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Aprotinin (0):
Recent article
Aprotinin
Abstract
We examined the effects of ASL volume expansion on ENaC activity in primary human bronchial epithelial (HBE) cell cultures. We found that ENaC activity increases dramatically after rapid dilution of endogenous ASL. Approximately 35% of the increase in Na(+) absorption was attributable to activation...
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PMID: 20097829
PDF is available here.
PDF is available here.
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Anesthesiology (113)6 2010
Abstract
We investigated (1) whether SevoPC is strengthened by multiple preconditioning cycles, (2) whether SevoPC is blocked by aprotinin, and (3) whether endothelial NOS plays a crucial role in SevoPC.
Anesthetized male Wistar rats were randomized to 15 groups (each n = 6) and underwent 25-min regional myo...
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PMID: 21068666
PDF is available here.
PDF is available here.
Abstract
We examined two fundamental processes in protein dynamics--protein folding and conformational change within the folded state--by means of extremely long all-atom MD simulations conducted on a special-purpose machine. Equilibrium simulations of a WW protein domain captured multiple folding and unfold...
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PMID: 20947758
PDF is available here.
PDF is available here.
Abstract
We hypothesized that treatment with aprotinin or inhaled nitric oxide after brain death would improve the donor inflammatory response and reduce lung reperfusion injury after transplantation.
Brain death was induced in 24 rats by intracranial balloon inflation. Subsequently, the animals received int...
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PMID: 20615728
PDF is available here.
PDF is available here.
Chinese Medical Journal (123)15 2010
Abstract
The over increase of sympathetic drive in chronic heart failure (CHF) is with main responsibility for the deterioration and mortality of the disease. Myocardial (123)I-metaiodobenzylganidine (MIBG) scintigraphy is a non-invasive convenient method to assess sympathetic dysfunction in patients with CH...
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PMID: 20819536
PDF is available here.
PDF is available here.
Biological Chemistry (391)7 2010
Abstract
We recently demonstrated that tissue kallikrein (TK) promotes keratinocyte migration through activation of protease-activated receptor-1 (PAR(1)) and transactivation of the epi-dermal growth factor receptor (EGFR). In this study, we investigated the potential role of PAR(1) in mediating the effect o...
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PMID: 20482314
PDF is available here.
PDF is available here.
Abstract
These data suggest aprotinin is not associated with increased mortality or dialysis in children undergoing congenital heart operations and that further evaluation of aprotinin in this population could be undertaken without undue risk.
Copyright 2010 The Society of Thoracic Surgeons. Published by Els...
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PMID: 20609740
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)1 2010
Abstract
In this experimental model of stroke occurring during CPB, aprotinin decreased the systemic inflammatory response to CPB. Although there was no difference in the cerebral infarct volume, there was a small improvement in the short-term functional neurologic outcome in the aprotinin group....
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PMID: 20519424
PDF is available here.
PDF is available here.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia (16)1 2010
Abstract
In a randomized controlled trial of sealing with a sheet-type collagen vs. a combined approach of fixing a collagen sponge, using fibrin glue for closure of air leaks, the use of Integran, a sheet-type absorbable topical collagen hemostat, is feasible to prevent pulmonary fistula after lung surgery....
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PMID: 20190704
PDF is available here.
PDF is available here.
Abstract
After cardiopulmonary bypass (CPB), elaboration of cytokines, and subsequent induction of interstitial proteases, such as matrix metalloproteinases (MMPs), can result in a complex postoperative course. The serine protease inhibitor, aprotinin, which has been used in congenital heart surgery putativel...
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PMID: 20494037
PDF is available here.
PDF is available here.
Abstract
Therapeutic concentrations of aprotinin dose-dependently inhibited plasmin's proteolytic activity, stimulated osteoblast proliferation, and inhibited osteoblast differentiation and matrix mineralization. Aprotinin inhibition of osteoblast differentiation and matrix mineralization could be recovered...
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PMID: 20407341
PDF is available here.
PDF is available here.
Abstract
The newly established breast cancer cell line G3S1, derived from EM-G3 breast cancer progenitors, was analyzed for functional changes related to neoplastic progression manifested by elevated invasiveness and enhanced capability to degrade gelatin. Degradation of gelatin and invasiveness of G3S1 cell...
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PMID: 20198326
PDF is available here.
PDF is available here.
Journal of Trauma (68)4 2010
Abstract
Time to hemostasis when using TachoSil compared with TachoComb was increased 14% (-13% to 48%) with heparin and 10% (-26% to 66%) without heparin (mean +/- 95% confidence interval; p > 0.05 in both). Time to hemostasis with heparin administration increased significantly in both treatments: TachoComb...
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PMID: 20386279
PDF is available here.
PDF is available here.
Abstract
Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy ()3 2010
Abstract
The efficacy of preparation "Tachocomb" application in 224 children, ageing from 1 day to 18 years old, was studied up. The spectrum of the preparation studying had included the investigation of its properties, which secure an additional isolation for the intestinal and vascular walls defects, and h...
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PMID: 20491260
PDF is available here.
PDF is available here.
Abstract
The aprotinin group had significantly less intraoperative blood loss (1114 +/- 992 mL; P < 0.01) than the tranexamic acid and control group (2102 +/- 1076 mL and 2260 +/- 1580 mL, respectively). The aprotinin group received significantly less blood (577 +/- 806 mL; P < 0.002) during the surgical pro...
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PMID: 20081519
PDF is available here.
PDF is available here.
Abstract
For indirect estimates, we identified 49 trials involving 182 deaths among 7439 participants. The summary relative risk (RR) for death with aprotinin versus placebo was 0.93 (95% confidence interval [CI] 0.69-1.25). In the 19 trials that included tranexamic acid, there were 24 deaths among 1802 part...
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PMID: 19050037
PDF is available here.
PDF is available here.
Abstract
The groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the Aprotinin Group. The drug had no benefit regarding time of mechanical pulmonary ventilation, permanence in the pediatric postoperative intensive care unit (ICU) and length of hospital...
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PMID: 20305926
PDF is available here.
PDF is available here.
Abstract
Preoperative characteristics, length of ICU and hospital stay were similar between the mostly medium-risk aprotinin and the control patients. Postoperative cardiac, renal, neurological, and respiratory complications and hospital mortality occurred with comparable frequencies in both groups. Levels o...
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PMID: 20013617
PDF is available here.
PDF is available here.
Abstract
Recent clinical trials have led to the worldwide suspension of aprotinin, the most commonly used antifibrinolytic agent in fibrin-based tissue engineering. For future clinical applications of fibrin-based scaffolds, a suitable, alternative fibrinolysis inhibitor must be identified. T...
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PMID: 19496679
PDF is available here.
PDF is available here.
Foot & Ankle International (30)11 2009
Abstract
Abstract
The groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the Aprotinin Group. The drug presented no benefit regarding time of mechanical pulmonary ventilation, stay in the postoperative intensive care unit and hospital, or regarding the use of...
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PMID: 20011886
PDF is available here.
PDF is available here.
Biomaterials (30)22 2009
Abstract
We investigated fibrin-mediated gene transfer by embedding pDNA within the hydrogel during polymerization and using two modes of gene transfection with cells placed either on the surface (2D transfection) or within the hydrogel (3D transfection). Using this model, we found that cell transfection dep...
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PMID: 19395019
PDF is available here.
PDF is available here.
Abstract
Growth and development are two major aspects of children not readily apparent in adults. Clearance in the pediatric population should be investigated using models that describe size, maturation and organ function influences. Glucuronide conjugation (hepatic phase II process) mirrors glomerular filtr...
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PMID: 19593898
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We investigated the published data on aprotinin's effect on acute phase protein and cytokine levels in cardiac surgery patients. Randomized placebo-controlled trials of aprotinin published between 1985 and 2007, in adult cardiac surgery using cardiopulmonary bypass, reporting tumor necrosis factor-a...
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PMID: 19681304
PDF is available here.
PDF is available here.
Abstract
We evaluate the effect of topical application of aprotinin to the heart, pericardia and mediastinum before sternal closure, on early post operative bleeding, blood transfusion requirement and ICU staying time after coronary artery bypass graft surgeries. In a randomized double blinded clinical trial...
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PMID: 19806814
PDF is available here.
PDF is available here.
Abstract
We showed that KPI-containing forms of AbetaPP regulates cerebral thrombosis in vivo (Xu et al., 2005, 2007). Amyloid precursor like protein-2 (APLP2), a closely related homolog to AbetaPP, also possesses a highly conserved KPI domain. Virtually nothing is known of its function. Here, we show that A...
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PMID: 19403832
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to evaluate the role of proteases on the degradation of parathyroid hormone (PTH) in blood samples.
Protease inhibitors with specificity against serine proteases (aprotinin), cysteine proteases (E-64), serine and cysteine proteases (leu...
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PMID: 19411775
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (101)4 2009
Abstract
We analysed changes in coagulation during normal pregnancy with a novel point-of-care device based on thrombelastometry (ROTEM). We compared the results obtained with those of standard coagulation tests in 104 patients: 20 non-pregnant women (controls) and 84 women in the first (T1, n = 17), second...
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PMID: 19350122
PDF is available here.
PDF is available here.
The Journal of Chemical Physics (130)12 2009
Abstract
We determined the collective vibrational modes in the frequency domain, which were identified by their vibrational frequencies and eigenvectors. At near zero temperature, the vibrational modes determined by MFDA agreed well with those calculated by normal mode analysis. At 300 K, the vibrational mod...
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PMID: 19334805
PDF is available here.
PDF is available here.
Abstract
There is no evidence that suggests that, compared with aprotinin, alternative antifibrinolytics such as tranexamic acid were less effective in reducing blood loss in major pediatric surgery....
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PMID: 19188875
PDF is available here.
PDF is available here.
Abstract
Aprotinin has been associated with increased renal failure and mortality when used in cardiac surgery. The purpose of this retrospective study was to compare the incidence of renal failure and mortality in our patient population to the published rates, accounting for risk factors associated with ren...
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PMID: 19654159
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Aprotinin reduces cerebral leukocyte activation and accelerates neurologic recovery in a dose-dependent fashion. Aprotinin has no measurable impact on standard indices of renal function in young piglets. The current lack of availability of aprotinin is a serious disadvantage for pediatric patients u...
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PMID: 19654152
PDF is available here.
PDF is available here.
Abstract
Antifibrinolytic therapy is effective in reducing postoperative bleeding and allogeneic transfusion in patients undergoing cardiac surgery with cardiopulmonary bypass. Aprotinin is a bovine serine protease inhibitor which potently inhibits plasmin, and two lysine analogues, epsilon-aminocaproic acid...
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PMID: 19306629
PDF is available here.
PDF is available here.
Abstract
Foreign surface pacification may significantly reduce the detrimental effects of the cardiopulmonary bypass (CPB) circuit. To date, albumin is the only intervention consistently shown to be beneficial. The cationic physical properties of aprotinin and the known negative charge on the plastic CPB cir...
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PMID: 19361025
PDF is available here.
PDF is available here.
Abstract
Aprotinin decreased blood loss. After accounting for covariate effects, there was a significant comparative benefit with aprotinin in postoperative survival. This finding was unexpected and could not be considered conclusive because of the small size of the current study. A confirmatory study may be...
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PMID: 19130460
PDF is available here.
PDF is available here.
Abstract
Abstract
The initial studies of Karkouti and Mangano provoked a considerable number of large-scale investigations focusing on the safety issues of aprotinin. These studies were of retrospective nature and used sophisticated statistical methods to overcome a possible selection bias. Recently, aprotinin was pr...
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PMID: 19295302
PDF is available here.
PDF is available here.
Plant Cell Reports (28)2 2009
Abstract
The inhibitory activity of bovine pancreatic trypsin inhibitor (aprotinin), a natural polypeptide and a proteinase inhibitor, was demonstrated on gut proteinases of three lepidopteran borers of sugarcane using commercially available aprotinin. A synthetic gene coding for aprotinin, designed and codo...
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PMID: 18985354
PDF is available here.
PDF is available here.
European Journal of Pharmacology (602)2-3 2009
Abstract
We have seen that aprotinin inhibits proteolysis of pleiotrophin by plasmin, the aim of the present study was to evaluate the possible role of pleiotrophin in the effects of aprotinin on angiogenesis and human endothelial cell migration. Our data demonstrate that aprotinin, in a concentration-depend...
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PMID: 19059395
PDF is available here.
PDF is available here.
Abstract
Abstract
The natural way: A sensitive NMR spectroscopic method is developed to obtain well-resolved two-dimensional spectra ((15)N-(1)H and (13)C-(1)H) for natural-abundance (that is, without the need for isotopic enrichment) large-molecule samples, such as biopharmaceuticals. This method gives structural in...
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PMID: 19130513
PDF is available here.
PDF is available here.
Abstract
The Cochrane report restricted the analysis to RCTs, but the largest study should not have been included given that it was a prospective observational study with 1,784 patients rather than an RCT. None of the RCTs had sufficient statistical power to detect differences in mortality. Most studies had...
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PMID: 19228407
PDF is available here.
PDF is available here.
Abstract
Assessment of the effect of treatment with aprotinin-containing drug on the clinical status of the periodontal tissue and on the concentrations of metalloproteinases released in the course of periodontitis (MMP-1, MMP-2) as well as their tissue inhibitors (TIMP-1 and TIMP-2) in the s...
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PMID: 19758971
PDF is available here.
PDF is available here.
Abstract
We have engaged in comparing some of these production systems with respect to their performance: protein yield and quality. Using a specific tester protein (aprotinin), it was shown that functional aprotinin can be manufactured in plants in substantial amounts, as illustrated in this chapter....
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PMID: 19183901
PDF is available here.
PDF is available here.
Abstract
We therefore investigated the influence of aprotinin on the osseous ingrowth of a titanium-implant in a rat model. Forty female Sprague-Dawley rats underwent unilateral retrograde nailing of the femur. Animals were divided in two groups, one receiving i.v. aprotinin intraoperatively, the other group...
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PMID: 18270722
PDF is available here.
PDF is available here.
Abstract
Anesthesiology (110)1 2009
Abstract
With its high affinity for plasmin (Ki, 2 nM), CU-2010 inhibited fibrinolysis comparable to aprotinin (Ki, 4 nM) and was ten times more potent than tranexamic acid. CU-2010 also inhibited plasma kallikrein (Ki < 1 nM) and factors Xa (Ki, 45 nM) and XIa (Ki, 18nM), which was reflected in prolongation...
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PMID: 19104179
PDF is available here.
PDF is available here.
Abstract
European Spine Journal (17)12 2008
Abstract
We had 14 patients in the aprotinin group and 17 in the control group. Total blood loss in the aprotinin group was significantly lower compared to the control group (715 vs. 2,110 ml; P = 0.007). Significantly less blood loss occurred in the aprotinin group when blood loss per kilogram was evaluated...
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PMID: 18820953
PDF is available here.
PDF is available here.
Abstract
These results indicate that Brownian dynamics simulations can be useful for investigating structural features of proteins that have some mutants, such as drug-metabolizing enzymes....
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PMID: 19043196
PDF is available here.
PDF is available here.
Abstract
We focus to avoid any transfusion (allogeneic and autologous blood). Therefore the most important techniques used are pharmacological: erythropoietin before surgery with a number of injections related to baseline Hb, and tranexamic acid during and after surgery. Cell saving is used only if bleeding...
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PMID: 18930421
PDF is available here.
PDF is available here.
Abstract
Aprotinin is a polypeptide serine protease inhibitor used to prevent bleeding and need for transfusions in patients having heart surgery. A recent analysis of an observational study data set suggested the use of aprotinin was associated with an increased risk of developing renal failure. The present...
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PMID: 18983214
PDF is available here.
PDF is available here.
The Lancet (372)9649 2008
Abstract
Journal of Molecular Biology (382)4 2008
Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
Abstract
The disulfide bond between Cys14 and Cys38 of bovine pancreatic trypsin inhibitor lies on the surface of the inhibitor and forms part of the protease-binding region. The functional properties of three variants lacking this disulfide, with one or both of the Cys residues replaced with Ser, were exami...
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PMID: 18692070
PDF is available here.
PDF is available here.
Abstract
We report the high-resolution crystal structures of an extensively simplified variant of bovine pancreatic trypsin inhibitor containing 20 alanines (BPTI-20st) and a reference single-disulfide-bonded variant (BPTI-[5,55]st) at, respectively, 1.39 and 1.09 A resolutions. The sequence was simplified b...
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PMID: 18829434
PDF is available here.
PDF is available here.