurrence, justifying exploration of potential therapeutic modalities targeting CD133(+) cancer stem-like cells (CSCs). For photothermolysis studies, GBM-CD...
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PMID: 20620237
PDF is available here.
PDF is available here.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] (Chapter 11) 2011
Abstract
Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented: one uses pyroglutamate aminopeptidase for N(α)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(α)-ac...
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PMID: 21400688
PDF is available here.
PDF is available here.
Abstract
Clinical Science (120)2 2011
Abstract
The aim of the present study was to test the effect of sitagliptin and exendin-4 upon metabolic alterations, β-cell mass decrease and hepatic steatosis induced by F (fructose) in rats. Normal adult male Wistar rats received a standard commercial diet without (C) or with 10% (w/v) F in the drinking...
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PMID: 20795946
PDF is available here.
PDF is available here.
Abstract
Botulinum type A toxin (BoNT/A) is defined by its specific endopeptidase cleavage of SNAP25 between Gln(197) and Arg(198) under reducing conditions. The neurotoxin is widely used for therapeutic or cosmetic purposes, but should not contain other toxin serotypes or unwanted protease activities. Using...
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PMID: 20832960
PDF is available here.
PDF is available here.
Abstract
We have used cytochrome c and model peptides to view adduction profiles of quinone-thioether metabolites, and have determined by MALDI-TOF analysis that these electrophiles target specific residues within these model systems....
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PMID: 20972761
PDF is available here.
PDF is available here.
Abstract
We describe the capacity of mouse embryonic stem cells (mESCs) to differentiate into osteoblast-like cells in a three-dimensional (3D) self-assembling peptide scaffold, a synthetic nanofiber biomaterial with future applications in regenerative medicine. We have previously demonstrated that classical...
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PMID: 21042996
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that acute blockade of the insulin responsive facilitative glucose transporter GLUT4 precipitates acute decompensated heart failure in mice with advanced dilated cardiomyopathy. Our current objective was to determine whether pharmacologic enhancement of insulin sensitivity...
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PMID: 21359201
PDF is available here.
PDF is available here.
Abstract
We experimentally assay-binding affinities for a variety of mutants and determine their relative free energy of binding, ΔΔG, to rank the importance of interface residues to binding. We then compare how accurately, precisely and reliably computational methods for calculating ΔΔG can replicate th...
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PMID: 20656696
PDF is available here.
PDF is available here.
Abstract
We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Multifunctional analysis of HBV-specific T cells during acute and chronic HBV infection revealed that H...
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PMID: 21876747
PDF is available here.
PDF is available here.
Abstract
Self-assembling peptide hydrogels were modified to deliver transforming growth factor β1 (TGF-β1) to encapsulated bone-marrow-derived stromal cells (BMSCs) for cartilage tissue engineering applications using two different approaches: (i) biotin-streptavidin tethering; (ii) adsorpti...
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PMID: 20672992
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Current cardiovascular therapies are limited by the loss of endothelium, restenosis and thrombosis. The goal of this study was to develop a biomimetic hybrid nanomatrix that combined the unique properties of electrospun polycaprolactone (ePCL) nanofibers with self-assembled peptide a...
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PMID: 20728588
PDF is available here.
PDF is available here.
Abstract
We discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis...
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PMID: 21048428
PDF is available here.
PDF is available here.
Abstract
We evaluated the putative neurorigenerative properties of RADA16-4G-BMHP1 SAP, proved to enhance in vitro neural stem cells survival and differentiation. This SAP (RADA16-I) has been functionalized with a bone marrow homing motif (BMHP1) and optimized via the insertion of a 4-glycine-spacer that ame...
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PMID: 21611127
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated that conventional dendritic cells (cDC) from 9-month-old animals exhibit sub-optimal response to E. cuniculi infection, suggesting that age associated immune senescence begins earlier than expected. We focused this study on how age affects plasmacytoid DC (pDC) function. M...
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PMID: 21695169
PDF is available here.
PDF is available here.
Abstract
We implemented an LC-MS/MS-based strategy to characterize the rat vocal fold mucosa proteome. Our sample preparation protocol successfully solubilized both proteins and certain high M(r) glycoconjugates and resulted in the identification of hundreds of mucosal proteins. A straightforward approach to...
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PMID: 21423617
PDF is available here.
PDF is available here.
Abstract
We have previously shown that transgenic (tg) mice that have been created to overexpress bovine FcRn (bFcRn) demonstrate increased half-life of mouse IgG, significantly increased antigen-specific IgG in serum and augmented expansion of antigen-specific B cells and plasma cells after immunization. On...
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PMID: 21239891
PDF is available here.
PDF is available here.
Abstract
We considered the possibility that this interaction involves a motif of the gp120 that may be structurally homologous to the chemokines. In the amino acid sequences of most chemokines there is a Trp residue located at the beginning of the C-terminal α-helix, which is separated by six residues from...
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PMID: 21264298
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
Our results provide evidence that the mAb D32.10 recognizes E1E2 envelope complexes expressed in the cell cytoplasm and on the surface of HCV RNA-containing particles released from short-term cultures of in vivo infected hepatocytes.
Copyright © 2010 S. Karger AG, Basel....
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PMID: 20689310
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We characterize the conformational changes in BAK and MCL-1 using detergents to mimic the membrane environment and study their interaction by in vitro pulldown experiments, size exclusion chromatography, titration calorimetry, and NMR spectroscopy. The nonionic detergent IGEPAL has little impact on...
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PMID: 21036904
PDF is available here.
PDF is available here.
Biochemical Journal (433)2 2010
Abstract
We identified 12 interacting proteins, including extracellular matrix proteins and proteins involved in collagen biosynthesis. Eleven interactions were confirmed by surface plasmon resonance and/or co-immunoprecipitation: α1(I)- and α2(I)-collagen chains, α1(VI)-, α2(VI)- and α3(VI)-collagen ch...
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PMID: 20979576
PDF is available here.
PDF is available here.
Abstract
We extended the study to the interaction of the peptide with circulating blood cells, by using the dipole potential sensitive probe di-8-ANEPPS. Sifuvirtide decreased the dipole potential of erythrocyte and lymphocyte membranes in a concentration dependent manner, demonstrating its interaction. Also...
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PMID: 21075080
PDF is available here.
PDF is available here.
Abstract
Abstract
We report here a designer self-assembling peptide nanofiber scaffold developed specifically for nerve tissue engineering. We synthesized a peptide FGL-RADA containing FGL (EVYVVAENQQGKSKA), the motif of neural cell adhesion molecule (NCAM), and then attended to make a FGL nanofiber scaffold (FGL-NS)...
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PMID: 20878982
PDF is available here.
PDF is available here.
Abstract
A wide range of 5-substituted thiazoles are easily accessible via cross coupling of thiazolyl triflates. These activated thiazoles can be obtained by Ugi reactions using thioacids (thio-Ugi-reaction) and subsequent cyclisation of the endo thiopeptides formed with triflic anhydride. In addition, cycl...
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PMID: 20927467
PDF is available here.
PDF is available here.
Abstract
A disruptive interaction of phosphoserine with tryptophan in peptides that autonomously fold into a β-hairpin structure in aqueous solution was explored in a positional context within the hairpin structure. All the peptides presented here have a serine or phosphoserine directly cross strand from a...
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PMID: 20856979
PDF is available here.
PDF is available here.
Abstract
β-Lactam peptides were envisioned as conformational constraints in antigenic peptides (APs). Three different β-lactam tripeptides of varying flexibility were prepared in solution and incorporated in place of the central part of the altered melanoma associated antigenic peptide Leu(27)-Melan-A(26-3...
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PMID: 20927455
PDF is available here.
PDF is available here.
Organic Letters (12)23 2010
Abstract
The first total synthesis of symplostatin 4, a marine cyanobacterium-derived natural product, is described. Notable features of the route include the efficient preparation of three key fragments and final assembly to the natural product via sequential imide and amide couplings. Sympl...
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PMID: 21049908
PDF is available here.
PDF is available here.
Abstract
We sought to develop an active method to increase the circulation half-life of proteins by binding to erythrocytes in blood. Screening a naive phage-displayed peptide library against whole mouse erythrocytes yielded a 12 amino acid peptide (ERY1) that binds the erythrocyte surface with high specific...
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PMID: 20831257
PDF is available here.
PDF is available here.
Abstract
We report that Treg promotes such neuroprotection by an even broader range of mechanisms than previously seen including inhibition of virus release, killing infected MP, and inducing phenotypic cell switches. Changes in individual Treg-induced macrophage proteins were quantified by iTRAQ labeling fo...
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PMID: 20954747
PDF is available here.
PDF is available here.
Abstract
The human Ether-à-go-go Related Gene (hERG) potassium channel mediates the rapid delayed rectifier current (IKr) in the cardiac action potential. Mutations in the 135 amino acid residue N-terminal domain (NTD) cause channel dysfunction or mis-translocation. To study the structure of NTD, it was ove...
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PMID: 21055387
PDF is available here.
PDF is available here.
Abstract
We have designed several peptidomimetics to inhibit HER2-mediated signaling for cell growth. One of the compounds (HERP5, Arg-beta Naph-Phe) exhibited antiproliferative activity with IC(50) values in the micromolar-to-nanomolar range in breast cancer cell lines. Binding of fluorescently labeled HERP...
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PMID: 20919746
PDF is available here.
PDF is available here.