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Isoantibodies (0):
Recent article
Isoantibodies
Abstract
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Abstract
We analyzed the B-cell response in a rat model of long-term cardiac allograft tolerance induced by a short-term immunosuppression. We observed that tolerated allografts are infiltrated by numerous B cells organized in germinal centers that are strongly regulated in their IgG alloantibody response. M...
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PMID: 21114655
PDF is available here.
PDF is available here.
Abstract
Traditional treatment of primary (idiopathic) immune thrombocytopenia (ITP) predominantly consists of immune suppression and/or modulation. In addition, many treated patients develop severe adverse effects, and approximately a third of patients do not respond. Two of the newly develo...
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PMID: 21322783
PDF is available here.
PDF is available here.
Abstract
Blood transfusion (BT) may elicit both harmful and beneficial immune responses against a subsequent organ graft. Immune parameters of a single, non leukocyte-depleted BT were investigated in two groups: non-human leukocyte antigen (HLA)-sensitized recipients with a one-HLA-DR matched donor (protocol...
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PMID: 21166103
PDF is available here.
PDF is available here.
Transplantation (90)11 2010
Abstract
As a significant determinant of T- and B-cell cooperation, CD154 has been used to identify allospecific T-cytotoxic memory cells (TcM) for rejection risk assessment with high sensitivity or specificity but not for alloreactive B-cells, especially among recipients predisposed to acute cellular and hu...
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PMID: 20881665
PDF is available here.
PDF is available here.
Hämostaseologie (30 Suppl 1) 2010
Abstract
We report on a boy with severe haemophilia A and intron 22 inversion of the FVIII gene who was diagnosed at ten months of age. After 16 exposure days to FVIII (81 days after initial exposure) he developed a FVIII inhibitor (maximum: 9.76 BU/ml). Therapy: We started immune tolerance induction (ITI) a...
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PMID: 21042665
PDF is available here.
PDF is available here.
Abstract
The DSA strength correlates well with crossmatch results. An MFI of 6540 predicted a positive antihuman globulin T-cell crossmatch....
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PMID: 20923311
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
We examined the effect of inhibition of glomerular capillary repair after capillary injury in GN. Experimental Thy-1 GN was induced in rats that were divided into two groups: rats that received anti-VEGF neutralizing antibody (50 μg per 100 g body weight per day) and those treated with the vehi...
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PMID: 20644521
PDF is available here.
PDF is available here.
Abstract
The purpose of this review is to summarize the recent experimental and clinical literature on the pathogenesis of transfusion-related acute lung injury (TRALI).
In both experimental and clinical TRALI, an immune priming step is generally necessary to produce lung injury. Experimental studies have us...
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PMID: 20601870
PDF is available here.
PDF is available here.
Abstract
We conclude that our Ab combination therapy extends allograft survival in presensitized recipients. When combined with intermittent Ab-mediated rescue therapy, this results in indefinite allograft survival and a loss of the preexisting, donor-specific Abs from the circulation....
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PMID: 20571468
PDF is available here.
PDF is available here.
Tissue Antigens (76)2 2010
Abstract
The introduction into routine diagnostic laboratories of solid phase assays for human leukocyte antigen (HLA) antibody detection has resulted in the application of new laboratory matching algorithms in clinical organ transplantation which have improved pre-transplant detection of immunization, in tu...
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PMID: 20403141
PDF is available here.
PDF is available here.
Abstract
We conclude that antenatal antibody screening should be done in all pregnant women irrespective of the D antigen status to detect and manage red cell alloimmunization to any other clinically significant blood group antigens.
(c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20558106
PDF is available here.
PDF is available here.
Vox Sanguinis (99)2 2010
Abstract
Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the incid...
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PMID: 20331536
PDF is available here.
PDF is available here.
Abstract
The development of Goodpasture's disease may be considered an autoimmune "conformeropathy" that involves perturbation of the quaternary structure of the alpha345NC1 hexamer, inducing a pathogenic conformational change in the alpha3NC1 and alpha5NC1 subunits, which in turn elicits an autoimmune respo...
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PMID: 20660402
PDF is available here.
PDF is available here.
Abstract
Transplant Immunology (23)3 2010
Abstract
We have previously shown that allo-Ag-specific CD3 negative (-) cells as analyzed by cytokine flow cytometry (CFC) are elevated in many highly HLA-sensitized (HS) patients, but not most normal individuals. HS patients with high(+) CFC, especially to donor Ags, may be at high risk for AMR and may nee...
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PMID: 20472061
PDF is available here.
PDF is available here.
Transplantation (89)11 2010
Abstract
This study assesses the immunologic, functional, and histologic course of kidney recipients with preformed donor-specific alloantibodies (DSA) receiving deceased donor kidneys according to two prophylactic strategies that have been sequentially applied posttransplant....
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PMID: 20386362
PDF is available here.
PDF is available here.
Abstract
In vitro Th1-polarized CD4 T cells did not express ST2L; however, most CD4 T cells became ST2L on repeated stimulation under Th2-polarizing conditions. Similarly, we found that IL-33 was able to enhance the expression of Th2-associated cytokines (IL-5 and IL-13) but not interferon (IFN)-gamma. Treat...
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PMID: 20220570
PDF is available here.
PDF is available here.
Abstract
We have searched glycoconjugates for the candidate antigens that therapeutic Abs target. To this end, we first focused on the difference in the glycogenes expression in terms of Epstein-Barr virus (EBV) infection of a Burkitt's lymphoma cell line, Akata. Using DNA array, flow cytometry and Western b...
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PMID: 20403334
PDF is available here.
PDF is available here.
Transfusion (50)6 2010
Abstract
The RHD alleles from BP, DJ, and 58 additional DIIIa samples had the three reported nucleotide changes as well as 186G>T, 410C>T, and 819G>A. The DIIIa allele was associated with several altered RHCE*ce-alleles, the prominent one being ceS (48C, 733G, 1006T). CONCLUSION: The DIIIa phenotype is assoc...
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PMID: 20088832
PDF is available here.
PDF is available here.
Abstract
Abstract
In conclusion, failure to significantly reduce antibody levels and prevent new formation was strongly predictive of allograft loss. This observation suggests that the therapeutic intervention that reduces antibody production may prolong graft survival in transplantation....
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PMID: 20075791
PDF is available here.
PDF is available here.
Abstract
Transplantation (89)7 2010
Abstract
We analyzed humoral and cellular immune reactivity in subjects undergoing influenza vaccination.
We serially obtained blood samples from 30 healthy subjects and 8 kidney and 9 lung transplant recipients who received influenza vaccination, and from 20 healthy unvaccinated controls. We measured cellul...
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PMID: 20179666
PDF is available here.
PDF is available here.
Abstract
Increased %E-C4d levels are found in patients with positive DSA, high antibody titers to KA1T and Col-V, and have C3d+ lung biopsy findings. Therefore, %E-C4d can serve as a potential marker for antibody-mediated rejection after LTx....
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PMID: 20022265
PDF is available here.
PDF is available here.
Abstract
Abstract
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Transfusion Medicine (20)2 2010
Abstract
I antibodies (HLA-I Abs) in acute non-hemolytic transfusion reactions (ANHTRs) using solid phase assays (SPAs) and conventional complement-dependent lymphocyte cytotoxicity test (LCT). ANHTRs are major issues in transfusion medicine. Anti-leukocyte antibodies have been implicated as one of the causa...
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PMID: 19883399
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
|
PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
|
PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
|
PMID: 19823821
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We report our experience with sc anti-D for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-D. They received a median of 2 sc anti-D applications (range 1-31) with a dosage of 250-375 IE/kg body weight. Only in one out of a...
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PMID: 19823821
PDF is available here.
PDF is available here.
Vox Sanguinis (98)3 Pt 1 2010
Abstract
Discovery medicine (9)46 2010
Abstract
Our recent studies have provided evidence for alloimmune-response-induced de novo development of immune responses to self-antigens in the post-transplant period in the pathogenesis of chronic rejection following lung, heart, and kidney transplantation. This review details our current understanding o...
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PMID: 20350490
PDF is available here.
PDF is available here.
Medicina Intensiva (34)2 2010
Abstract
The term Transfusion-Related Acute Lung Injury (TRALI) was coined in 1985. It is a relatively rare, life-threatening clinical syndrome characterized by acute respiratory failure and non-cardiogenic pulmonary edema during or following a blood transfusion. Although its true incidence is unknown, a rat...
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PMID: 20156708
PDF is available here.
PDF is available here.
Abstract
We assessed the feasibility and efficacy of chronic transfusion with an HbS target of 30% in children with SCD living in the Paris area.
We retrospectively studied 29 children aged 6.8 +/- 3.0 yr (3-15 yr) at inclusion who received chronic transfusion either because of abnormal TCD f...
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PMID: 19912310
PDF is available here.
PDF is available here.
Abstract
We identified 74 RBC alloantibodies in 70 (23%) patients when the indirect antiglobulin test (IAT) was performed. The most common RBC alloantibodies were against Rh system antigens. The majority (41.9%) were directed against the E antigen. Despite the ethnic heterogeneity of our population there wer...
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PMID: 20304174
PDF is available here.
PDF is available here.
Abstract
The contribution of both humoral and cell-mediated alloimmune responses against mismatched donor histocompatibility antigens (HLA) in the pathogenesis of chronic rejection is well established. Recent studies have focused on development of immune responses to self-antigens during the posttransplant p...
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PMID: 19898237
PDF is available here.
PDF is available here.
Vox Sanguinis (98)2 2010
Abstract
We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis....
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PMID: 19708889
PDF is available here.
PDF is available here.
Vox Sanguinis (98)2 2010
Abstract
We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis....
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PMID: 19708889
PDF is available here.
PDF is available here.
Vox Sanguinis (98)2 2010
Abstract
We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis....
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PMID: 19708889
PDF is available here.
PDF is available here.
Vox Sanguinis (98)2 2010
Abstract
We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis....
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PMID: 19708889
PDF is available here.
PDF is available here.
Vox Sanguinis (98)2 2010
Abstract
We recommend the introduction of pretransfusion antibody tests in Uganda depending on the recipient's diagnosis....
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PMID: 19708889
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought.
Serologic and molecular studies were perform...
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PMID: 19821948
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Patients with human platelet antigen (HPA) specific antibodies in cases of neonatal alloimmune thrombocytopenia and platelet (PLT) refractoriness derive clinical benefit from the use of HPA-selected PLTs.
This study describes three patients with underlying diagnoses o...
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PMID: 19874563
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought.
Serologic and molecular studies were perform...
|
PMID: 19821948
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Patients with human platelet antigen (HPA) specific antibodies in cases of neonatal alloimmune thrombocytopenia and platelet (PLT) refractoriness derive clinical benefit from the use of HPA-selected PLTs.
This study describes three patients with underlying diagnoses o...
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PMID: 19874563
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought.
Serologic and molecular studies were perform...
|
PMID: 19821948
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Patients with human platelet antigen (HPA) specific antibodies in cases of neonatal alloimmune thrombocytopenia and platelet (PLT) refractoriness derive clinical benefit from the use of HPA-selected PLTs.
This study describes three patients with underlying diagnoses o...
|
PMID: 19874563
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought.
Serologic and molecular studies were perform...
|
PMID: 19821948
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Patients with human platelet antigen (HPA) specific antibodies in cases of neonatal alloimmune thrombocytopenia and platelet (PLT) refractoriness derive clinical benefit from the use of HPA-selected PLTs.
This study describes three patients with underlying diagnoses o...
|
PMID: 19874563
PDF is available here.
PDF is available here.
Transfusion (50)2 2010
Abstract
Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought.
Serologic and molecular studies were perform...
|
PMID: 19821948
PDF is available here.
PDF is available here.