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Penicillin-Binding Proteins (0):
Recent article
Penicillin-Binding Proteins
Abstract
Neisseria gonorrhoeae with mosaic penicillin-binding protein 2 (PBP2) is associated with reduced susceptibility to third-generation oral cephalosporins. A simple and rapid PCR method using three primers was designed to identify mosaic PBP2, which could help predict reduced susceptibility to expanded...
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PMID: 20801168
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We studied the mechanism behind this indispensability. We could construct a viable prsA null mutant in the presence of a high concentration of magnesium. Various changes in cell morphology in the absence of PrsA suggested that PrsA is involved in the biosynthesis of the cylindrical lateral wall. Con...
|
PMID: 20487272
PDF is available here.
PDF is available here.
Journal of Molecular Biology (399)4 2010
Abstract
We have taken advantage of the peptidoglycan synthesis that occurs during sporulation in Bacillus subtilis to examine the interactions between SpoVE, a nonessential, sporulation-specific homolog of the well-conserved and essential SEDS (shape elongation, division, and sporulation) proteins, and SpoV...
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PMID: 20417640
PDF is available here.
PDF is available here.
Microbiology (156)Pt 6 2010
Abstract
We studied its cellular localization. We found that the C-terminally located PASTA (penicillin-binding protein and serine/threonine kinase associated) domains, but not the N-terminal kinase domain of StkP, were located on the surface of live pneumococcal cells grown in vitro and were also accessible...
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PMID: 20223804
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)12 2010
Abstract
We report here that the genomes of Mycobacterium smegmatis and other soil mycobacteria contain an additional gene encoding a third class A penicillin-binding protein, PonA3, which is a paralog of PonA2. Both the PonA2 and PonA3 proteins contain a penicillin-binding protein and serine/threonine prote...
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PMID: 20400545
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to characterize invasive penicillin non-susceptible pneumococci (PNSP) isolated in Denmark from 2001 to 2005, describe the genetic changes in the penicillin-binding proteins (PBPs) and compare the isolates to the international recognized PNSP clones. All isolates were chara...
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PMID: 20121651
PDF is available here.
PDF is available here.
Abstract
We analyzed 118 penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) isolates (MICs, >or=0.12 microg/ml) recovered in Poland in 2003 to 2005 from patients with respiratory tract diseases and invasive infections. Seven different serotypes (14, 9V, 23F, 19F, 6B, 19A, and 6A, in order of descendin...
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PMID: 20194703
PDF is available here.
PDF is available here.
Abstract
We identified amino acid (aa) substitutions in penicillin-binding protein 3 for the BLNAR strains. Of 191 H. influenzae strains isolated from middle ear fluid of pediatric AOM patients between October 2005 and March 2008, BLNAR strains determined by PCR accounted for 49.2%. Of the BLNAR strains, 91....
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PMID: 20087619
PDF is available here.
PDF is available here.
Abstract
Penicillin-binding protein 5 (PBP 5) of Escherichia coli is a membrane-bound cell wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane of this Gram-negative bacterium. Not only is it the most abundant PBP of E. coli, but it is as well a target for penicillins and is the...
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PMID: 20192190
PDF is available here.
PDF is available here.
Abstract
Penicillium chrysogenum Acyl coenzyme A:isopenicillin N acyltransferase (AT) performs the last step in the biosynthesis of hydrophobic penicillins, exchanging the hydrophilic side chain of a precursor for various hydrophobic side chains. Like other N-terminal nucleophile hydrolases AT is produced as...
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PMID: 20223213
PDF is available here.
PDF is available here.
Journal of Molecular Biology (396)3 2010
Abstract
We have determined high-resolution apo crystal structures of two low molecular weight penicillin-binding proteins (PBPs), PBP4 and PBP5, from Haemophilus influenzae, one of the most frequently found pathogens in the upper respiratory tract of children. Novel beta-lactams with notable antimicrobial a...
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PMID: 19958776
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)3 2010
A comprehensive proteomics and transcriptomics analysis of Bacillus subtilis salt stress adaptation.
Abstract
We applied whole-genome microarray technology and metabolic labeling, combined with state-of-the-art proteomic techniques, to provide a global and time-resolved picture of the physiological response of B. subtilis cells exposed to a severe and sudden osmotic upshift. This combined experimental appro...
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PMID: 19948795
PDF is available here.
PDF is available here.
EMBO Journal (29)2 2010
Abstract
We report the identification of a new class of polymer-forming proteins, termed bactofilins, that are widely conserved among bacteria. In Caulobacter crescentus, two bactofilin paralogues cooperate to form a sheet-like structure lining the cytoplasmic membrane in proximity of the stalked cell pole....
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PMID: 19959992
PDF is available here.
PDF is available here.
BMC Microbiology (10) 2010
Abstract
Nine out of the ten putative L. monocytogenes PBP genes were shown to encode proteins that bind derivatives of β-lactam antibiotics, thus enabling their positive identification. PBPD2 (Lmo2812) was not visualized in whole cell extracts, most probably due to its low abundance, but it was shown to bi...
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PMID: 20843347
PDF is available here.
PDF is available here.
Abstract
Beta-lactam antibiotics remain the drugs of choice for treatment of S. pneumoniae infections in spite of growing level of resistance. The formation of S. pneumoniae resistance to these drugs is mediated by modifications of the penicillin-binding proteins (PBPs), the targets of the antibiotic action....
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PMID: 20882772
PDF is available here.
PDF is available here.
Abstract
Antimicrobial susceptibility patterns and beta-lactam resistance mechanisms of 544 Haemophilus influenzae isolates through the nationwide Acute Respiratory Infections Surveillance (ARIS) network in Korea during 2005 and 2006 were determined. Resistance to ampicillin was 58.5%, followed by resistance...
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PMID: 19884366
PDF is available here.
PDF is available here.
Abstract
Eighteen hundred Neisseria gonorrhoeae isolates collected in Sydney, Australia, in 2007 and 2008 were examined for mosaic penA alleles that mediated cephalosporin resistance, and the genotypes of the isolates were evaluated. In 2008, there were substantial increases in numbers (from 15 to 85) and pr...
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PMID: 19917755
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)1 2010
Abstract
We describe the crystal structure, biochemical characteristics, and expression profile of PBP4, a low-molecular-mass PBP from Staphylococcus aureus strain COL. The crystal structures of PBP4-antibiotic complexes reported here were determined by molecular replacement, using the atomic coordinates dep...
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PMID: 19854906
PDF is available here.
PDF is available here.
Abstract
6-Beta-halogenopenicillanates are powerful, irreversible inhibitors of various beta-lactamases and penicillin-binding proteins. Upon acylation of these enzymes, the inhibitors are thought to undergo a structural rearrangement associated with the departure of the iodide and formation of a dihydrothia...
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PMID: 19919161
PDF is available here.
PDF is available here.
Abstract
We report the first X-ray crystal structures of PBP6, capturing its apo state (2.1 A), an acyl-enzyme intermediate with the antibiotic ampicillin (1.8 A), and for the first time for a PBP, a preacylation complex (a "Michaelis complex", determined at 1.8 A) with a peptidoglycan substrate fragment con...
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PMID: 19807181
PDF is available here.
PDF is available here.
Abstract
Penicillin binding proteins (PBPs) are involved in the biosynthesis of the peptidoglycan layer constitutive of the bacterial envelope. They have been targeted for more than half a century by extensively derived molecular scaffolds of penicillins and cephalosporins. Streptococcus pneumoniae resists t...
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PMID: 19746934
PDF is available here.
PDF is available here.
Abstract
I (n=30), type II (n=7), type III (n=1) and type IV (n=1). No TEM gene was detected in all the 44 S. pneumoniae isolates.
The S.pneumoniae isolates from Guangzhou children with respiratory tract infection are resistant to penicillin and erythromycin. Amoxicillin and the third generation cephalospori...
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PMID: 19695184
PDF is available here.
PDF is available here.
Abstract
We isolated 122 strains from the adult respiratory tract in 2007, determined MIC for different antibiotics, and analyzed TEM-1 beta-lactamase resistant genes and ftsI encoding PBP3 mutation compared to results in 2005 and 2007. We found that ABPC-susceptible strains with MIC <1 microg/mL (BLNAS) acc...
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PMID: 19697870
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)12 2009
Abstract
Escherichia coli PBP4 is the archetypal class C, low molecular mass penicillin binding protein (LMM-PBP) and possesses both dd-carboxypeptidase and dd-endopeptidase activity. In contrast to other classes of PBP, class C LMM-PBPs show high dd-carboxypeptidase activity and rapidly hydrolyze synthetic...
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PMID: 19209901
PDF is available here.
PDF is available here.
Molecular Microbiology (71)5 2009
Regulation of cell wall morphogenesis in Bacillus subtilis by recruitment of PBP1 to the MreB helix.
Abstract
We found that inactivation of the major bi-functional penicillin-binding protein (PBP) PBP1 of B. subtilis restored the viability of an mreB null mutant as well as preventing bulging in both mutant and wild-type backgrounds. Bulging was associated with delocalization of PBP1. We show that the normal...
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PMID: 19192185
PDF is available here.
PDF is available here.
Research in Microbiology (160)2 2009
Abstract
We found that transcription of the pbpE gene is induced in stationary phase and by increased salinity. This increase was also corroborated at the translation level for PBP4* by western blot. Furthermore, we showed that a strain harboring gene disruption in the structural gene (pbpE) for the PBP4* en...
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PMID: 19063962
PDF is available here.
PDF is available here.
Abstract
These findings demonstrate that PBP-7/8 contributes to the pathogenesis of A. baumannii. PBP-7/8 either directly or indirectly contributes to the resistance of AB307-0294 to complement-mediated bactericidal activity. An understanding of how PBP-7/8 contributes to serum resistance will lend insight i...
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PMID: 19143563
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (291)2 2009
Abstract
These results support the previous assertion that a threshold core density as well as a high ratio of cortex peptidoglycan relative to the germ cell wall contribute to the formation of a more heat-resistant spore in this species....
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PMID: 19189487
PDF is available here.
PDF is available here.
BMC Genomics (10)1 2009
Abstract
Comparative genomic analysis revealed that the CGSP14 acquired a number of new genes by horizontal gene transfer (HGT), most of which were associated with virulence and antimicrobial resistance and clustered in mobile genetic elements. The most remarkable feature is the acquisition of two conjugativ...
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PMID: 19361343
PDF is available here.
PDF is available here.