Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Antibodies, Anti-Idiotypic (0):
Recent article
Antibodies, Anti-Idiotypic
Abstract
The incidence of life-threatening viral and microbial infections has dramatically increased over recent decades. Despite significant developments in anti-infective chemotherapy, many issues have increasingly narrowed the therapeutic options, making it imperative to discover new effec...
|
PMID: 21806382
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Prescrire international (20)115 2011
Abstract
We concluded that omalizumab had a negative risk-benefit balance in this setting. In mid-2010, we found no new data on the efficacy of omalizumab. At best, omalizumab prevents 1 emergency room visit approximately every 2.5 years. Post-marketing follow-up data confirm the infectious adverse effects a...
|
PMID: 21648207
PDF is available here.
PDF is available here.
Prescrire international (20)115 2011
Abstract
New England Journal of Medicine (364)11 2011
Abstract
We enrolled inner-city children, adolescents, and young adults with persistent asthma in a randomized, double-blind, placebo-controlled, parallel-group trial at multiple centers to assess the effectiveness of omalizumab, as compared with placebo, when added to guidelines-based therapy. The trial was...
|
PMID: 21410369
PDF is available here.
PDF is available here.
Abstract
We review the current evidence of biological agents in patients with severe asthma recently assessed for safety and efficacy. Some of these agents have shown to be useful in specifically targeted subpopulations of patients with severe asthma, whereas others have proven to be unsafe and/or unsuccessf...
|
PMID: 21150434
PDF is available here.
PDF is available here.
Abstract
We were able to determine the cutoff value for the HRT threshold in relation to outcomes of OFCs. The cutoff value was 6 ng/ml of egg white antigen in HEA and REA (p < 0.01), 40 ng/ml of milk antigen in CMA (p < 0.01), and 500 ng/ml of wheat antigen in WA (p < 0.05). The efficiency was 70.3% for HEA...
|
PMID: 21646803
PDF is available here.
PDF is available here.
Protease-Mediated House Dust Mite Allergen-Induced Reactive Oxygen Species Production by Neutrophils
Abstract
We harvested neutrophils isolated from 15 HDM-sensitized asthmatic subjects and 18 HDM-sensitized nonasthmatic subjects and measured the amounts of neutrophil reactive oxygen species (ROS) production in response to the major HDM allergens Der-f and Der-f1. Der-f and Der-f1 significantly increased RO...
|
PMID: 21646804
PDF is available here.
PDF is available here.
Abstract
An important molecular target for metastatic CRC treatment is the epidermal growth factor receptor (EGFR). Many potential biomarkers predictive of response to anti-EGFR monoclonal antibodies (cetuximab and panitumumab) have been retrospectively evaluated, including EGFR activation markers and EGFR l...
|
PMID: 21129611
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
We investigated the clinical relevance of anti-E1E2A,B response in the serum of patients infected with HCV. To this end, an enzyme-linked immunosorbent assay (ELISA) using synthetic E1-, E2A-, and E2B-derived peptides was used. The ELISA was validated in terms of sensitivity, specificity, and test e...
|
PMID: 20890942
PDF is available here.
PDF is available here.
American Naturalist (176)4 2010
Abstract
We measured male and female humoral antibody responses to a novel antigen (bovine gamma globulin), total immunoglobulin G, and the male testosterone level of a laboratory population of the bank vole (Myodes glareolus). Although we studied five traits, factor-analytic modeling of the additive genetic...
|
PMID: 20712516
PDF is available here.
PDF is available here.
Abstract
We demonstrated that MAb 6B6 could inhibit the proliferation of Caco-2 cells that were derived from a human colorectal carcinoma. This functional anti-human CD133 MAb provides a valuable tool for further study of biological functions of cancer stem cell that expressed CD133....
|
PMID: 20715988
PDF is available here.
PDF is available here.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (35)8 2010
Abstract
To compare the in vitro antitumor immune responses induced by bivalent bispecific anti-idiotype antibody G22-I50 and monovalent anti-idiotype antibody G22 and I50, and explore its possible mechanism.
Proteins G22-I50, G22, and I50 were induced and identified by Wester...
|
PMID: 20818068
PDF is available here.
PDF is available here.
Experimental Dermatology (19)8 2010
Abstract
Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous a...
|
PMID: 20653774
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We characterized a novel anti-CD20 chimeric antibody, TGLA, which binds to various B-cell lines specially and shares an epitope with rituximab. TGLA shows equal activities with rituximab, such as CDC, cell growth arrest and so on. Interestingly, TGLA also shows significant ADCC activity. Immunothera...
|
PMID: 20202740
PDF is available here.
PDF is available here.
Vox Sanguinis (99)2 2010
Abstract
IgA deficiency is common (1/500) and up to 40% of affected individuals will develop anti-IgA. A few studies suggested that passive transfusion of anti-IgA was not associated with an increased risk of allergic reactions. This study was designed to assess the safety of transfusing blood components con...
|
PMID: 20345516
PDF is available here.
PDF is available here.
Abstract
These results support the novel concept that Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development BOS. The expression of anti-Hsp27 antibodies found only in the BAL fluid suggests a local response occurring at the level of the alveoli and terminal airways....
|
PMID: 20456980
PDF is available here.
PDF is available here.
Abstract
We showed that the binding of anti-tTG antibodies to trophoblast might represent a key mechanism by which the embryo implantation and pregnancy outcome are impaired in untreated celiac pregnant women. Because healthy trophoblast development is essential for placental and fetal development, these data...
|
PMID: 20571491
PDF is available here.
PDF is available here.
Pediatrics (125)6 2010
Abstract
We report the case of a 3-month-old boy with probable CAPS who presented to us with digital necrosis and pulmonary hemorrhage. In addition, a skin biopsy demonstrated multiple small-vessel thromboses without signs of vasculitis. Results of testing for autoantibodies were positive for anti-beta(2) gl...
|
PMID: 20478943
PDF is available here.
PDF is available here.
Journal of Rheumatology (37)6 2010
Abstract
Autoantibody frequency in patients with RA and relatives: ACPA 91% vs 19%, respectively; IgM RF 82% vs 17%; IgA RF 48% vs 22%. Anti-P. gingivalis levels were higher in patients with RA compared to relatives and controls (p = 0.005) and higher in ACPA-positive patients with RA than in ACPA-negative p...
|
PMID: 20436074
PDF is available here.
PDF is available here.
Theriogenology (73)9 2010
Abstract
We aimed to develop a quantifiable staining method for IR protein on histological sections of bovine follicles in different developmental stages, and to apply this technique on GC obtained in living cows. In a first experiment, bovine ovaries were collected post mortem, formalin fixed, routinely pro...
|
PMID: 20226514
PDF is available here.
PDF is available here.
Abstract
Up to one third of candidates for organ or hematopoietic stem cell transplantation in the United States have antibodies to histocompatibility antigens, the most problematic of which are those of the HLA genetic system. The presence of high levels of HLA-specific antibodies reduces access to transpla...
|
PMID: 20515617
PDF is available here.
PDF is available here.
Abstract
Infliximab is a potent therapy for induction and maintenance of remission in Crohn's disease. Unfortunately, many patients lose response and/or develop allergic reactions caused by the chimeric antibody. By means of measuring the presence of antibodies against infliximab and the trough levels of the...
|
PMID: 20445512
PDF is available here.
PDF is available here.
Abstract
We generated a panel of optimized neutralizing antibodies against the human and mouse receptors for interleukin 21 (IL-21), a cytokine that is implicated in the pathogenesis of many types of autoimmune disease. Two antibodies, Ab-01 and Ab-02, which differed by only four amino acids in V(L) CDR3, sh...
|
PMID: 20424514
PDF is available here.
PDF is available here.
Abstract
The median (interquartile range) level of dog dander IgE was 8.31 kU(A)/L (1.895-14.5 kU(A)/L) and of dog epithelium IgE was 3.19 kU(A)/L (0.835-6.27 kU(A)L). Median (range) maximum NHR (at the first 10-fold dilution) was 0% (0%-1.4%) to vaccine and 10.2% (0%-35.9%) to dog dander (P < .001). In an e...
|
PMID: 20486334
PDF is available here.
PDF is available here.
Journal of Asthma (47)4 2010
Abstract
Mice that were chronically exposed to OVA developed sustained eosinophilic airway inflammation and airway hyperresponsiveness (AHR) to methacholine and showed increased levels of collagen, hydroxyproline, and alpha-smooth muscle actin, as compared with control mice. Treatment with anti-IgE antibody...
|
PMID: 20528589
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
We highlight the studies that led to these discoveries and our current knowledge about the possible role of anti-PLA2R autoantibodies in the pathogenesis of IMN. Given that the sensitivity and specificity of anti-PLA2R for IMN are >75 and 100%, respectively, we foresee that a widely available assay...
|
PMID: 20182413
PDF is available here.
PDF is available here.
Abstract
CCR5 blockade combined with cyclosporine is effective in protecting the cardiac allograft in a robust murine model. This effect is partly mediated by regulatory cell recruitment and control of effector cell infiltration....
|
PMID: 20060322
PDF is available here.
PDF is available here.
Molecular Immunology (47)7-8 2010
Abstract
We show that the strategy of complex formation between epitope-tagged rAbFs and anti-epitope IgG monoclonal antibodies (mAb) can improve the therapeutic potential of rAbFs by both enhancing their serum persistence and conferring on them the ability to recruit Fc-mediated effector functions. These tw...
|
PMID: 20153529
PDF is available here.
PDF is available here.
Abstract
We hypothesized that maternal IgE mediates the onset of innate IL-4 production in equine neonatal basophils. Intracellular IL-4 production was measured in PBMC of newborn and older foals by flow cytometric analysis. A small population of IL-4(+) cells was observed in the peripheral blood at days 3-5...
|
PMID: 19995577
PDF is available here.
PDF is available here.
Planta Medica (76)4 2010
Abstract
We investigated the effect of warifteine on B lymphocyte function and characterized its mechanism of action. Purified splenic murine B lymphocytes were stimulated with either Toll-like receptor (TLR) ligands (LPS, Pam (3)Cys and CpG oligodeoxynucleotides) or anti-IgM antibody and the effect of warif...
|
PMID: 19787569
PDF is available here.
PDF is available here.
Acta Neurologica Belgica (110)1 2010
Abstract
We report the case of a 58-year-old patient who developed distal paraparesis. Serum electrophoresis demonstrated monoclonal IgM paraproteinemia having an anti-GM1 but no anti-MAG activity. Conduction velocities showed demyelinating pattern. Work-up excluded a lymphoproliferative disorder After IVIg...
|
PMID: 20514936
PDF is available here.
PDF is available here.
Haematologica (95)3 2010
Abstract
Our current data indicate a critical role for IGF-1 autocriny in constitutive PI3K/Akt activation in primary acute myeloid leukemia cells and provide a strong rationale for targeting IGF-1R as a potential new therapy for this disease....
|
PMID: 20007139
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials, and demonstrated an efficacy profile similar to other biological agents approved for rheumatoid arthritis. At the time of publication, phase II trials were ongoing in patients with rheumatoid arthritis. TRU-015 could represent a novel therapy for the treatment of rheumatoid...
|
PMID: 20140823
PDF is available here.
PDF is available here.
Abstract
Objective of this study is to retrospectively compare the third generation anti-cyclic citrullinated peptide (anti-CCP3) test with the second generation (anti-CCP2) assay as markers of disease activity and predictors of clinical response in rheumatoid arthritis (RA) patients treated with TNF-alpha b...
|
PMID: 19506882
PDF is available here.
PDF is available here.
Clinical laboratory (56)9-10 2010
Abstract
We report a case of erythroblastic synartesis, a rare disease characterized by ineffective erythropoiesis, clusters of erythroblasts due to membrane invaginations, in which an autoimmune pathogenesis is hypothesized. We investigated the presence of anti-erythroblast autoimmunity in bone marrow cultu...
|
PMID: 21086791
PDF is available here.
PDF is available here.
Clinical laboratory (56)3-4 2010
Abstract
This study demonstrates that anti-CCP IgG is a highly specific marker for RA and has diagnostic value especially in RF negative patients....
|
PMID: 20476640
PDF is available here.
PDF is available here.
Medical Science Monitor (16)7 2010
Abstract
Adrenaline is known to inhibit the immunological activation of human basophils. The same effect can be obtained with ultra-low doses of histamine.
The present investigation was undertaken to verify the effects of ultra-low doses of adrenaline on the immunological activation of human basophils. For t...
|
PMID: 20581771
PDF is available here.
PDF is available here.
Abstract
We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 (HLA-DRB1) shared epitope (SE) alleles and s...
|
PMID: 20537173
PDF is available here.
PDF is available here.
Abstract
Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early...
|
PMID: 20569500
PDF is available here.
PDF is available here.
Abstract
We wanted to assess the importance of the levels of anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development of persistent arthritis from undifferentiated arthritis (UA), and to investigate whether there is an added predictive value f...
|
PMID: 20444271
PDF is available here.
PDF is available here.
Abstract
For anti-IL-21R antibodies Ab-01 and Ab-02, there was good correlation between PD activity and PK profiles following IV administration to cynomolgus monkeys. Compared with Ab-01, Ab-02 was eliminated markedly faster from the circulation, which correlated with a shorter duration of PD activity....
|
PMID: 20420683
PDF is available here.
PDF is available here.
Abstract
The levels of idiotypic (AB1) and antiidiotypic (AB2) antibodies were investigated in pregnants (n = 248) suffer from diabetes. It was proved that AB2 to insulin conditionally can be regards as antibodies to insulin receptor. It was shown that condition of newborns much depends on levels of these an...
|
PMID: 20804070
PDF is available here.
PDF is available here.
Abstract
There were no operative deaths or complications. There was no statistically significant difference between the titers of anti alpha-Gal antibodies of the PVR and re-PVR groups. The titer of anti alpha-Gal antibodies (IgM and IgG) was decreased on the first postoperative day, but increased in the fir...
|
PMID: 20329498
PDF is available here.
PDF is available here.
Abstract
We report a 13-year-old girl with positive mycoplasma immunoglobulin (Ig)M and IgG serology who presented with one-sided horizontal gaze palsy, ataxia, areflexia, and bulbar palsy. Her cranial magnetic resonance imaging was normal and blood serum was negative for anti-GQ1b IgG antibodies....
|
PMID: 20718193
PDF is available here.
PDF is available here.
Abstract
A high prevalence of anti-livin antibodies in patients with GIC indicates that they may be useful in the diagnosis of these malignancies....
|
PMID: 20150841
PDF is available here.
PDF is available here.
Abstract
Clinical and Experimental Rheumatology (28)4 Suppl 60 2010
Abstract
To investigate the prevalence and levels of anti-cyclic citrullinated peptide antibodies (anti-CCP) in patients with familial Mediterranean fever (FMF) with and without arthritis.
Eighty-three patients with FMF and 43 healthy controls were included in the study. Thirty seven FMF patients had a histo...
|
PMID: 20868572
PDF is available here.
PDF is available here.
Abstract
The pilot study resulted in a significant difference of IgG antibodies in serum between CD patients and healthy controls. In 84 and 83% of the patients, respectively, IgG antibodies against processed cheese and yeast were detected. The daily stool frequency significantly decreased by 11% during a sp...
|
PMID: 20130407
PDF is available here.
PDF is available here.
Thrombosis Research (125)1 2010
Abstract
This study suggests that anti-PT autoantibodies may be common risk factors for thrombosis in children, and it confirms the multifactorial nature of pediatric thrombosis.
Copyright 2009 Elsevier Ltd. All rights reserved....
|
PMID: 19303627
PDF is available here.
PDF is available here.
Abstract
Rupatadine (10-50 microM) inhibited IL-6 release (80% at 50 microM) from HMC-1 cells, whether added 10 min or 24 h prior to stimulation. Rupatadine (10-50 microM for 10 min) inhibited IL-8 (80%), vascular endothelial growth factor (73%) and histamine (88%) release from LAD2 cells, as well as IL-6, I...
|
PMID: 19672095
PDF is available here.
PDF is available here.
médecine/sciences (25)12 2009
Abstract
Monoclonal antibodies and their derivatives such as antibody fragments, immunoconjugates and Fc fusions, represent the majority of therapeutic proteins in clinical development. Recent successes of such molecules in cancer and in the treatment of autoimmune diseases found a great hope in biotherapeut...
|
PMID: 20035680
PDF is available here.
PDF is available here.
médecine/sciences (25)12 2009
Abstract
The human Fc portion of humanized monoclonal antibodies (mAb) gives them a half-life of around 21 days, similar to that of endogenous immunoglobulin G (IgG). Neonatal Fc receptor (FcRn) plays a major role in the pharmacokinetics (PK) of mAbs. By protecting them from degradation, it is responsible fo...
|
PMID: 20035679
PDF is available here.
PDF is available here.
médecine/sciences (25)12 2009
Abstract
The extensive use of therapeutic monoclonal antibodies in clinic has shown that toxic effects may occur in patients. Examples such as muromonab (anti-CD3) and recently TGN1412 (anti-CD28) clearly establish that prediction of toxic effects for these targeted therapies is still complex. These undesira...
|
PMID: 20035692
PDF is available here.
PDF is available here.
médecine/sciences (25)12 2009
Abstract
The properties of monoclonal antibodies explain why they are such a successful class of therapeutic molecules. However, pionneered initial antibodies were of murine origin and triggered an immune response which limited the therapeutic potential of the antibody and generated deleterious effects. Cons...
|
PMID: 20035696
PDF is available here.
PDF is available here.
médecine/sciences (25)12 2009
Abstract
Unwanted immunogenicity, i.e., the developpement by patients of anti-drug antibodies is a significant problem with biologicals therapeutic reagents and can compromise clinical response. Over 20 antibodies currently on the market and over 100 drug candidates are currently in clinical trials; all ther...
|
PMID: 20035681
PDF is available here.
PDF is available here.
Biochemistry (New York) (74)12 2009
Abstract
Polyclonal and monoclonal antibodies (MABs) to human laminin-binding protein (LBP) can efficiently block the penetration of some alpha- and flaviviruses into the cell. A panel of 13 types of MABs to human recombinant LBP was used for more detailed study of the mechanism of this process. Competitive...
|
PMID: 19961413
PDF is available here.
PDF is available here.
Rheumatology International (29)12 2009
Abstract
We assessed 34 RA patients who received keishinieppiittokaryojutsubu (KER), one of the representative THM. The observational term was 12 months, and we calculated the disease activity score of 28 joints every 3 months and evaluated the response to KER using European League Against Rheumatism (EULAR)...
|
PMID: 19234855
PDF is available here.
PDF is available here.
Rheumatology International (29)12 2009
Abstract
PADI4 that catalyzes the conversion of peptidylarginine to citrulline is associated with rheumatoid arthritis in some populations. The current study investigated the expressions of PADI4 in synovial fluid of RA (n = 73), osteoarthritis (OA, n = 96) and ankylosing spondylitis (AS, n = 32) using ELISA...
|
PMID: 19199100
PDF is available here.
PDF is available here.
Phytomedicine (16)10 2009
Abstract
We investigated the inhibitory effects of curcumin on the response of normal murine splenic B cells. Curcumin inhibited the proliferative response of purified splenic B cells from BALB/c mice stimulated with the Toll-like receptor ligands LPS and CpG oligodeoxynucleotides. LPS-induced IgM secretion...
|
PMID: 19303754
PDF is available here.
PDF is available here.
Analytical Biochemistry (395)1 2009
Abstract
We believe that the effectiveness of the competitive panning elution method and antigen-specific recombinant scFv antibodies obtained in this study are excellent candidates for antimycotic drugs....
|
PMID: 19665444
PDF is available here.
PDF is available here.