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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cystatins (5):
Recent article
Cystatins
Abstract
The role of phosphatases in the impairment of MAPK signaling, which is directly responsible for Leishmania-induced macrophage dysfunction, is still poorly understood. Gene expression profiling revealed that Leishmania donovani infection markedly up-regulated the expression of three p...
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PMID: 20200403
PDF is available here.
PDF is available here.
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Abstract
We previously reported that 1,25(OH)2D3 increases cytosolic Ca2+ concentration and transiently activates RhoA and its effector the Rho-associated coiled-kinase (ROCK), and later p38MAPK-MSK. We found that the inhibition of ROCK signaling by Y27632 or that of MSK by Ro318220 prevent the formation of...
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PMID: 20223287
PDF is available here.
PDF is available here.
Abstract
We have performed evolutionary studies of the CTES genes based on gene searches in genomes from 11 species. Ancestors of the cystatin family can be traced back to plants. We have localized the evolutionary origin of the CTES genes to the split of marsupial and placental mammals. A model for the evol...
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PMID: 20565543
PDF is available here.
PDF is available here.
Biological Chemistry (391)4 2010
Abstract
We present a protein network that is built up on three-dimensional domain-domain interactions. The essential domains that link these systems are as follows: Cystatin, Peptidase_C1, Thyroglobulin_1, Insulin, CIMR (Cation-independent mannose-6-phosphate receptor repeat), fn2 (Fibronectin type II domai...
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PMID: 20180650
PDF is available here.
PDF is available here.
Reproduction (139)4 2010
Abstract
A successful implantation of a mammalian embryo into the maternal endometrium depends on a highly synchronized fetal-maternal dialogue involving chemokines, growth factors, and matrix-modifying enzymes. A growing body of evidence suggests an important role for proteinases playing a role in matrix de...
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PMID: 20093401
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
A thiol proteinase inhibitor from Capra hircus (goat) pancreas (PTPI) isolated by ammonium sulphate precipitation (20-80%) and gel filtration chromatography on Sephacryl S-100HR, with 20.4% yield and 500-fold purification, gave molecular mass of 44 kDa determined by its electrophoretic and gel filtr...
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PMID: 19597935
PDF is available here.
PDF is available here.
Plant Cell Reports (29)3 2010
Abstract
Plant-parasitic nematodes are a major pest of many plant species and cause global economic loss. A phytocystatin gene, Colocasia esculenta cysteine proteinase inhibitor (CeCPI), isolated from a local taro Kaosiang No. 1, and driven by a CaMV35S promoter was delivered into CLN2468D, a heat-tolerant c...
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PMID: 20054551
PDF is available here.
PDF is available here.
Anticancer Research (30)3 2010
Abstract
The geometric mean of CB to SA was 1.45 in BPH and 2.99 in cancer specimens (p=0.0001). The percentage of S-phase cells and DNA ploidy status in needle biopsy was associated with cancer volume in RP cases (p=0.03). CONCLUSION: Our study has indicated that the ratio of CB to SA is significantly highe...
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PMID: 20392989
PDF is available here.
PDF is available here.
Abstract
Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described...
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PMID: 20173285
PDF is available here.
PDF is available here.
Parazitologiya (44)4 2010
Abstract
We investigated the expression of genes encoding defense factors in gastropods by the example of the snail Planorbarius corneus from water bodies of the Leningrad Oblast under infestation with trematods. The snails naturally infested with the parthenites of trematode species belonging to the familie...
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PMID: 21061590
PDF is available here.
PDF is available here.
Abstract
I collagen, have been studied at the mRNA, protein and cathepsin activity levels. Analyses of the two types of cells showed that the three cathepsins were up-regulated post-translationally, their specific activities increasing in the invading cells. The cystatin levels were also differentially alter...
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PMID: 19434518
PDF is available here.
PDF is available here.
Abstract
We describe type 1 cystatin, a cysteine protease inhibitor, as a major released antigen of the tropical liver fluke Fasciola gigantica (FgStefin-1). Immunohistochemical analysis showed that FgStefin-1 is abundant in (a) tissue of tegumental type, including oral and ventral sucker, pharynx, genital a...
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PMID: 19416741
PDF is available here.
PDF is available here.
Abstract
We report that 1alpha,25(OH)2D3 induced vitamin D receptor (VDR) binding to, and activation of, the CST5 promoter and increased CST5 RNA and protein levels in human colon cancer cells. In cells lacking endogenous cystatin D, ectopic cystatin D expression inhibited both proliferation in vitro and xen...
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PMID: 19662683
PDF is available here.
PDF is available here.
Abstract
Dendritic cells (DCs) play a key role in the pathogenesis of HIV infection. HIV interacts with these cells through 2 pathways in 2 temporal phases, initially via endocytosis and then via de novo replication. Here the transcriptional response of human DCs to HIV-1 was studied in these phases and at d...
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PMID: 19436054
PDF is available here.
PDF is available here.
Abstract
At least more than half of the patients after ischemic stroke/TIA need intensive statin therapy to target the LDL-C lowering goal. The dosage-effective relation of atorvastatin and LDL-C lowering in Chinese is similar to the reported data in other races....
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PMID: 19576114
PDF is available here.
PDF is available here.
Abstract
We show that efficient targeting of cystatin F to the endocytic pathway is dependent not on its unique dimeric conformation but rather on its oligosaccharide chains. We demonstrate the unusual addition of N-linked sugars to an Asn-X-Cys motif in cystatin F and provide evidence that the mannose 6-pho...
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PMID: 19192250
PDF is available here.
PDF is available here.
Abstract
This review describes the properties of four structurally related, abundant plasma proteins denoted fetuin-A/alpha-2-Heremans Schmid-glycoprotein (AHSG), fetuin-B (FETUB), kininogen (KNG) and histidine-rich glycoprotein (HRG). These proteins form a subgroup (denoted type 3) within the cystatin super...
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PMID: 19273244
PDF is available here.
PDF is available here.
Abstract
Cystatins function as cysteine protease inhibitors, are expressed in numerous cell types, and regulate a number of physiological processes. Four cystatins have been extensively studied: cystatin A, cystatin B, cystatin C, and cystatin M. Aberrant regulation of cystatins occurs in a number of disease...
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PMID: 19273077
PDF is available here.
PDF is available here.
Abstract
Cystatins are natural cysteine protease inhibitors which belong to a superfamily of proteins with wide occurrence in tissues. The cystatins have been shown to play multiple roles in normal and disease processes. In many different cancers the cathepsins, enzymes inhibited by cystatins, are elevated a...
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PMID: 19273078
PDF is available here.
PDF is available here.
Biological Chemistry (390)5-6 2009
Abstract
We characterized for the first time four M. sexta C1A cysteine proteases corresponding to cathepsin L and cathepsin B and two different '26-29 kDa' cysteine proteases (MsCath1 and MsCath2). Our analyses revealed that MsCath1 and MsCath2 are transcriptionally downregulated in the course of parasitism...
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PMID: 19361282
PDF is available here.
PDF is available here.
Abstract
We will focus on angiogenesis regulation by extracellular matrix processing. Therefore, possible regulatory mechanisms in vascular biology controlled by different cleavage products of basement membrane proteins (e.g. endostatin and tumstatin, endorepellin), their activation by proteases and inhibito...
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PMID: 19199966
PDF is available here.
PDF is available here.
Archives of Internal Medicine (168)20 2008
Abstract
Mean (SD) levels of creatinine and cystatin C were 0.93 (0.30) mg/dL and 1.03 (0.25) mg/L, respectively; mean (SD) eGFR(creat) and eGFR(cys) were 79 (23) mL/min/1.73 m(2) and 79 (19) mL/min/1.73 m(2), respectively. Individuals with rapid decline measured by eGFR(creat) (n = 714; 16%) had increased r...
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PMID: 19001197
PDF is available here.
PDF is available here.
Diabetes Research and Clinical Practice (82 Suppl 1) 2008
Abstract
Renal functional changes in diabetic nephropathy conventionally have been linked to progression of urinary albumin excretion. This paradigm was based on historic evidence noting that hyperfiltration occurred in the setting of normoalbuminuria and microalbuminuria and that loss of renal function bega...
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PMID: 18849087
PDF is available here.
PDF is available here.
Abstract
In participants without chronic kidney disease, eGFR(cysC) of 75 mL/min/1.73 m(2) or less was associated with a greater odds of LVH....
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PMID: 18845370
PDF is available here.
PDF is available here.
Journal of Immunology (181)8 2008
Abstract
We show that guinea pig vaccination against a secreted tick salivary immunomodulator, sialostatin L2, can lead to decreased feeding ability of I. scapularis nymphs. Increased rejection rate, prolonged feeding time, and apparent signs of inflammation were observed for nymphs attached to vaccinated an...
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PMID: 18832673
PDF is available here.
PDF is available here.
Abstract
Congenital nephron number varies five-fold among normal humans, and individuals at the lower end of this range may have an increased lifetime risk for essential hypertension or renal insufficiency; however, the mechanisms that determine nephron number are unknown. This study tested the hypothesis th...
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PMID: 18820179
PDF is available here.
PDF is available here.
Abstract
Low levels of serum cystatin C precede clinically manifest Alzheimer disease (AD) in elderly men free of dementia at baseline and may be a marker of future risk of AD. These findings strengthen the evidence for a role for cystatin C in the development of clinical AD....
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PMID: 18824671
PDF is available here.
PDF is available here.
Abstract
Experimental Animals (57)5 2008
Abstract
We examined the effect of pioglitazone, an insulin sensitizer, on diabetic nephropathy. Feed containing pioglitazone at 0.01 or 0.02% was given to Zucker-fatty rats for 27 weeks. Pioglitazone reduced plasma glucose, plasma insulin, and blood HbAlc levels. It also decreased plasma total cholesterol,...
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PMID: 18946178
PDF is available here.
PDF is available here.
Chemistry & Biology (15)9 2008
Abstract
Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it in...
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PMID: 18804024
PDF is available here.
PDF is available here.
Chemistry & Biology (15)9 2008
Abstract
We present here an unexpected function of cystatin C. Instead of acting as an inhibitor, cystatin C acts as a facultative, endogenous cofactor for the papain-like IgG-cleaving enzyme IdeS of the human pathogen Streptococcus pyogenes. IdeS activity is not dependent on cystatin C, but is significantly...
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PMID: 18804033
PDF is available here.
PDF is available here.
Abstract
CKD prevalence estimates vary across racial/ethnic groups, and the degree of variability depends on the method used to estimate GFR, especially among women. Further research is needed to determine the accuracy and precision of GFR prediction equations in racially diverse populations....
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PMID: 18550650
PDF is available here.
PDF is available here.
Abstract
Data obtained by using NC-2300 revealed an important role of cysteine cathepsins in the progression of CAs. Our findings strongly suggest that an imbalance between cysteine cathepsins and their inhibitor may cause the excessive breakdown of extracellular matrix in the arterial walls leading to the p...
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PMID: 18635848
PDF is available here.
PDF is available here.
Abstract
We computed the new 3- and 5-variable Japanese equations. Using 350 patient data, we evaluated resulted GFR for accuracy. The new equations performed with significantly lower bias and higher accuracy within 30% deviation in comparison with the original MDRD Study equation. The new Japanese equations...
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PMID: 18788401
PDF is available here.
PDF is available here.
Abstract
We believe a randomized controlled trial to that end should be undertaken....
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PMID: 18788415
PDF is available here.
PDF is available here.
Abstract
A variety of methods for evaluation of renal function have been discovered, among which glomerular filtration rate (GFR) attracts much attention because of the major determinant of renal function. Recently, novel technique to evaluate glomerular filtration has been developed, including cystatin C, w...
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PMID: 18788400
PDF is available here.
PDF is available here.
Abstract
We partially purified an endogenous cysteine protease inhibitor from spargana and characterized its biochemical properties. The cysteine protease inhibitor was purified by sequential chromatographies using Resource Q anion exchanger and Superdex 200 HR gel filtration from crude extracts of spargana....
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PMID: 18830060
PDF is available here.
PDF is available here.
Laboratory Investigation (88)9 2008
Abstract
We identified cystatin E/M (CST6) as a frequent target of epigenetic silencing in glioma. Cystatin E/M is a potent inhibitor of cathepsin B, which is frequently overexpressed in glioma. Here, we study the expression of cystatin E/M in normal brain and show that it is highly and moderately expressed...
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PMID: 18607344
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (83)9 2008
Abstract
We describe a systematic approach that can be used by the nonspecialist to identify most but not all causes of renal insufficiency. Although this approach should allow for earlier recognition of treatable causes of CKD, it does not eliminate the involvement of a nephrologist in the care and manageme...
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PMID: 18775206
PDF is available here.
PDF is available here.
Clinica Chimica Acta (395)1-2 2008
Abstract
The low W-I variation of both serum cystatin C and serum creatinine suggests that serial measurements of either would detect a changes in renal function earlier than would GFR by creatinine clearance or MDRD equation, which allows reporting only for GFRs<60 ml/min/1.7 m(2). While we measured only cr...
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PMID: 18573244
PDF is available here.
PDF is available here.
Abstract
We have previously localized a cervical cancer tumor suppressor gene to a 300 kb interval of 11q13. Analysis of candidate genes revealed loss of expression of cystatin E/M, a lysosomal cysteine protease inhibitor, in 6 cervical cancer cell lines and 9 of 11 primary cervical tumors. Examination of th...
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PMID: 18506750
PDF is available here.
PDF is available here.
Abstract
We suggest that unless renal function is completely compromised, measurement of biochemical markers of renal function might be relatively unimportant to improve clinical usefulness of Lp(a) testing....
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PMID: 18788856
PDF is available here.
PDF is available here.
Abstract
We evaluated whether the serum ribavirin concentration can be predicted on the basis of renal function estimates. Serum creatinine and cystatin C concentrations were measured at the start of treatment in a total of 148 patients with chronic hepatitis C who underwent combination PEG-IFN and ribavirin...
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PMID: 18637076
PDF is available here.
PDF is available here.
Annals of Internal Medicine (149)4 2008
Abstract
Risk prediction in chest pain patients by biochemical markers including estimates of renal function.
Abstract
During follow-up, 14 deaths and 21 myocardial (re)-infarctions occurred. Independent predictors for the combined endpoint of death or (re)-infarction were peak cTnI >or=0.1 microg/L within 24 h (OR 3.9; 95% confidence interval [CI]1.5-10.4), cystatin C >or=1.28 mg/L (OR 5.6; 95% CI 1.9-16.3) and NT-...
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PMID: 17662484
PDF is available here.
PDF is available here.
Abstract
We used logistic and linear regression analyses to relate CKD (glomerular filtration rate <60 ml/min/1.73 m(2)), cystatin C (cysC), and microalbuminuria (MA) with CAC and AAC obtained using multidetector computed tomography in Framingham Heart Study Offspring participants (mean age 59 years, 55.3% w...
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PMID: 18678302
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)33 2008
Abstract
We have analyzed the structure and function of cathepsin B in complexes with the Trypanosoma cruzi inhibitor, chagasin. Kinetic analysis revealed that substitution of His-110e, which anchors the loop in occluding position, results in 3-fold increased chagasin affinity (Ki for H110A cathepsin B, 0.35...
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PMID: 18515357
PDF is available here.
PDF is available here.
Diabetes Care (31)8 2008
Abstract
Our data suggest that impaired insulin sensitivity may be involved in the development of renal dysfunction at an early stage, before the onset of diabetes or prediabetic glucose elevations. Further studies are needed in order to establish causality....
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PMID: 18509205
PDF is available here.
PDF is available here.
Abstract
The odds ratio (OR) for hip fracture was 2.50 (95% confidence interval (CI)=1.32-4.72) for eGFR(cys-c) less than 60 mL/min per 1.73 m(2) compared with Stages 0 to 1, after adjustment for body mass, parental hip fracture, smoking, alcohol consumption, and physical function. No association was observe...
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PMID: 18662213
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)15 2008
Abstract
We identified and validated new PTC-associated transcripts. Three genes (CST6, CXCL14, and DHRS3) are strongly associated with PTC. Immunohistochemical analysis of CXCL14 confirmed the qPCR data and showed protein expression in PTC epithelial cells. We also observed that CST6, CXCL14, DHRS3, and SPP...
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PMID: 18676742
PDF is available here.
PDF is available here.
Abstract
We employed conditional logistic regression on the family data. The CSTA TCC haplotype is only associated with psoriasis in those individuals carrying the risk allele at the HLA-Cw6 locus (OR=2.22, P=0.0004, 95% CI= 1.42, 3.49). These results represent a major step towards the dissection of genetic...
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PMID: 18364739
PDF is available here.
PDF is available here.
Abstract
Abstract
Significant differences in the rate of U-NAG/U-creatinine were noted before and after treatment with amikacin (P < 0.001). Serum creatinine levels and creatinine clearance at the end of amikacin therapy (12th day) did not show any significant differences in comparison with the levels measured before...
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PMID: 18613859
PDF is available here.
PDF is available here.
Atherosclerosis (199)2 2008
Abstract
Cystatin C-concentration was higher in PAD-patients compared to controls; 1.09+/-0.40 vs. 0.95+/-0.17 mg/L (p<0.01). There was no difference in CCr; 81+/-27 vs. 82+/-22 mL/min or eGFR; 76+/-21 vs. 79+/-14 mL/min. Cystatin C correlated to CCr, logIL-6 and logCRP in both patients (r=-0.60, p<0.001), (...
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PMID: 18187137
PDF is available here.
PDF is available here.
Cancer Science (99)8 2008
Abstract
We here report CST6 (Cystatin 6 or E/M) as a candidate of molecular targets for PDAC treatment. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemical analysis confirmed over-expression of CST6 in PDAC cells, but no or limited expression of CST6 was observed in normal pancr...
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PMID: 18754876
PDF is available here.
PDF is available here.
Abstract
Multiple regression analysis revealed C (thio) and age as independent variables for serum creatinine concentration (Cr), while only C thio affected cysC. The equations using Cr or cysC showed significant correlation with C thio. Receiver-operating curve ROC analysis revealed that cysC and 24-hCcr sh...
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PMID: 18418694
PDF is available here.
PDF is available here.
Parasitology Research (103)3 2008
Abstract
Identifying parasitism genes encoding proteins secreted from nematodes is the key to understanding the molecular basis of nematode parasitism to insects. In this paper, a cDNA with two introns and three exons encoding a cysteine protease inhibitor was identified by screening a cDNA subtractive libra...
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PMID: 18543000
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (270)1-2 2008
Abstract
We have developed a novel delivery system for BDNF using transformed bone marrow stem cells (BMSC) and undertook studies of EAE to determine whether the delivery of BDNF could reduce inflammation and apoptosis. Mice receiving BDNF producing BMSC had reduced clinical impairment compared to control mi...
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PMID: 18374360
PDF is available here.
PDF is available here.
Clinica Chimica Acta (393)2 2008
Abstract
Artificial Organs (32)7 2008
Abstract
Optimizing solute removal at minimized albumin loss is a major goal of dialyzer engineering. In a prospective, randomized, crossover study on eight patients (age 63 +/- 14 years) on maintenance hemodialysis, the new Baxter Xenium 170 high-flux dialyzer (BX), which contains a 1.7-m(2) PUREMA H dialys...
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PMID: 18638309
PDF is available here.
PDF is available here.