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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Blood Proteins (22):
- Thyroxine-Binding Proteins
- Anion Exchange Protein 1, Erythrocyte
- Vitronectin
- Spectrin
- Ankyrins
- Acute-Phase Proteins
- Serum Albumin
- Hemoglobins
- Hemocyanin
- Somatomedins
- Fibrin
- beta 2-Glycoprotein I
- Serum Globulins
- Immunoproteins
- Cholesterol Ester Transfer Proteins
- Retinol-Binding Proteins, Plasma
- Protein S
- Protein C
- Glycophorin
- Blood Coagulation Factors
- Tumor Necrosis Factor-alpha
- Platelet-Derived Growth Factor
Recent article
Blood Proteins
Molecular BioSystems (7)10 2011
Abstract
We analyzed by proteomics modifications in plasma proteome of patients with AAA. Therefore, the present study analyzed the soluble plasma proteins using two dimensional electrophoresis (2-DE) and mass spectrometry (MS). We identified 33 protein spots, 31 of which show an up-regulation in AAA patient...
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PMID: 21805001
PDF is available here.
PDF is available here.
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Biomacromolecules (12)9 2011
Abstract
We propose substrate-independent modification for creating a protein-repellent surface based on dopamine-melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-melanin layer can be formed on literally any substrate and could serve a...
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PMID: 21823677
PDF is available here.
PDF is available here.
Abstract
Nano-/micrometer-scaled films and capsules made of low-fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low-fouling, alkyne-functionalized PEG (PEG(Alk) ) multilayer fi...
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PMID: 21425467
PDF is available here.
PDF is available here.
Proteomics (11)7 2011
Abstract
We analyzed global protein expression patterns in plasma of control and sibutramine-treated rats using proteomic analysis for a better understanding of the two conflicting functions of this drug, appetite regulation, and cardiovascular risk. The control (n=6) and sibutramine-treated groups (n=6) wer...
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PMID: 21337517
PDF is available here.
PDF is available here.
Abstract
We performed a global lung cancer serum biomarker discovery study using liquid chromatography-tandem mass spectrometry in a set of pooled non-small cell lung cancer case sera and matched controls. Immunoaffinity subtraction was used to deplete the top most abundant serum proteins; the remaining seru...
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PMID: 21304412
PDF is available here.
PDF is available here.
Abstract
Currently available technologies allow in-depth analysis of multiple facets of the proteome that have clinical relevance and that complement current genomics-based approaches. Although some progress has been made in our knowledge of the human proteome in health and in disease, there...
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PMID: 21375461
PDF is available here.
PDF is available here.
Abstract
We report that L56A, a PA-binding-affinity-elevated mutant of sTEM8, could inhibit anthrax intoxication as effectively as sCMG2 in Fisher 344 rats. Additionally, pharmacokinetics showed that L56A and sTEM8 exhibit advantages over sCMG2 with better lung-targeting and longer plasma retention time, whi...
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PMID: 21674060
PDF is available here.
PDF is available here.
Abstract
We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We evaluated the human plasma proteome in healthy neonates, children and adults using the 2D-DIGE approach. We demonstrate significan...
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PMID: 21365000
PDF is available here.
PDF is available here.
Abstract
Erythropoietin (Epo) is produced primarily in the kidneys upon low blood oxygen availability and stimulates erythropoiesis in the bone marrow. Recombinant human Epo (rHuEpo), a drug developed to increase arterial oxygen content in patients, is also illicitly used by athletes to impro...
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PMID: 20966191
PDF is available here.
PDF is available here.
Abstract
We apparently need compounds with low tissue binding. Our theoretical analysis and experimental data demonstrate that unbound plasma concentration is not determined by plasma protein binding but by hepatic intrinsic clearance after oral dose, and unbound tissue concentration is not determined by tis...
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PMID: 21320069
PDF is available here.
PDF is available here.
Abstract
The self-assembling of cationic liposomes (CLs) and DNA can give rise to a variety of nanostructures and morphologies. Multilamellar complexes are made of DNA intercalated between opposing lipid bilayers, while clusters formed by intact vesicles may exist as 'beads-on-a-string' (i.e. CLs attached to...
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PMID: 20843667
PDF is available here.
PDF is available here.
Critical Care Medicine (39)1 2011
Abstract
Critical Care Medicine (39)1 2011
Abstract
We hypothesized that plasma protein levels predict increased vascular permeability and acute respiratory distress syndrome.
A prospective, observational study.
Eighty-three consecutive, mechanically ventilated patients with or at risk for acute lung injury/acute respiratory distress syndrome, of who...
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PMID: 21057316
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)52 2010
Abstract
We identified an alternative pathway by demonstrating that nonadsorbing macromolecules can also have a marked impact on the adhesion efficiency of red blood cells with enhanced phosphatidylserine exposure to endothelial cells. It is concluded that this adhesion-promoting effect originates from macro...
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PMID: 20952392
PDF is available here.
PDF is available here.
Molecular Biology Reports (36 Suppl 1) 2010
Abstract
Proteomics (10)24 2010
Abstract
We categorized identified proteins into three groups by analysis of both average spot density in each group and individual spot density of six rats as a function of body weight. Consequently, category (1) included inter-α-inhibitor H4 heavy chain and fetuin B precursor, which can be used as novel p...
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PMID: 21136593
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We describe an automated, self-powered chip based on lateral flow immunoassay for rapid, quantitative, and multiplex protein detection from pinpricks of whole blood. The device incorporates on-chip purification of blood plasma by employing inertial forces to focus blood cells away from the assay sur...
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PMID: 20924527
PDF is available here.
PDF is available here.
Abstract
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signaling of multiple cytokines importan...
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PMID: 21105711
PDF is available here.
PDF is available here.
Journal of Chromatography B (878)30 2010
Abstract
We described here an effective approach termed Enzymatic Digestion-Organic Solvent Extraction (eDOSE) that utilizes the enzymatic approach to disrupt the folded structures of proteins and release entrapped or adsorbed pesticide residues. In this approach, samples were first reduced, alkylated, trypt...
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PMID: 20970391
PDF is available here.
PDF is available here.
Abstract
We report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC₅₀= 3, 30, 30, 250, and 90 nmol/L, respectively). Cell-based studies showed inhibition of the phosphorylation of...
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PMID: 21080703
PDF is available here.
PDF is available here.
Clinical calcium (20)11 2010
Abstract
We discuss for regulatory mechanisms of vascular calcification....
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PMID: 21037390
PDF is available here.
PDF is available here.
Clinical calcium (20)11 2010
Abstract
Hyperphosphatemia with decline of kidney function has been associated with increased mortality and the development of cardiovascular calcification. Sevelamer hydrochloride was the first synthetic non-aluminum and calcium-free phosphate binder commercially available. Sevelamer is as effective as calc...
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PMID: 21037391
PDF is available here.
PDF is available here.
Abstract
To compare serum total protein (sTP) and serum IgG (sIgG) concentrations In neonatal calves administered colostrum or a bovine serum-based colostrum replacement (CR) product followed by a bovine serum-based colostrum supplement (CS) product.
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PMID: 20946083
PDF is available here.
PDF is available here.
Abstract
A new high-sensitivity detection of protein assay at the nanogram level is proposed based on multi-spectroscopic methods including resonance light scattering (RLS), atomic force microscopy (AFM), ultraviolet spectra (UV) and fluorescence spectra etc. Under the optimum conditions, the amplified RLS s...
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PMID: 20638325
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of top 7/top 14 immunodepletion on the shotgun proteomic analysis of human plasma. Our goal was to evaluate the impact of immunodepletion on detection of proteins across detectable ranges of abundance. The depletion columns afforded highly repeatable and efficient plasma pro...
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PMID: 20677825
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)10 2010
Abstract
Our objective was to demonstrate the effect of various processing factors on the performance of a microfiltration system designed to process skim milk and separate casein (CN) from serum proteins (SP). A mathematical model of a skim milk microfiltration process was developed with 3 stages plus an ad...
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PMID: 20855027
PDF is available here.
PDF is available here.
EMBO Journal (29)18 2010
Abstract
We describe studies of dynamin PH domain mutations found in centronuclear myopathy (CNM) that increase dynamin's GTPase activity without altering phosphoinositide binding. CNM mutations in the PH domain C-terminal α-helix appear to cause conformational changes in dynamin that alter control of the G...
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PMID: 20700106
PDF is available here.
PDF is available here.
Abstract
Medication management is a major part of nursing practice. Ensuring safety in medication management is all the more important in the community, where patients are not under constant observation of a health-care professional. One of the prime factors in maintaining safety with medication is establish...
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PMID: 20852525
PDF is available here.
PDF is available here.
Abstract
Recent studies have identified a new family of ammonia-specific transporters, Rh glycoproteins, which enable NH3-specific transport. The purpose of this review is to summarize recent evidence regarding the role of Rh glycoproteins in renal ammonia transport.
The Rh glycoproteins, RhAG/Rhag, RhBG/Rhb...
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PMID: 20539225
PDF is available here.
PDF is available here.
Abstract
We report a new approach to identify carbohydrate-targeting serum biomarkers, termed isotopic glycosidase elution and labeling on lectin-column chromatography (IGEL). This technology is based on glycan structure-specific enrichment of glycopeptides by lectin-column chromatography and site-directed t...
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PMID: 20811073
PDF is available here.
PDF is available here.
Abstract
We determined the changes of body growth, blood profiles of metabolism and hormones caused by intensified nutrition (sufficient total digestible nutrients and digestible crude protein for a target daily gain set at 1.2-1.3 kg/day) in three cattle. The daily gain (DG) was increased during the intensi...
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PMID: 20379086
PDF is available here.
PDF is available here.
Association of serum fetuin-A with valvular calcium concentration in rheumatic mitral valve disease.
Abstract
Fetuin-A is an acute-phase glycoprotein that inhibits ectopic calcification. The study aim was to assess serum fetuin-A levels in patients with rheumatic mitral valve disease (RMVD), and to evaluate the association of fetuin-A with the extent of mitral valve calcification, determined either echocard...
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PMID: 21053744
PDF is available here.
PDF is available here.
Abstract
Status of serum electrolyte and nonelectrolyte variables can be used for managing sturgeon species cultured in freshwater or living in seawater. The aim of the present study was to evaluate serum biochemical variables in clinically healthy juvenile Persian sturgeon Acipenser persicus cultured in fre...
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PMID: 21192546
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Our results revealed changes in intestinal growth after soy protein feeding that were associated with effects on intestinal RNA and protein synthesis but that were not ameliorated by AA supplementation.
Copyright (c) 2010 American Dairy Science Association. Published by Elsevier Inc. All rights rese...
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PMID: 20723691
PDF is available here.
PDF is available here.
Journal of Dairy Science (93)9 2010
Abstract
Feed management is one of the principal levers by which the production and composition of milk by dairy cows can be modulated in the short term. The response of milk yield and milk composition to variations in either energy or protein supplies is well known. However, in practice, dietary supplies of...
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PMID: 20723688
PDF is available here.
PDF is available here.
Abstract
It is often postulated that both inherited and acquired thrombophilias increase the risk of stillbirth. In an attempt to reduce this theoretical risk, pregnant patients with prior fetal losses and thrombophilias are anticoagulated. However, there is no definitive proof that thrombophilias are causal...
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PMID: 20661046
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
I and VI; the DC protein bound only to collagens I and VI; however, no binding of BJ-PI to these proteins was detected. N-deglycosylation caused loss of structural stability of bothropasin and BJ-PI but HF3 remained intact, although its haemorrhagic and fibrinogenolytic activities were partially imp...
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PMID: 20664911
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
We assessed the diagnostic performance of two total PS antigen assays, four free PS assays and three PS activity assays in a group of 28 heterozygous carriers of mutations in PROS1 and 165 control subjects. Several control groups were formed, one of healthy volunteers and - because PS levels are inf...
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PMID: 20539904
PDF is available here.
PDF is available here.
Abstract
We herein report the discovery of a series of potent and selective serotonin 5-HT(2A) receptor antagonists based on a phenethylpiperazine amide core structure. When tested in a rat sleep pharmacology model, these compounds increased both sleep consolidation and deep sleep. Within this series of comp...
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PMID: 20684606
PDF is available here.
PDF is available here.
Biomacromolecules (11)8 2010
Abstract
We synthesized bone-like composites using synthetic hydrogels having pendant side chains terminating with carboxyl groups as a template for mineralization. The role of matrix hydrophobicity on mineralization was examined using poly(ethylene glycol) hydrogels modified with varying lengths of anionic...
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PMID: 20690714
PDF is available here.
PDF is available here.
Dental Materials Journal (29)4 2010
Abstract
Chromatography technology was employed to clarify the mechanism of interaction between multi-wall carbon nanotubes (MWCNT) and proteins. A column (16x100 mm) was packed with purified MWCNT, and various proteins were eluted with phosphate buffered saline (PBS) with and without gradient systems. It wa...
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PMID: 20610879
PDF is available here.
PDF is available here.
Abstract
Abstract
In POST1, FRAP and TEAC decreased in both groups, however, the TEAC decrease persisted in POST14 for HG only. Lycopene and beta-carotene decreased in POST1 for HG and remained lower in POST14. Finally, AOPP increased only for HG in POST1. The general decline of antioxidant status for both groups mig...
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PMID: 19943078
PDF is available here.
PDF is available here.
Abstract
Hereditary stomatocytosis (HSt) is a group of haemolytic anaemias in which the common symptom is an increased permeability of the red cell membrane for monovalent cations. HSt is diagnosed really seldom and the difficulties in diagnosing are connected to the fact that the clinical presentation of in...
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PMID: 20842826
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
BAD (BCL-2 antagonist of cell death) is a pro-apoptotic BCL-2 family protein that plays a critical role in the regulation of apoptotic response. This study presents direct evidence that AF1q increased the radiation-induced apoptosis through up-regulation of BAD in human squamous carcinoma A431 cells...
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PMID: 20596645
PDF is available here.
PDF is available here.
Abstract
Hemorheological measurements were not different between the 2 groups. Systolic, mean, and diastolic PAP were higher in old dogs, compared with values in young dogs; this difference was attributed to a high pulmonary vascular resistance and low arterial compliance in old dogs. Systolic time intervals...
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PMID: 20673087
PDF is available here.
PDF is available here.
Bioanalysis (2)8 2010
Abstract
Dried blood spots (DBS) sampling is a well-known technology for qualitative determination such as DNA analysis and screening of newborn metabolic disorders. The scientific community has recently expressed interest in applying the DBS technique for quantitative determination of drugs...
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PMID: 21083350
PDF is available here.
PDF is available here.
Bioanalysis (2)8 2010
Abstract
We have evaluated three distinct sample preparation procedures of DBS samples for LC-MS/MS assay development.
A new term 'elution efficiency' is introduced to evaluate the effectiveness of eluting compounds from the DBS cards into the liquid phase. Three different types of DBS cards...
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PMID: 21083341
PDF is available here.
PDF is available here.
Proteomics (10)16 2010
Abstract
We examined the hepatotoxic mechanism of Z24 at the protein level and looked for potential biomarkers. We used 2-DE and MALDI-TOF/TOF MS to analyze alternatively expressed proteins in rat liver and plasma after Z24 administration. We also examined apoptosis in rat liver and measured levels of intram...
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PMID: 20544730
PDF is available here.
PDF is available here.
Abstract
Malnutrition is a common feature of inflammatory bowel disease (IBD). There are numerous methods for the assessment of nutritional status, but the gold standard has not yet been established. The aims of the study were to estimate the prevalence of undernutrition and to evaluate methods for routine n...
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PMID: 20603043
PDF is available here.
PDF is available here.
Abstract
We have identified a set of biomarkers that could discriminate breast cancer from non-cancer controls. An efficient strategy, including SELDI-TOF-MS analysis, HPLC purification, MALDI-TOF-MS trace and LC-MS/MS identification, has been proved very successful....
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PMID: 20237941
PDF is available here.
PDF is available here.
Abstract
We compared the serum protein profiles of patients with small RCC to those of healthy individuals to identify the differentially expressed proteins with potential to serve as biomarkers. Serum samples were collected from 10 patients with small RCC and 10 healthy individuals. The serum protein expres...
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PMID: 21174948
PDF is available here.
PDF is available here.
Clinical Nephrology (74)2 2010
Abstract
We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severel...
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PMID: 20630138
PDF is available here.
PDF is available here.
Abstract
We have developed a rat model of intestinal inflammation post weaning, based on the systemic administration of Staphylococcus aureus enterotoxin B (SEB). Since the inflammatory response obtained is mild, the food intake pattern is not affected, which makes this model useful for studies of nutritiona...
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PMID: 20576204
PDF is available here.
PDF is available here.
Abstract
BMS-690514, a potent inhibitor of human epidermal growth factor receptor (HER) 1 (EGFR), 2, and 4, and vascular endothelial growth factor receptors (VEGFR) 1-3, is currently under investigation as an oral agent for the treatment of solid tumors. In vitro and in vivo studies were cond...
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PMID: 20166197
PDF is available here.
PDF is available here.
Abstract
We inserted one loaded titanium implant intra-articularly in each medial femoral condyle of eight dogs. Each implant was surrounded by a 0.75 mm gap. One implant in each dog was coated with AGF prior to implantation whereas the contralateral implant served as a control. AGF was prepared by isolating...
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PMID: 19856178
PDF is available here.
PDF is available here.
Abstract
We therefore analyzed its molecular evolution on the basis of coding sequences of 16 primate species. Ratios of non-synonymous to synonymous substitution rates (d(n)/d(s)=omega) suggest that a previously reported acceleration of sequence evolution of exon 7, which encodes domain D3, is driven by pos...
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PMID: 20471458
PDF is available here.
PDF is available here.
Abstract
Vox Sanguinis (99)2 2010
Abstract
Platelet function in thrombosis and haemostasis is reasonably well understood at the molecular level with respect to the proteins involved in cellular structure, signalling networks and platelet interaction with clotting factors and other cells. However, the natural history of these proteins has onl...
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PMID: 20345520
PDF is available here.
PDF is available here.
Circulation (122)3 2010
Abstract
Hemoconcentration is significantly associated with measures of aggressive fluid removal and deterioration in renal function. Despite this relationship, hemoconcentration is associated with substantially improved survival. These observations raise the question of whether aggressive decongestion, even...
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PMID: 20606118
PDF is available here.
PDF is available here.