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Opsonin Proteins (0):
Recent article
Opsonin Proteins
Science progress (94)Pt 1 2011
Abstract
The exact role of engineered nanomaterials in immune system modulation remains unclear. The aim of this concise review is to give a comprehensive insight into recent published scientific data concerning the modulation of innate and adaptive immune responses by engineered nanoparticles, and to provide...
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PMID: 21548529
PDF is available here.
PDF is available here.
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Abstract
We have assessed the relationship between IgG titers measured by the pneumococcal ELISA and functional titers measured by opsonophagocytic assay of anti-pneumococcal antibodies. We found a significant correlation between titers for both assays, and conclude that the response to PCV7 after SCT induce...
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PMID: 20023707
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We characterize a novel pathogen recognition protein obtained from the lepidopteran Galleria mellonella. This protein recognizes Escherichia coli, Micrococcus luteus, and Candida albicans via specific binding to lipopolysaccharides, lipoteichoic acid, and beta-1,3-glucan, respectively. As a multilig...
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PMID: 20519517
PDF is available here.
PDF is available here.
Autoimmunity (43)3 2010
Abstract
We observed a significant secretion of the inflammatory cytokines IL-8 and TNF-alpha by phagocytes which had engulfed different types of opsonized SNEC. Phagocytosis of SNEC and the subsequent production of inflammatory cytokines were strongly influenced by the presence of DNA in this prey, since DN...
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PMID: 20187705
PDF is available here.
PDF is available here.
Seminars in Hematology (47)2 2010
Abstract
Several types of B-cell lymphoma have been successfully treated with rituximab, and approval by the US Food and Drug Administration for use of rituximab in the treatment of rheumatoid arthritis has increased interest in targeting CD20 on B cells for other indications. Although large amounts of ritux...
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PMID: 20350659
PDF is available here.
PDF is available here.
Abstract
These results suggest that subcutaneously implanted TCP inhibits tumor growth of implanted WiDr cells, and that the activation by TCP of macrophages plays a role in that inhibition.
(c) 2009 Wiley Periodicals, Inc....
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PMID: 19235211
PDF is available here.
PDF is available here.
Revista Medico-Chirurgicala (114)2 2010
Abstract
Retro auricular and later cervical nodes mass increases after administration of textile dyes, compared to control group. Basophiles percentages were increased after administration of two dyes (stronger after yellow dye). Peripheral neutrophils activity was increased after administration of two dyes,...
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PMID: 20700994
PDF is available here.
PDF is available here.
Revista Medico-Chirurgicala (114)1 2010
Abstract
Reactive Red 183, Reactive Red 2 and Reactive Blue 204 (red dye, green dye and blue dye) are three reactive dyes frequently used in textile industry. In some atmospheric conditions ( high temperature, perspiration, pH values, UV/IR radiations), some quantities of these hydrolyzed dyes, could pass fr...
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PMID: 20509316
PDF is available here.
PDF is available here.
Abstract
It was shown that antibodies specific to studied polypeptides opsonized several strains of group A and B streptococci as well as pneumococci. Immunization of mice with ScpB1 polypeptide resulted in more rapid recovery of animals from challenge systemic group B streptococcal infection. Antisera speci...
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PMID: 20465000
PDF is available here.
PDF is available here.
Experimental Hematology (37)11 2009
Abstract
These findings suggest that platelet WASP deficiency results in an increase in platelet clearance rates by two mechanisms: an antibody-independent mechanism that largely requires WASP deficiency in trans, and an antibody-dependent mechanism that does not. Both an increased incidence of antiplatelet...
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PMID: 19733207
PDF is available here.
PDF is available here.
Abstract
In this study, PCV7 given 2 or 6 months before PPV23 was well tolerated but did not improve immune response to PPV23 in older Alaska Native adults....
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PMID: 19522655
PDF is available here.
PDF is available here.
Abstract
We describe a fluorescence-based OPA (flOPA) that measures the ability of specific antibody to opsonize fixed, fluorescently labeled GBS or antigen-coated fluorescent microspheres for uptake by differentiated HL-60 cells in the presence of complement. Compared to the classical OPA, the flOPA is stan...
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PMID: 19377284
PDF is available here.
PDF is available here.
Nature Immunology (10)7 2009
Abstract
We show SCS macrophage development depended on lymphotoxin-alpha1beta2, and the cells had low lysosomal enzyme expression and retained opsonized antigens on their surface. Intravital imaging revealed immune complexes moving along macrophage processes into the follicle. Moreover, noncognate B cells r...
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PMID: 19503106
PDF is available here.
PDF is available here.
Abstract
Phagocytosis is a complex mechanism involving a variety of receptors and opsonins. The heterogeneity of phagocytic mechanisms allows the optimization of bacteria recognition, phagocytosis, and killing. Notably, Toll-like receptors were known to play a role in phagocytosis, both by modulating opsonin...
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PMID: 19395959
PDF is available here.
PDF is available here.
Pediatric Infectious Disease Journal (28)4 Suppl 2009
Abstract
Pediatric Infectious Disease Journal (28)4 Suppl 2009
Abstract
PHiD-CV induces ELISA and functional OPA antibodies for all vaccine serotypes after primary vaccination and is noninferior to 7vCRM in terms of ELISA and/or OPA threshold responses. Effective priming is further indicated by robust booster responses....
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PMID: 19325449
PDF is available here.
PDF is available here.
Pediatric Infectious Disease Journal (28)4 Suppl 2009
Abstract
PHiD-CV was immunogenic when coadministered with other routine pediatric vaccines including MenC conjugate vaccines....
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PMID: 19325450
PDF is available here.
PDF is available here.
Pediatric Infectious Disease Journal (28)4 Suppl 2009
Abstract
PHiD-CV was immunogenic against each of the 10 pneumococcal vaccine serotypes when coadministered with DTPw-HBV/Hib and poliovirus vaccines....
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PMID: 19325451
PDF is available here.
PDF is available here.
Infection and Immunity (77)4 2009
Abstract
We investigated the in vitro opsonophagocytic activities of three PPS-specific mouse immunoglobulin G1 monoclonal antibodies (MAbs), 1E2, 5F6, and 7A9, and determined their in vivo efficacies against intranasal challenge with WU2, a serotype 3 pneumococcal strain, in normal and immunodeficient mice....
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PMID: 19168739
PDF is available here.
PDF is available here.
Abstract
Abstract
We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome. Tissue cultures simultaneously showed colonies with high hemolysis (HH) and low hemolysis (LH). Conversely, the HH and LH variants exhibited low ca...
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PMID: 19193266
PDF is available here.
PDF is available here.
Journal of Immunology (182)3 2009
Abstract
We hypothesized that these anti-endothelial Abs promote thrombosis through interference with clearance of dying cells. We show that healthy endothelial cell monolayers effectively remove apoptotic endothelial cells, but this clearance is markedly inhibited by serum or IgG from patients with antiphos...
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PMID: 19155525
PDF is available here.
PDF is available here.
Microbes and Infection (11)8-9 2009
Abstract
We have observed that, unlike the live vaccine strain (LVS) of F. tularensis subsp. holarctica, F. tularensis subsp. novicida U112 opsonized in pooled human serum activated the NADPH oxidase when incubated with human neutrophils. Given previous observations that F. tularensis fixes relatively small...
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PMID: 19409509
PDF is available here.
PDF is available here.
BMC Microbiology (9)1 2009
Abstract
In 31 clinical isolates of E. coli tested, C3-dependent internalisation was evident in 10 isolates. Type 1 fimbriae mediated-binding is essential for C3-dependent internalisation as shown by phenotypic association, type 1 fimbrial blockade with soluble ligand (mannose) and by assessment of a type 1...
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PMID: 19335887
PDF is available here.
PDF is available here.
Abstract
Anti-D is routinely and effectively used to prevent hemolytic disease of the fetus and newborn (HDFN) caused by the antibody response to the D antigen on fetal RBCs. Anti-D is a polyclonal IgG product purified from the plasma of D-alloimmunized individuals. The mechanism of anti-D has not been fully...
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PMID: 20008198
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
We used the luminal-dependent chemiluminescence (LmCL) to measure reactive oxygen species generation from pooled human neutrophils as an indicator of SOA. We also measured plasma myeloperoxidase (MPO) and plasma cytokine levels. Twenty-two female college runners took part in this study after giving...
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PMID: 19591246
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
We used the luminal-dependent chemiluminescence (LmCL) to measure reactive oxygen species generation from pooled human neutrophils as an indicator of SOA. We also measured plasma myeloperoxidase (MPO) and plasma cytokine levels. Twenty-two female college runners took part in this study after giving...
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PMID: 19591246
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
We used the luminal-dependent chemiluminescence (LmCL) to measure reactive oxygen species generation from pooled human neutrophils as an indicator of SOA. We also measured plasma myeloperoxidase (MPO) and plasma cytokine levels. Twenty-two female college runners took part in this study after giving...
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PMID: 19591246
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
We used the luminal-dependent chemiluminescence (LmCL) to measure reactive oxygen species generation from pooled human neutrophils as an indicator of SOA. We also measured plasma myeloperoxidase (MPO) and plasma cytokine levels. Twenty-two female college runners took part in this study after giving...
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PMID: 19591246
PDF is available here.
PDF is available here.
Luminescence (24)6 2009
Abstract
We used the luminal-dependent chemiluminescence (LmCL) to measure reactive oxygen species generation from pooled human neutrophils as an indicator of SOA. We also measured plasma myeloperoxidase (MPO) and plasma cytokine levels. Twenty-two female college runners took part in this study after giving...
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PMID: 19591246
PDF is available here.
PDF is available here.
Abstract
Immunogenic properties of recombinant protein ScaAB mixed with polypeptide P6 as well as conjugate of the former with capsular polysaccharide type III (PSIII) were assessed. Protein-polysaccharide conjugate was synthesized by reductive amination method. Immunogenicity was studied on the mouse model...
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PMID: 19338234
PDF is available here.
PDF is available here.
Abstract
We report that dynamic membrane ruffles in activated macrophages promote binding of C3bi-opsonized particles. We identify these ruffles as components of the macropinocytosis machinery in both PMA- and LPS-stimulated macrophages. C3bi-particle capture is facilitated by enrichment of high-affinity Mac...
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PMID: 18768756
PDF is available here.
PDF is available here.
Abstract
We conducted cDNA sequencing in diverse early vertebrates for members of homeobox-containing (Dlx and ParaHox) and other gene families that would serve as landmarks for genome duplications. Including these new sequences, we performed a molecular phylogenetic census using the maximum likelihood metho...
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PMID: 18842688
PDF is available here.
PDF is available here.
Abstract
We have measured antibody concentrations and opsonization titers for multiple serotypes amongst both old adults and young, healthy controls. To avoid specificity problems associated with pneumococcal antibody ELISA, we absorbed the serum samples with c-polysaccharide and capsular polysaccharide of 2...
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PMID: 18706464
PDF is available here.
PDF is available here.
Infection and Immunity (76)10 2008
Abstract
Synthetic overlapping oligosaccharide fragments of Streptococcus pneumoniae serotype 14 capsular polysaccharide (Pn14PS), [6)-[beta-D-Galp-(1-->4)-]beta-D-GlcpNAc-(1-->3)-beta-D-Galp-(1-->4)-beta-D-Glcp-(1-->](n), were conjugated to CRM(197) protein and injected into mice to determine the smallest i...
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PMID: 18678667
PDF is available here.
PDF is available here.
Infection and Immunity (76)10 2008
Abstract
We examined here whether a fully human immunoglobulin G1 monoclonal antibody (MAb) specific to the conserved alginate surface polysaccharide of P. aeruginosa could mediate protective immunity against typically nonmucoid strains isolated from human cases of keratitis. MAb F429 effectively opsonized a...
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PMID: 18644881
PDF is available here.
PDF is available here.
Infection and Immunity (76)10 2008
Abstract
We hypothesized that C. neoformans traffics to the endosome and the lysosome following phagocytosis by DCs and is eventually killed in the lysosome. Murine bone marrow-derived DCs (BMDCs) or human monocyte-derived DCs (HDCs) were incubated with live, encapsulated C. neoformans yeast cells and opsoni...
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PMID: 18678670
PDF is available here.
PDF is available here.
Journal of Immunology (181)6 2008
Abstract
We show that murine pDC, as well as myDC, express Fcgamma receptors (CD16/CD32) and can use these receptors to acquire Ag from immune complexes (IC), resulting in the induction of robust Ag-specific CD4(+) and CD8(+) T cell responses. IC-loaded pDC stimulate CD4(+) T cells to proliferate and secrete...
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PMID: 18768834
PDF is available here.
PDF is available here.
Abstract
The levels of IgG determined by ELISA may have limited relevance in human immunodeficiency virus (HIV)-infected adults because of non-functional antibodies. 58 HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate vaccine (CV) followed by polysaccharide vaccine (PV) after...
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PMID: 18639599
PDF is available here.
PDF is available here.
Journal of Immunology (181)5 2008
Abstract
We investigated whether iC3b opsonized apoptotic cells could induce the same changes reported with artificial ligands such as mAbs or iC3b-opsonized RBC. We explored the kinetics of iC3b opsonization in two models of murine cell apoptosis, gamma-irradiated thymocytes and cytokine deprivation of the...
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PMID: 18713972
PDF is available here.
PDF is available here.
Journal of Immunology (181)4 2008
Abstract
We term shaving, can compromise the therapeutic efficacy of RTX, and in vitro models reveal that shaving is mediated by effector cells which express Fc gammaRI. THP-1 monocytes and PBMC promote shaving, but PBMC also kill antibody-opsonized cells by antibody-dependent cellular cytotoxicity (ADCC), a...
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PMID: 18684983
PDF is available here.
PDF is available here.
Experimental Hematology (36)8 2008
Abstract
Western blot analysis indicated that Nramp1 protein levels increased with hemin, opsonized erythrocytes, or erythropoietin treatment. The pool of chelatable iron was also found to transiently increase following iron-loading with hemin or opsonized RBCs, with a greater increase observed in macrophage...
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PMID: 18456389
PDF is available here.
PDF is available here.
Journal of Immunology (181)2 2008
Abstract
We hypothesized that the effect of the IgG on the immune system under AMIS conditions may involve a deficiency in B cell priming. We therefore challenged mice with either untreated RBCs or IgG-opsonized RBCs (AMIS) and assessed B cell priming. B cells from mice transfused with untreated RBCs, but no...
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PMID: 18606646
PDF is available here.
PDF is available here.
Journal of Immunology (181)2 2008
Abstract
We provide evidence that Fcgamma receptor cross-linking triggers a rapid release of soluble, biologically active BLyS/BAFF from myeloid cells. Surprisingly, this function is primarily mediated by FcgammaRI, but not FcgammaRIIa as defined by specific mAb, and can be initiated by both IgG and C reacti...
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PMID: 18606652
PDF is available here.
PDF is available here.
Abstract
The objective of this study is to evaluate the biodistribution characteristics of liposomes surface-modified with the mixture of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) as a drug carrier for passive targeting of drugs. The liposomes (egg phosphatidylcholine:cholesterol=55:40, molar rat...
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PMID: 18486370
PDF is available here.
PDF is available here.
Abstract
We show that C3 fragments, deposited on Ft, are detected by anti-C3d and -iC3b mAb and that the classical and the alternative pathways are involved in this event. This was demonstrated using C2-depleted sera and specific inhibitors of the classical-versus-alternative pathways of complement activatio...
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PMID: 18430786
PDF is available here.
PDF is available here.
Abstract
We discuss the role of complement in early and late stages of HIV pathogenesis and review the escape mechanisms, which protect HIV from destruction by the complement system....
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PMID: 18191309
PDF is available here.
PDF is available here.
Journal of Autoimmunity (30)4 2008
Abstract
Primary biliary cirrhosis is characterized by chronic hepatic inflammation and immune mediated apoptosis of bile duct epithelial cells. Delayed macrophage phagocytosis of opsonized apoptotic cells, noted in other autoimmune diseases, may promote inflammation. Recent studies suggest serum anti-CD16 a...
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PMID: 18023559
PDF is available here.
PDF is available here.
Microbial Pathogenesis (44)6 2008
Abstract
We report here that B. pertussis binding and internalization is cholesterol dependent. Furthermore, we found cholesterol to be implicated in B. pertussis survival upon interaction with human neutrophils. Pre-treatment of PMN with cholesterol sequestering drugs like nystatin or methyl-beta-cyclodextr...
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PMID: 18276103
PDF is available here.
PDF is available here.
Abstract
These results suggest that multivalent vaccines encoding conserved antigens can feasibly induce immune cross-reactivity that span Plasmodium strains and subspecies and can protect hosts of distinct major histocompatibility complex haplotypes....
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PMID: 18062974
PDF is available here.
PDF is available here.
Abstract
We assayed complement-mediated BA and OP bactericidal activity in sera from 32 adults immunized with an outer membrane vesicle vaccine given alone or combined with an investigational recombinant protein, genome-derived neisserial antigen (GNA2132). The sera were heat inactivated to remove internal c...
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PMID: 18353918
PDF is available here.
PDF is available here.
Cellular Microbiology (10)5 2008
Abstract
We show that EspJ is the type three secretion system effector protein responsible for trans-inhibition of macrophage opsono-phagocytosis by both EPEC and EHEC. While EspF plays no role in trans-inhibition of opsono-phagocytosis, espJ mutants of EPEC or EHEC are unable to block uptake of opsonized sh...
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PMID: 18201246
PDF is available here.
PDF is available here.
Experimental Hematology (36)5 2008
Abstract
CMFDA-labeled WASP(-) platelets are consumed more rapidly than WT platelets in either WT or WASP(-) recipients. In vivo biotinylation studies corroborate these findings and show a normal consumption rate for WASP(-) reticulated platelets. The number of reticulated platelets is reduced in WASP(-) mic...
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PMID: 18346836
PDF is available here.
PDF is available here.
Abstract
We show that both recombinant and endogenous soluble MD-2 bind tightly to the surface of live gram-negative bacteria. As a consequence, MD-2 enhances cellular activation, bacterial internalization, and intracellular killing, all in a TLR4-dependent manner. The enhanced internalization of MD-2-coated...
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PMID: 18203953
PDF is available here.
PDF is available here.
Abstract
The results indicate that prevention of C3b and IgG deposition on the bacterial surface contributes to the biofilm-mediated protection of S. epidermidis from killing by PMNs....
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PMID: 18419540
PDF is available here.
PDF is available here.
Journal of Immunology (180)6 2008
Abstract
We investigated the role of MBL in complement activation and phagocytosis of various bacteria and yeast species by flow cytometry. We measured both the C3 deposition during serum opsonization of fluorescent-labeled microorganisms as well as subsequent uptake of these microorganisms by human neutroph...
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PMID: 18322223
PDF is available here.
PDF is available here.
Molecular Immunology (45)4 2008
Abstract
We have therefore investigated the mechanism by which uropathogenic E. coli activate complement and the potential for this to occur during clinical infection. The classical pathway is responsible for bacterial opsonisation when complement proteins are present at low concentrations. At higher concent...
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PMID: 17870166
PDF is available here.
PDF is available here.
Cancer Research (68)2 2008
Abstract
We have determined their gene expression profiles and we show that bone marrow-derived macrophages show widely different intrinsic expression patterns. The profiles classify macrophages derived from CBA/Ca mice as M1-like (pro-inflammatory) and those from C57BL/6 mice as M2-like (anti-inflammatory);...
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PMID: 18199539
PDF is available here.
PDF is available here.
Abstract
This study shows that fish Vg plays an integrative function in regulating immunity via its pleiotropic effects on both recognizing pathogen-associated molecular patterns and promoting macrophage phagocytosis. It also supports the notion that factors normally involved in control of female reproductio...
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PMID: 18398466
PDF is available here.
PDF is available here.
Luminescence (23)1 2008
Abstract
We measured and studied changes in the neutrophil and its related functions in 22 male university judoists immediately before (Pre values) and immediately after (Post values) a 2 h training session: reactive oxygen species (ROS) production capability, phagocytic activities (PA) and serum opsonic act...
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PMID: 18175295
PDF is available here.
PDF is available here.