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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Bacterial Capsules (0):
Recent article
Bacterial Capsules
Cell Host & Microbe (9)3 2011
Abstract
We have determined that Gat201 controls the mRNA levels of ∼1100 genes (16% of the genome) and binds the upstream regions of ∼130 genes. Seven Gat201-bound genes encode for putative and known transcription factors--including two previously implicated in virulence--suggesting an extensive regulat...
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PMID: 21402362
PDF is available here.
PDF is available here.
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Abstract
We found that a systemic strain of C. jejuni, isolated from the cerebrospinal fluid of an infant with meningitis, is relatively more resistant to human serum, the Bactericidal/Permeability-Increasing Protein (BPI), an endogenous cationic antimicrobial protein, and the cationic peptide antibiotic pol...
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PMID: 21266840
PDF is available here.
PDF is available here.
Innate Immunity (16)5 2010
Abstract
We demonstrate that macrophages and dendritic cells (DCs), the most prevalent professional antigen-presenting cells involved in the formation of abscesses, secrete Interleukin (IL)-6 and are incorporated in the abscess capsule. Sp1 inhibits apoptosis of CD4+ T-cells and causes IL-17 expression by CD...
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PMID: 19897529
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Abstract
The capsular polysaccharide (CPS) of Streptococcus suis serotype 2 was isolated, purified, chemically modified, and characterized. Sugar and absolute configuration analyses of the CPS gave the following composition: D-Gal, 3; D-Glc, 1; D-GlcNAc, 1; D-Neu5Ac, 1; L-Rha, 1. Sialic acid was found to be...
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PMID: 20555393
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)12 2010
Abstract
We further demonstrated that Fur exerts its regulatory activity by binding directly to the promoter. As a result, the fur deletion mutant exhibited an increase in colony mucoidy, CPS production, and virulence in mice. In summary, our results suggested that RmpA activates CPS biosynthesis in K. pneum...
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PMID: 20382770
PDF is available here.
PDF is available here.
Biochemistry (New York) (75)5 2010
Abstract
Antigenic differences were revealed between the cell wall outer membrane lipopolysaccharides and the capsular high molecular weight bioglycans for a typical strain of the nitrogen-fixing rhizobacterium Azospirillum lipoferum Sp59b using antibodies prepared against the homologous lipopolysaccharide a...
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PMID: 20632940
PDF is available here.
PDF is available here.
Microbiology (156)Pt 5 2010
Abstract
We examined the effect of modulating capD expression on B. anthracis capsule phenotype, interaction with phagocytic cells and virulence in guinea pigs. Transcriptional fusions of capD were made to the genes encoding heat-shock protein 60 (hsp60) and elongation factor Tu (EFTu), and to capA, a B. ant...
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PMID: 20110296
PDF is available here.
PDF is available here.
New England Journal of Medicine (362)16 2010
Abstract
Der Urologe (49)5 2010
Abstract
In contrast to many commensal bacteria, uropathogens are equipped with many virulence-associated factors that facilitate infection of different areas of the urinary tract. Different extra- and intracellular bacterial lifestyles result in acute or recurrent urinary tract infection. Adhesins promote a...
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PMID: 20411372
PDF is available here.
PDF is available here.
Abstract
We reported that a wbpP gene mutation in Vibrio vulnificus was significantly impaired in its ability to synthesize surface capsular polysaccharide (CPS). In this study, we evaluated the functions of the V. vulnificus capsular polysaccharide on interleukin (IL)-8 production, as well as its underlying...
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PMID: 20198307
PDF is available here.
PDF is available here.
Journal of Immunology (184)7 2010
Abstract
Our findings lead to a model in which oxidation of carbohydrates from encapsulated microbes facilitates adaptive immune responses against microbial protein and carbohydrate Ags through promoting Ag processing for MHC II-mediated presentation as well as innate responses against released microbial DNA...
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PMID: 20200279
PDF is available here.
PDF is available here.
Abstract
We analysed 125 NT Hi isolates collected from individual patients with either invasive disease (70 isolates) or respiratory tract infections (55 isolates). Serotype-specific and capsular transport genes were absent by PCR analysis, confirming their nonencapsulated status, which also suggested the NT...
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PMID: 20041949
PDF is available here.
PDF is available here.
Abstract
A multiplex PCR assay for the identification of serotypes Ia to IX of Streptococcus agalactiae was developed. By using a single PCR reaction containing a mix of 19 primers the assay identified each serotype by the analysis of the unique two or three bands pattern on agarose gel.
Copyright 2009 Else...
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PMID: 19958797
PDF is available here.
PDF is available here.
Abstract
The production of industrially relevant microbial polysaccharides has recently gained much interest. The capsular polysaccharide of Escherichia coli K4 is almost identical to chondroitin, a commercially valuable biopolymer that is so far obtained from animal tissues entailing complex...
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PMID: 19795118
PDF is available here.
PDF is available here.
Microbiology (156)Pt 2 2010
Abstract
We now report the discovery of two naturally occurring pneumococcal isolates from Korea that have the serological, genetic and biochemical features predicted for serotype 6D....
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PMID: 19942663
PDF is available here.
PDF is available here.
Infection and Immunity (78)2 2010
Abstract
We synthesized both beta-(1-->6)-d-glucosamine (GlcNH(2)) and beta-(1-->6)-d-N-acetylglucosamine (GlcNAc) oligosaccharides with linkers on the reducing termini that could be activated to produce sulfhydryl groups for conjugation to bromoacetyl groups introduced onto carrier proteins. Synthetic 5-mer...
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PMID: 19948836
PDF is available here.
PDF is available here.
Infection and Immunity (78)2 2010
Abstract
We have confirmed that the capsule has several effects on complement activity. The capsule impaired bacterial opsonization with C3b/iC3b by both the alternative and classical complement pathways and also inhibited conversion of C3b bound to the bacterial surface to iC3b. There was increased binding...
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PMID: 19948837
PDF is available here.
PDF is available here.
Infection and Immunity (78)2 2010
Abstract
We have therefore used capsular serotype-switched TIGR4 mutant strains to investigate the effects of the capsular serotype on S. pneumoniae interactions with complement. Flow cytometry assays demonstrated large differences in C3b/iC3b deposition on opaque-phase variants of TIGR4(-)+4, +6A, +7F, and...
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PMID: 19948838
PDF is available here.
PDF is available here.
Abstract
Individuals who do not have a spleen are highly susceptible to severe infections. The purpose of this article was to present vaccination guidelines for prophylactic treatment of sepsis following splenectomy. Nursing considerations for the prevention of sepsis after splenectomy are discussed.
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PMID: 20160541
PDF is available here.
PDF is available here.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells...
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PMID: 19858261
PDF is available here.
PDF is available here.
Abstract
Global challenges of Haemophilus vaccinations quarter of a century after the Hib project In 2000, 8.13 million children contracted invasive Haemophilus infection globally, 0.37 million of which died. These were unnecessary disease cases and deaths that would have been preventable with the Hib vaccin...
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PMID: 20593628
PDF is available here.
PDF is available here.
Abstract
In this study, an unencapsulated Streptococcus suis mutant was used to investigate the pleiotropic effects resulting from capsule loss. The capsule deficient mutant of S. suis acquired a biofilm-positive phenotype, which was associated with significantly increased cell surface hydrophobicity. Cell-a...
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PMID: 20357962
PDF is available here.
PDF is available here.
Abstract
The effect of several cultivation conditions on the kinetics of bacterial growth and polysaccharide production of Streptococcus pneumoniae serotype 14 was studied. The presence in the supernatant of serotype-specific CPS (capsular polysaccharide) during growth was followed by size-exclusion HPLC and...
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PMID: 19891609
PDF is available here.
PDF is available here.
Abstract
We present data on AGID and IELISA tests using the B. ovis antigen, RSAT and IELISA using the B. canis antigen and IELISA using the B. abortus RB51 antigen. The cut-off values were adjusted by the ROC analysis; the IELISA-B. ovis cut-off value was 23 (%P) and the IELISA-B. abortus RB51, 24 (%P), wit...
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PMID: 20461292
PDF is available here.
PDF is available here.
Abstract
Modern data on metabolism of hyaluronic acid by bacteria from Streptococcus genus are presented. Several species of bacteria forming capsule from hyaluronic acid, which is analogous to glycosaminoglycan of vertebrates, are considered. Different aspects of hyaluronic acid synthesis are described: bio...
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PMID: 21061584
PDF is available here.
PDF is available here.
Abstract
Infection and Immunity (78)1 2010
Abstract
We characterized the innate immune response elicited by PGA in the human monocytic cell line THP-1, which was differentiated into macrophages with phorbol 12-myristate 13-acetate (PMA) and human monocyte-derived dendritic cells (hMoDCs). PGA capsules were isolated from the culture supernatant of eit...
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PMID: 19737897
PDF is available here.
PDF is available here.
Infection and Immunity (78)1 2010
Abstract
We investigated the response of immature human monocyte-derived DCs to bacterial challenge with a wild-type strain and its isogenic mutants deficient in CPS or LPS O-antigen production. As observed by flow cytometry and confocal laser microscopy, the rate of phagocytosis was inversely proportional t...
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PMID: 19841082
PDF is available here.
PDF is available here.
Infection and Immunity (78)1 2010
Abstract
We have investigated interactions with complement for several S. pneumoniae strains in which the gene encoding PspC has been deleted. The degree of FH binding varied between strains and was entirely dependent on PspC for seven strains. Data obtained with TIGR4 strains expressing different capsular s...
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PMID: 19884335
PDF is available here.
PDF is available here.
Abstract
We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKlin...
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PMID: 19893995
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Response surface methodology (RSM) examining the effects of five-level-three-factors and their mutual interactions was utilized to optimize the fermentation conditions to enhance capsular polysaccharide (CPS) production of Streptococcus pneumoniae type 3. Twenty experiments conducted in an 8-l lab-s...
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PMID: 19996690
PDF is available here.
PDF is available here.
Abstract
We suggest that the above methods can be useful in specific identification of virulent B. anthracis in clinical and environmental samples....
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PMID: 19996704
PDF is available here.
PDF is available here.
Eukaryotic Cell (8)9 2009
Abstract
We report the use of fluorescent membrane tracers to stain lipophilic structures in cryptococcal culture supernatants and capsules. Two dialkylcarbocyanine probes with different spectral characteristics were used to visualize purified vesicles by fluorescence microscopy and flow cytometry. Dual stai...
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PMID: 19465562
PDF is available here.
PDF is available here.
Abstract
Streptococcus pneumoniae remains an important pathogen despite licensure of a seven-valent pneumococcal protein conjugate vaccine. As a result, serotyping strains remains of paramount importance to both assess the effectiveness of current vaccines and closely monitor for the emergence of nonvaccine...
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PMID: 19722839
PDF is available here.
PDF is available here.
Pharmacology & Therapeutics (123)3 2009
Abstract
Antiviral microbicides, topical agents that prevent sexually transmitted infections, mainly work by blocking the interaction between viral proteins and cell surface components. In many instances, virus-cell interaction is mediated by cell surface heparan sulfate proteoglycans (HSPGs). HSPGs are expl...
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PMID: 19447134
PDF is available here.
PDF is available here.
Abstract
Military Medicine (174)6 2009
Abstract
Burkholderia pseudomallei and mallei are biological agents of military significance. There has been significant research in recent years to develop medical countermeasures for these organisms. This review summarizes work which details aspects of the pathogenesis of B. pseudomallei and mallei and dis...
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PMID: 19585782
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (199)11 2009
Abstract
No significant differences were observed regarding the abilities of the mutant and the wild-type CFT073 strains to colonize the murine urinary tract in single-challenge infection experiments. However, in competitive-colonization experiments, the mutant was significantly outcompeted by the wild-type...
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PMID: 19432551
PDF is available here.
PDF is available here.
Abstract
We address the latest taxonomy developments of Sphingomonas, details about structure, characteristics and biosynthetic pathway of sphingans, current knowledge on the molecular genetics and genetic engineering of sphingans. In addition, we indicate future research needs....
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PMID: 19637560
PDF is available here.
PDF is available here.
Encapsulated Staphylococcus aureus strains vary in adhesiveness assessed by atomic force microscopy.
Abstract
Staphylococcus aureus capsular polysaccharides are believed to play a role in adhesion to surfaces and may contribute to their antimicrobial resistance, thereby increasing the rates and severity of associated infections. The purpose of this study was to compare the adhesiveness of distinct S. aureus...
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PMID: 18431772
PDF is available here.
PDF is available here.
Abstract
Syntheses of two oligosaccharides as methyl glycosides related to the repeating unit of S. enteritidis capsular polysaccharide (CPS) are presented. The trisaccharide corresponds to the backbone of the CPS whereas the tetrasaccharide is a model for the repeating unit which has a branched structure. M...
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PMID: 19343247
PDF is available here.
PDF is available here.
Infection and Immunity (77)4 2009
Abstract
We investigated the in vitro opsonophagocytic activities of three PPS-specific mouse immunoglobulin G1 monoclonal antibodies (MAbs), 1E2, 5F6, and 7A9, and determined their in vivo efficacies against intranasal challenge with WU2, a serotype 3 pneumococcal strain, in normal and immunodeficient mice....
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PMID: 19168739
PDF is available here.
PDF is available here.
Abstract
In this study, concomitant administration of PRV with hexavalent vaccine was well tolerated and the immune responses to the antigens of the hexavalent vaccine were noninferior when compared with those of the control group. In addition, PRV was immunogenic when administered concomitantly with hexaval...
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PMID: 19209092
PDF is available here.
PDF is available here.
Abstract
We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome. Tissue cultures simultaneously showed colonies with high hemolysis (HH) and low hemolysis (LH). Conversely, the HH and LH variants exhibited low ca...
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PMID: 19193266
PDF is available here.
PDF is available here.
Genetika (Moskva) (45)2 2009
Abstract
Comparison of Pseudomonas putida group of phages attributed to five species (af, phi15, phi27, phi2F, and pf16) with their common property of halo-formation (formation of lightening zones) around phage plaques was conducted. The halo around phage plaques appears as a result of reduction or disappear...
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PMID: 19334612
PDF is available here.
PDF is available here.
Journal of Immunology (182)2 2009
Abstract
We engineered an attenuated Salmonella Typhi strain to express and export the F1 Ag of Y. pestis (S. Typhi(F1)) and investigated its immunogenicity early in life using a heterologous prime-boost regimen. Newborn mice primed intranasally with a single dose of S. Typhi(F1) elicited mucosal Ab- and IFN...
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PMID: 19124765
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (15)3 2009
Abstract
We recommend Hib vaccination be included in the Iranian national programme of immunization....
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PMID: 19731770
PDF is available here.
PDF is available here.
BMC Microbiology (9)1 2009
Abstract
The interaction between Klebsiella pneumoniae and cultured airway epithelial cells was analysed. K. pneumoniae infection triggered cytotoxicity, evident by cell rounding and detachment from the substrate. This effect required the presence of live bacteria and of capsule polysaccharide, since it was...
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PMID: 19650888
PDF is available here.
PDF is available here.
Abstract
The Haemophilus influenzae type b (Hib) conjugate vaccine has been administered for almost 20 years in developed countries with remarkable success. More recently, the vaccine has been introduced in resource-poor settings, mainly those in Africa. African countries have documented large declines in Hi...
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PMID: 19093776
PDF is available here.
PDF is available here.
Abstract
rHSP70 modified immune response to chemically conjugated and unconjugated CPSHib. rHSP70 enhanced expression of TLRs 2, 4, 9 on mice splenocytes; increased levels of CD3+, CD8+, NK, CD3/NK (NKT) lymphocytes. Levels of CD4+, CD25+ (markers of early activation of T-helpers) as well as MHC class II mol...
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PMID: 20095431
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (58)Pt 1 2009
Abstract
Vibrio cholerae, the causative agent of cholera, has the ability to grow and survive in the aquatic free-living amoeba Acanthamoeba castellanii. The aim of the present study was to examine the ability of the clinical isolate V. cholerae O139 MO10 to grow in A. castellanii and to determine the effect...
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PMID: 19074664
PDF is available here.
PDF is available here.
Infection and Immunity (77)1 2009
Abstract
We examined the cellular uptake and organelle localization of PGA in the murine macrophage-like cell line J774.2. We found that PGA binds to and is internalized by J774.2 cells and accumulates in CD71 transferrin receptor-positive endosomes. The receptor-mediated endocytosis inhibitors amantadine an...
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PMID: 19001075
PDF is available here.
PDF is available here.
Infection and Immunity (77)1 2009
Abstract
We found that monoclonal antibody (MAb) to type 3 capsule increases complement C3, C1q, and C4 deposition on WU2 and enhanced the immune adherence of WU2 to erythrocytes. The MAb to type 3 capsule also enhanced the transfer of WU2 from erythrocytes to macrophages. Moreover, the transfer reaction was...
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PMID: 19001076
PDF is available here.
PDF is available here.