Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Antigen-Antibody Complex (0):
Recent article
Antigen-Antibody Complex
Xenobiotica (41)5 2011
Abstract
Immunoelectrophoresis can be used for analysis of individual proteins in complex mixtures. The conditions involved in immunoelectrophoresis are mild, avoiding the risk of denaturation, and it is possible to perform relative quantification of individual components. The principle disadvantage is the d...
|
PMID: 18612606
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Autoimmunity Reviews (10)5 2011
Abstract
Autoimmune and inflammatory phenomena are characteristically present in systemic sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition, hallmark of the disease in conjunction with fibroproliferative vasculopathy. Oligoclonal T helper 2-like cells are p...
|
PMID: 20863906
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that stable and vulnerable human plaques differentially express genes associated with matrix degradation. Examination established that femoral, and the distal region of carotid, plaques were histologically stable while the proximal carotid plaque regions were vulnerable. Qua...
|
PMID: 21814555
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (53)5 2011
Abstract
Abstract
We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monocl...
|
PMID: 21088136
PDF is available here.
PDF is available here.
Abstract
Ménière's disease (MD), which by definition is idiopathic, has been ascribed to various causes, including inhalant and food allergies. Patients with MD report higher rates of allergy history and positive skin or in vitro tests compared with a control group of patients with other otologic diseases...
|
PMID: 20713244
PDF is available here.
PDF is available here.
Abstract
We have previously shown that murine IgG2a-autoreactive AM14 B cells respond robustly to chromatin-associated IC through a mechanism dependent on both the BCR and the endosomal TLR9, despite FcγRIIB coexpression. To further evaluate the potential contribution of FcγRIIB to the regulation of autore...
|
PMID: 20809520
PDF is available here.
PDF is available here.
Abstract
An antibody Fab fragment, AbD1556, was selected against the extracellular domain of BMP receptor type IA, which blocks the binding of BMP-2 to BMPR-IA and thereby neutralizes BMP-2 activity. To study the mechanism by which BMPR-IA is recognized and bound by the Fab fragment, the complex of AbD1556 b...
|
PMID: 20693682
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
To analyze contribution of short aggregation-prone regions (APRs), which may self-associate via cross-beta motif and were earlier identified in therapeutic mAbs, towards antigen recognition via structural analyses of antibody-antigen complexes.
A dataset of 29 publica...
|
PMID: 20422267
PDF is available here.
PDF is available here.
Abstract
We showed that the co-expression of antigen-antibody pairs is feasible in both the periplasm and the cytoplasm of bacteria. Moreover, the complexes that were formed in vivo could be purified using a tag fused to the recombinant antibody and remained stable during gel-filtration. The co-expression an...
|
PMID: 20060475
PDF is available here.
PDF is available here.
Clinical Nephrology (74)1 2010
Abstract
Immunoglobulin and a complement were significantly detected in IgAN and manifested as special distribution of intensive salmon pink fluorescence. Compared with fluorescein isothiocyanate (FITC) tagging, QD signal showed better specificity and signal to noise ratio, and QD signal was not significantl...
|
PMID: 20557864
PDF is available here.
PDF is available here.
Infection and Immunity (78)7 2010
Abstract
We have investigated this question by comparing results for erythrocytes from transgenic mice expressing human CR1 on their erythrocytes to the results for wild-type mouse erythrocytes that do not express CR1. We demonstrate that human CR1 expression on murine erythrocytes allows immune adherence to...
|
PMID: 20439480
PDF is available here.
PDF is available here.
Abstract
Sera from both diffuse SSc and limited SSc contained interferogenic antibodies, which correlated with the presence of anti-ribonucleoprotein and anti-Sjögren syndrome antigen autoantibodies. The pDCs were responsible for the IFNalpha production which required interaction with FcgammaRII and endocyt...
|
PMID: 20472592
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
To exploit the physiologic Fcgamma receptor IIb (CD32B) inhibitory coupling mechanism to control B cell activation by constructing a novel bispecific diabody scaffold, termed a dual-affinity retargeting (DART) molecule, for therapeutic applications.
DART molecules wer...
|
PMID: 20506263
PDF is available here.
PDF is available here.
Abstract
We used porcine monocytic-derived DC (MoDC) as a model system. The results in this study demonstrate that FcgammaRI, II and III mRNA is expressed by porcine MoDC. Furthermore, we show that FcgammaRII and III are expressed on the cell surface and that F4-IC are internalized by MoDC via FcgammaR. This...
|
PMID: 20022123
PDF is available here.
PDF is available here.
Abstract
We identified specific amino acid propensities at the interfaces of antigen-antibody interactions in non-redundant qualified antigen-antibody complex structures from Protein Data Bank. Propensities were expressed by the frequency of each of the 20 x 20 standard amino acid pairs that appeared at the...
|
PMID: 20304974
PDF is available here.
PDF is available here.
Abstract
We report the structural basis of binding of a complex of a monoclonal antibody (237mAb) with a truly tumor-specific glycopeptide containing the Tn antigen. In contrast to glycopeptide-specific antibodies in complex with simple peptides, 237mAb does not recognize a conformational epitope induced in...
|
PMID: 20479270
PDF is available here.
PDF is available here.
Abstract
We have used gold nanoparticles (AuNPs) to covalently attach an antibody (Ab(1)) using a spacer arm. The AuNPs/Ab(1) modified gold electrode was used for a sandwich electrochemical immunoassay. The detection was done using cyclic voltammetry and impedance measurements using Horse Radish Peroxidase (...
|
PMID: 20171869
PDF is available here.
PDF is available here.
Abstract
Hypersensitivity pneumonitis (HP) is a complex syndrome caused by an exaggerated immune response to the inhalation of a large variety of organic particles. The most frequent antigens that cause HP worldwide are bird proteins (pigeon breeders' disease) and bacteria (Saccharopolyspora rectivirgula). H...
|
PMID: 20463253
PDF is available here.
PDF is available here.
Clinical Nephrology (73)5 2010
Abstract
Comparison of cytokine production patterns among different disease-associated TINs revealed that IgG4-related TIN exhibited a quite distinct pattern. On the one hand, there was no expression of IL-2, IFN-gamma IL-17 and IL-6, whereas production of IL-4, IL-10 and TGF-beta was, on the other hand, rem...
|
PMID: 20420800
PDF is available here.
PDF is available here.
Archives de Pédiatrie (17)4 2010
Abstract
Clinical Science (118)8 2010
Abstract
We hypothesize that FcgammaRs such as FcgammaRIIa could contribute to the pathogenesis of ALI/ARDS....
|
PMID: 20088831
PDF is available here.
PDF is available here.
Abstract
Decreased sensitivity has been a limiting factor of antigen assay for detection of tuberculosis. Assay of more than one antigen may improve sensitivity of an assay.
To develop a simple, rapid and less-expensive serodiagnostic method compared to culture method for Pulmonary Tuberculosis.
A cocktail o...
|
PMID: 21114172
PDF is available here.
PDF is available here.
Abstract
We propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies....
|
PMID: 20168318
PDF is available here.
PDF is available here.
Abstract
To assess the ability of an anti-lysozyme antibody to stabilize the plasma pharmacokinetics of lysozyme through a 'buffering' effect.
Hen egg lysozyme was radiolabeled with (14)C and infused with or without the murine anti-lysozyme antibody D1.3 into the jugular vein...
|
PMID: 19922461
PDF is available here.
PDF is available here.
Abstract
We favour the hypothesis that post-apoptotic debris accumulates in germinal centres, activates complement, and serves as a survival signal for B-cells that had stochastically become autoreactive in the process of somatic hypermutation (etiology). In the presence of autoantibodies against apoptotic c...
|
PMID: 20107814
PDF is available here.
PDF is available here.
Abstract
The equivalence of both SCCA-IgM assays and the absence of reactivity not related to immune complexes support the analytical specificity of SCCA-IgM measurements. The results validate the assessment of SCCA-IgM for prognostic purposes in patients with cirrhosis....
|
PMID: 20001440
PDF is available here.
PDF is available here.
Abstract
We analyzed these patients with focus on serological aspects to invest whether there are autoantigens in SIPS. We evaluated 28 patients with SIPS who presented at Sapporo Medical University Hospital and the collaborated institutions. They were mainly middle-aged (eight male), and consisted of 26 pat...
|
PMID: 19609529
PDF is available here.
PDF is available here.
Abstract
We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody co...
|
PMID: 20133862
PDF is available here.
PDF is available here.
BMC Structural Biology (10 Suppl 1) 2010
Abstract
The proposed method leads to a new way of identifying B-cell epitopes. Besides, this antibody-specified epitope prediction can provide more precise and helpful information for wet-lab experiments....
|
PMID: 20487513
PDF is available here.
PDF is available here.
Abstract
We illustrate a novel approach, named SnugDock, to predict high-resolution antibody-antigen complex structures by simultaneously structurally optimizing the antibody-antigen rigid-body positions, the relative orientation of the antibody light and heavy chains, and the conformations of the six comple...
|
PMID: 20098500
PDF is available here.
PDF is available here.
Abstract
I (FCgamma RI). This study examined differences in intracellular trafficking of lipid and apolipoprotein moieties of oxLDL and oxLDL-IC and the impact on oxidative stress.
Fluorescently labeled lipid and protein moieties of oxLDL co-localized within endosomal and lysosomal compartmen...
|
PMID: 20824093
PDF is available here.
PDF is available here.
Analytical Sciences (26)7 2010
Abstract
Liposomes prepared with biotinylated phospholipids and luminol entrapped were shown to be of 187 nm in size, 59% of which were unilamellar and with 43% luminol trapping efficiency. Liposome prepared from biotinylated phospholipids with a longer hydrophilic PEG2000 spacer, but not with the shorter hy...
|
PMID: 20631437
PDF is available here.
PDF is available here.
Tsitologiia (52)6 2010
Abstract
We used SJL/J mice which are known to develop autoimmune process accompanied by the appearance of anti-fibrillarin antibodies following regular administrations of sublethal dozes of HgCl2. Using antibodies to the total murine ummunoglobulins we showed that immunodeposits were present in glomeruli of...
|
PMID: 20737906
PDF is available here.
PDF is available here.
Abstract
Interacting with erythrocytes which transport immune complexes and xenogenic antigens myelocariocytes and leukocytes of circulating blood produce from them erythroclasic clusters in bone marrow and autorosettes in circulating blood. Formation of these cellular associations is completed with exocytic...
|
PMID: 20804072
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (52)1 2010
Abstract
We report here a 37-year-old female patient with HSP nephritis (HSPN) associated with steroid-resistant nephrotic syndrome and renal dysfunction despite conventional therapy. The patient was successfully treated with intravenous cyclophosphamide following treatment with intravenous pulse methylpredn...
|
PMID: 20166544
PDF is available here.
PDF is available here.
Medicinski arhiv (64)2 2010
Abstract
We analyzed a numerous serum samples from patients suspected to autoimmune diseases (SLE especially). The samples were collected from several clinics in the Clinical Center of University of Sarajevo, mostly from Clinic of Infectious Diseases, Pediatrics, Internal Medicine and Gastroenterohepatology...
|
PMID: 20514769
PDF is available here.
PDF is available here.
Abstract
Heparin-induced thrombocytopenia (HIT) is a potentially life-threatening adverse drug reaction that may develop in certain patients exposed to heparin and is caused by antibodies with specificity for chemokine CXCL4 (formerly known as platelet factor 4)/heparin complexes. Rapid diagnosis and interve...
|
PMID: 20369319
PDF is available here.
PDF is available here.
Abstract
Immunoadsorption (IAS) with various methods is used as a rescue therapy in severely ill SLE patients who are refractory to conventional therapeutic procedures. The method aims at the rapid and extensive removal of pathogenic immunocomplexes (IC) and (auto-) antibodies (Abs). Long-ter...
|
PMID: 20129387
PDF is available here.
PDF is available here.
Parasitology (91 ( Pt 3))03 2009
Abstract
This ultrastructural study has shown that there is a layer of dense flocculent material on the surface of juvenile Fasciola hepatica incubated in vitro with specific bovine antiserum. This material corresponds to the complexes of secreted glycocalyx and bovine antibody previously characterized by fl...
|
PMID: 4080419
PDF is available here.
PDF is available here.
Voenno-meditsinskii zhurnal (330)12 2009
Abstract
There were examined 124 medical histories of patients with psoriatic disease in progressing stage. It's found that including of hardware-generated filtrational-membrane plasmapheresis, providing a middle-volume exfusion of plasma and following compensation of missing volume by water-electrolytic bal...
|
PMID: 20201365
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (66)12 2009
Abstract
Primary retinal vasculitis was diagnosed in 85/1254 (6.8%) of total uveitis. In more than half of the cases of vasculitis (58.8%), both arteries and veins were involved in inflammatory process. Periphlebitis was diagnosed far more commonly (36.5%) than periarteritis (4.7%). Retinal vasculitis associ...
|
PMID: 20095515
PDF is available here.
PDF is available here.
Abstract
I (anti-beta 2 GPI) antibody. Our previous study suggested that ANX2 was also involved in anti-beta 2 GPI/beta 2 GPI-induced TF expression on monocytes. In the current study, it was further demonstrated that beta 2 GPI interacts with ANX2 not only in a cell-dependent form but also in a cell-free sys...
|
PMID: 19724897
PDF is available here.
PDF is available here.
Parasitology (91 ( Pt 2))02 2009
Abstract
We describe the immunochemical analysis of surface antigen expression on [125I]lactoperoxidase-labelled erythrocytes infected either with a SICA[-] clone or with non-cloned SICA[+] parasites using the methods developed for identification of variant antigens with cloned SICA[+] parasites. No 125I-lab...
|
PMID: 3906520
PDF is available here.
PDF is available here.
Parasitology (91 ( Pt 2))02 2009
Abstract
The immune status of a group of sheep naturally infected with hydatid cysts was investigated. Low specific anti-hydatid antibody (Sab) titres and negative results in intradermal and leucocyte migration tests occurred in hosts with high hydatid antigen-stimulated lymphocyte transformation (LT). Total...
|
PMID: 4069754
PDF is available here.
PDF is available here.
Abstract
The pathophysiological role of soluble immune complexes (SICXs) and its relationship with neutrophils were investigated in LPS-induced acute lung injury (ALI) animal model (Sprague-Dawley rat) and through the in vitro studies. Results showed that LPS-induced SICX was timely related to changes of tum...
|
PMID: 19106808
PDF is available here.
PDF is available here.
Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors.
Abstract
We demonstrate the ability of anti-IL-8:IL-8 complexes to promote an inflammatory phenotype of human umbilical vein endothelial cells via interaction with FcgammaRIIa. Human umbilical vein endothelial cells cultured in the presence of the complexes become activated, as shown by increased phosphoryla...
|
PMID: 19109244
PDF is available here.
PDF is available here.
Abstract
Monoclonal antibodies (mAbs) have taken on an increasing importance for the treatment of various diseases including cancers, immunological disorders, and other pathologies. These large biomolecules display specific structural features, which affect their efficiency and need, therefore, to be extensi...
|
PMID: 19588976
PDF is available here.
PDF is available here.
Nature Immunology (10)7 2009
Abstract
We show SCS macrophage development depended on lymphotoxin-alpha1beta2, and the cells had low lysosomal enzyme expression and retained opsonized antigens on their surface. Intravital imaging revealed immune complexes moving along macrophage processes into the follicle. Moreover, noncognate B cells r...
|
PMID: 19503106
PDF is available here.
PDF is available here.
Abstract
Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently. The most well-recognized renal manifestations of APS are the renal artery thrombosis/stenosis, renal infarction, hypertension, renal vein thrombosis,...
|
PMID: 19048414
PDF is available here.
PDF is available here.
Abstract
Journal of Immunological Methods (345)1-2 2009
Abstract
We have thus developed a robust and sensitive assay for the detection and quantification of Bet v 1-IgE immune complexes which should be useful to measure allergen-bound IgE in human body fluids and in in vitro experiments....
|
PMID: 19376122
PDF is available here.
PDF is available here.
Abstract
Dextran-binding immunoglobulin (DIg) was detected in circulating immune complexes in young healthy blood donors. High molecular weight dextran or non-dialysable polysaccharides of edible sugar added to serum markedly increased DIg-containing immune complexes. DIg from plasma was purified by an improv...
|
PMID: 19330624
PDF is available here.
PDF is available here.
International Immunology (21)5 2009
Abstract
We have revealed a novel B cell intrinsic receptor for IgM and IgG which is present in C57BL/6 (B6) mice and is more abundant in non-obese diabetic (NOD) mice. As a consequence, the level of extramembranous IgG monomers and IgM pentamers on peripheral blood B cells from NOD mice was significantly hi...
|
PMID: 19299625
PDF is available here.
PDF is available here.
Autoimmunity (42)4 2009
Abstract
We analysed this complex and Ab against the complex in SLE patients and evaluated their relationship with clinical and serological findings, traditional risk factors for atherosclerosis, and subclinical atherosclerosis. The prevalence and the levels of the complex and of anti-complex Ab were signifi...
|
PMID: 19811279
PDF is available here.
PDF is available here.
Abstract
We show that human macrophages secreted MIF after IC recognition, which in turn controlled the secretion of TNF. Macrophages from Mif-/- mice produced smaller amounts of TNF when stimulated with IgG-opsonized erythrocytes than wild-type (WT) cells. Using passive reverse Arthus reaction in the perito...
|
PMID: 19188484
PDF is available here.
PDF is available here.
Abstract
Our study revealed that direct immunofluorescence on paraffin-embedded sections pre-treated with proteinase K for 30 or 60 min is a less sensitive method than immunofluorescence on frozen sections; therefore a number of glomerulopathies may be overlooked. Immunofluorescence on paraffin sections show...
|
PMID: 19670698
PDF is available here.
PDF is available here.
Abstract
IC have shown effects in an hepatitis B surface antigen positive transgenic mouse model by reducing HBsAg, inducing anti-HBs and initiating cytolytic responses. Phase I, IIA and IIB clinical trials in around 300 viral hepatitis B patients have shown promising results. The mechanisms of IC are mainly...
|
PMID: 19216618
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (84)3 2009
Abstract
We identified English-language publications on hypersensitivity reactions to xenobiotics through the PubMed database, using the search terms drug and/or xenobiotic, hypersensitivity reaction, mechanism, and immune mediated. We analyzed articles pertaining to the mechanism and the role of T cells. Im...
|
PMID: 19252115
PDF is available here.
PDF is available here.
Abstract
We have developed a methodology for preparing ICs containing defined DNA fragments that recapitulate the immunostimulatory activity of the previous "black box" ICs. These reagents reveal an important role for nucleic acid sequence, even when the ligand is mammalian DNA....
|
PMID: 19378022
PDF is available here.
PDF is available here.