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Colipases (0):
Recent article
Colipases
Brain research (1349) 2010
Abstract
We used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. The release of both DA and 5HT from striatal slices of rats fed a high fat diet for 10 days, but not 3 days, was reduced when compared to striatal slices taken from rats fed a l...
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PMID: 20599830
PDF is available here.
PDF is available here.
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Abstract
The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastroint...
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PMID: 20193096
PDF is available here.
PDF is available here.
Endocrinology (149)12 2008
Abstract
We showed circulatory levels of ATRA decreased in mice under constant darkness and elevated by light exposure. Fat gene pancreatic lipase-related protein 2 (mPlrp2) and its partner procolipase (mClps), but not hepatic lipase (mHl), activated in livers for responding to lack of light illuminating. Li...
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PMID: 18669599
PDF is available here.
PDF is available here.
Abstract
The results presented in this article indicate that despite the primitive character of the turtle, no significant difference has been observed between TuPL and known mammalian PLs. However, partial proteolysis of TuPL with chymotrypsin shows the absence of the 14-kDa fragment identified as the C-ter...
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PMID: 18362845
PDF is available here.
PDF is available here.
Abstract
We found that APGPR inhibited morphine-induced analgesia after intracerebroventricular administration in mice at a dose of 10nmol/mouse. The anti-analgesic effect of APGPR was inhibited by pretreatment with lorglumide and LY225910, antagonists for cholecystokinin 1 (CCK1) and cholecystokinin 2 (CCK2...
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PMID: 18304696
PDF is available here.
PDF is available here.
Abstract
We cover the novel receptors for the hormones atrial naturetic hormone, enterostatin, hepcidin, thyroid hormones, estradiol, progesterone, and the vitamin D metabolites 1,25(OH)(2)D(3) and 24,25(OH)(2)D(3).
(c) 2007 Wiley-Liss, Inc....
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PMID: 17546587
PDF is available here.
PDF is available here.
Abstract
Recombinant porcine pancreatic colipase (pCoL) was produced in the methylotrophic yeast Pichia pastoris. A synthetic yeast secretion cassette was constructed with the constitutive promoter of the glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) gene and the yeast alpha-mating factor signal peptide....
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PMID: 19194948
PDF is available here.
PDF is available here.
Biochemistry (Washington) (46)51 2007
Abstract
We clearly show that colipase fully inserts into a dilaurin monolayer and promotes the formation of lipid/protein domains, whereas in a phospholipid environment its insertion is only partial, limited to the polar head group. In a mixed 70% phosphatidylcholine/30% dilaurin environment, colipase adsor...
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PMID: 18052211
PDF is available here.
PDF is available here.
Brain Research (1185) 2007
Abstract
We found PLRP2 and colipase mRNA to be expressed in the hypothalamus. An overnight fast resulted in down-regulated colipase (3-fold) and PLRP2 (7-fold) mRNA compared to freely fed rats. Conversely, high-fat feeding resulted in up-regulated colipase and PLRP2 mRNA (1.3-fold and 1.8-fold, respectively...
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PMID: 17936733
PDF is available here.
PDF is available here.
Journal of Lipid Research (48)11 2007
Abstract
We hypothesized that the Arg92Cys polymorphism has functional consequences. To test our hypothesis, we expressed recombinant cysteine 92 (Cys92) procolipase in a yeast expression system and compared the function and stability of purified Cys92 with that of the more common arginine 92 (Arg92) procoli...
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PMID: 17715423
PDF is available here.
PDF is available here.
Abstract
OPL, TPL, and mammal pancreatic lipases share a high amino acid sequence homology. Further investigations are, however, needed to identify key residues involved in substrate recognition responsible for biochemical differences between the 2 classes of lipases....
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PMID: 17895836
PDF is available here.
PDF is available here.
Abstract
In recent years, recovery and characterization of enzymes from fish and aquatic invertebrates have taken place and this had led to the emergence of some interesting new applications of these enzymes. However, much less is known about lipases from crustaceans. A lipolytic activity was located in the...
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PMID: 17395356
PDF is available here.
PDF is available here.
Abstract
Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensit...
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PMID: 17401110
PDF is available here.
PDF is available here.
Abstract
We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of...
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PMID: 17175068
PDF is available here.
PDF is available here.
Abstract
We have investigated the role of melanocortin signaling in the response to enterostatin by studies in melanocortin 4 receptor (MC4R) knock out mice and by the use of the MC4R and MC3R antagonist SHU9119, and by neurochemical phenotyping of enterostatin activated cells. We also determined the effect...
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PMID: 17113194
PDF is available here.
PDF is available here.
Abstract
Access to the active site of human pancreatic lipase (HPL) is controlled by a surface loop (the lid) that undergoes a conformational change in the presence of amphiphiles and lipid substrate. The question of how and when the lid opens still remains to be elucidated, however. A parama...
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PMID: 17269661
PDF is available here.
PDF is available here.
Abstract
A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the availability of the sequence of the human genom...
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PMID: 17205399
PDF is available here.
PDF is available here.
Abstract
Among numerous regulatory peptide (RP) it is possible to presumably indicate the relict, evolutionary ancient RP. They combine three features: formation from non-specialized proteins-precursors, a comparatively high resistance to action of proteases in the organism media, and maximal simplicity of t...
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PMID: 17408100
PDF is available here.
PDF is available here.
Abstract
Environmental light is a potent modulator of mammalian circadian rhythm and expression of clock genes. Constant darkness (DD) is regarded as a "free-running" circadian state. In nature, hibernating mammals encounter constant darkness (DD) seasonally. Circadian expression of enzymes involved in fat c...
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PMID: 18419285
PDF is available here.
PDF is available here.
Physiology & Behavior (89)4 2006
Abstract
We investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absence of steatorrhea is explained by an increased pancr...
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PMID: 16952381
PDF is available here.
PDF is available here.
Journal of Lipid Research (47)12 2006
Abstract
Our comparative study showed that mammal colipase presents a lower activation level toward bird lipases than the bird counterpart. Three-dimensional modeling of ostrich colipase suggested a structural explanation of this fact....
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PMID: 16957180
PDF is available here.
PDF is available here.
Diabetes Care (29)10 2006
Abstract
Abstract
We have concluded that a slight increase in the exposed hydrophobic residues on the surface of CPL, as compared to HPL, could be responsible for a higher tolerance to the presence of long-chain free fatty acids at the lipid/water interface....
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PMID: 16780787
PDF is available here.
PDF is available here.
Brain Research (1087)1 2006
Abstract
We hypothesized that the procolipase may also be expressed in the brain. We confirmed the presence of preprocolipase gene expression in amygdala by reverse transcription-polymerase chain reaction and Northern blot analysis and of protein expression by Western blots. Immunohistochemical analysis usin...
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PMID: 16624258
PDF is available here.
PDF is available here.
Abstract
We have investigated the effect of enterostatin on energy metabolism. Male Sprague-Dawley rats adapted to a high-fat diet were implanted with lateral cerebral ventricular or amygdala cannulas. The metabolic effects were determined by indirect calorimetry. After habituation to the test cages, fasted...
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PMID: 16339388
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)12 2006
Abstract
We demonstrated that the beta5'-loop in the C-terminal domain of human pancreatic triglyceride lipase (hPTL) makes a major contribution in the function of hPTL (Chahinian et al. (2002) Biochemistry 41, 13725-13735). In the present study, we characterized the contribution of three residues in the bet...
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PMID: 16431912
PDF is available here.
PDF is available here.
Abstract
We report a mechanism by which constant darkness regulates the gene expression of fat catabolic enzymes in mice. Genes for murine procolipase (mClps) and pancreatic lipase-related protein 2 (mPlrp2) are activated in a circadian manner in peripheral organs during 12 h dark:12 h dark (DD) but not ligh...
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PMID: 16421573
PDF is available here.
PDF is available here.
Brain Research (1062)1-2 2005
Abstract
Serotonin (5-HT) is considered to play an important role in control of appetite. Enterostatin has been shown to alter 5-HT release in the brain, and non-specific 5-HT antagonists blocked the anorectic response to icv enterostatin. The aim of this study was to further identify which 5-HT receptor sub...
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PMID: 16256085
PDF is available here.
PDF is available here.
Analytical Biochemistry (346)1 2005
Abstract
We report a novel optical method for measuring the adsorption of macromolecules, such as proteins and nucleic acids, and smaller solutes, such as drugs, to lipid monolayers at the gas-liquid interface. Using fluorescence emission from proteins and a small molecule, we demonstrate that the emissions...
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PMID: 16188221
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Abstract
We measured peroxisome proliferator-activated receptor (PPAR) expression in tissues and observed that PPARalpha, -beta, -gamma1, and -gamma2 expression were modified by enterostatin in epididymal fat, pancreas, and liver. This further links altered lipid metabolism with body weight loss. Our data su...
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PMID: 15713687
PDF is available here.
PDF is available here.
Physiology & Behavior (83)4 2004
Abstract
We frame a hypothesis that regulation of fat intake through enterostatin contains a reward component, which is an F1-ATPase-mediated pathway, possibly complemented with an opioidergic pathway....
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PMID: 15621068
PDF is available here.
PDF is available here.
Abstract
We investigated the binding activity of the purified protein with a labeled antagonist, beta-casomorphin1-7, in the absence and presence of cold enterostatin. 125I-beta-casomorphin1-7 weakly binds to the rat F1-ATPase beta-subunit. Binding was promoted by low concentrations of cold enterostatin but...
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PMID: 15572201
PDF is available here.
PDF is available here.
Brain Research (1020)1-2 2004
Abstract
Our previous studies have shown that a central site of action is the central nucleus of amygdala. Serotonergic agonists administered into the paraventricular nucleus (PVN) inhibit fat intake and serotonergic antagonists block the feeding suppression induced by amygdala enterostatin, suggesting that...
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PMID: 15312796
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1701)1-2 2004
Abstract
Human pancreatic lipase-related protein 2 (HPLRP2) was identified for the first time in pancreatic juice using specific anti-peptide antibodies and purified to homogeneity. Antibodies were raised in the rabbit using a synthetic peptide from the HPLRP2 protein sequence deduced from cDNA. Western blot...
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PMID: 15450178
PDF is available here.
PDF is available here.
Biochemistry (Washington) (43)31 2004
Abstract
Human pancreatic lipase-related protein 2 (HPLRP2) was found to be expressed in the pancreas, but its biochemical properties were not investigated in detail. A recombinant HPLRP2 was produced in insect cells and the yeast Pichia pastoris and purified by cation exchange chromatography...
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PMID: 15287741
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1682)1-3 2004
Abstract
These results indicate hopping of lipase between emulsion droplets. Alternative explanations were excluded. Hopping of PL between triolein droplets stabilized with gum arabic at supramicellar bile salt concentrations was observed only in the presence, not in the absence, of lecithin. Displacement fr...
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PMID: 15158758
PDF is available here.
PDF is available here.
Journal of Nutrition (134)1 2004
Abstract
We determined whether PLRP2 or another lipase depends on colipase for maximal activity in newborn mice by analyzing extracts from the pancreas of 4-d-old colipase-deficient and PLRP2-deficient mice. Pancreatic extracts from colipase-deficient pups had lipase activity that was stimulated onefold by t...
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PMID: 14704305
PDF is available here.
PDF is available here.
Physiological Genomics (16)1 2003
Abstract
Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) exploit the low-temperature activity of pancreatic triacylglycerol lipase (PTL) during hibernation. Lipolytic activity at body temperatures associated with hibernation was examined using recombinant ground squirrel and human PTLs expres...
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PMID: 14583599
PDF is available here.
PDF is available here.
Abstract
Enterostatin, a pentapeptide released from the exocrine pancreas and gastrointestinal tract, selectively inhibits fat intake through activation of an afferent vagal signaling pathway. This study investigated if the effects of enterostatin were mediated through a CCK-dependent pathway. The series of...
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PMID: 12855414
PDF is available here.
PDF is available here.
Abstract
We conclude that oral ENT administration did not affect food intake, energy expenditure or body weight in subjects with a preference for a high-fat diet experiencing a negative energy and fat balance....
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PMID: 12844393
PDF is available here.
PDF is available here.
Abstract
The high-fat-fed mice became obese and glucose-intolerant by 113 days. The high-fat diet increased lipase (p < 0.05) expression initially. At the end of the experiment, the lipase levels had decreased to the level of the control. Colipase levels did not change during the first 57 days of high-fat fe...
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PMID: 12604926
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1645)2 2003
Abstract
We established that the chemically inhibited HPL, probably in its open conformation, had a much greater affinity for colipase than the closed native form of HPL. These inhibitory effects are quite substantial, because a 0.2-M excess of the chemically inhibited HPL form relative to HPL reduced the ca...
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PMID: 12573254
PDF is available here.
PDF is available here.
Abstract
We previously determined sequenced the PNLIP gene encoding pancreatic lipase in cell lines of subjects with clinical deficiency of pancreatic lipase (MIM 246600) and found no putative disease-causing mutations. As part of the ongoing analysis of the genomic DNA of these subjects, we now report the d...
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PMID: 12898288
PDF is available here.
PDF is available here.
Physiological Genomics (11)3 2002
Abstract
These results provide new insight into the genetic basis of naturally occurring variation in nutrient intake phenotypes....
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PMID: 12388789
PDF is available here.
PDF is available here.
Journal of Lipid Research (43)12 2002
Abstract
Pancreatic triglyceride lipase (PTL) and its protein cofactor, colipase, are required for efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structural hom...
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PMID: 12454260
PDF is available here.
PDF is available here.
Abstract
We conclude that canine classical pancreatic lipase can be successfully purified from canine pancreatic tissue....
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PMID: 12628302
PDF is available here.
PDF is available here.
Biochemistry (Washington) (41)46 2002
Abstract
We determined the contribution to lipid interactions of a hydrophobic loop (beta 5') in C-HPL by investigating a HPL mutant in which beta 5' loop hydrophobicity was increased by introducing the homologous lipoprotein lipase (LPL) beta 5' loop. This mutant (HPL-beta 5'LPL) penetrated into phospholipi...
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PMID: 12427035
PDF is available here.
PDF is available here.
Journal of Gastroenterology (37 Suppl 14) 2002
Abstract
We investigated the effects of galanin and enterostatin, injected into the third ventricle, on food intake, gastric emptying, and the sympathetic activity of nerves innervating interscapular brown adipose tissue in rats. Galanin dose-dependently increased the intake of a high-fat diet after overnigh...
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PMID: 12572879
PDF is available here.
PDF is available here.
Chemistry and Physics of Lipids (119)1-2 2002
Abstract
We investigated the partitioning of orlistat between the aqueous and oil phases, in the absence or presence of bile salts above their CMC (4 mM NaTDC, final concentration). Under these emulsified conditions, orlistat was found to be mostly associated with the oil phase, since more than 98.8% of the...
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PMID: 12270672
PDF is available here.
PDF is available here.
Animal Genetics (33)5 2002
Abstract
Physiology & Behavior (77)1 2002
Abstract
We investigated uptake across the blood-brain barrier (BBB) and tissue distribution of enterostatin by giving radioactive-labeled enterostatin (3H-VPDPR) intravenously. Low levels of 3H-VPDPR were detected in many areas of the brain, with greatest radioactivity in the frontal cortex, hippocampus and...
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PMID: 12213496
PDF is available here.
PDF is available here.
Obesity Research (10)7 2002
Abstract
The enterostatin levels were increased by all diets; the response to the high-fat and the high-fat/-sucrose meals was greater in magnitude and duration than that to the low-fat meal. In addition, enterostatin levels correlated with the intake of dietary fat. Plasma enterostatin levels after high-fat...
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PMID: 12105292
PDF is available here.
PDF is available here.
Biochemistry (Washington) (41)26 2002
Abstract
Although structurally similar to pancreatic lipase (PL), the key enzyme of intestinal fat digestion, pancreatic lipase-related protein type 2 (PLRP2) differs from PL in certain functional properties. Notably, PLRP2 has a broader substrate specificity than PL, and unlike that of PL, its activity is n...
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PMID: 12081491
PDF is available here.
PDF is available here.
Abstract
We show here that mitochondrial F1F0-ATP synthase itself is a target protein for an anorectic peptide, enterostatin, demonstrated both after affinity purification of rat brain membranes and through a direct physical interaction between enterostatin and purified F1-ATP synthase. In insulinoma cells (...
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PMID: 12041876
PDF is available here.
PDF is available here.
Neuroscience Letters (320)1-2 2002
Abstract
We found a significant elevation in serotonin release in the LHA. The enterostatin perfusion also induced a smaller but significant increase in dopamine level than serotonin one. This result suggests that enterostatin plays some sort of role in the control of feeding of fat through the control serot...
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PMID: 11849772
PDF is available here.
PDF is available here.
Abstract
We created a mouse model of procolipase deficiency. The Clps-/- mice appeared normal at birth, but unexpectedly 60% died within the first 2 weeks of life. The survivors had fat malabsorption as newborns and as adults, but only when fed a high fat diet. On a low fat diet, the Clps-/- mice did not hav...
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PMID: 11751900
PDF is available here.
PDF is available here.
Abstract
We repeat that the enterostatin amino acid sequence from the genomic DNA of 5 different rat strains is APGPR. 125I-APGPR bound to three proteins (300, 205 and 60 kDa) in rat serum and one 60 kDa protein in chicken serum. These serum binding proteins were also eluted by APGPR affinity chromatography....
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PMID: 11836004
PDF is available here.
PDF is available here.
Journal of Nutrition (131)12 2001
Abstract
An experiment was conducted to study the effect of feeding diets containing fat sources with different fatty acid composition (fish oil, coconut oil or lard, 10 g/100 g diet) on exocrine pancreatic secretion in piglets after weaning. A total of 16 barrows were weaned at 4 wk of age; 3 d later, they...
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PMID: 11739870
PDF is available here.
PDF is available here.
Biophysical Journal (81)6 2001
Abstract
Colipase, a cofactor of pancreatic triacylglycerol lipase, binds to surfaces of lipolysis reactants, like fatty acid and diacylglycerol, but not to the nonsubstrate phosphatidylcholine. The initial rate of colipase binding to fluid, single-phase lipid monolayers was used to characterize the interfac...
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PMID: 11721001
PDF is available here.
PDF is available here.