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Insulin Antibodies (0):
Recent article
Insulin Antibodies
Abstract
Sertoli cells (SCs) provide an immunoprotective environment to pancreatic islet grafts for treatment of insulin-dependent diabetes. Aim of this work was to verify whether intraperitoneal graft of SCs, enveloped in barium alginate-based microcapsules, would reverse overt spontaneous diabetes in nonob...
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PMID: 21197711
PDF is available here.
PDF is available here.
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Abstract
Based on etiology, diabetes is classified as type 1 diabetes mellitus, type 2 diabetes mellitus, latent autoimmune diabetes, maturity-onset diabetes of youth, and miscellaneous causes. The diagnosis is based on measurement of A1C level, fasting or random blood glucose level, or oral glucose toleranc...
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PMID: 20353144
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
We attempted to review current knowledge concerning allergic reactions to human insulin and discuss the available treatment options of insulin allergy....
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PMID: 19876775
PDF is available here.
PDF is available here.
Abstract
Abstract
This work provides demonstration of the essential prodiabetogenic activities of IL-21 on diverse genetic backgrounds (NOD and C57BL/6) and indicates that IL-21 blockade could be a promising strategy for interventions in human type 1 diabetes....
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PMID: 19208913
PDF is available here.
PDF is available here.
Abstract
Our results clearly indicate that low levels of insulin autoantibodies can be detected in an ELISA-like format. Combining a europium-based ELISA with competition with fluid-phase autoantigen can be applicable to many autoantigens to achieve high specificity and sensitivity in an ELISA format....
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PMID: 19344197
PDF is available here.
PDF is available here.
Abstract
Combination therapy with GLP-1 and gastrin restores normoglycemia in diabetic NOD mice by increasing the pancreatic beta-cell mass and downregulating the autoimmune response....
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PMID: 18835930
PDF is available here.
PDF is available here.
Abstract
We describe herein a patient with hypoglycemia due to anti-insulin receptor antibodies in systemic lupus erythematosus (SLE). A 40-year-old Japanese woman with a 10-year follow-up for SLE was admitted with hypoglycemia. Her blood test revealed the presence of anti-insulin receptor antibody, normal l...
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PMID: 18500459
PDF is available here.
PDF is available here.
Diabetes Care (31)11 2008
Abstract
Diabetes Care (31)9 2008
Abstract
Single AAb positivity did not affect the outcome of pancreas transplantation in our study....
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PMID: 18556338
PDF is available here.
PDF is available here.
Abstract
Bovine and human insulins are antigenic, and there is no significant difference in AIAB titer. Prospective studies are required to determine the long-term clinical significance of these antibodies....
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PMID: 18715205
PDF is available here.
PDF is available here.
Abstract
We show that the conserved T cell receptor alpha-chain generates insulin autoantibodies when transgenically or retrogenically introduced into mice without its corresponding Vbeta. We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary in...
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PMID: 18626021
PDF is available here.
PDF is available here.
Diabetic Medicine (25)7 2008
Abstract
Treatment with IAsp and with HI was associated with an increase in HI-cross-Ab in insulin-naive children, but this did not influence treatment efficacy or safety. These results support the safe use of IAsp in children and adolescents with Type 1 diabetes....
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PMID: 18644065
PDF is available here.
PDF is available here.
Abstract
These data show that children with newly diagnosed T1D, who test positive only for IA-2A out of the three molecular antibodies predictive of T1D, have a broader IA-2-specific isotype response and stronger association with the high-risk HLA haplotype than those testing positive for all three molecula...
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PMID: 18573919
PDF is available here.
PDF is available here.
Pediatric Diabetes (9)3 Pt 1 2008
Abstract
We have evaluated the use of the immunosuppressant mycophenolate mofetil (MMF) in the treatment of severe insulin resistance caused by neutralising anti-insulin antibodies in type 1 diabetes mellitus (T1DM). A 12-yr-old boy with a 5-month history of T1DM developed severe immunological insulin resist...
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PMID: 18547238
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to determine if immune mechanisms in GAD positive patients' contribute to the pathogenesis of a specific sub-type of Type 2 diabetes. GAD positive (n=8) and GAD negative (n=8) subjects diagnosed with Type 2 diabetes were matched for age, gender, body mass index, duratio...
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PMID: 18405999
PDF is available here.
PDF is available here.
Abstract
Adiponectin is a better predictor of coronary endothelial function than other factors such as HOMA-R, body mass index, immunoreactive insulin, and triglycerides....
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PMID: 17477992
PDF is available here.
PDF is available here.
Abstract
Our findings supported the view that children with DM1 should be screened annually for ATD. Relatively lower frequency of CD in the present study indicated that screening for CD-related autoantibodies might be postponed to older ages in asymptomatic patients. The present findings also suggested that...
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PMID: 18241952
PDF is available here.
PDF is available here.
Diabetologia (51)5 2008
Abstract
Serum alpha- or gamma-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for micromol/l increase in serum concentration of the first-year sample was 0.97 (0.92-1.03) for alpha-tocopherol and 1.10 (0.70-1.74) for gamma...
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PMID: 18317723
PDF is available here.
PDF is available here.
Pediatric Diabetes (9)2 2008
Abstract
Our preliminary data suggest that exposure to cord blood islet autoantibodies may influence the presence of islet autoantibodies at the time of diagnosis of type 1 diabetes and explain why some type 1 diabetes children are islet autoantibody negative at clinical diagnosis....
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PMID: 18221435
PDF is available here.
PDF is available here.
Abstract
We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very s...
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PMID: 18438525
PDF is available here.
PDF is available here.
Pediatric Diabetes (9)1 2008
Abstract
Our past and present observations support the hypothesis that the autoimmune process leading to childhood T1D is in part triggered in the perinatal period by viral infections in genetically susceptible individuals. The present study suggests that the process is linked to titer levels of autoantibodi...
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PMID: 18036133
PDF is available here.
PDF is available here.
Clinical Chemistry (54)2 2008
Abstract
BACKGROUND: Hypoglycemia in infants and children can lead to seizures, developmental delay, and permanent brain damage. Hyperinsulinism (HI) is the most common cause of both transient and permanent disorders of hypoglycemia. HI is characterized by dysregulated insulin secretion, which results in per...
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PMID: 18156285
PDF is available here.
PDF is available here.
Abstract
We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) i...
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PMID: 18588707
PDF is available here.
PDF is available here.
Abstract
Inhaled insulin has attractive pharmacodynamic properties with a fast onset of action which should lead to improved postprandial blood glucose concentrations. Comparisons with regular subcutaneous (sc) insulin in clinical studies, however, showed lower fasting blood glucose concentrations. Overall,...
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PMID: 18054735
PDF is available here.
PDF is available here.
Tissue Antigens (70)5 2007
Abstract
The objective of this study was to explore the relationship between islet autoantibodies of glutamic acid decarboxylase (GADA), islet antigen-2A (IA-2A), insulin autoantibody (IAA), and human leukocyte antigen (HLA)-DQ genotypes in type 1 diabetes (T1D) patients and their first-degree relatives (FDR...
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PMID: 17919266
PDF is available here.
PDF is available here.
Diabetic Medicine (24)11 2007
Abstract
The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy....
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PMID: 17956452
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (87)34 2007
Abstract
(1) The frequencies of DQA1*03-DQB1 *0303, DQA1*05-DQB1*0201, and DQA1*03-DQB1*0401 haplotypes in the T1DM patients were 32.6%, 14.1% and 10.2% respectively, all significantly higher than those in the controls (21.9%, 3.5%, and 2.9% respectively, all P < 0.01), however, the frequency of DQA1*0102-DQ...
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PMID: 18036312
PDF is available here.
PDF is available here.
Diabetes Research and Clinical Practice (77 Suppl 1) 2007
Abstract
We have established insulin 1 or insulin 2 knockout (KO) non-obese diabetic (NOD) colonies in the animal institute of Kobe University and evaluated anti-insulin autoimmunity. Similar to the previous report, insulin 1-KO provides strong protection from insulitis (islet-infiltration of mononuclear cel...
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PMID: 17459508
PDF is available here.
PDF is available here.
Abstract
We investigated whether organs from adult donors that are positive for autoantibodies (aAbs) against islet cell antigens exhibit insulitis and/or a reduced beta-cell mass. Serum from 1,507 organ donors (age 25-60 years) was analyzed for islet cell antibodies (ICAs), glutamate decarboxylase aAbs (GAD...
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PMID: 17563060
PDF is available here.
PDF is available here.
Pediatric Diabetes (8)4 2007
Abstract
Peptide of heat shock protein 60 induced a higher interferon-gamma (IFN-gamma) response in subjects with risk-associated CTLA-4 polymorphism (GG genotype) (p = 0.02) while glutamic acid decarboxylase 65-induced interleukin-4 (IL-4) secretion was lower in GG genotype subjects (p = 0.02). CONCLUSION:...
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PMID: 17659059
PDF is available here.
PDF is available here.
Diabetologia (50)8 2007
Abstract
Longitudinal data analysis showed that treatment did not affect levels of IAA over time. After controlling for age, the IAA levels at randomisation and the last visit and the maximum values were different in the four groups. Significantly higher levels were noted in groups that developed diabetes co...
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PMID: 17583798
PDF is available here.
PDF is available here.
Clinical Immunology (124)1 2007
Abstract
Insulin autoantibodies (IAA) precede clinical type 1 diabetes in children. Immunization events leading to IAA are unknown. The aim of this study was to determine whether some IAA result from mucosal immunization. IgA-IAA and binding of IAA to non-human insulin were examined in selected high and low...
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PMID: 17524809
PDF is available here.
PDF is available here.
Abstract
As compared with group I, FBG and INS increased, ISI decreased in the group II (all P < 0.01); as compared with the group II , FBG and INS decreased (all P < 0.01) and ISI increased (P < 0.05, P < 0.01) in the group [II, IV, V; no case with INS antibody (+) in all groups; TNF-alpha in the group II i...
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PMID: 17722835
PDF is available here.
PDF is available here.
Diabetes Technology & Therapeutics (9 Suppl 1) 2007
Abstract
Diabetes Technology & Therapeutics (9 Suppl 1) 2007
Abstract
Inhaled human insulin, whether formulated as a powder or liquid, has been shown to be more immunogenic than comparator insulins given by subcutaneous routes; however, adverse effects of antibody formation have not been demonstrated....
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PMID: 17563298
PDF is available here.
PDF is available here.
Clinical Immunology (122)1 2007
Abstract
The aim of the workshop was to assess whether four laboratories could reproducibly measure insulin autoantibody (IAA) affinity in coded sera from non-diabetic relatives of patients with type 1 diabetes, newly diagnosed patients, and healthy blood donors, and whether combining affinity with autoantib...
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PMID: 17059894
PDF is available here.
PDF is available here.
Przeglad lekarski (64)4-5 2007
Abstract
In the article some merits and some limitations of inhaled insulin (Exubera produced by Pfizer) in the treatment of adult patients with type 1 or 2 diabetes were presented. Up till now about 3500 volunteers usually in short-term study periods (6 months) were examined. Some patients were observed in...
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PMID: 17724916
PDF is available here.
PDF is available here.
New Zealand Medical Journal (120)1262 2007
Abstract
The cohort included 164 people with predominantly either Type 1 (133, 81%) or Type 2 (27, 16%) diabetes, diagnosed between 1997 and 2002. Twenty-four (18%) patients with Type 1 diabetes had one or more admissions for DKA. Logistic regression suggested male gender was associated with subsequent poore...
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PMID: 17891220
PDF is available here.
PDF is available here.
Abstract
We investigated the relation between duration of breast-feeding and beta-cell autoantibodies in 5-year-old non-diabetic children who participated in a prospective population-based follow-up study (the All Babies in Southeast Sweden study). Autoantibodies to insulin (IAA), glutamic acid decarboxylase...
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PMID: 17217566
PDF is available here.
PDF is available here.
Diabetes & Metabolism (32)6 2006
Abstract
We describe a case of hypoglycaemia with high insulinemia in which insulinoma could not be evidenced. Surprisingly, we found in the patient's serum both insulin autoantibodies and insulin receptor autoantibodies. Available data eventually supported the predominant role of insulin autoantibodies rath...
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PMID: 17296513
PDF is available here.
PDF is available here.
Abstract
Diabetes associated autoantibodies were detected in the majority of Type 1 DM subjects, suggesting a major role for autoimmunity in the pathogenesis of Type 1 DM in Sri Lankans. The prevalence of TgAb and TPOAb in Type 1 DM subjects and non-diabetic controls was relatively high and similar in both g...
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PMID: 17259793
PDF is available here.
PDF is available here.
Annals of Internal Medicine (145)9 2006
Abstract
Inhaled insulin offers an alternative noninvasive option for premeal insulin administration, with glycemic efficacy slightly less than subcutaneous regular insulin and increased patient acceptability. Until long-term safety data are available, inhaled insulin should be reserved for nonpregnant adult...
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PMID: 17088580
PDF is available here.
PDF is available here.
Acta Diabetologica (43)3 2006
Abstract
We investigated 57 patients (31 males and 26 females) at clinical diagnosis of type 1 diabetes. 35 patients were 21-40 years and 22 were 41-72 years of age. Autoantibodies to islet-cells (ICA) were detected by indirect immunofluorescence, while those against glutamic acid decarboxylase (GADA), tyros...
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PMID: 17143785
PDF is available here.
PDF is available here.
Abstract
Autoimmune diabetes is due to destruction of insulin-secreting beta islet cells by an immune-mediated process, which is induced and promoted by the interaction of genetic and environmental factors. This form of diabetes is one of a group of autoimmune diseases that affect about 10% of the population...
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PMID: 17130535
PDF is available here.
PDF is available here.
Abstract
We analyzed double native insulin gene knockout NOD mice with a mutated (B16:alanine) proinsulin transgene at multiple ages for the development of insulin autoantibodies, insulitis, and diabetes. In contrast to mice with at least one copy of a native insulin gene that expressed insulin antibodies, o...
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PMID: 17130542
PDF is available here.
PDF is available here.
Abstract
We looked at microsatellite polymorphism of MICA and its association with autoantibodies (IAA, IA2, and GAD65) in Swedish T1DM patients and if the association explains its importance in early events in autoimmune response. We studied 635 T1DM patients between 0-35 years. Frequency of MICA5/5 was pos...
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PMID: 17130560
PDF is available here.
PDF is available here.
Abstract
We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment differ in their epitope specificities from IAA. We analysed insulin antibody binding specificities in longitudinal samples of T1D patients (n = 49). Samples were taken at clinical diagnosis of disease and a...
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PMID: 16968392
PDF is available here.
PDF is available here.
Abstract
Journal of Immunological Methods (314)1-2 2006
Abstract
We investigated whether pre-incubation of gel with glycine or ethanolamine could overcome this problem. Batches of PAS/PGS shown to have high NSB (0.3-3.2%) were incubated with glycine or ethanolamine at various pHs between 8 and 10.6 for 2-18 h at 4 degrees C or room temperature. Treating PAS at pH...
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PMID: 16843481
PDF is available here.
PDF is available here.
Abstract
Abstract
Administration of insulin by inhalation was first attempted > 50 years ago. At that time, little was known concerning effective delivery systems and insulin formulations. The recent development of pulmonary delivery systems for the administration of insulin is driven by the reluctance of patients an...
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PMID: 16787139
PDF is available here.
PDF is available here.
Abstract
There was a temporal dissociation between pulmonary function changes and insulin antibody generation. Small treatment group differences in changes in FEV1 from baseline, favoring SC insulin, were fully manifest by 2 wk of INH therapy, did not increase during the remainder of the comparative phase, a...
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PMID: 16556690
PDF is available here.
PDF is available here.
Abstract
We compared the prevalence of beta-cell autoantibodies and genetic risk factors in Sweden and Lithuania. Ninety-six patients from Sweden and 96 from Lithuania matched for age and gender (1-15 years old, median age 9.0 years) were included. We analyzed autoantibodies to insulin (IAA), glutamic acid d...
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PMID: 16442659
PDF is available here.
PDF is available here.