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Cerebrospinal Fluid Proteins (0):
Recent article
Cerebrospinal Fluid Proteins
Journal of Chromatography B (878)22 2010
Abstract
Traumatic brain injury (TBI) is an acute event resulting from external force to the brain and is a major cause of death and disability associated with high health care costs in the western world. Additional injuries, originating from the secondary molecular events after the initial i...
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PMID: 20542479
PDF is available here.
PDF is available here.
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Abstract
By comparing the recurrent features of sequences surrounding 86 Ser/Thr residues phosphorylated in peptides from human plasma collected from literature with those generated from the whole human phosphoproteome, and from repertoires of validated substrates of the acidophilic protein k...
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PMID: 20450225
PDF is available here.
PDF is available here.
Abstract
Inflammation (33)3 2010
Abstract
This study aimed to examine effects of adjunctive baicalin therapy to ampicillin for experimental bacterial meningitis in rabbits. After Escherichia Coli inoculation, mean leukocyte counts, concentrations of protein, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) and lactate in cerebr...
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PMID: 20033479
PDF is available here.
PDF is available here.
Neurosurgery (66)5 2010
Abstract
The mean interval from EVD to VP shunt placement was 6.4 days. The mean volume of IVH was 9.44 mL, and the mean value of IVH/whole ventricle volume ratio (ie, percentage of blood suspension in the CSF) was 9.81%. The mean perioperative protein level in the CSF was 149 mg/dL. During the follow-up per...
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PMID: 20404694
PDF is available here.
PDF is available here.
Abstract
We used the combinatorial peptide ligand library technology (ProteoMiner) to reduce the dynamic range of protein concentration in CSF and unmask previously undetected proteins by nano-LC-MS/MS analysis on an LTQ-Orbitrap mass spectrometer. This method was first applied on a large pool of CSF from di...
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PMID: 20093276
PDF is available here.
PDF is available here.
Journal of Proteomics (73)6 2010
Abstract
The continuing expansion of proteomic technology has been fueled by the potential for discovering novel biomarkers that may be used for the early detection of disease. It has been proposed that human cerebrospinal fluid (CSF), which surrounds and protects the brain and spinal cord fr...
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PMID: 20176152
PDF is available here.
PDF is available here.
Abstract
Glial cells in the CNS are likely to communicate with other glial cells and neurons through secreted proteins. Glia-derived proteins also participate in neuroinflammation, which is a major component of neurodegenerative disease. Cerebrospinal fluid (CSF) is the biological fluid that best reflects th...
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PMID: 20377392
PDF is available here.
PDF is available here.
Pediatric Neurology (42)4 2010
Abstract
Between 1991-2006, nine patients below age 18 years, with a microbiologic documentation of Cryptococcus neoformans infection and no evidence of human immunodeficiency virus infection, were identified and treated at Chang Gung Children's Hospital. All exhibited central nervous system involvement. Sev...
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PMID: 20304330
PDF is available here.
PDF is available here.
Abstract
We describe an interesting case of a previously healthy 11-year-old boy who initially complained of vague gastroenteritis-like symptoms while visiting a mountain lake. The boy's symptoms evolved to include severe headache and dizziness, necessitating a visit to a rural emergency department. He prese...
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PMID: 20010289
PDF is available here.
PDF is available here.
Abstract
Recent evidence suggests that using intravenous isotonic albumin solution for haemodynamic resuscitation in neurotrauma is associated with adverse outcomes. This study assessed the correlations between cerebrospinal fluid protein concentrations, serum albumin concentrations and intracranial pressure...
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PMID: 20369759
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (50)3 2010
Abstract
We retrospectively investigated prognostic factors of 27 consecutive patients with bacterial meningitis seen at Niigata University Medical and Dental Hospital between 1980 and 2006. Patients were divided into the two categories using the Glasgow outcome scale (GOS) at discharge; the poor outcome gro...
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PMID: 20235480
PDF is available here.
PDF is available here.
Abstract
We have developed a software named Mass Spectrometry based Quantification (MSQ). This software can be used to automate the quantification and identification of targeted peptides/proteins by the MALDI TOF/TOF platform. MSQ was applied to the detection of a selected group of targeted peptides in poole...
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PMID: 20069694
PDF is available here.
PDF is available here.
Abstract
We specifically aimed to differentiate between the PP and RR subtypes of MScl by comparing CSF proteins.
CSF samples (n = 31) were handled according to the same protocol for quantitative mass spectrometry measurements we reported previously. In the comparison of PP MScl versus RR MSc...
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PMID: 20805994
PDF is available here.
PDF is available here.
Cell Research (19)12 2009
Abstract
Abstract
Ventriculo-atrial shunt infection (VASI) may lead to sepsis and/or nephritis, making early diagnosis critical. VASI is usually diagnosed by cerebrospinal fluid culture conducted after ventricular puncture or shunt removal, both of which are invasive. Non-invasive attempts at diagnosis, however, pres...
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PMID: 19860261
PDF is available here.
PDF is available here.
Abstract
We describe and demonstrate the proteomics computational toolkit provided in the open-source msInspect software distribution. The toolkit includes modules written in Java and in the R statistical programming language to aid the rapid development of proteomics software applications. It contains tools...
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PMID: 19309175
PDF is available here.
PDF is available here.
Abstract
This prospective study showed that in certain limits, covering mostly low molecular weighted proteins like albumin, prealbumin, even high cell counts in cerebrospinal fluid, does not affect shunt function....
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PMID: 19546843
PDF is available here.
PDF is available here.
Abstract
We were able to follow characteristic changes in protein concentrations over time allowing new conclusions to be drawn about ongoing pathological processes during TBI. Certain suggested protein-biomarker candidates for TBI, like acute phase reactants (APRs), fibrinogens (FIB), cystatin C (CC) or mor...
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PMID: 19263575
PDF is available here.
PDF is available here.
Abstract
We performed a retrospective comparison of cerebrospinal fluid (CSF) characteristics and drug susceptibility profile in human immunodeficiency virus (HIV) infected and non-infected patients with a diagnosis of tuberculous meningitis. HIV-infected patients had a higher frequency of non-inflammatory C...
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PMID: 19146759
PDF is available here.
PDF is available here.
Abstract
Various approaches for removal of high-abundance components in body fluids are currently available. While most methods are constructed for plasma depletion, there is a need for body-fluid-specific strategies. The aim of the present study was to design an affinity matrix suitable for the depletion of...
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PMID: 18412540
PDF is available here.
PDF is available here.
Clinica Chimica Acta (400)1-2 2009
Abstract
The results obtained thus suggest that differential display of CSF serum albumin precursor, serum albumin chain-A, PRR 14 and serum transferrin N-terminal lobe could be associated with neuronal dysfunction and hemoglobin/globin with the onset/progression of PD in humans....
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PMID: 18977210
PDF is available here.
PDF is available here.
Abstract
The model produced high- and low-risk groups based on the following: 1) Gram stain, 2) CSF neutrophil percent < or =15%, 3) CSF neutrophil count < or =150 cells/mm(3), and, 4) mental status change. Among the derivation cohort, there were 65 patients with BM in the high-risk group (n=76), while only...
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PMID: 19336955
PDF is available here.
PDF is available here.
Abstract
We sought to investigate the association between symptom duration and cerebrospinal fluid (CSF) pressure, protein concentration, and cell counts in patients with intracranial hypotension, in addition to examining differences between spontaneous and post-traumatic types. We investigated 115 consecuti...
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PMID: 19116838
PDF is available here.
PDF is available here.
Neurology India (57)3 2009
Abstract
B-CSFB dysfunction was present in only half of the patients with GBS during the first week from onset and it was directly associated with progression and clinical severity; nevertheless, a low B-CSFB dysfunction response during follow-up was associated with a lethal outcome, suggesting it could also...
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PMID: 19587469
PDF is available here.
PDF is available here.
Abstract
The cerebrospinal fluid of the two groups differed significantly (P < 0.05) in the levels of total protein, albumin, immunoglobulin G, glucose and osmolarity. Sensory and motor block was established more rapidly in the diabetic group (P < 0.05), and the total duration from maximum block until regres...
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PMID: 18990259
PDF is available here.
PDF is available here.
Medicina Clínica (131)11 2008
Abstract
Protein analysis in biological fluids has been used for many years for diagnosis and monitoring of diseases. First it was quantification of total protein, afterwards the electrophoretic separation of proteins and later the quantification of specific proteins using immunoassays. These proteins are us...
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PMID: 18928725
PDF is available here.
PDF is available here.
Abstract
We performed a retrospective chart review. On 160 pediatric patients a total of 2,172 LPs were performed (median per patient = 15; range 1-38). Overall, 314 (14%) of CSF protein measurements were abnormal: 141 (7%) were abnormally low (<15 mg/dL) and 158 (7%) were abnormally high (>45 mg/dL). In no...
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PMID: 18454465
PDF is available here.
PDF is available here.
Abstract
We therefore used an enzyme-linked immunosorbent assay to measure PAR-modified proteins in cerebrospinal fluid (CSF). Cerebrospinal fluid samples from 17 pediatric TBI patients and 15 controls were plated overnight and then incubated with polyclonal antibody against PAR. Histone-1, a PARP substrate,...
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PMID: 18506195
PDF is available here.
PDF is available here.
Abstract
Demyelination is the prominent histopathological hallmark in the acute stage of canine distemper virus infection. Magnetic resonance imaging is an important diagnostic tool in human beings to determine demyelination in the brain, for example in multiple sclerosis. Five young dogs with clinically sus...
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PMID: 18482329
PDF is available here.
PDF is available here.
Clinical Radiology (63)9 2008
Abstract
Abstract
We here describe a method for a comprehensive isolation and identification of phosphorylated tryptic peptides derived from CSF proteins using a simple sample preparation step and titanium dioxide-affinity chromatography followed by MALDI-TOF or LC-MS/MS linear ion-trap-FT mass spectrometry. Whereas...
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PMID: 18702456
PDF is available here.
PDF is available here.
Neuroscience Letters (440)3 2008
Abstract
We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recor...
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PMID: 18571320
PDF is available here.
PDF is available here.
Abstract
We sought to determine current values for preterm neonate cerebrospinal fluid parameters and assess the association of cerebrospinal fluid parameters with culture proven meningitis. We performed a cohort study of the first lumbar puncture from 4632 neonates < 34 weeks' gestation performed in the yea...
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PMID: 18726835
PDF is available here.
PDF is available here.
Abstract
We detected this complication in six children who were treated for acute lymphoblastic leukemia (ALL) and presented with an elevated protein concentration of the cerebrospinal fluid (CSF) during routine LP. Contrary to expectation the lumbar fluid collections persisted in two cases and in one case r...
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PMID: 18454469
PDF is available here.
PDF is available here.
Abstract
To better understand the pathophysiologic mechanisms underlying Guillain-Barré syndrome (GBS), Comparative proteomic analysis of cerebrospinal fluid (CSF) between patients with GBS (the experiment group) and control subjects suffering from other neurological disorders (the control group) was carr...
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PMID: 18343991
PDF is available here.
PDF is available here.
Abstract
Wild C. aethiops monkeys developed CSF changes resulting, most probably, from infection with M. peruzii. Moreover, the monkeys could be acting as an important reservoir. The study highlights the need for epidemiological and pathogenological studies of this parasite, which is of public health signifi...
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PMID: 18759948
PDF is available here.
PDF is available here.
Clinical Biochemistry (41)12 2008
Abstract
Three cases (4%) of bacterial meningitis and 11 cases (15%) of aseptic meningitis were confirmed by culture. The sensitivity and specificity of total CK CSF level alone to diagnose bacterial meningitis were found to be 33% and 91% respectively. The positive and negative predictive values were found...
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PMID: 18501707
PDF is available here.
PDF is available here.
Abstract
CASE REPORT: A 46-year-old woman, who presented with right visual acuity loss, was found to have papilledema, and subsequently shown to have ventricular dilatation in a cerebral Magnetic Resonance Imaging (MRI) assessment. Elevated protein levels were found in the cerebrospinal fluid. Spinal MRI rev...
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PMID: 18592445
PDF is available here.
PDF is available here.
Nature Medicine (14)6 2008
Abstract
We describe a method for correlating the immunoglobulin (Ig) proteomes with the B cell transcriptomes in human fluid and tissue samples, using multiple sclerosis as a paradigm. Oligoclonal Ig bands and elevated numbers of clonally expanded B cells in the cerebrospinal fluid (CSF) are diagnostic hall...
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PMID: 18488038
PDF is available here.
PDF is available here.
Abstract
Abstract
A 2-DE profile of CSF proteome was successfully established in SeM and normal children through proteomic technique. By the differentiated analysis of these CSF 2-DE gels, the differences of CSF proteome profiles were found between SeM and normal children. Future analysis and identification of these...
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PMID: 18554448
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (48)6 2008
Abstract
We report herein a 54-year-old man who first noticed muscle weakness of the hands and legs and hypesthesia of the legs at 20-years-old. Symptoms gradually worsened. Charcot-Marie-Tooth disease type 1A (CMT 1A) was diagnosed on the basis of a nerve conduction study and PMP22 gene duplication. Increas...
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PMID: 18616154
PDF is available here.
PDF is available here.
Abstract
Based on classical criteria, bacterial meningitis occurred in 26.7% of patients. Patients with VRI manifested significantly (p<0.001) higher median values of IL-6 (CSF) (up to 2,000-fold increase) the day before (day -1) infection was diagnosed by conventional parameters. Using a cut-off value of IL...
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PMID: 18444215
PDF is available here.
PDF is available here.
Clinical Radiology (63)5 2008
Abstract
Abstract
A new 6-plex isobaric mass tagging technology is presented, and proof of principle studies are carried out using standard protein mixtures and human cerebrospinal fluid (CSF) samples. The Tandem Mass Tags (TMT) comprise a set of structurally identical tags which label peptides on free amino-terminus...
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PMID: 18312001
PDF is available here.
PDF is available here.
Seminars in Neurology (28)2 2008
Abstract
Several entities can be put under the heading of chronic acquired demyelinating polyneuropathy. Future research will hopefully provide a greater understanding of pathophysiology, which may suggest the ideal way to classify and manage these patients. In the meantime, it is reasonable and useful to us...
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PMID: 18351519
PDF is available here.
PDF is available here.
Mikrobiyoloji bulteni (42)2 2008
Abstract
In this study, a total of 17 adult patients ((> or =18 years old; 12 male, 5 female) with encephalitis followed up in neurology and infectious diseases clinics of Trace University Hospital between the years 2000-2005 were retrospectively analyzed. The most common signs and symptoms were confusion (n...
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PMID: 18697429
PDF is available here.
PDF is available here.
Clinical Chemistry (54)4 2008
Abstract
Abstract
We here reanalyze two CNS-related proteomics datasets, one from the HUPO's Brain Proteome Project, and one from a comprehensive analysis of cerebrospinal fluid in light of the expression of specific splice isoforms from CNS-related genes. We also evaluate the empirically observed peptides of interes...
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PMID: 18283668
PDF is available here.
PDF is available here.
Journal of Pediatrics (152)3 2008
Abstract
The sensitivity of the BMS to detect disease was very high, but a few cases of BM were missed. Further refinements of the BMS may be warranted to lower the false-negative rate....
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PMID: 18280844
PDF is available here.
PDF is available here.
Pediatric Nephrology (23)2 2008
Abstract
We report on the relationships between serum cystatin C level, glomerular filtration rate (GFR) estimated from a cystatin C-based prediction equation (that of Filler and Lepage), GFR calculated by the Schwartz formula and technetium 99m-diethylene triamine penta-acetic acid ((99)Tc-DTPA)-determined...
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PMID: 17922294
PDF is available here.
PDF is available here.
Abstract
We demonstrated the application of targeted quantitative proteomics in searching, identifying, and quantifying selected peptides in human cerebrospinal spinal fluid (CSF) using a matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (MALDI TOF/TOF)-based platform. The a...
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PMID: 18186601
PDF is available here.
PDF is available here.
Neurologist (14)1 2008
Abstract
Abstract
We demonstrated that cystatin C microinjection into rat hippocampus induced neuronal cell death in dentate gyrus. Furthermore, apoptotic cell death was observed in neuronal cells treated with cystatin C in vitro. Up-regulation of cystatin C was observed in glial cells with neuronal cell death in viv...
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PMID: 18508448
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (15)18 2008
Abstract
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron diseases (MND) characterized by progressive selective degeneration of motor neurons. Although several mutations underlying rare cases of familial ALS were identified during the last decade, the pathogenesis of ALS remains po...
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PMID: 18691039
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (193)1-2 2008
Abstract
We have pursued a comparative proteomics approach on cerebrospinal fluid (CSF) samples from LHON and MS patients, as well as healthy donors by employing 2-DE gel separations coupled to MALDI-TOF-MS and nLC-MS/MS investigations. 7 protein spots showed significant differential distribution among the t...
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PMID: 18061280
PDF is available here.
PDF is available here.
Abstract
Abstract
During follow-up, 142 participants (15%) developed cardiovascular events. The highest quartiles (vs lower 3 quartiles) of 5 biomarkers were individually associated with cardiovascular risk after multivariate analysis: Nt-proBNP hazard ratio (HR)=2.13 (95% confidence interval [CI], 1.43-3.18); cystat...
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PMID: 18187073
PDF is available here.
PDF is available here.
European Neurology (60)3 2008
Abstract
We investigated the relationships between total cerebrospinal fluid (CSF) protein in diabetic patients and the clinical characteristics of diabetes mellitus. The subjects comprised 16 diabetic patients (median age = 60.5 years, range = 47-71) who were studied retrospectively. Patients with diseases...
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PMID: 18628631
PDF is available here.
PDF is available here.