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Immunoglobulins, Thyroid-Stimulating (1):
Recent article
Immunoglobulins, Thyroid-Stimulating
Annales d'Endocrinologie (72)1 2011
Abstract
We report the case of a 53-year-old woman who underwent two-phase total thyroidectomy (June and December 2001) for a multinodular goiter with incidental discovery at the first procedure of a multicentric papillary carcinoma of the right thyroid lobe. Thyroidectomy was followed by an ablative dose of...
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PMID: 21195999
PDF is available here.
PDF is available here.
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Autoimmunity Reviews (10)2 2010
Abstract
Immunoglobulins in patients with Graves' disease (GD) that modulate the thyroid stimulating hormone receptor (TSH-R) do so via stimulating cAMP dependent signals (TSI), blocking TSH or inhibition of TSH-receptor activation (TBI) or inducing apoptotic signals. These functional immunog...
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PMID: 20807591
PDF is available here.
PDF is available here.
Abstract
These results showed that normal thyroid recorded by US matches with normal thyroid laboratory assessment to a large degree. These preliminary data need to be confirmed in a prospective study and in a larger series and should suggest the evaluation of thyrotropin and thyroid antibodies in subjects w...
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PMID: 19998241
PDF is available here.
PDF is available here.
Abstract
Our results suggest that YE ompF is involved in the production of TRAb and the pathogenesis of GD through molecular mimicry. These findings are potentially important for understanding the role molecular mimicry plays in the disturbance of immune tolerance and the induction of autoimmunity to the TSH...
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PMID: 20484489
PDF is available here.
PDF is available here.
Abstract
We report a case of Graves' disease in a patient on regular hemodialysis. CASE REPORT: A 26-year-old man undergoing regular hemodialysis from unknown chronic nephropathy since four years. The patient suffered from unexplained slimming and aggressiveness. On admission, he had an irritability, tremor...
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PMID: 20488772
PDF is available here.
PDF is available here.
Abstract
Abstract
ITA-PSV and thyroid volume were higher in women with GD immediately after delivery compared to normal women, but the levels of TSH receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) did not differ significantly between the two groups. Of the 42 patients, 23 had relapse of GD and the sm...
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PMID: 20006462
PDF is available here.
PDF is available here.
Endocrine Journal (57)4 2010
Abstract
We examined the inhibitory effect of thyroid blocking antibody (TBAb) on the thyroid stimulating activity of human chorionic gonadotropin (HCG) and equine CG (ECG). Five TBAb positive sera obtained from patients who had been hypothyroid but were currently on T4 treatment. The TSH binding inhibitory...
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PMID: 20351465
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
We tested the hypothesis that eukaryotic A-subunit injected into BALB/c mice without immune stimulation would generate tolerance and protect against hyperthyroidism induced by subsequent immunization with A-subunit adenovirus. Indeed, one sc injection of eukaryotic, glycosylated A-subunit protein 1...
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PMID: 19389831
PDF is available here.
PDF is available here.
Abstract
In the pediatric population, initial normal or slightly elevated TSH levels are likely to remain normal or spontaneously normalize without treatment. Patients with initial levels greater than 7.5 mIU/liter, particularly girls, are at a greater risk for sustained abnormal TSH levels....
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PMID: 19240148
PDF is available here.
PDF is available here.
Abstract
We present a case of TH associated with hyperthyroidism due to Graves' disease....
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PMID: 19627717
PDF is available here.
PDF is available here.
Abstract
Abstract
Interference by TSH-immunoglobulin complexes should be ruled out in euthyroid and hyperthyroid patients presenting with inappropriately increased or non-suppressed TSH values....
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PMID: 19397486
PDF is available here.
PDF is available here.
Abstract
We have compared both analytical and clinical performances of hTRAK with those of five new methods using a porcine TSHR: two 2G methods and three assays using the monoclonal M22 directed against the TSHR pocket. We showed a bad reproducibility of these new methods with inter assay CVs higher than 10...
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PMID: 19939769
PDF is available here.
PDF is available here.
Abstract
Five patients treated for TRO at Singapore National Eye Centre from January 2007 to December 2008 were included in the study. There were 2 males and 3 females with mean age of 54.6 years (range 51-86). Surgery included phacoemulsification with implantation of intraocular lens. The mean interval betw...
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PMID: 19929665
PDF is available here.
PDF is available here.
Abstract
We conclude that iodine deficiency disorders are still a major problem in this region and hypothyroidism due to iodine deficiency is more prevalent than the non iodine deficiency causes. Hence lacunae in the iodine supplementation process needs to be reviewed....
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PMID: 20509329
PDF is available here.
PDF is available here.
Abstract
Although the neonatal hyperthyroidism is a very rare disease it is essential to apply specific protocol assistance, both during pregnancy and the neonatal period, in the presence of maternal TRAb positive for the risk of serious cardiovascular complications....
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PMID: 19642499
PDF is available here.
PDF is available here.
Abstract
An overall PPT prevalence of about 18% may be estimated. PPT was also observed in autoantibody- negative women. Differences with other surveys may be related to both study protocol and characteristics of the population studied....
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PMID: 19246971
PDF is available here.
PDF is available here.
Abstract
In patients with GD, the finding of a negative TSI titer usually creates diagnostic uncertainty. However, the fact that nearly half of our patients with GD were TSI negative suggests that this is common in children....
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PMID: 19189704
PDF is available here.
PDF is available here.
Clinical Endocrinology (69)4 2008
Abstract
Abstract
We retrospectively analyzed 384 consecutive patients newly diagnosed with Graves' disease in the years 1990-2002 to ascertain whether long-term therapy with low doses of MMI may prevent relapse of thyrotoxicosis. Two hundred and forty-nine patients were included in our study. The date of reduction o...
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PMID: 19092290
PDF is available here.
PDF is available here.
Abstract
Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed...
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PMID: 19092289
PDF is available here.
PDF is available here.
Abstract
In a 58-year-old woman with nontoxic nodular goiter, a fine-needle aspiration biopsy showed the presence of papillary thyroid cancer, which was treated with total thyroidectomy in June 2000 and a subsequent ablative dose of 131-radioiodine. A posttherapy whole body scan showed the presence of residu...
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PMID: 18794628
PDF is available here.
PDF is available here.
Abstract
The therapy of thyroid arterial embolization could effectively decrease the activity/titer and positive rate of TRAb and the ratio of CD4+/ CD8+ to normal levels at 6 months following embolization, while the ratio of CD3+CD8+ increased gradually to normal level at 1 year following embolization. In p...
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PMID: 18633697
PDF is available here.
PDF is available here.
Acta clinica Croatica (47)3 2008
Abstract
A young female patient suffering from Graves' disease is presented, who raised some diagnostic and therapeutic dilemmas after being diagnosed with subclinical hyperthyroidism following total thyroidectomy. This 20-year-old female patient, carrier of HLA B8 DR3 genes, was referred to our hospital for...
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PMID: 19175067
PDF is available here.
PDF is available here.
Southern Medical Journal (101)8 2008
Abstract
We present a case of fetal and neonatal thyrotoxicosis from maternal Graves disease. Fetal symptoms were controlled with maternal administration of antithyroid drugs leading to fetal thyroid inhibition. We present this case with a brief review of the literature....
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PMID: 18622337
PDF is available here.
PDF is available here.
Clinical Chemistry (54)8 2008
Abstract
Clinical Endocrinology (69)2 2008
Abstract
Serum TBII was positive in 245 (94.6%) patients and negative (< 2 IU/l) in 14 (5.4%) patients. TBII-seronegative patients had lower fT4 (median 42.5 vs. 53.9 pmol/l, P = 0.02), T3 (median 3.55 vs. 4.90 nmol/l, P < 0.01) and fT3-index (median 4.30 vs. 6.27, P < 0.01) compared to TBII-seropositive pat...
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PMID: 18208575
PDF is available here.
PDF is available here.
Abstract
We evaluated the relationship between second-generation TRAb assays and TcTUs in 139 patients with untreated autoimmune hyperthyroidism. An increase in TRAb levels was found in 114 of 139 patients (82%). All patients with TcTUs >2% and 66% of those with lower values had positive TRAb measurements. W...
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PMID: 18393171
PDF is available here.
PDF is available here.
Abstract
We propose a higher cutoff value correlating with a between-run CV of 20% (functional assay sensitivity). Our results indicate that due to a worse imprecision the TRAb ELISA has a slightly lower sensitivity and specificity compared to the TRAb LIA assay. These findings suggest that the M22 monoclona...
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PMID: 18504673
PDF is available here.
PDF is available here.
Abstract
This study compared the ocular manifestations of Graves' disease in different age groups and between genders. This was a retrospective study with a chart review of 210 patients seen in the Kaohsiung Veterans General Hospital Ophthalmology Department from 1990 to 2006. Clinical manifestations were re...
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PMID: 18635413
PDF is available here.
PDF is available here.
Abstract
We measured circulating concentrations of CCL2, CCL5, CXCL9, and CXCL10 in patients with GD, HT, and nontoxic nodular thyroid disease (NNT). While CCL2 and CXCL9 concentrations were comparable in patients with either AITD or NNT, CCL5 was significantly increased in GD patients compared with HT or NN...
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PMID: 18415893
PDF is available here.
PDF is available here.
Endocrinology (149)4 2008
Abstract
We found that C3H/He mice develop TSHR antibodies, and some animals become hyperthyroid after A-subunit immunization. In contrast, the responses of the F1 progeny of C3H/He x B6 mice, as well as most BXH RI strains, are dominated by the B6 resistance to hyperthyroidism. As in the CXB set, linkage an...
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PMID: 18162518
PDF is available here.
PDF is available here.
Abstract
Graves disease patients with large thyroid size, high levels of TRAb and FT3 to FT4 ratio before drug treatment are more likely to fail to respond to antithyroid drug treatment. We also found that patients with continuing thyrotropin suppression and attainment of euthyroid state in the course of tre...
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PMID: 18785498
PDF is available here.
PDF is available here.
Przeglad lekarski (65)3 2008
Abstract
Patients with autoimmune type 1 diabetes mellitus have often, besides immune diabetic markers, also other organ-specific antibodies. In many diabetic patients autoimmune thyroid diseases, i.e. Hashimoto thyroiditis and Grave's disease, with silent clinical course can be diagnosed. Because 50% of chi...
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PMID: 18624123
PDF is available here.
PDF is available here.
Abstract
Lakartidningen (105)3 2008
Abstract
Abstract
Abstract
Transient thyrotoxicosis after ATD withdrawal in patients with Graves' disease is not a rare phenomenon. Clinicians should be aware that the recurrence of Graves' disease after the withdrawal of ATD may be transient....
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PMID: 18302519
PDF is available here.
PDF is available here.
Abstract
Medical therapy (n=48) and surgery (n=47) were followed by a gradual decrease in TRAb in serum, with the disappearance of TRAb in 70-80% of the patients after 18 months. Radioiodine therapy (n=36) led to a 1-year long worsening of autoimmunity against the TSH receptor, and the number of patients ent...
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PMID: 18166819
PDF is available here.
PDF is available here.
Abstract
Elevated UIC was the most frequent finding in newborns with TCH but the distribution of excessive UIC was not significantly different among TCH, THT, and normal neonates. Since no other etiologies were found in TCH neonates without elevated UIC values, evaluation of other environmental and/or geneti...
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PMID: 18296902
PDF is available here.
PDF is available here.
Endocrine Journal (54)5 2007
Abstract
We report a 31-year-old female case with massive ascites and elevated serum CA 125 concentrations. The patient had no typical feature of hypothyroidism except an accumulation of ascitic fluid which showed elevated total protein concentration and a high serum-ascites albumin gradient (SAAG). There wa...
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PMID: 17878609
PDF is available here.
PDF is available here.
Endocrine Journal (54)5 2007
Abstract
We evaluated the ability of their levels and of their rate of change to predict long-term prognosis. In our study 216 consecutive patients with newly diagnosed Graves' disease started a therapy with methimazole. Patients were treated until they achieved euthyroidism and TRAb were measured at 6-month...
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PMID: 17675761
PDF is available here.
PDF is available here.
Endocrinology (148)12 2007
Abstract
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies. In some Graves' patients, thyroiditis becomes sufficiently extensiv...
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PMID: 17823263
PDF is available here.
PDF is available here.
Abstract
We describe a rare, but interesting, case of TSH-producing adenoma (TSHoma), accompanied by increases in both anti-TSH receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) after tumor resection. A 21-yr-old woman was referred to our department for further evaluation of pituitary tumor. I...
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PMID: 18250618
PDF is available here.
PDF is available here.
Ear, Nose and Throat Journal (86)11 2007
Abstract
Abstract
OBJECTIVE: To determine the course of thyrotropin (thyroid-stimulating hormone [TSH]) receptor antibodies (TRAbs) in children and adolescents with Graves' disease treated using antithyroid drugs (ATDs). DESIGN: Retrospective, cross-sectional study of 86 children and adolescents with Graves' disease...
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PMID: 17822376
PDF is available here.
PDF is available here.
Abstract
Angelman Syndrome (AS, MIM 105830), classified among neurogenetic disorders, occurs with estimated frequency of 1:10 000 to 1:40 000. The characteristics features apart from neurodevelopmental impairment and seizures include peculiar face traits, absent speech, outburst of laughter, ataxia, stereoty...
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PMID: 17984955
PDF is available here.
PDF is available here.
Abstract
We review the phenomenon of TSHR intramolecular cleavage, the shedding of the A-subunit component of the ectodomain, and the importance of the latter in generating thyroid-stimulating antibodies. The epitopes of thyroid-stimulating and -blocking autoantibodies have been a confusing and controversial...
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PMID: 17822379
PDF is available here.
PDF is available here.
Abstract
The discovery of thyroid-stimulating autoantibodies by Adams and Purves 50 years ago was one of the most important observations in the history of thyroidology. Since that time, the thyroid-stimulating hormone receptor (TSHR) has been shown to be the antigen recognized by these autoantibodies (1974)...
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PMID: 17900238
PDF is available here.
PDF is available here.
Immunology (122)2 2007
Abstract
We have examined the induction of autoimmunity and the maintenance of sustained hyperthyroidism in autoimmunity-prone human leucocyte antigen (HLA) DR3 transgenic non-obese diabetic (NOD) mice following chronic stimulation of the thyrotropin receptor (TSHR) by monoclonal thyroid-stimulating autoanti...
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PMID: 17535305
PDF is available here.
PDF is available here.
Abstract
ITA-PSV, thyroid volume, VEGF and IgE were significantly higher in hyperthyroid GD patients than in normal subjects. ITA-PSV in hyperthyroid GD patients was correlated positively with serum levels of FT(3), FT(4) and IgE, smoking index and thyroid volume, and negatively with total, HDL- and LDL-chol...
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PMID: 17420111
PDF is available here.
PDF is available here.
Endocrine Journal (54)4 2007
Abstract
We measured TRAb in these four methods late in pregnancy in a total of 62 pregnant women with Graves' disease. The data showed that no cases with TRAb1 >50% has been missed if the TRAb1 assay was replaced by the pTRAb2, hTRAb2 or TRAb3 assay using their equivalent cut-off value of 70%, 10 IU/l, and...
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PMID: 17641440
PDF is available here.
PDF is available here.
Endocrinology (148)7 2007
Abstract
We previously hypothesized that to achieve high fidelity and specificity of TSH ligand or TSHR autoantibody signaling, the TSHR may compartmentalize into microdomains within the plasma membrane. In support of this hypothesis we have shown previously that TSHRs reside in GM1 ganglioside-enriched lipi...
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PMID: 17412816
PDF is available here.
PDF is available here.
Neuropediatrics (38)3 2007
Abstract
We compared the prevalence of autoimmune disorders and autoantibodies in parents of children with OMS and in a group of controls of same age and sex. Autoimmune diseases were found in 15.8% of the parents of OMS children, but only in 2.0% of the controls (p<0.001) There was also an increased prevale...
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PMID: 17985258
PDF is available here.
PDF is available here.
Abstract
A 72-year-old white woman with an abnormal serum thyroid-stimulating hormone (TSH) concentration was referred to our facility for a comprehensive evaluation. Circulating thyroxine (T4) and free thyroxine (FT4) concentrations were all in the normal range. Tri-iodothyronine (T3) concentrations were in...
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PMID: 17505173
PDF is available here.
PDF is available here.
Abstract
Lithium may be associated with hypothyroidism in particular in the presence of circulating thyroid antibodies. Incidence of thyroid antibodies is comparable with that reported for the general population. Hyperthyroidism and thyroid cancer are rare....
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PMID: 17598966
PDF is available here.
PDF is available here.
Abstract
TRAb may persist after total thyroidectomy: clinical and instrumental follow-up of the newborn is recommended....
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PMID: 17550218
PDF is available here.
PDF is available here.
Ceylon Medical Journal (52)1 2007
Abstract
Abstract
TRAbs could be purified to 80-93% purity with recovery of the TBII and TSAb and TBAb activity. No TRAbs could be purified from healthy individuals. The mean +/- SD concentration of TRAb was 17.3 +/- 5.4 microg/IU for the TSAb sera (range, 9.6-25.9) and 18.2 +/- 8.5 microg/IU for the TBAb sera (range...
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PMID: 17179194
PDF is available here.
PDF is available here.