Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Flagellin (0):
Recent article
Flagellin
Abstract
Previously, a modified HIV Env protein with a heterologous membrane anchor was found to be incorporated into HIV virus-like particles (VLPs) at 10-fold-higher levels than those of unmodified Env. To further improve the immunogenicity of such VLPs, membrane-anchored forms of bacterial...
|
PMID: 21325038
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Irish breeder and intensive broiler flocks together with the corresponding poultry farm environment were sampled for the presence of Campylobacter with the aim of identifying potential sources and transmission routes of poultry flock contamination. The genetic diversity of a subset o...
|
PMID: 21039133
PDF is available here.
PDF is available here.
Abstract
Study of the ability of Western Siberian Borrelia garinii 20047 isolate recombinant protein FlaA to react with sera antibodies of ixodes tick borreliosis patients.
Recombinant antigen FlaA, sera of ixodes tick borreliosis patients, genetic engineering methods, solid p...
|
PMID: 21913395
PDF is available here.
PDF is available here.
Abstract
We employed the use of hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) in a focused metabolomic study of sugar-nucleotides relevant to the biosynthesis of highly novel carbohydrate modifications on the flagellin of Campylobacter sp. We exploited the unique selectivity of t...
|
PMID: 19882128
PDF is available here.
PDF is available here.
Abstract
Evidence exists of a link between chronic infection by Salmonella typhi (S. typhi) and the development of gallbladder cancer (GBC), but several studies from endemic regions contradict its role in the etiopathogenesis of GBC. This study used various tools to assess the prevalence of S. typhi in patie...
|
PMID: 20943463
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
Pseudomonas aeruginosa is a prevalent opportunistic human pathogen that, like other Gram-negative pathogens, secretes outer membrane vesicles. Vesicles are complex entities composed of a subset of envelope lipid and protein components that have been observed to interact with and be internalized by h...
|
PMID: 20605984
PDF is available here.
PDF is available here.
Biofouling (26)6 2010
Abstract
The antifoulant, zosteric acid, was synthesized using a non-patented process. Zosteric acid at 500 mg l(-1) caused a reduction of bacterial (Escherichia coli, Bacillus cereus) and fungal (Aspergillus niger, Penicillium citrinum) coverage by 90% and 57%, respectively. Calculated models allowed its an...
|
PMID: 20711895
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (59)Pt 8 2010
Abstract
Our data provide strong evidence that S. maltophilia flagellin stimulates innate immunity in mouse lung....
|
PMID: 20488935
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We evaluated the effect of the TLR5 ligand flagellin on stimulation of antibacterial mucosal immunity in a lethal murine Pseudomonas aeruginosa pneumonia model. The intranasal pretreatment of mice with purified P. aeruginosa flagellin induced strong protection against intratracheal P. aeruginosa-ind...
|
PMID: 20566829
PDF is available here.
PDF is available here.
Plant Physiology (153)3 2010
Abstract
We provide evidence here that T3SS effector-based suppression does not appear to be sufficient to overcome FLS2-based immunity during Pst DC3000 infection, but that the phytotoxin coronatine (COR) produced by Pst DC3000 also plays a critical role. COR-deficient mutants of Pst DC3000 are severely red...
|
PMID: 20457804
PDF is available here.
PDF is available here.
Infection and Immunity (78)7 2010
Abstract
We investigated the hypothesis that flagellin acts in conjunction with Shiga toxin to augment this chemokine expression. We investigated the relative contributions of nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling to transcription and translation of interleuk...
|
PMID: 20439475
PDF is available here.
PDF is available here.
Abstract
We show that the integral membrane protein FlhA from the gram-positive bacterium Bacillus subtilis acts as an adaptor for late export substrates at the T3SS. The major filament protein (flagellin) and the filament-cap protein (FliD) bind to the FlhA cytoplasmic domain (FlhA-C) only in complex with t...
|
PMID: 20534509
PDF is available here.
PDF is available here.
Abstract
We show that stimulation of innate pathways by microbiota-derived ligands and antigen-specific T cell stimulation are both required for intestinal inflammation. Microbiota-derived ligands promoted spontaneous T cell proliferation by activating dendritic cells (DCs) to produce IL-6 via Myd88, as show...
|
PMID: 20498021
PDF is available here.
PDF is available here.
Pediatrics (125)6 2010
Abstract
A total of 394 records were identified. We excluded 90 records on the basis of age of >21 years, previous diagnosis of IBD, or unclear diagnosis. The prevalence of IBD in this cohort was 38%. The sensitivity, specificity, positive predictive value, negative predictive value, and kappa value for the...
|
PMID: 20439597
PDF is available here.
PDF is available here.
Microbiology (156)Pt 6 2010
Abstract
We describe the regulatory roles of VisN, VisR and Rem in the expression of flagellar, motility and chemotaxis genes in Rhizobium leguminosarum biovar viciae strains VF39SM and 3841. Individual mutations in the genes encoding these proteins resulted in a loss of motility and an absence of flagella,...
|
PMID: 20203055
PDF is available here.
PDF is available here.
Abstract
We used Tn5 transposon mutagenesis to identify genes that may affect PB resistance in P. mirabilis. Two genes, ugd and galU, which may encode UDP-glucose dehydrogenase (Ugd) and UDP-glucose pyrophosphorylase (GalU), respectively, were identified. Knockout mutants of ugd and galU were found to be ext...
|
PMID: 20160049
PDF is available here.
PDF is available here.
Abstract
The main aims of this study were to clone and express flagellin flaA gene from Vibrio alginolyticus strain HY9901, also to prepare mouse anti-FlaA polyclonal antibody for future pathogen or vaccine study.
The full-length flaA gene was amplified by PCR with designed pr...
|
PMID: 19951364
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that the 26-47 segment of Salmonella enterica serovar Typhimurium flagellin is capable of mediating flagellar export. In order to reveal whether other parts of the N-terminal region have any significant influence on secretion, a series of plasmids were constructed containing the...
|
PMID: 20008166
PDF is available here.
PDF is available here.
Infection and Immunity (78)2 2010
Abstract
We compared immunization with flagella and that with flagellin for in vitro effects on motility, opsonic killing, and protective efficacy using a mouse pneumonia model. Antibodies to flagella were superior to antibodies to flagellin at inhibiting motility, promoting opsonic killing, and mediating pr...
|
PMID: 19995892
PDF is available here.
PDF is available here.
Abstract
In the last years, many efforts have been directed toward the enhancement of vaccine delivery by using polymeric nanoparticles as adjuvants for mucosal immunization. However, conventional nanoparticles usually display a low capability to target specific sites within the gut and, thus, the elicited i...
|
PMID: 20515831
PDF is available here.
PDF is available here.
Abstract
We hypothesized that Muc1 would influence in vitro generation and primary DC activation in response to the TLR4 and TLR5 ligands lipopolysaccharide and flagellin. Compared with Muc1(+/+) DC, we found that Muc1(-/-) DC were constitutively activated, as determined by higher expression of co-stimulator...
|
PMID: 20375631
PDF is available here.
PDF is available here.
Abstract
TLR-1-6 stimulation produced higher concentrations of proinflammatory cytokines (IL-1beta, IL-6, and IL-8) in cord blood compared to adult blood, with the exception of TLR-4-stimulated TNF-alpha production, which was significantly lower in cord blood (319 pg/ml) compared to adult blood (645 pg/ml; p...
|
PMID: 19955831
PDF is available here.
PDF is available here.
Abstract
We propose that flagellar class II genes are controlled by FleQ and RpoN, whereas the transcription of the class III gene fliA is controlled in a FleQ-dependent but RpoN-independent manner. However, RpoN and FleR might influence flagellin synthesis on a posttranscriptional level. In contrast to the...
|
PMID: 19915024
PDF is available here.
PDF is available here.
Abstract
We identified the receptor-like cytoplasmic kinase BIK1 that is rapidly phosphorylated upon flagellin perception, depending on both FLS2 and BAK1. BIK1 associates with FLS2 and BAK1 in vivo and in vitro. BIK1 is phosphorylated by BAK1, and BIK1 also directly phosphorylates BAK1 and FLS2 in vitro. Th...
|
PMID: 20018686
PDF is available here.
PDF is available here.
Abstract
Our project involved the cloning of the immunodominant regions of the RSV F, M2 and G proteins into a bacterial vector, pET-32a (+). The recombinant RFM2G protein was expressed in Escherichia coli and purified using His Bind columns. The purified rRFM2G protein was analyzed by polyacrylamide gel ele...
|
PMID: 20608172
PDF is available here.
PDF is available here.
Abstract
Burkholderia pseudomallei, a gram-negative bacterium that causes melioidosis, was reported to produce biofilm. As the disease causes high relapse rate when compared to other bacterial infections, it therefore might be due to the reactivation of the biofilm forming bacteria which also...
|
PMID: 20169199
PDF is available here.
PDF is available here.
Abstract
We showed that the hamster Muc1 on Chinese hamster ovary (CHO) cells served as a binding site for Pseudomonas aeruginosa (PA) through interaction between bacterial flagellin and the Muc1 ectodomain. Because CHO cells are known to produce an atypical pattern of protein glycosylation, we determined wh...
|
PMID: 20036855
PDF is available here.
PDF is available here.
Abstract
The highly variable flagellin-encoding flaA gene has long been used for genotyping Campylobacter jejuni and Campylobacter coli. High-resolution melting (HRM) analysis is emerging as an efficient and robust method for discriminating DNA sequence variants. The objective of this study was to apply HRM...
|
PMID: 19933351
PDF is available here.
PDF is available here.
Infection and Immunity (78)1 2010
Abstract
We compared their impacts on macrophages. L. parisiensis and L. tucsonensis do not induce proinflammatory cell death, as measured by lactate dehydrogenase (LDH) release and interleukin-1beta (IL-1beta) secretion. However, flagellin isolated from L. parisiensis and L. tucsonensis triggers cell death...
|
PMID: 19841075
PDF is available here.
PDF is available here.
Abstract
Further investigations on a molecular basis are warranted in order to clarify whether certain C. jejuni flaA types are associated with specific antimicrobial resistance attributes....
|
PMID: 19925037
PDF is available here.
PDF is available here.
Nippon Saikingaku Zasshi (64)2-4 2009
Abstract
Biochemical Journal (423)1 2009
Abstract
These results indicate that epithelial responses to flagellin are potentiated by IFNgamma, most likely mediated by increased MyD88 expression. The present study adds to our understanding of the spectrum of effects of this cytokine on gut epithelium that may contribute to bacterial-driven inflammatio...
|
PMID: 19619129
PDF is available here.
PDF is available here.
Abstract
Our study shows that on more primitive cord blood derived MSCs, the expression of TLRs and ligand-induced triggering differs from that of bone marrow derived MSCs. At the RNA level, cord blood MSCs (unrestricted somatic stem cells; USSCs) express low levels of TLR1,3,5,9 and high levels of TLR4 and...
|
PMID: 20196781
PDF is available here.
PDF is available here.
Biotechnology Letters (31)9 2009
Abstract
Pseudomonas aeruginosa as an opportunistic pathogen causes lethal infections in immunocompromised individuals. This bacterium possesses a polar flagellum made up of flagellin subunits. Flagella have important roles in motility, chemotaxis, and establishment of P. aeruginosa in acute phase of infecti...
|
PMID: 19466558
PDF is available here.
PDF is available here.
Abstract
We investigate the effect of c-di-GMP signalling on virulence phenotypes of S. typhimurium. After saturation of the cell with c-di-GMP by overexpression of a di-guanylate cyclase, we studied invasion and induction of a pro-inflammatory cytokine in epithelial cells, basic phenotypes that are major de...
|
PMID: 19691499
PDF is available here.
PDF is available here.
Abstract
We demonstrate that TLR5 stimulation induces activation of NF-kappaB and reactivate latent HIV-1 in CD4+ T lymphoid cells. Interestingly, we report also that TLR5 engagement leads to virus gene expression in quiescent central memory CD4+ T cells, a cell population recognized as a major reservoir in...
|
PMID: 19447460
PDF is available here.
PDF is available here.
Abstract
Abstract
High hydrostatic pressure (HHP) is a new method used to reduce or eliminate microorganisms that are present in food. Proteins are known to be the most important target of high pressure in living organisms. The main goal of this investigation was focused on the changes that occur on the proteins of B...
|
PMID: 19338277
PDF is available here.
PDF is available here.
Cellular Microbiology (11)4 2009
Abstract
We investigated the ability of 13 E. coli strains isolated from the urine of patients with pyelonephritis and cystitis and normal stools to invade collecting duct cells, which constitute the first epithelium encountered by bacteria ascending from the bladder. The AL511 clinical isolate adhered to mo...
|
PMID: 19134121
PDF is available here.
PDF is available here.
Abstract
Comparative genome indexing (CGI) using whole-genome DNA microarrays was evaluated as a means of genotyping Campylobacter jejuni relative to two standard methods, pulsed-field gel electrophoresis (PFGE) and flaA short variable region sequencing (flaA SVR typing). Thirty-six geographically diverse C....
|
PMID: 19272009
PDF is available here.
PDF is available here.
Abstract
We investigated whether raccoons (Procyon lotor) carried leptospires in their kidneys in Japan. Leptospira was isolated from 2 of 71 raccoons captured in Kanagawa Prefecture and 1 of 53 raccoons at a zoological park in Nagasaki Prefecture. Anti-Leptospira antibodies were detected in 16 of 124 raccoo...
|
PMID: 19420844
PDF is available here.
PDF is available here.
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (27)2 2009
Abstract
To explore the protein profile and identify developmentally regulated proteins of the promastigotes and axenic amastigotes with comparative proteomics technique.
The total proteins of promastigotes and axenic amastigotes of Leishmania donovani SC6 strain were separated by two-dimensional electrophor...
|
PMID: 19856494
PDF is available here.
PDF is available here.
Infection and Immunity (77)4 2009
Abstract
We evaluated new anti-PCM vaccine formulations based on the intranasal administration of P. brasiliensis gp43 or the P10 peptide in combination with the Salmonella enterica FliC flagellin, an innate immunity agonist binding specifically to the Toll-like receptor 5, in a murine model. BALB/c mice imm...
|
PMID: 19204092
PDF is available here.
PDF is available here.
Abstract
The contribution of growth history and flagella to adhesion of Listeria monocytogenes was analysed. An in-frame deletion on the flagellin encoding gene (flaA) was performed in L. monocytogenes EGD-e to compare its adhesion ability with the parental strain, after cultivation at various pH values and...
|
PMID: 19295651
PDF is available here.
PDF is available here.
Abstract
We examined the role of TLR5 and MyD88 in promoting innate and humoral immunity to flagellin using a prime/boost immunization regimen. We observed that eliminating TLR5 greatly reduced flagellin-induced cytokine production, except for IL-18, and ablated DC maturation but did not significantly impact...
|
PMID: 19152336
PDF is available here.
PDF is available here.
BMC Genomics (10)1 2009
Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum.
Abstract
Whole genome microarray analysis revealed that 63% of the coding sequences (CDSs) present in reference strain ATCC 3502 were common to all 61 widely-representative strains of proteolytic C. botulinum and the closely related C. sporogenes tested. This indicates a relatively stable genome. There was,...
|
PMID: 19298644
PDF is available here.
PDF is available here.
BMC Microbiology (9)1 2009
Abstract
We observed that flagellin was consistently and strongly present in the secretome of wild type EPEC and the DeltaespADB mutant but present only weakly in the secretome of the DeltaescF mutant. Given the ancestral relationship between the flagella export apparatus and virulence associated T3SSs, we i...
|
PMID: 19200386
PDF is available here.
PDF is available here.
BMC Microbiology (9) 2009
Abstract
To investigate the mechanism of ROS resistance mediated by ArcAB, we generated deletion mutants of ArcA and ArcB in E. coli. Our results demonstrated that both ArcA and ArcB were necessary for resistance to hydrogen peroxide (H2O2), a type of ROS, and their function in this resistance was independen...
|
PMID: 19715602
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that host defence peptide LL-37 induced cytokine (IL-6) and chemokine (CXCL-1/GRO-alpha and CXCL-8/IL-8) release from human bronchial epithelial cells. It was demonstrated that LL-37-mediated IL-6 release was time and dose dependent and that LL-37 up-regulated this pleiotropic c...
|
PMID: 20375583
PDF is available here.
PDF is available here.
Abstract
The flagellin type III secretion pathway of Bacillus halodurans BhFC01 (Deltahag) was modified by the inactivation of fliD. An in-frame flagellin gene fusion polypeptide construct was expressed, and the heterologous peptides were secreted as flagellin fusion monomers. The stability of the secreted m...
|
PMID: 18997028
PDF is available here.
PDF is available here.
Plant Journal (57)1 2009
Abstract
We identified Arabidopsis suppressor of rps4-RLD 1 (srfr1) mutants with enhanced resistance to the bacterial effector AvrRps4. These mutants were recessive and retained full susceptibility to virulent bacteria, suggesting that SRFR1 functions as a negative regulator and that AvrRps4-triggered immuni...
|
PMID: 18774967
PDF is available here.
PDF is available here.
Journal of Immunology (182)1 2009
Abstract
We examined the ex vivo responsiveness of highly purified human cord blood-derived CD8(+) T cells to direct TLR ligation by a repertoire of TLR agonists. In concert with TCR stimulation, only Pam(3)Cys (palmitoyl-3-Cys-Ser-(Lys)(4)) and flagellin monomers significantly enhanced proliferation, CD25(+...
|
PMID: 19109135
PDF is available here.
PDF is available here.
Abstract
These results suggest that NFKB1 haplotypes induce dysregulation of innate immune responses by altering NF-kappaB expression. The results also show the use of EBV-transformed lymphoblastoid cell lines to conduct phenotypic studies of genetic variation....
|
PMID: 18832525
PDF is available here.
PDF is available here.
Journal of Bacteriology (191)1 2009
Abstract
Recent advances in the field of prokaryotic N-glycosylation have established a foundation for the pathways and proteins involved in this important posttranslational protein modification process. To continue the study of the Methanococcus voltae N-glycosylation pathway, characteristics of known eukar...
|
PMID: 18978056
PDF is available here.
PDF is available here.
Abstract
We hypothesized that flagellin-specific immune responses might activate mast cells that then contribute to the initiation and maintenance of intestinal inflammation. Thirty-two colonic biopsy samples were collected from IBD patients. A flagellin/flagellin-specific IgG/Fc gamma receptor I complex was...
|
PMID: 18974296
PDF is available here.
PDF is available here.
Toxicology In Vitro (22)8 2008
Abstract
There is considerable interest in the development of in vitro methods for the identification of contact sensitizers, including those that use cultured dendritic cells (DC), key players in cutaneous immune responses. Chemical allergens, such as dinitrobenzene sulfonic acid (DNBS), or skin irritants,...
|
PMID: 18848616
PDF is available here.
PDF is available here.
Inflammatory Bowel Diseases (14)12 2008
Abstract
CBir1 induces enhanced peripheral innate and peripheral and mucosal antigen-specific T-cell responses in CD. Consistent with results from the mouse, CBir1 immune activation could play a role in CD....
|
PMID: 18825772
PDF is available here.
PDF is available here.
Journal of Virology (82)23 2008
Abstract
We have designed a membrane-anchored form of the Toll-like receptor 5 ligand flagellin, the major proinflammatory determinant of enteropathogenic Salmonella, which was found to be glycosylated and expressed on cell surfaces. A chimeric influenza virus-like particle (cVLP) vaccine candidate containin...
|
PMID: 18786995
PDF is available here.
PDF is available here.
Infection and Immunity (76)12 2008
Abstract
We hypothesized that V. cholerae flagellins may contribute to IL-8 induction through TLR5 and mitogen-activated protein kinase (MAPK) signaling. Each purified recombinant V. cholerae flagellin induced IL-8 production in T84 intestinal epithelial cells and also induced nuclear factor kappa B (NF-kapp...
|
PMID: 18809662
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)24 2008
Abstract
We conclude that HP0958 is a posttranscriptional regulator that modulates the amount of the flaA message available for translation in H. pylori....
|
PMID: 18931105
PDF is available here.
PDF is available here.