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Amyloid (0):
Recent article
Amyloid
Abstract
Atherosclerotic vascular disease, diabetes mellitus (DM) and dementia are major global health problems. Both endogenous and exogenous factors activate genes functioning in biological processes. This review article focuses on gene-activation mechanisms that regress atherosclerosis, el...
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PMID: 21568932
PDF is available here.
PDF is available here.
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Abstract
In the cell, protein folding into stable globular conformations is in competition with aggregation into non-functional and usually toxic structures, since the biophysical properties that promote folding also tend to favor intermolecular contacts, leading to the formation of β-sheet-...
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PMID: 21538897
PDF is available here.
PDF is available here.
Abstract
We combine the accelerated sampling properties of replica exchange molecular dynamics simulations based on the OPEP coarse-grained potential with the atomic resolution description of interactions provided by all-atom MD simulations, and investigate the oligomerization process of the GNNQQNY for thre...
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PMID: 21625573
PDF is available here.
PDF is available here.
Molecular Cell (41)2 2011
Abstract
We use ΔN6, a truncation variant of the naturally amyloidogenic protein β(2)-microglobulin (β(2)m), to determine the solution structure of a nonnative amyloidogenic intermediate at high resolution. The structure of ΔN6 reveals a major repacking of the hydrophobic core to accommodate the nonnativ...
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PMID: 21255727
PDF is available here.
PDF is available here.
Abstract
Type 2 diabetes mellitus is a chronic hyperglycaemic disorder caused by defective action and secretion of insulin. It is characterized by a progressive decline in pancreatic β-cell function and mass and the occurrence of insoluble amyloid deposits within the islets of Langerhans. Th...
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PMID: 21266844
PDF is available here.
PDF is available here.
Abstract
We extended these studies in the presence of human SP. PAP-derived peptides were agitated to form SEVI and incubated in the presence or absence of SP. While PAP-derived peptides and SEVI alone were proviral, the presence of 1% SP ablated their proviral activity in several different anti-HIV-1 assays...
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PMID: 21283773
PDF is available here.
PDF is available here.
Abstract
We identified the effects of mutation on the structure and dynamics of the amyloidogenic peptide apoC-II(60-70), in monomeric and oligomeric states. Methionine (Met60) substitutions to hydrophilic Gln, hydrophobic Val, and methionine sulfoxide residues were investigated and the results compared with...
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PMID: 20938536
PDF is available here.
PDF is available here.
Abstract
We describe here how conformational preferences of non-polar amino acid residues can affect amyloid formation. The most non-polar residues promote either β-strands (Val, Ile, Phe, and Cys, VIFC) or α-helices (Leu, Ala, and Met, LAM), while the most polar residues promote only α-helices. For 12 pr...
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PMID: 20971069
PDF is available here.
PDF is available here.
Abstract
We show that fibrillogenesis of a cleavage variant of β2m, ΔK58-β2m, which can be found in the circulation of hemodialysis patients and is able to fibrillate at near-physiological pH in vitro, is affected by the presence of copper ions and heparan sulfate. It is found that the fibrils generated w...
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PMID: 20939999
PDF is available here.
PDF is available here.
Abstract
We have recently reported that mutant Notch3 shows a greater propensity to form aggregates, and these aggregates resist degradation, leading to accumulation in the endoplasmic reticulum (ER). In this study, we searched for low-molecular compounds that decrease the amount of mutant Notch3 aggregates....
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PMID: 20888320
PDF is available here.
PDF is available here.
Chemical Communications (46)38 2010
Abstract
The controlled reversal of supramolecular helical chirality in protein fibrils is reported for the first time. Normal or reversed insulin fibrils were grown by precise adjustment of pH. AFM images show two polymorphs corresponding to opposite senses of helical twist of the supramolecular structure w...
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PMID: 20820535
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)42 2010
Abstract
We utilize amide hydrogen exchange measurements to probe the organization of the peptide in its fibrillar form. We determined the extent of hydrogen exchange first by tandem proteolysis, liquid chromatography, and mass spectrometry (HXMS) and then by exchange-quenched NMR. Although single amide reso...
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PMID: 20679344
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)10 2010
Abstract
Our group demonstrated that amyloid formation by amyloid β-protein (Aβ) was facilitated by gangliosides in lipid raft-like model membranes. Phosphatidylserine and phosphatidylglycerol were also reported to trigger fibril formation by human islet amyloid polypeptide (hIAPP). However, it is not veri...
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PMID: 20930481
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (152)36 2010
Abstract
Abstract
We report an unusual case of a 76-year-old woman with primary cutaneous amyloidosis who initially presented with features of asteatotic eczema that was unresponsive to topical corticosteroid treatment. Histological examination revealed amyloid deposits involving the superficial and deep dermis. Thes...
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PMID: 20938601
PDF is available here.
PDF is available here.
Abstract
Under favorable conditions, many proteins can assemble into macroscopically large aggregates such as the amyloid fibrils that are associated with Alzheimer's, Parkinson's, and other neurological and systemic diseases. The overall process of protein aggregation is characterized by initial lag time du...
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PMID: 20602358
PDF is available here.
PDF is available here.
Abstract
Our previous work showed that Abeta undergoes alpha-helix/beta-sheet intermediate structures during the conformational transition, and an Abeta aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivativ...
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PMID: 20684593
PDF is available here.
PDF is available here.
Regulatory Peptides (163)1-3 2010
Abstract
We present a new perspective on the roles of Abeta42 in Cu(II)-mediated oxidative stress and add new evidence to the viewpoint that Abeta42 oligomer may be primarily responsible for the pathogenesis of AD.
Copyright (c) 2010 Elsevier B.V. All rights reserved....
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PMID: 20478342
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We previously generated a toxic mutant of the nontoxic HET-s((218-289)) amyloid in yeast. Here we report that toxic and nontoxic amyloids differ not only in their structures but also in their assembling process. We used multiple and complementary methods to investigate the intermediates formed by th...
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PMID: 20713008
PDF is available here.
PDF is available here.
Abstract
We evaluated the active core sequences using B133 deletion peptides. B133a, lacking the N-terminal Asp residue, promoted cell spreading via integrin alpha2beta1, whereas B133g, lacking the C-terminal Glu residue, lost the activity. Congo red analysis using the truncated peptides determined that B133...
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PMID: 20452326
PDF is available here.
PDF is available here.
Abstract
We present a site-specific MAS NMR analysis of fibrils formed by the full-length beta(2)m protein and compare spectra of fibrils prepared under two different conditions. Specifically, long straight (LS) fibrils are formed at pH 2.5, while a very different morphology denoted as worm-like (WL) fibrils...
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PMID: 20662519
PDF is available here.
PDF is available here.
Abstract
We have identified a monomer with the low plasma values of CRP and its bulk (this is a pentamere) with its high plasma values....
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PMID: 20891039
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to examine correlations of the islet-specific microRNA-375 expression to islet amyloid formation and pancreatic islet damage in human type 2 diabetes.
Autopsy pancreas samples from 40 type 2 diabetic and 15 nondiabetic patients were used to detect microRNA-375 expression us...
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PMID: 20467341
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
We investigated the relationship between IAPP expression and glucose homeostasis in pancreatectomized patients. Human pancreatic head tissues were collected from 46 pancreatic tumor patients. We divided the diabetic cases into two groups, patients with higher IAPP-expressing islets (DM-H) and patien...
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PMID: 20421596
PDF is available here.
PDF is available here.
Abstract
Familial amyloidotic polyneuropathy (FAP) is strictly associated with point mutations of transthyretin (TTR) protein. The Tyr116-->Ser (Y116S) mutant TTR is an important amyloidogenic variant responsible for FAP. Structural dynamics of monomeric TR and its mutant (Y116S) may give some clue relating...
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PMID: 21174946
PDF is available here.
PDF is available here.
Abstract
Amyloid fibrils from 3 subjects who died without having received a liver transplant were composed of 60%-65% variant TTR and 35%-40% wild-type. Amyloid fibrils from a subject who died 5 years after liver transplantation contained 25% variant and 75% wild-type TTR. CONCLUSION: Ratios of variant to wi...
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PMID: 20660862
PDF is available here.
PDF is available here.
Abstract
We show that phosphorylation and glycosylation can affect folding and aggregation kinetics differently. Incorporation of phosphoserines, regardless of their quantity and position, turned out to be most efficient in preventing amyloid formation, whereas O-glycosylation has a more subtle effect. The i...
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PMID: 20491120
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu. METHODS. Primary RPE cell cultures were established from human donor...
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PMID: 20207970
PDF is available here.
PDF is available here.
Journal of Fluorescence (20)4 2010
Abstract
The spectroscopic properties of 2-[4'-(dimethylamino)phenyl]-benzothiazole (BTA-2) in solution and in the presence of amyloid fibrils were investigated using absorption and fluorescence spectroscopy. Solution studies show that BTA-2 forms micelles in aqueous solutions, but that the dye can be solvat...
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PMID: 20204681
PDF is available here.
PDF is available here.
Abstract
Biochimica et Biophysica Acta (1804)7 2010
Abstract
We identified oxidative modification of the 10th cysteine of TTR through S-sulfonation in vitro. Based on mass spectrometric analysis, we determined the spectrophotometric, western blotting, and fluorescent microscopic properties of TTR incubated with and without cysteine-S-sulfonate in acidic (pH 4...
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PMID: 20388560
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1804)7 2010
Abstract
We review recent progress in the understanding of ThT-fibril interactions at an atomic resolution. These studies have yielded important insights into amyloid structures and the processes of fibril formation, and they also offer guidance for designing the next generation of amyloid assembly diagnosti...
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PMID: 20399286
PDF is available here.
PDF is available here.
Abstract
We previously found primary human astrocytes and microglia able to bind and ingest A beta 1-42 in vitro, which appeared to be limited by A beta 1-42 fibril formation. We now confirm that astrocytic A beta-uptake depends on size and/or composition of A beta-aggregates as astrocytes preferably take up...
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PMID: 20544859
PDF is available here.
PDF is available here.
Abstract
Our NMR studies showed that residues with high average area buried upon folding (AABUF) parameter collapsed to form the clusters. Interestingly, the hydrophobic collapses were not stabilized by long-range tertiary interactions among the clusters that were typically observed in non-amyloidogenic unfo...
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PMID: 20438713
PDF is available here.
PDF is available here.
Physical Review Letters (104)22 2010
Abstract
We develop a kinetic picture of protein conversion from a soluble to a fibrillar state which shows that a single free energy barrier to aggregation controls the addition of protein molecules into amyloid fibrils, while the characteristic sublinear concentration dependence emerges as a natural conseq...
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PMID: 20873942
PDF is available here.
PDF is available here.
Molecular Microbiology (76)6 2010
Abstract
Self-perpetuating amyloid-based protein isoforms (prions) transmit neurodegenerative diseases in mammals and phenotypic traits in yeast. Although mechanisms that control species specificity of prion transmission are poorly understood, studies of closely related orthologues of yeast prion protein Sup...
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PMID: 20444092
PDF is available here.
PDF is available here.
Abstract
The inhibition of fibril formation of amyloid beta proteins (A beta) would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). Dopamine (DA) and other catechol derivatives were used as inhibitory factors for A beta fibril formation. The fibril formation of A beta was mon...
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PMID: 20471605
PDF is available here.
PDF is available here.
Biophysical Chemistry (149)1-2 2010
Abstract
We present the results of MD simulations that provide the atomistic details of the process, by which the small molecules may destabilize the ordered amyloid oligomers formed by the model hexapeptide. We select a heptapeptide fragment (GNNQQNY) from Sup-35 yeast prion protein, which is capable to for...
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PMID: 20456856
PDF is available here.
PDF is available here.
Abstract
Amyloid consists of cross-beta-sheet fibrils and is associated with about 25 human diseases, including several neurodegenerative diseases, systemic and localized amyloidoses and type II diabetes mellitus. Amyloid-forming proteins differ in structures and sequences, and it is to a large extent unknow...
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PMID: 20494101
PDF is available here.
PDF is available here.
Chemical Communications (46)18 2010
Abstract
A strategy has been demonstrated that utilizes a phosphatase as a natural tool for the triggering and control of amyloid formation in a coiled coil peptide model under conditions that closely approximate a physiological environment.
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PMID: 20424744
PDF is available here.
PDF is available here.
Neuroscience Letters (475)2 2010
Abstract
We evidenced that Caesalpinia crista leaf aqueous extract has anti-amyloidogenic potential. The studies on pharmacological properties of C. crista are very limited. Our study focused on ability of C. crista leaf aqueous extract on the prevention of (i) the formation of oligomers and aggregates from...
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PMID: 20356566
PDF is available here.
PDF is available here.
Abstract
We have investigated the earliest steps of assembly by the folding nucleus of the Alzheimer's disease Abeta peptide with real-time imaging and fluorescence correlation spectroscopy. These analyses reveal the immediate formation of large micrometer size clusters maintaining properties of intermolecul...
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PMID: 20397724
PDF is available here.
PDF is available here.
Abstract
We previously reported that amyloidogenic light chain protein AL-09 adopts an altered dimer while its germline protein (kappaI O18/O8) forms a canonical dimer observed in other light chain crystal structures. In solution, conformational heterogeneity obscures all NMR signals at the AL-09 and kappaI...
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PMID: 20462490
PDF is available here.
PDF is available here.
Neurotoxicity Research (17)4 2010
Abstract
We evaluated the effects of a new tacrine-melatonin hybrid on behavior and the biochemical and neuropathologic changes observed in amyloid precursor protein/presenilin 1 (APP/Ps1) transgenic mice. Our findings showed that direct intracerebral administration of this hybrid decreased amyloid beta pept...
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PMID: 19774434
PDF is available here.
PDF is available here.
Abstract
Our results highlight an emerging trend in structural biology showing that amyloid, historically associated with disease, also has functional roles....
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PMID: 20170114
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
We received 285 renal amyloid samples, of which 31 remained unclassified. In an effort to determine whether any of the latter samples were LECT2 related, tandem mass spectrometry was performed. In all, 7 of the 31 cases were identified as an amyloid LECT2 (ALECT2), a finding confirmed immunohistoche...
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PMID: 20182418
PDF is available here.
PDF is available here.
Abstract
Adding pramlintide on a background of basal insulin improved some aspects of treatment satisfaction and quality of life relative to adding rapid-acting insulin analogs....
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PMID: 20199136
PDF is available here.
PDF is available here.
Abstract
GLP-1 exerts its effect on gastric emptying, appetite, food intake, and glucagon secretion directly, although secretion of amylin may contribute to some of these effects in healthy control subjects....
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PMID: 20194711
PDF is available here.
PDF is available here.