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Immunoglobulins, Intravenous (0):
Recent article
Immunoglobulins, Intravenous
New England Journal of Medicine (365)13 2011
Abstract
We enrolled 3493 infants receiving antibiotics for suspected or proven serious infection and randomly assigned them to receive two infusions of either polyvalent IgG immune globulin (at a dose of 500 mg per kilogram of body weight) or matching placebo 48 hours apart. The primary outcome was death or...
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PMID: 21962214
PDF is available here.
PDF is available here.
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Autoimmunity Reviews (10)11 2011
Abstract
Anti-phospholipid syndrome (APS) is an autoimmune prothrombotic disorder characterised by the predisposition to venous and/or arterial thrombosis and obstetric morbidity. Management of APS centres on attenuating the procoagulant state whilst balancing the risks of anticoagulant thera...
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PMID: 21558021
PDF is available here.
PDF is available here.
Abstract
Anemia, leukopenia, and/or thrombocytopenia can occur as a result of non-immune- and immune-mediated mechanisms in patients with systemic lupus erythematosus. Although the differential diagnosis of these cytopenias is broad and warrants a thorough evaluation, lupus disease activity a...
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PMID: 21503695
PDF is available here.
PDF is available here.
Abstract
We discuss these important advancements and their relevance to transplant medicine....
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PMID: 21595600
PDF is available here.
PDF is available here.
Abstract
Immunoglobulin (Ig) therapy is an important method of treatment for a number of immunological, hematological, neurological and dermatological disorders. Over the years, the range of indications in which Ig therapy, either replacement or immunomodulatory, is effective has substantiall...
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PMID: 21595597
PDF is available here.
PDF is available here.
Abstract
Traditional treatment of primary (idiopathic) immune thrombocytopenia (ITP) predominantly consists of immune suppression and/or modulation. In addition, many treated patients develop severe adverse effects, and approximately a third of patients do not respond. Two of the newly develo...
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PMID: 21322783
PDF is available here.
PDF is available here.
Immunotherapy (3)2 2011
Abstract
Liquid IgG preparations are preferred over lyophilized preparations because reconstitution is not required. Formation of dimers and aggregates in liquid preparations increases adverse effects and limits the shelf life of most liquid IgG products. Improved understanding of the binding...
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PMID: 21322757
PDF is available here.
PDF is available here.
Cardiology in the Young (20)6 2010
Abstract
We evaluated the long-term histopathology of the myocardium, especially of intramural small vessels in asymptomatic Kawasaki disease with giant aneurysms.
The initial study comprised 16 consecutive Kawasaki patients - male-to-female ratio was 12:4 - aged from 2 to 12 years, and in the subsequent stu...
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PMID: 20584347
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)47 2010
Abstract
We present treatment data from 17 paediatric departments in Denmark (1998-2000), focusing on regional differences in treatment strategy.
As part of a prospective Nordic study, clinical findings and treatment were recorded for 109 children with newly diagnosed ITP. The course in the following six mon...
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PMID: 21092720
PDF is available here.
PDF is available here.
Abstract
Immune thrombocytopenia (ITP) is caused by immune-mediated platelet destruction and reduced platelet production. The aim of this review article is to provide an updated overview of pathophysiology and new therapeutic modalities in ITP.
The article is based on literature identified through a non-syst...
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PMID: 21052113
PDF is available here.
PDF is available here.
Abstract
We should always be careful for the side effects of long-term treatment. Intravenous immunoglobulin (IVIG) is one potential and promising therapy for patients with pemphigus, and evidence of its effectiveness and safety is increasing. A number of pemphigus patients in which IVIG treatment was benefi...
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PMID: 21061546
PDF is available here.
PDF is available here.
Hämostaseologie (30 Suppl 1) 2010
Abstract
We report on a boy with severe haemophilia A and intron 22 inversion of the FVIII gene who was diagnosed at ten months of age. After 16 exposure days to FVIII (81 days after initial exposure) he developed a FVIII inhibitor (maximum: 9.76 BU/ml). Therapy: We started immune tolerance induction (ITI) a...
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PMID: 21042665
PDF is available here.
PDF is available here.
Abstract
Abstract
Intravenously applied immunoglobulin (IVIg) are used in medicine over 50 years. Beneficial effects of IVIg therapy have been described in the treatment of primary immunodeficiencies, inflammatory and autoimmune diseases, and new applications are still searched. Nevertheless, the mechanisms responsib...
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PMID: 21207645
PDF is available here.
PDF is available here.
Abstract
We describe the combined use of new agents (bortezomib and eculizumab) and modalities (nontraditional vascular access, splanchnic drainage of graft and domino paired donation) in a patient who would have died without transplantation.
© 2010 The Authors Journal compilation © 2010 The American Socie...
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PMID: 20636451
PDF is available here.
PDF is available here.
Immunotherapy (2)5 2010
Abstract
This meeting was dedicated to various autoimmune diseases and their mechanisms, diagnosis and therapies. The autoimmunity-promoting factors included genetic variations and environmental injuries. A broad array of cytokines, including the B-cell activating factor, and autoantibodies,...
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PMID: 20874644
PDF is available here.
PDF is available here.
Abstract
I and II generation and steroids are used. Severe adverse events are indication for withdraw the immunoglobulins intravenous infusions. In these patients the subcutaneous way of immunoglobulins substitution is an alternative with hope that low singular dose and slow uptake may be better tolerated....
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PMID: 20931833
PDF is available here.
PDF is available here.
Abstract
We determined the prevalence of TMA in patients with C4d positive (n = 243) and C4d negative (n = 715) biopsies. Over 90% of patients received cyclosporine in both groups. De novo TMA was seen in 59 (6.1%) patients; most of them (55%) with C4d positive biopsy. Among patients with C4d positive biopsi...
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PMID: 20659088
PDF is available here.
PDF is available here.
Abstract
Yearly influenza vaccination is recommended for patients with humoral primary immunodeficiency (hPID). However, humoral responses following vaccination can be expected to be reduced in these patients. The efficacy of influenza vaccination in patients with hPID, anti-influenza antibody responses was...
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PMID: 20421178
PDF is available here.
PDF is available here.
Abstract
Abstract
Obstetrics & Gynecology (116 Suppl 2) 2010
Abstract
We report the use of IVIG to prevent progression of 2:1 congenital heart block with intermittent complete heart block. After two maternal infusions of IVIG (0.4 g/kg) at 31 weeks of gestation, the fetal heart rate reverted to long periods of sinus rhythm, which was sustained until postnatal life.
Ou...
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PMID: 20664449
PDF is available here.
PDF is available here.
Military Medicine (175)8 2010
Abstract
We present a case in which a 25-year-old, Hispanic woman presented with seizures, memory loss, and unusual behavioral changes. The woman had a teratoma removed 2 months earlier. Because of the time course, a paraneoplastic syndrome was initially considered unlikely. Brain imaging, electroencephalogr...
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PMID: 20731268
PDF is available here.
PDF is available here.
Cardiology in the Young (20)4 2010
Abstract
A total of 735 children with Kawasaki disease were enrolled in this study with 483 boys and 252 girls. The ratio of male to female was 1.92:1. The ages of the children at onset varied from 51 days to 12 years with a mean age of 2.8 years. The children under the age of 5 years accounted for 79.5%, bu...
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PMID: 20420740
PDF is available here.
PDF is available here.
Nursing Management (41)8 2010
Abstract
Archives of Neurology (67)7 2010
Abstract
Data suggest that treatment with 2 courses of IGIV-C administered 3 weeks apart may be required for initial improvement, and continued maintenance therapy may be necessary to achieve a maximal therapeutic response. Trial Registration clinicaltrials.gov Identifier: NCT00220740....
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PMID: 20457948
PDF is available here.
PDF is available here.
Abstract
We report a 70-year-old man who developed severe Clostridium difficile infection, was admitted to the intensive care unit and eventually succumbed to complications of his illness despite receiving tigecycline for approximately three weeks in combination with vancomycin, metronidazole and intravenous...
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PMID: 20715744
PDF is available here.
PDF is available here.
Transplant Immunology (23)3 2010
Abstract
We examined the possible synergistic effects of combined MMF and IVIG on cell proliferation and apoptosis induction in the MLR.
Two-way MLRs were performed with mycophenolic acid (MPA), IVIG and both in combination. Cell proliferation and apoptosis were detected by 3H-thymidine incorporation and Ann...
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PMID: 20450974
PDF is available here.
PDF is available here.
Abstract
We report a patient with Lewis-Sumner syndrome (LSS) who showed an improvement only with plasma exchange (PE). The patient, 32-yr old man, had progressive multifocal motor-sensory deficits with persistent, multiple conduction blocks and marked slowing of NCVs. Nerve pathology supported a diagnosis o...
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PMID: 20592909
PDF is available here.
PDF is available here.
Abstract
I and II) or without (Group III) conventional immunotherapy. Serum rituximab levels, drawn before and after each infusion and at later intervals, were analyzed by enzyme-linked immunosorbent assay. Rituximab concentration increased stepwise with each infusion, dropping by the next infusion, thereby...
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PMID: 20606544
PDF is available here.
PDF is available here.
Abstract
Our data show that IVIg suppress allogeneic T-cell responses by direct activation of Tregs. IVIg treatment, which has been proven safe, may have therapeutic potential in tolerance-inducing strategies in transplant medicine....
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PMID: 20463648
PDF is available here.
PDF is available here.
Annals of Internal Medicine (152)12 2010
Abstract
Transplantation (89)11 2010
Abstract
This study assesses the immunologic, functional, and histologic course of kidney recipients with preformed donor-specific alloantibodies (DSA) receiving deceased donor kidneys according to two prophylactic strategies that have been sequentially applied posttransplant....
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PMID: 20386362
PDF is available here.
PDF is available here.
Abstract
Acta Cardiologica (65)3 2010
Abstract
The mid-term outcome of patients who suffered from Kawasaki disease during childhood is excellent. However, almost half of them were treated with oral aspirin during follow-up....
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PMID: 20666266
PDF is available here.
PDF is available here.
Abstract
IVIG is prescribed for a significant number of non-authorised and non-accepted indications with a notable cost. There is an important variability in IVIG prescriptions between hospitals, indicating room for improvement in IVIG use and the need for a consensus of protocol use....
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PMID: 20204337
PDF is available here.
PDF is available here.
Abstract
Guillain-Barré syndrome, a randomly acquired inflammatory condition that can lead to progressive muscle weakness and paralysis, is a rare presentation in emergency departments, and differentiating its early stages from common viral illnesses can be difficult. Emergency practitioners should be aware...
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PMID: 20608399
PDF is available here.
PDF is available here.
The Surgeon (8)3 2010
Abstract
Abstract
We have shown that high-dose intravenous immune globulin (IVIG; 2 g/kg x2 doses)+rituximab (1 g x2 doses) was effective in lowering anti-human leukocyte antigen (HLA) antibodies and improving rates of transplantation. The aim of this report was to evaluate the efficacy of IVIG+rituximab on reduction...
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PMID: 20110854
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (292)1-2 2010
Abstract
We report on a female allogeneic bone marrow transplanted patient who developed GBS as a leading manifestation of GvHD subsequent to discontinuation of her immunosuppressive medication with cyclosporine. In contrast to former case reports both IVIg and plasma exchange failed while resumption of immu...
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PMID: 20163810
PDF is available here.
PDF is available here.
Medicine (Baltimore) (89)3 2010
Abstract
We report 10 cases of adult KD, including 6 patients who fulfilled the criteria for incomplete KD, diagnosed either at presentation (n = 4) or retrospectively (n = 2). At the time of clinical presentation, complete KD was diagnosed in 4 patients, while 4 patients fulfilled the criteria for incomplet...
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PMID: 20453601
PDF is available here.
PDF is available here.
Abstract
We assess the evidence on the efficacy of IVIG in certain infectious diseases....
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PMID: 20447982
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (50)5 2010
Abstract
We regarded this case as one of chronic progression of Encephalo-myelo-radiculo-neuropathy....
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PMID: 20535982
PDF is available here.
PDF is available here.
Abstract
Abstract
To determine whether two different intravenous immunoglobulin (IVIG) preparations were equally efficacious in the treatment of Kawasaki disease (KD). Single centre retrospective review of all patients treated with IVIG for KD between January 1990 and April 2007. Comparison of IVIG (dose 2 g/kg) from...
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PMID: 20546528
PDF is available here.
PDF is available here.
Abstract
A 13-year-old girl with a known diagnosis of systemic lupus erythematosus presented with seizures and psychosis. An electroencephalogram (EEG) revealed continuous, non-evolving periodic lateralized epileptiform discharges (PLEDs) in the left temporal region, which did not resolve wit...
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PMID: 20133346
PDF is available here.
PDF is available here.
Abstract
A 13-year-old girl with a known diagnosis of systemic lupus erythematosus presented with seizures and psychosis. An electroencephalogram (EEG) revealed continuous, non-evolving periodic lateralized epileptiform discharges (PLEDs) in the left temporal region, which did not resolve wit...
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PMID: 20133346
PDF is available here.
PDF is available here.
Abstract
A 13-year-old girl with a known diagnosis of systemic lupus erythematosus presented with seizures and psychosis. An electroencephalogram (EEG) revealed continuous, non-evolving periodic lateralized epileptiform discharges (PLEDs) in the left temporal region, which did not resolve wit...
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PMID: 20133346
PDF is available here.
PDF is available here.
Abstract
A 13-year-old girl with a known diagnosis of systemic lupus erythematosus presented with seizures and psychosis. An electroencephalogram (EEG) revealed continuous, non-evolving periodic lateralized epileptiform discharges (PLEDs) in the left temporal region, which did not resolve wit...
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PMID: 20133346
PDF is available here.
PDF is available here.
Abstract
A 13-year-old girl with a known diagnosis of systemic lupus erythematosus presented with seizures and psychosis. An electroencephalogram (EEG) revealed continuous, non-evolving periodic lateralized epileptiform discharges (PLEDs) in the left temporal region, which did not resolve wit...
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PMID: 20133346
PDF is available here.
PDF is available here.
Abstract
Three patients with extensive necrotizing pneumonia due to Panton-Valentine leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3x10(9)/liter in all three cases and hemoptysis in two cases) were successfully treated with toxin-suppressing age...
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PMID: 20129956
PDF is available here.
PDF is available here.
Abstract
Vox Sanguinis (98)3 Pt 1 2010
Abstract
The different complement batches had a significant impact on the test result of the ACA assay. It was demonstrated that polymers, provoked by heat treatment at pH values above 5.5, consumed complement almost completely whereas a polymer content up to 12% formed under acidic conditions did not lead t...
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PMID: 20432511
PDF is available here.
PDF is available here.
Critical Care Medicine (38)4 Suppl 2010
Abstract
The world is experiencing a pandemic of swine-origin influenza virus H1N1. A vaccine to prevent disease is now available, and millions have or will become ill before they can be vaccinated. The ability to use swine-origin influenza virus vaccines as a public health tool has been described as a "race...
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PMID: 20154602
PDF is available here.
PDF is available here.
Abstract
Stiff-person syndrome (SPS) is an autoimmune neurological disorder characterized by rigidity of the trunk and proximal limb muscles, intermittent superimposed spasms, and increased sensitivity to external stimuli. It has been more than 50 years since Moerch and Woltman reported the f...
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PMID: 20420178
PDF is available here.
PDF is available here.
Abstract
The aim of this article is to review the paraneoplastic opsoclonus-myoclonus syndrome (POMS). Opsoclonus is characterized by involuntary, arrhythmic, chaotic, multi-directional saccades with horizontal, vertical and torsional components, and it is commonly accompanied by cerebellar ataxia and myoclo...
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PMID: 20420176
PDF is available here.
PDF is available here.
Abstract
Anti-voltage-gated potassium channel antibodies (anti-VGKC-Ab) cause hyperexcitability of the peripheral nerve and central nervous system. Peripheral nerve hyperexcitability is the chief manifestation of Issacs syndrome and cramp-fasciculation syndrome. Morvan syndrome is characterized by neuromyoto...
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PMID: 20420173
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
Annals of Hematology (89)4 2010
Abstract