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Immunoglobulins (8):
Recent article
Immunoglobulins
The Lancet (377)9773 2011
Abstract
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Haemophilia (17)2 2011
Abstract
We were interested in characterizing the spectrum of FVIII antibody formation and the primary and secondary immune responses after FVIII administration in two different exon 16-disrupted haemophilia A mouse strains, Balb/c and C57BL/6. Balb/c and C57BL/6 E16 haemophilia A mice were used in all exper...
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PMID: 21091850
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to examine the effects of a probiotic supplement during 4 mo of winter training in men and women engaged in endurance-based physical activities on incidence of upper respiratory-tract infections (URTIs) and immune markers. Eighty-four highly active indiv...
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PMID: 21411836
PDF is available here.
PDF is available here.
Cancer Investigation (29)2 2011
Abstract
We summarize TSLC1 function, highlighting the concept that TSLC1 mediates the formation of tumor suppressor network via its multidomain structure and bridges extracellular adhesive activity with intracellular signaling. Next, we focus on the histopathology of TSLC1 in various cancers and the associa...
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PMID: 21329006
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)1 2011
Abstract
We explored the potential of dendritic-cell (DC)-based immunotherapy in 9 patients with stage-I disease. Mature monocyte-derived Id-pulsed DCs and keyhole limpet hemocyanin (KLH) were administered at dose levels between 2 and 20×10⁶ cells. Patients received 5 immunizations every 4 weeks. A median...
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PMID: 21150718
PDF is available here.
PDF is available here.
Abstract
A new protocol for producing polyclonal antibody against hepatitis A virus (HAV) is described. Twenty hens were immunized three times with a commercial HAV vaccine and HAV from a cell culture with three types of adjuvants: CpG oligodeoxynucleotides (CpG-ODN), incomplete Freund's adju...
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PMID: 20971134
PDF is available here.
PDF is available here.
Abstract
Human nasal epithelium is an important physical barrier and innate immune defense protecting against inhaled substances and pathogens. Toll-like receptor (TLR) signaling, which plays a key role in the innate immune response, has not been well characterized in human nasal epithelial cells (HNECs), in...
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PMID: 20932985
PDF is available here.
PDF is available here.
Pediatric Blood & Cancer (55)7 2010
Abstract
We recently reported on the prognostic value of MRD during the induction of remission through a simplified PCR method. Here, we report on gene rearrangement frequencies and offer guidelines for the application of the technique.
Two hundred thirty-three children had DNA extracted from...
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PMID: 20730889
PDF is available here.
PDF is available here.
Abstract
We show that cellular extracts from both human and mouse ESCs retain the immune modulatory properties of intact cells. ESC-extracts that contained 12-24 μg of total protein effectively prevented T cell proliferation in allogeneic mixed lymphocyte reactions (MLR), whereas control fibroblast extracts...
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PMID: 20711689
PDF is available here.
PDF is available here.
Abstract
Cutaneous marginal zone lymphomas (CMZL) were segregated in the WHO/EORTC consensus classification but grouped with other MALT lymphomas in the subsequent WHO classification. It has been suggested, however, that CMZL have distinctive features and might include 2 subsets. To address these issues, the...
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PMID: 21107089
PDF is available here.
PDF is available here.
Abstract
The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liqui...
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PMID: 20837170
PDF is available here.
PDF is available here.
Abstract
We showed that loxoribine up-regulated the expression of TLR7, CD40, CD54, CD80, CD83 and CCR7 and stimulated the production of IL-12, IL-23, IL-27 and IL-10 by MoDCs, whereas the level of interferon (IFN)-β was not modulated. Allogeneic CD4(+)T cells in co-culture with loxoribine-treated MoDCs pro...
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PMID: 20817120
PDF is available here.
PDF is available here.
Hämostaseologie (30 Suppl 1) 2010
Abstract
We report on a boy with severe haemophilia A and intron 22 inversion of the FVIII gene who was diagnosed at ten months of age. After 16 exposure days to FVIII (81 days after initial exposure) he developed a FVIII inhibitor (maximum: 9.76 BU/ml). Therapy: We started immune tolerance induction (ITI) a...
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PMID: 21042665
PDF is available here.
PDF is available here.
Hepatology (52)5 2010
Abstract
We investigated the clinical relevance of anti-E1E2A,B response in the serum of patients infected with HCV. To this end, an enzyme-linked immunosorbent assay (ELISA) using synthetic E1-, E2A-, and E2B-derived peptides was used. The ELISA was validated in terms of sensitivity, specificity, and test e...
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PMID: 20890942
PDF is available here.
PDF is available here.
Abstract
An acute alcohol intoxication in occasional drinkers is much more common problem than chronic intoxication in alcohol dependent persons. Acute alcohol intoxication, often called binge drinking, results in specific defects in innate immunity. Chronic alcohol intoxication leads to defects in both the...
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PMID: 21207646
PDF is available here.
PDF is available here.
Abstract
Bovine growth hormone (bGH) transgenic mice develop severe kidney damage. This damage may be due, at least in part, to changes in gene expression. Identification of genes with altered expression in the bGH kidney may identify mechanisms leading to damage in this system that may also be relevant to o...
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PMID: 20655258
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (26)10 2010
Abstract
to investigate the effects of apolipoprotein A-I (ApoA-I) on the peripherial blood dendritic cell (PBDC) and monocyte derived DC (MDDC) in vitro.
isolate PBDC or monocyte by cell isolation kit, monocyte were induced to MDDC by treated with GM-CSF plus IL-4 for 6 days, and then collect PBDC and MDDC...
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PMID: 20937235
PDF is available here.
PDF is available here.
Abstract
I and II generation and steroids are used. Severe adverse events are indication for withdraw the immunoglobulins intravenous infusions. In these patients the subcutaneous way of immunoglobulins substitution is an alternative with hope that low singular dose and slow uptake may be better tolerated....
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PMID: 20931833
PDF is available here.
PDF is available here.
Nature Immunology (11)9 2010
Abstract
We show that IgT, an immunoglobulin isotype of unknown function, acts like a mucosal antibody. We detected responses of rainbow trout IgT to an intestinal parasite only in the gut, whereas IgM responses were confined to the serum. IgT coated most intestinal bacteria. As IgT and IgA are phylogenetica...
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PMID: 20676094
PDF is available here.
PDF is available here.
Nature Immunology (11)9 2010
Abstract
Abstract
We investigated the sequential effects of hypothermic preservation on ischemia-reperfusion injury (IRI), subsequent innate immune activation, and adaptive immune response in rat cardiac allografts.
Allografts were transplanted from fully major histocompatibility complex-mismatched Dark Agouti to Wis...
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PMID: 20591689
PDF is available here.
PDF is available here.
Archives de Pédiatrie (17)9 2010
Abstract
We describe the cases of infant botulism identified in France between 1991 and 2009. All clinical suspicions of botulism must be declared in France. Biological confirmation of the disease is provided by the National reference laboratory for anaerobic bacteria and botulism at the Pasteur Institute. D...
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PMID: 20724121
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
We focus on a subsequent event in plaque development--the migration of smooth muscle cells (SMCs) from the media to the intima of inflamed vessels. Here we report our investigation of the expression of F11R in atherosclerotic arteries of coronary artery disease (CAD) patients, and of the role of F11...
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PMID: 20627246
PDF is available here.
PDF is available here.
Abstract
We have presented evidence that actin polymerization inhibitors block the movement of IZUMO1 that accompany the acrosome reaction. These results suggest that actin dynamics play a role in the observed changes in IZUMO1 localization. This finding is significant because IZUMO1 localization in acrosome...
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PMID: 20458735
PDF is available here.
PDF is available here.
Southern Medical Journal (103)9 2010
Abstract
Home SCIG therapy was safe and led to improved perceptions of general health, higher serum IgG levels, and very low rates of infections and days missed from work/school....
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PMID: 20689467
PDF is available here.
PDF is available here.
Abstract
Major histocompatibility complex class II plays a key role in the immune response, by presenting processed antigens to CD4+ lymphocytes. Major histocompatibility complex class II expression is controlled at the transcriptional level by at least four trans-acting genes: CIITA, RFXANK, RFX5 and RFXAP....
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PMID: 20414676
PDF is available here.
PDF is available here.
Abstract
We evaluated the safety and efficacy of another strategy using LAM and individualized low-dose intramuscular (IM) HBIG. Between May 2002 and December 2009, a total of 254 adult patients undergoing LT for HBV-related benign end-stage liver diseases received this regimen in our center. The mean follow...
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PMID: 20659092
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)2 2010
Abstract
We have developed a sensitive assay in the form of a sandwich ELISA where monoclonal antibodies against P-selectin or alphaIIbbeta3 and GPIbalpha were used to capture and detect platelets, respectively, in the presence of five different agonists [ADP, TRAP (thrombin receptor agonist), U46619 (thromb...
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PMID: 20508902
PDF is available here.
PDF is available here.
Abstract
After nearly 10 years of follow-up, gene therapy was shown to have corrected the immunodeficiency associated with SCID-X1. Gene therapy may be an option for patients who do not have an HLA-identical donor for hematopoietic stem-cell transplantation and for whom the risks are deemed acceptable. This...
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PMID: 20660403
PDF is available here.
PDF is available here.
Mucosal Immunology (3)4 2010
Abstract
We were interested in identifying genes with a possible involvement in these functions. A global gene expression analysis in mouse B cells showed that CT regulated <100 annotated genes, which encoded transcription factors, G proteins, cell-cycle regulators, and immunoregulating molecules. Interestin...
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PMID: 20375997
PDF is available here.
PDF is available here.
Revista de Neurologia (51)1 2010
Abstract
INTRODUCTION: After cerebral ischemia, necrotic cell death occurs specially for neurons, mainly due to the deprivation of oxygen and glucose. Cell necrosis triggers the activation of the immune system followed by an inflammatory response. This reaction is characterized by the activation of astrocyte...
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PMID: 20568066
PDF is available here.
PDF is available here.
Molecular Immunology (47)11-12 2010
Abstract
We provide a first analysis of this region. For this purpose bacterial artificial chromosome (BAC) sequences originating from a single inbred red jungle fowl that served as basis for the chicken genome project were screened for the presence of CHIR sequences and eight BACs were identified as major C...
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PMID: 20510455
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
To exploit the physiologic Fcgamma receptor IIb (CD32B) inhibitory coupling mechanism to control B cell activation by constructing a novel bispecific diabody scaffold, termed a dual-affinity retargeting (DART) molecule, for therapeutic applications.
DART molecules wer...
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PMID: 20506263
PDF is available here.
PDF is available here.
Abstract
We aim to give an overview about the generation, structure, properties of IgY, as well as the advantages of chicken antibodies use over mammalian antibodies in immunodiagnostics and immunotherapy.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20083313
PDF is available here.
PDF is available here.
Abstract
We use the Tc1 transchromosomic mouse model of DS to dissect the contribution of extra copies of genes on Hsa21 to tumour angiogenesis. This mouse expresses roughly 81% of Hsa21 genes but not the human DSCR1 region. We transplanted B16F0 and Lewis lung carcinoma tumour cells into Tc1 mice and showed...
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PMID: 20535211
PDF is available here.
PDF is available here.
Abstract
We examined emotional behaviors, social behaviors and motor performances in Cadm1-knockout (KO) mice. Cadm1-KO mice showed increased anxiety-related behavior in open-field and light-dark transition tests. Social behaviors of Cadm1-KO mice were impaired in social interaction, resident-intruder and so...
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PMID: 20450890
PDF is available here.
PDF is available here.
Abstract
We sought to obtain longer term follow-up data regarding the changes in the diameters of large CAAs in patients receiving both abciximab and standard therapy and to compare these changes to those of a similar group receiving standard therapy alone. All patients with Kawasaki disease and large CAAs (...
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PMID: 20494673
PDF is available here.
PDF is available here.
Melanoma Research (20)3 2010
Abstract
Tumor suppressor in lung cancer 1 (TSLC1) is a tumor suppressor gene that encodes a member of the immunoglobulin superfamily, which is involved in the progression of some types of cancer. Several studies have shown that loss of TSLC1 expression is strongly correlated to methylation of the gene promo...
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PMID: 20375924
PDF is available here.
PDF is available here.
Abstract
We performed a glycoproteomics approach to identify the underlying protein scaffolds. Affinity purification of polysialylated molecules from Ncam(-/-) brain followed by peptide mass fingerprinting led to the identification of the synaptic cell adhesion molecule SynCAM 1 as a so far unknown polySia c...
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PMID: 20479255
PDF is available here.
PDF is available here.
Minerva medica (101)3 2010
Abstract
We summarize the recent progress in understanding the biology of cell adhesion molecules (CAMs) as well as their clinical significance as prognostic biomarkers or as potential therapeutic targets in a variety of malignancies....
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PMID: 20562803
PDF is available here.
PDF is available here.
Abstract
High risk human papilloma virus DNA was detected in 25 per cent of patients (three of 12) with laryngeal cancer. Low risk human papilloma virus DNA was detected only in three laryngeal papilloma patients. The mean laryngeal secretion concentrations of immunoglobulins M, G and A and secretory immunog...
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PMID: 20370947
PDF is available here.
PDF is available here.
Abstract
We will discuss the pathogenesis, diagnosis, and treatment of primary antibody deficiency syndromes, with some attention to recent advances in this field....
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PMID: 20535975
PDF is available here.
PDF is available here.
Abstract
We reported that transcripts of immunoglobulins were increased in coronary arteries dissected from cardiac transplants with arteriopathy, but the prevelance and patterns of B cell and plasma cell infiltration in cardiac allografts has not been documented. METHODS.: In this study, we documented the f...
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PMID: 20386145
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE-To assess the use of stored equine colostrum for the treatment of foals perceived to be at risk for failure of transfer of passive immunity (FTPI). DESIGN-Cohort study. ANIMALS-232 Thoroughbred foals and 191 Thoroughbred mares (41 mares gave birth to 1 foal on 2 occasions). PROCEDURES-Post...
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PMID: 20470070
PDF is available here.
PDF is available here.
Abstract
Liver transplantation (LT) is the treatment of choice for end-stage liver disease, but is controversial in patients with human immunodeficiency virus (HIV) infection. Using a prospective cohort of HIV-hepatitis B virus (HBV) coinfected patients transplanted between 2001-2007; outcomes including survi...
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PMID: 20346065
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
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PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
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PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
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PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
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PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
|
PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
|
PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
|
PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
|
PMID: 20200204
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
We previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of the mouse seminiferous epithelial cycle with 'in vivo cryotechnique' and al...
|
PMID: 20200204
PDF is available here.
PDF is available here.
Abstract
There was no methylation in TSLC1 promoter region in normal lung tissue and A549 cell line in which TSLC1 expressed; while there was DNA hypermethylation in TSLC1 promoter region in NCI-H446 and Calu-3 cell lines in which TSLC1 was abrogated, also the expression of TSLC1 in NCI-H446 and Calu-3 cell...
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PMID: 20677643
PDF is available here.
PDF is available here.
Molecular Immunology (47)9 2010
Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm.
Abstract
We tested the impact of chronic ER stress on protein insertion into the ER with special emphasis on antibody secreting cells (ASCs), as these cells cope physiologically with prolonged stress conditions. We show that XBP-1 in plasmablasts and fibroblasts controls the ER translocation of US2, a viral-...
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PMID: 20353876
PDF is available here.
PDF is available here.
Pediatric Research (67)5 2010
Abstract
We determined B-lymphocyte subpopulations in 95 children with DS compared with 33 age-matched control (AMC) children. DS serum immunoglobulin levels were compared with 962 non-DS children with recurrent infections. The results were combined with clinical data. Transitional and naive B lymphocytes ar...
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PMID: 20098344
PDF is available here.
PDF is available here.
Abstract
Abstract
We report on a patient who was diagnosed with XLA at the age of 10years. The diagnosis was delayed due to near-normal levels of serum immunoglobulins, although he presented with severe and recurrent bacterial infections since the age of 1year. He was demonstrated to have a novel non-invariant splice...
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PMID: 20122858
PDF is available here.
PDF is available here.
Abstract
Rituximab administered at standard doses induces universal B-cell depletion. It shows good efficacy in patients with a variety of autoimmune diseases and has been licensed for use in rheumatoid arthritis. Despite prolonged B-cell depletion, side effects appear to be minimal. The use of B-cell deplet...
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PMID: 20425017
PDF is available here.
PDF is available here.