Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Immunoglobulin Allotypes (2):
Recent article
Immunoglobulin Allotypes
Abstract
MR-CoNS are probably disseminated in the community, notably in subjects without previous exposure to the health care system. MRSE, the most prevalent species, may act as a reservoir of SCCmec IVa for CA-MRSA....
|
PMID: 20550456
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Annals of the Rheumatic Diseases (67 Suppl 3) 2008
Abstract
Natural killer (NK) cells express surface receptors that regulate potent effector functions, such as cytolytic activity and release of cytokines, which play a central role in inflammatory response and immunoregulation. In this paper, major advances are outlined from the original discovery of HLA-cla...
|
PMID: 19022812
PDF is available here.
PDF is available here.
Clinical Immunology (128)2 2008
Abstract
Some primary immunodeficiencies (PIDs) express low serum levels of antibodies. The constant heavy G chain (IGHG) genes, also representing Fc domains of gamma 3, gamma 1 and gamma 2 on chromosome 14q32.3, genotyped by the alternative IgG subclass allotypes, found in four fixed IGHG haplotypes, design...
|
PMID: 18502179
PDF is available here.
PDF is available here.
Molecular Immunology (45)14 2008
Abstract
We analyzed the natural killer cell immunoglobulin-like receptor (KIR) genes and immunoglobulin allotypes in the development of type 2 diabetes (T2D) based on body mass index (BMI) measurements (obese vs. non-obese) in Puerto Rican Americans. Genetic interactions between the KIR haplotype A homozygo...
|
PMID: 18632158
PDF is available here.
PDF is available here.
Cancer Research (68)11 2008
Abstract
These results show, for the first time, that GM and KM allotypes contribute to the interindividual differences in humoral immunity to MUC1....
|
PMID: 18519707
PDF is available here.
PDF is available here.
Cancer Research (68)4 2008
Abstract
We indeed observed higher binding of the anti-CD16 monoclonal antibody (mAb) 3G8 on NK cells from V carriers (VV = VF > FF). However, the binding of two other anti-CD16 mAbs, LNK16 and DJ130c, decreased with the number of V allele (VV < VF < FF). CD16 transcript levels were independent on the genoty...
|
PMID: 18281470
PDF is available here.
PDF is available here.
Immunologic Research (40)2 2008
Abstract
The IGHG (ImmunoGlobulin constant Heavy G chain) genes are situated close to the IGHE gene on chromosome 14q32, 5'mu, delta, gamma3, gamma1, alpha1, gamma2, gamma4, epsilon, alpha2, 3', in linkage disequilibrium. The polymorphism of gamma3, gamma1 and gamma2 genes, is investigated as alternative all...
|
PMID: 18213529
PDF is available here.
PDF is available here.
Human Immunology (68)12 2007
Abstract
We conclude that positive B-cell flow crossmatch was likely the result of single MM in the DP locus....
|
PMID: 18191721
PDF is available here.
PDF is available here.
Journal of Immunology (179)2 2007
Abstract
We have analyzed gene-targeted mice that carry a human and a mouse Igk C region genes. Using different methodologies, we found that cells expressing two distinct kappa-chains were 1.4-3% of all B cells and that they were present in the follicular, marginal zone, and B1 mature B cell subsets. When st...
|
PMID: 17617597
PDF is available here.
PDF is available here.
Molecular Immunology (44)13 2007
Abstract
We show that while myeloma cells secrete IgA2m(2) predominantly as H(2)L(2), CHO cells secrete H(2)L and H(2) in addition to fully assembled H(2)L(2). When the CHO cells also synthesize J chain and secretory component (SC), polymeric IgA and secretory IgA in which SC is disulfide bonded to the polym...
|
PMID: 17467056
PDF is available here.
PDF is available here.
Abstract
We tested the effect of hydralazine, an antihypertensive drug that triggers lupus, on receptor editing, a chief mechanism of B lymphocyte tolerance to self-antigens. Using mice expressing transgenic human Igs, we found that hydralazine impairs up-regulation of RAG-2 gene expression and reduces secon...
|
PMID: 17404230
PDF is available here.
PDF is available here.
Molecular Immunology (44)11 2007
Abstract
We finally propose a possible immunoregulatory role for idiotypic immunogenicity....
|
PMID: 17306373
PDF is available here.
PDF is available here.
Abstract
The time in WBC>1.0x10(9)/L was (13.1+/-2.4) d and (16.3+/-3.0) d (P=0.003), the time in PLT>20x10(9)/L was (14.9+/-6.6) d and (20.2+/-7.3) d (P=0.042), respectively, RD-BMT and URD-BMT. The time with WBC>1.0x10(9)/L was (12.5+/-2.9) d and (13.1+/-4.1) d (P=0.488), the time with PLT>20x10(9)/L was (...
|
PMID: 17445441
PDF is available here.
PDF is available here.
Abstract
Journal of Immunology (177)10 2006
Abstract
I transmembrane protein with five extracellular Ig domains and a cytoplasmic tail with a consensus ITIM and a noncanonical ITAM. Analysis of full-length cDNAs from five different mouse strains defines two FcRH3 alleles. A panel of FcRH3-specific mAbs was generated to define its expression pattern an...
|
PMID: 17082595
PDF is available here.
PDF is available here.
Human Immunology (67)11 2006
Abstract
We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Puerto Rican ethnic background. We found a slight inc...
|
PMID: 17145370
PDF is available here.
PDF is available here.
Abstract
We report a clear-cut demonstration of the induction of anti-infliximab antibodies during the treatment of a patient with ankylosing spondylitis (AS). Assessment of anti-infliximab antibodies in sera obtained at various time periods were performed using a highly specific double antigen assay system...
|
PMID: 16341700
PDF is available here.
PDF is available here.
Abstract
We have purified two of these g200 distinct forms from two individuals of the same sponge species. Comparison of allotypic versus isotypic g200 binding forces reveals significant differences. Surface plasmon resonance measurements show that g200 self-adhesion is much stronger than its binding to oth...
|
PMID: 16373355
PDF is available here.
PDF is available here.
Genetika (Moskva) (42)3 2006
Abstract
Variation of serum protein allotypes serving as genetic markers of the blood has been analyzed in 29 populations of the domestic pig and subspecies of the wild boar. The population biodiversity and genetic structure have been estimated by two methods: by the frequencies of allotype combinations and...
|
PMID: 16649668
PDF is available here.
PDF is available here.
Abstract
Abstract
The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. A novel FcgammaR that binds IgG2 but not IgG1 has just been identified, potentially explaining differences in biological activity that are seen with various IgG isotypes....
|
PMID: 16039573
PDF is available here.
PDF is available here.
Molecular Immunology (42)11 2005
Abstract
Although a rich database of Igh a allotype mouse immunoglobulin germline genes exists, current information on Igh b allotype immunoglobulin germline genes is limited. Among the immunoglobulin VH genes, single-cell amplified from six Igh b (C57BL/6 background) spleens in this study, 602 clonally inde...
|
PMID: 15950725
PDF is available here.
PDF is available here.
Journal of Immunology (174)11 2005
Abstract
We show in rheumatoid factor (RF) Ig-transgenic autoimmune-prone mice that the appearance of RF B cells in blood signifies the onset of RF B cell activation in spleen, providing a novel window into the initiation of an autoantibody response. This allowed us to study the early and late phases of spon...
|
PMID: 15905529
PDF is available here.
PDF is available here.
Abstract
Goodpasture's disease is characterized by crescentic glomerulonephritis and lung hemorrhage in the presence of anti-glomerular basement membrane (anti-GBM) antibodies. This disease usually is mediated by IgG autoantibodies directed against the noncollagenous domain of the alpha3(IV) collagen chain,...
|
PMID: 15685519
PDF is available here.
PDF is available here.
Abstract
We demonstrate a delay in the recovery of the B-lymphocyte repertoire, measured by variation in size distribution of the immunoglobulin H CDR3 in patients conditioned with RIC compared to MAC. We found no general explanation for this finding, but when clinical data for each patient were studied in d...
|
PMID: 15644125
PDF is available here.
PDF is available here.
Abstract
We immunized rabbits of the same Ig phenotype but born to homozygous mothers, and therefore not exposed to that allotype. Immunization was done in a3/a3 offspring of either a1/a3 or a3/a3 mothers, by injecting al IgG, and in b6/b6 offspring of b4/b6 or b6/b6 mothers, by injecting b4 IgG. The IgG was...
|
PMID: 1915556
PDF is available here.
PDF is available here.
Abstract
We wished to determine whether their immunization protocol would reproducibly elicit expression of ldquohiddenrdquo allotypes. None of the 36 immunized rabbits developed elevated expression of an unexpected allotype during the 7-38 weeks of immunization and bleeding. However, we did observe elevated...
|
PMID: 408155
PDF is available here.
PDF is available here.
Abstract
We failed in revealing any sign of a T cell reactivity against Igh-6b similar to the reactivity against Igh-lb. The use of Igh-6b+ myeloma cells grown in an Ighprime or in an Igha background allowed us to assume that the cells responsible for the sensitization are, in the Ighb B lymphocyte populatio...
|
PMID: 2964374
PDF is available here.
PDF is available here.
Abstract
We have shown that a radioresistant, low-density fraction, consisting mainly of macrophages (MPhi) and dendritic cells, triggers only weak Igchi;-1b-specific T cell response. The high level of response was observed against radiosensitive spleen cell fractions of intermediate and high density, sugges...
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that normal B cells, including small B cells, are capable of presenting Igchi;-1b allotypic determinants of their endogeneously synthesized Ig+ to Igchi;-1b-immune major histocompatibility complex (MHC) class II-restricted T cells. A panel of Igchi;-1b allotype-specific T cell c...
PDF is available here.
PDF is available here.
Abstract
We have analyzed 210 lambda-producing hybridomas derived from lipopolysaccharidestimulated spleen cells from a single x-suppressed mouse. All were classified as lambda1, lambda2 or lambda3 with the exception of four unusual lines. Two of these were due to Vlambda2 Jlambda1 and the other two to Vlambd...
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the repertoire shift from V(H)n to V(H)a B cells results from interactions between GALT and intestinal microflora. To test this hypothesis, we surgically removed organized GALT from newborn Alicia pups and ligated the appendix to sequester it from intestinal microflora. Flow cyt...
|
PMID: 15623575
PDF is available here.
PDF is available here.
Hepatology (40)3 2004
Abstract
Abstract
These results suggest that GM genotypes make a significant contribution to the risk of acquiring HCV infection.
Copyright 2004 Wiley-Liss, Inc....
|
PMID: 15170632
PDF is available here.
PDF is available here.
Journal of Immunological Methods (288)1-2 2004
Abstract
We describe here the development of antibodies that cross-react with mouse and human VEGFR2. High-affinity, species cross-reactive, Fabs specific for KDR/Flk-1 were selected from an antibody phage display library generated from an immunized rabbit of b9 allotype. The selected chimeric rabbit/human F...
|
PMID: 15183093
PDF is available here.
PDF is available here.
Journal of Virology (78)9 2004
Abstract
We hypothesized that GM and KM allotypes affect the outcome of hepatitis C virus (HCV) infection. To test this hypothesis, we serologically allotyped 100 persons with well-documented clearance of HCV infection and 198 matched persistently infected persons. None of the GM or KM phenotypes by itself w...
|
PMID: 15078937
PDF is available here.
PDF is available here.
Journal of Immunology (172)2 2004
Abstract
We studied the V(H) loci in the original species range to obtain a better understanding of the evolutionary history of this unusual polymorphism. Serological surveys revealed that sera from the subspecies algirus, when tested with V(H)a locus-specific alloantisera, showed either cross-reactivity ("a...
|
PMID: 14707078
PDF is available here.
PDF is available here.
Joint Bone Spine (71)1 2004
Abstract
We report a 74-year-old woman with widespread and substantial osteosclerotic lesions, associated with IgA-lambda myeloma, and with no other criteria for POEMS syndrome, and who was rapidly diagnosed with compression of the spinal cord. Detailed knowledge of imaging features in myeloma emphasises the...
|
PMID: 14769529
PDF is available here.
PDF is available here.
Clinical and Experimental Rheumatology (22)3 Suppl 33 2004
Abstract
In SSc patients, GM f,z genotypes were strongly associated with the occurrence of anti-HCMV IgG antibodies. The frequency of the GM f homozygotes was lower (42.2 vs 62.2%; p= 0.02; OR=0.4) and the frequency of the GM f,z heterozygotes was higher (51.1 vs 26.7%; p = 0.006; OR = 2.8) in SSc patients w...
|
PMID: 15344596
PDF is available here.
PDF is available here.
Immunogenetics (55)10 2004
Abstract
We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1m (1,2,3,17), G2m (23), G3m (5,6,10,11,13,14,15,16,21,24,28) and Km (1) allotypes by the standard agglutination-inhibition method. We found the typical genetic patterns of...
|
PMID: 14652700
PDF is available here.
PDF is available here.
Annals of Saudi Medicine (24)1 2004
Abstract
The MHC class II alleles (DRB1, DQA1, DQB1) and C4 null associations noted in other ethnic groups are also found in Tunisians, suggesting shared susceptibility factors across ethnic lines in predisposition to SLE. In contrast to other ethnic groups, MHC class II alleles are not associated with the p...
|
PMID: 15310011
PDF is available here.
PDF is available here.
Tissue Antigens (62)4 2003
Abstract
We present evidence of association between complement C3 and BF allotypes, and the susceptibility to Chagas disease and the development of cardiomyopathy. C3, BF, C4A, C4B and C2 polymorphism were determined in 100 seropositive Chagasic patients [cardiomyopathic (CARD), n = 57; asymptomatic indeterm...
|
PMID: 12974797
PDF is available here.
PDF is available here.
Abstract
In a sample of n = 133 non-related patients suffering from pulmonary tuberculosis, Gm and Km typings have been carried out and compared with healthy controls from the same geographical area. All the Gm allotypes tested were found to be more preponderant in the patients than in the healthy controls a...
|
PMID: 14524005
PDF is available here.
PDF is available here.
Journal of Immunology (170)9 2003
Abstract
We generated gnotobiotic and conventionally reared Ig allotype chimeric mice. In this system B1- and B2-derived Abs can be distinguished based on different allotypes. FACS analysis of peritoneal cavity cells and analysis of B1- and B2-derived serum IgM indicated stable B1/B2 chimerism and the establ...
|
PMID: 12707334
PDF is available here.
PDF is available here.
Journal of Molecular Biology (325)2 2003
Abstract
We recently reported the first humanization of a rabbit monoclonal antibody. The allotypic diversity of rabbit immunoglobulins prompted us to compare different rabbit immune repertoires for the generation and humanization of monoclonal antibodies that bind with strong affinity to antigens involved i...
|
PMID: 12488098
PDF is available here.
PDF is available here.
Abstract
The traditional methods of investigations according to systems AB0, Gm and Hp were used to define the serological specificity of home gooses' blood. The experimental examinations' results related with mixed bloodstains of man and home gooses are described. A possibility is demonstrated to identify t...
|
PMID: 12939841
PDF is available here.
PDF is available here.
Abstract
The presence of PP1Pk antibody is considered a main cause of repeated spontaneous abortions in early pregnancy. Because PP1Pk antibody generated in maternal blood may disturb the feto-maternal environment, plasmapheresis is supposed to be a beneficial method of lowering PP1Pk antibody levels in wome...
|
PMID: 12939562
PDF is available here.
PDF is available here.
Abstract
We attempt to provide an overview of this body of knowledge. Direct comparison of the different studies is difficult. Different ethnic populations, different JRA/JIA subgroups, and different systems of nomenclature and classification all impose various limitations. Adding to the complexity is the po...
|
PMID: 14611119
PDF is available here.
PDF is available here.
Abstract
We induced cGVH in two anti-DNA H chain site-directed transgenic mouse strains. This resulted in clonal expansion and selection of specific mutations in the anti-double-stranded (ds) DNA B cell population. These data, together with a high frequency of anti-dsDNA B cell clones recovered as hybridomas...
|
PMID: 12515811
PDF is available here.
PDF is available here.
Abstract
The aim of the study was to determine possible factors related to the risk of developing recurrent bacterial respiratory tract infections in HIV-1-infected patients, regardless of the degree of immune cellular impairment. Thirty-three HIV-1 seropositive patients with previous repetitive bacterial re...
|
PMID: 12390315
PDF is available here.
PDF is available here.
Journal of Immunology (169)9 2002
Abstract
We show that covalent assembly of the H and L chains in IgA2(n) requires hinge-proximal Cys(241) and Cys(242) in C(H)2 and not Cys(196) or Cys(220) in C(H)1. Using pulse-chase experiments, we have demonstrated that wild-type IgA2(n) with Arg(221) and Cys(241) and Cys(242) assembles through a disulfi...
|
PMID: 12391223
PDF is available here.
PDF is available here.
Journal of Immunology (169)7 2002
Abstract
On the non-autoimmune C57BL/6 (B6) background, the chromosome 7-derived lupus susceptibility loci Sle3 and Sle5 have been shown to mediate an elevated CD4:CD8 ratio with an increase in activated CD4(+) T cells, decreased susceptibility to apoptosis, and a break in humoral tolerance. Development of s...
|
PMID: 12244205
PDF is available here.
PDF is available here.
Abstract
We show that the Enpp1a and Enpp1b alleles differ by only two amino acids, at positions 650 and 679 in the C-terminal nuclease-like domain. Histidine 650 but not arginine 679 forms an essential part of the Enpp1a epitope recognized by monoclonal antibody IR-518. Sequences of LEW and LOU rats and the...
|
PMID: 12121276
PDF is available here.
PDF is available here.
Abstract
Human Immunology (63)6 2002
Abstract
In order to determine whether TNF-alpha, IL1-beta, GM, and KM genes affect susceptibility to sarcoidosis, coded DNA samples from 278 Caucasian and 219 African-American patients and an equal number of matched controls were genotyped by polymerase chain reaction methods. All genotypes were in Hardy-We...
|
PMID: 12039524
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (277)19 2002
Abstract
HLA-B*2704 is strongly associated with ankylosing spondylitis. B*2706, which differs from B*2704 by two amino acid changes, is not associated with this disease. A systematic comparison of the B*2704- and B*2706-bound peptide repertoires was carried out to elucidate their overlap and differential fea...
|
PMID: 11875071
PDF is available here.
PDF is available here.
Molecular Immunology (38)14 2002
Abstract
I MHC molecules expressed on target cells. KIR recognition provides vital information to NK cells about whether a target cell should be lysed or spared. Understanding the molecular mechanism of this recognition has remained a strong focus of investigation. This has resulted in the crystal structures...
|
PMID: 11955593
PDF is available here.
PDF is available here.
Immunogenetics (53)12 2002
Abstract
Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the l...
|
PMID: 11904680
PDF is available here.
PDF is available here.
Genes and Immunity (3)1 2002
Abstract
The kappa light chain constant region of immunoglobulins bears polymorphic markers involved in susceptibility to various autoimmune diseases. To determine whether it also contributes to the occurrence of pemphigus, a group of autoimmune blistering skin diseases owing to pathogenic autoantibodies, th...
|
PMID: 11857063
PDF is available here.
PDF is available here.