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Antibodies, Viral (2):
Recent article
Antibodies, Viral
Abstract
We found that MMTV, when ingested by newborn mice, stimulates a state of unresponsiveness toward viral antigens. This process required the intestinal microbiota, as antibiotic-treated mice or germ-free mice did not transmit infectious virus to their offspring. MMTV-bound bacterial lipopolysaccharide...
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PMID: 21998394
PDF is available here.
PDF is available here.
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Federal Register (76)153 2011
Abstract
The Food and Drug Administration (FDA) is amending the special controls for the herpes simplex virus (HSV) serological assay device type, which is classified as class II (special controls). These device types are devices that consist of antigens and antisera used in various serologic...
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PMID: 21826824
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)20 2011
Abstract
Xenobiotica (41)5 2011
Abstract
We describe in detail the PBMC-based assay, which is more laborious but in our opinion represents a closer approximation of the in vivo situation. As with all other in vitro assays the results of such measurements are only an indication of the antibody potency in vivo, and animal studies and ultimat...
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PMID: 19252841
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We have adapted the HCVpp infection assay with HCVpp harboring a luciferase reporter to a 96-well format and screened a small-molecule compound library to identify inhibitors of HCV entry. Such active viral entry inhibitors have the potential to be first-in-class antiviral drugs that can be incorpor...
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PMID: 19009270
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
The discovery of novel target antigens for antibody-based immunotherapy is still a major challenge. Antibody phage display is one of the technologies that is widely applied for the identification of novel cell surface molecules on intact eukaryotic cells and many reports describe the isolation of ph...
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PMID: 19153691
PDF is available here.
PDF is available here.
The Lancet (377)9773 2011
Abstract
The Lancet (377)9773 2011
Abstract
We undertook a phase-2 randomised placebo controlled trial in adults awaiting kidney or liver transplantation at the Royal Free Hospital, London, UK. Exclusion criteria were pregnancy, receipt of blood products (except albumin) in the previous 3 months, and simultaneous multiorgan transplantation. 7...
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PMID: 21481708
PDF is available here.
PDF is available here.
Abstract
Previously, a modified HIV Env protein with a heterologous membrane anchor was found to be incorporated into HIV virus-like particles (VLPs) at 10-fold-higher levels than those of unmodified Env. To further improve the immunogenicity of such VLPs, membrane-anchored forms of bacterial...
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PMID: 21325038
PDF is available here.
PDF is available here.
Abstract
We have previously shown that transgenic (tg) mice that have been created to overexpress bovine FcRn (bFcRn) demonstrate increased half-life of mouse IgG, significantly increased antigen-specific IgG in serum and augmented expansion of antigen-specific B cells and plasma cells after immunization. On...
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PMID: 21239891
PDF is available here.
PDF is available here.
Abstract
We evaluated the immunogenicity and cross-reactivity of 2009-2010 inactivated trivalent influenza vaccine (TIV) in US adult and elderly populations. Vaccination of TIV resulted in a robust boost on the antibody response of all subjects to seasonal A/Brisbane/59/2007 (H1N1) and A/Uruguay/716/2007 (H3...
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PMID: 21304946
PDF is available here.
PDF is available here.
Abstract
Our study is to analyse the coinfection effects of porcine circovirus type 2 (PCV2) and porcine parvovirus (PPV) in vivo on phagocytosis and interferon mRNA expression level of porcine alveolar macrophages (PAM).
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PMID: 21465796
PDF is available here.
PDF is available here.
Abstract
The data are consistent with a model whereby viral replication in response to SIV antigen stimulation limits the generation of SIV antigen-specific responses and suggests a potential mechanism for the early loss and poor HIV-specific CD4+ T cell response observed in HIV-infected individuals....
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PMID: 21752277
PDF is available here.
PDF is available here.
Abstract
In the present investigation hepatitis B surface antigen (HBsAg) encapsulated liposomes were developed and coupled with Ulex europaeus agglutinin 1 (UEA-1) to increase transmucosal uptake by M-cells of the Peyer's patches. The liposomes were characterized for shape, size, polydispersity and encapsul...
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PMID: 20843665
PDF is available here.
PDF is available here.
Epidemiology and Infection (139)1 2011
Abstract
We conducted a serological survey in 710 subjects, 1 month after the epidemic peak. We found that 13·8% of our cohort was seropositive. Subjects aged ≥60 years recorded the lowest seroprevalence (4·5%). The age-weighted seroprevalence of 14·0% was far lower than the supposed infection rate at t...
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PMID: 20854713
PDF is available here.
PDF is available here.
Abstract
This review focuses on arborviral infections associated with California serocomplex (Bunyaviridae, Orthobunyavirus). Results of relevant eco-epidemiological and clinical studies in Russia are presented suggesting the ubiquitious nature of diseases caused by viruses of the California encephalitis sero...
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PMID: 21786596
PDF is available here.
PDF is available here.
Intervirology (54)1 2011
Abstract
We reported that EBV can infect rabbits by intravenous, intranasal and/or peroral inoculation, which caused primary EBV infection in rabbits with heterogeneous host reactions. Some rabbits showed chronic and lifelong EBV infection with hemophagocytosis. In this study, to reveal detailed mechanisms i...
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PMID: 20689312
PDF is available here.
PDF is available here.
Abstract
We previously reported that antibodies targeting the first 14 amino acids of the N-terminus of the fusion peptide could bind to virtually all influenza virus strains and quantify hemagglutinins in vaccines produced in embryonated eggs. Here we demonstrate that these universal antibodies bind to the...
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PMID: 21078301
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)12 2010
Abstract
Although pneumonia is a leading cause of death from infectious disease worldwide, comprehensive information about its causes and incidence in low- and middle-income countries is lacking. Active surveillance of hospitalized patients with pneumonia is ongoing in Thailand. Consenting patients are teste...
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PMID: 20353622
PDF is available here.
PDF is available here.
Abstract
A 42-year-old man without pre-existing health problems presented to his family practitioner in Baden-Württemberg with fever (up to 39˚ C for two days), headache, abdominal pain, back pain and aching limbs. Ten days before, he had done heavy gardening work. He felt diffuse pain on abdominal palpati...
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PMID: 21140328
PDF is available here.
PDF is available here.
Abstract
Abstract
These results demonstrate that intranasal inoculation with B. subtilis spore-based rotavirus vaccines is effective in generating protective immunity against rotavirus challenge in mice....
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PMID: 20810679
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
We investigated the clinical relevance of anti-E1E2A,B response in the serum of patients infected with HCV. To this end, an enzyme-linked immunosorbent assay (ELISA) using synthetic E1-, E2A-, and E2B-derived peptides was used. The ELISA was validated in terms of sensitivity, specificity, and test e...
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PMID: 20890942
PDF is available here.
PDF is available here.
Abstract
We compared the antibody responses to LAIV or TIV in HIV-infected children.
Blood and saliva obtained at enrollment, 4 and 24 weeks postimmunization from 243 HIV-infected children randomly assigned to TIV or LAIV were analyzed.
Both vaccines increased the anti-influen...
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PMID: 20581690
PDF is available here.
PDF is available here.
Abstract
The interaction between recombinant Fab57P and the coat protein of tobacco mosaic virus was studied using quantitative structure-activity relationship (QSAR) method. The development of quantitative multivariate model has shown to be a promising approach for unraveling protein-protein interactions by...
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PMID: 20807221
PDF is available here.
PDF is available here.
New Microbiologica (33)4 2010
Abstract
We have shown that monoclonal antibodies targeting the ectodomain of the A/M2 proton channel have antiviral activity in vitro. In this study, we generated both monoclonal antibody and phage displayed peptide against the eight amino acids comprising the ectodomain of the BM2 proton channel and invest...
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PMID: 21213589
PDF is available here.
PDF is available here.
Abstract
To evaluate the safety, tolerability and immunogenicity of an AS03(B)/oil-in-water emulsion-adjuvanted (AS03(B)) split-virion versus non-adjuvanted whole-virion H1N1 influenza vaccine in UK children aged 6 months to 12 years.
Multicentre, randomised, head-to-head, open-label trial.
Five UK sites (Ox...
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PMID: 20923610
PDF is available here.
PDF is available here.
Emerging Infectious Diseases (16)10 2010
Abstract
We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a ≥4-fold increase in hemagglutination in...
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PMID: 20875280
PDF is available here.
PDF is available here.
Emerging Infectious Diseases (16)10 2010
Abstract
We demonstrate frequent seropositivity for antibody to parvovirus 4 viral protein 2 among adult populations throughout sub-Saharan Africa (Burkina Faso, 37%; Cameroon, 25%; Democratic Republic of the Congo, 35%; South Africa, 20%), which implies existence of alternative transmission routes....
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PMID: 20875290
PDF is available here.
PDF is available here.
Emerging Infectious Diseases (16)10 2010
Abstract
We conducted a retrospective investigation. MPXV was identified in a sub-Sahelian savannah environment. Three case notification categories were used: suspected, probable, and confirmed. Molecular, virologic, and serologic assays were used to test blood specimens, vesicular swabs, and crust specimens...
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PMID: 20875278
PDF is available here.
PDF is available here.
Abstract
An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features.
AES cases among children<15 yr, from Nagpur division, hospitalized between June-September 2007, were investiga...
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PMID: 20966517
PDF is available here.
PDF is available here.
Abstract
We assessed whether the neutralizing activity of breast milk could lower the titer of vaccine virus and explain this difference in vitro.
Breast milk samples were collected from mothers who were breast-feeding infants 4 to 29 weeks of age (ie, vaccine eligible age) in India (N = 40), Vietnam (N = 77...
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PMID: 20442687
PDF is available here.
PDF is available here.
Abstract
An indirect enzyme immunoassay (EIA) using the purified fraction of surface viral glycoproteins (GP) as an antigen for solid phase sensitization was not shown to be a specific method for the differential detection of influenza A(HS) (HS-Ab) virus antibodies (Abs) due to total conservative epitopes i...
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PMID: 21162183
PDF is available here.
PDF is available here.
Abstract
Infectious myonecrosis virus (IMNV) has been causing a progressive disease in farm-reared shrimps in Brazil and Indonesia. Immunodiagnostic methods for IMNV detection, although reliable, are not employed currently because monoclonal antibodies (MAbs) against this virus are not available. In this stu...
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PMID: 20678523
PDF is available here.
PDF is available here.
Abstract
Two ELISAs to quantify antibodies to BoHV-1 in the sera of cattle and immunized guinea pigs were developed and validated using ISO/IEC 17025 standards. The cut-off value of the assay was established at 20% positivity of a high positive control for screening of cattle. Using this threshold, the assay...
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PMID: 20655331
PDF is available here.
PDF is available here.
Abstract
We measured WNV-specific antibodies in 81 falcons captured in 2006. None of the nestlings but 14.8% of the adults had WNV-neutralizing antibodies. RT-PCR did not detect flaviviruses in nonculicine ectoparasites (n=231) of the falcons. These findings suggest that WNV infection did not occur locally,...
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PMID: 20966288
PDF is available here.
PDF is available here.
Abstract
Rabies virus is a pathogen of major concern in free-ranging wild carnivores in several regions of the world, but little is known about its circulation in Brazilian wild carnivores. Sera from 211 free-ranging wild carnivores, captured from 2000 to 2006 in four locations of two Brazilian biomes (Panta...
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PMID: 20966286
PDF is available here.
PDF is available here.
Abstract
We examine prevalence of antibodies to Toxoplasma gondii, and four morbilliviruses (canine distemper [CDV], phocine distemper [PDV], dolphin morbillivirus [DMV], porpoise morbillivirus [PMV]) including risk factors for exposure. We also examine the relationships between antibody levels and hematolog...
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PMID: 20607348
PDF is available here.
PDF is available here.
Abstract
We discuss the above phenomena, describe the current status of research in the field, and present several testable hypotheses regarding possible links between virus infection, innate immune sensing and disease....
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PMID: 20860480
PDF is available here.
PDF is available here.
Abstract
Infection with Herpes Simplex Virus Type-2 (HSV-2) is the primary cause of genital herpes and the most common cause of genital ulcer disease (GUD) worldwide. There is little information on the prevalence of HSV-2 in Nigeria.
Specimens were collected from 162 volunteers attending Jos University Tea...
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PMID: 21045370
PDF is available here.
PDF is available here.
Sexual Health (7)3 2010
Abstract
Abstract
Abstract
We reviewed publications on the development of EV71 vaccines in order to provide an overview of the field.
Fifty-five articles on EV71 vaccine development, published from 1974 to 2009, were collected from Sun Yat-sen University library and reviewed.
Various types of vaccine have been developed for E...
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PMID: 20400350
PDF is available here.
PDF is available here.
Abstract
Abstract
Avian polyomavirus (APV) causes a range of disease syndromes in psittacine birds, from acute fatal disease to subclinical infections, depending on age, species, and other unidentified risk factors. To determine the prevalence of APV-specific antibodies in a captive population of Spix's macaws (Cyano...
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PMID: 21046939
PDF is available here.
PDF is available here.
Abstract
We varied assumptions regarding both the percentage of children who would receive LAIV in lieu of trivalent inactivated influenza virus (TIV) and the extent of off-label use.
Model of expected benefits and risks of immunization of young children against influenza.
We estimated expected numbers of ca...
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PMID: 21250400
PDF is available here.
PDF is available here.
Abstract
The relationship between canine respiratory coronavirus (CRCoV) and canine influenza virus (CIV) seropositivity in dogs in Korea was examined. Sixty-two of the 483 samples (12.8%) were seropositive for CRCoV by indirect fluorescent antibody (IFA) analysis. Nineteen animals were seropositive for CIV...
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PMID: 20410676
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)9 2010
Abstract
We conducted a serological survey to determine the extent of subclinical infection caused by the outbreak. Single serum samples were collected from five individuals with avian influenza whose nasopharyngeal swabs tested positive for H5 RNA by polymerase chain reaction, 28 family contacts of the case...
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PMID: 20092669
PDF is available here.
PDF is available here.
Abstract
Early diagnosis of nasopharyngeal carcinoma (NPC) is difficult due to the insufficient specificity of the conventional examination method. This study was to investigate potential and consistent biomarkers for NPC, particularly for early detection of NPC.
A proteomic p...
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PMID: 20663318
PDF is available here.
PDF is available here.
Abstract
To investigate the intestinal mucosal immune responses in ducklings orally inoculated with attenuated Duck enteritis virus (DEV), the kinetics of the viral load, the specific humoral immune responses, and the distribution of immunoglobulin (Ig)A-secreting cells in the intestine were evaluated. Oral...
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PMID: 19442544
PDF is available here.
PDF is available here.
Abstract
An indirect ELISA for the serological detection of bovine ephemeral fever virus (BEFV) infection in cattle is described in which a glycosylated protein of approximately 25 kDa (including the G1 antigenic site of the virus glycoprotein) expressed in Pichia pastoris GS115 was used as the coating antig...
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PMID: 19586786
PDF is available here.
PDF is available here.
Abstract
Yearly influenza vaccination is recommended for patients with humoral primary immunodeficiency (hPID). However, humoral responses following vaccination can be expected to be reduced in these patients. The efficacy of influenza vaccination in patients with hPID, anti-influenza antibody responses was...
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PMID: 20421178
PDF is available here.
PDF is available here.
Abstract
We identified a continuous epitope (55)WIRNNF(60) that was recognized by MAb N2C3. Subsequent studies found that this MAb could recognize several different strains of Noroviruses, not just GII/4. In the present study, we used homology modeling to confirm that the epitope of N2C3 was exposed on the s...
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PMID: 20417671
PDF is available here.
PDF is available here.
Abstract
We report here the successful immunization of mice with DNA vaccines expressing the secreted form of HEV-p179 (fused with a human tissue plasminogen activator (tPA) signal sequence) and the tPA-p179-C3d fusion protein (fused with three tandem copies of the murine complement C3d). Analysis of antibod...
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PMID: 20451569
PDF is available here.
PDF is available here.
Abstract
The human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine has been demonstrated to be highly efficacious and immunogenic with a favorable safety profile. This study assessed the immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Korean girls aged 10-14 y...
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PMID: 20676333
PDF is available here.
PDF is available here.
Abstract
This is the first case of virus-associated encephalitis/encephalopathy in which the pathogen was Hantaan virus. A 53-yr-old man presented fever, renal failure and a hemorrhagic tendency and he was diagnosed with hemorrhagic fever with renal failure syndrome (HFRS). In the course of his illness, mild...
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PMID: 20676343
PDF is available here.
PDF is available here.
Epidemiology and Infection (138)8 2010
Abstract
The extent of hantavirus seroprevalence in the healthy population from Bosnia and Herzegovina has not yet been investigated; therefore, the aim of this study was to assess the hantavirus seroprevalence in the population from different regions of Bosnia and Herzegovina and in different risk groups. T...
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PMID: 19951455
PDF is available here.
PDF is available here.
Immunology (130)4 2010
Abstract
We previously identified a novel, continuous B-cell epitope from domain III of the WNV envelope protein, termed Ep15. To test whether this epitope can protect against WNV infection, we synthesized a linear chimeric peptide composed of Ep15 and the heat-shock protein 60 peptide, p458. The p458 peptid...
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PMID: 20331473
PDF is available here.
PDF is available here.
Journal of General Virology (91)Pt 8 2010
Abstract
Betapapillomaviruses (betaPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This st...
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PMID: 20392895
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (59)Pt 8 2010
Abstract
We assumed that a rare HCMV and M. pneumoniae coinfection was the aetiology of the fulminant pneumonia. Under broad antibiotic and antiviral treatment, the situation of the patient improved only very slowly....
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PMID: 20466842
PDF is available here.
PDF is available here.