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Early Growth Response Transcription Factors (3):
Recent article
Early Growth Response Transcription Factors
Autoimmunity Reviews (9)6 2010
Abstract
Early Growth Response (EGR) zinc finger transcription factors are induced under diverse mitogenic signals on different cell types such as lymphocytes. Their genetic expression does not require de novo protein synthesis, which suggests its role as immediate response mediators between...
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PMID: 20035903
PDF is available here.
PDF is available here.
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BioFactors (36)1 2010
Abstract
Since the discovery by this laboratory of the zinc finger transcription factor, KLF10, a member of the Krüppel-like family of transcription factors, there have been multiple publications regarding its functions and its immediate family members, in numerous cell types. KLF10 has been shown to be rap...
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PMID: 20087894
PDF is available here.
PDF is available here.
International Journal of Cancer (123)12 2008
Abstract
We have explored the role of transforming growth factor beta (TGFbeta) and bone morphogenetic protein-6 (BMP-6) and one target gene, TGFbeta inducible early gene 1 (TIEG1), in the communication between stroma cells and acute lymphoblastic leukemia (ALL) cell lines and their escape from chemotherapy....
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PMID: 18798273
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)7 2008
Abstract
We demonstrate that TIEG is rapidly induced in response to estrogen in osteoblasts by ERbeta, but not ERalpha. We have identified the regulatory elements utilized by ERbeta and have demonstrated that ERbeta recruits steroid receptor coactivator (SRC)1 and SRC2 to this regulatory region. Additionally...
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PMID: 18483178
PDF is available here.
PDF is available here.
Abstract
We used expression arrays and cell lines with different VHL status to identify ECM-associated genes controlled by VHL. One of them, adhesion-associated TGFBI, was repressed by VHL and overexpressed in renal, gastrointestinal, brain, and other tumors. Analyzing the mechanism of TGFBI up-regulation in...
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PMID: 18359287
PDF is available here.
PDF is available here.
Abstract
We present known and potential roles of TIEG, Runx2, and other transcription factors as important mediators of signaling between these two pathways.
(c) 2007 Wiley-Liss, Inc....
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PMID: 17541956
PDF is available here.
PDF is available here.
FEBS Letters (582)2 2008
Abstract
We have mapped the minimal human SREBP-1a promoter region to 75bp upstream of the translation start site where we discovered a functional role for the 3 GC-boxes containing overlapping sites for the Sp1 and EGR-1 transcription factors. Intact SP1-binding sites are essential for promoter activity, wh...
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PMID: 18068676
PDF is available here.
PDF is available here.
Circulation Research (102)1 2008
Abstract
Diabetes & Metabolism (33)5 2007
Abstract
Two variants showed a significant association under a recessive model: The intronic SMAD7 IVS2 -21 had an odds ratio of 0.62 (P=0.007, 95% CI=0.44-0.88; P=0.034 when adjusting for age, sex and BMI by logistic regression), and the KLF10 3'UTR +1002 variant had an Odds Ratio of 0.81 (P=0.009, 95% CI=0...
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PMID: 17931948
PDF is available here.
PDF is available here.
Abstract
A novel TGFbeta Inducible Early Gene-1 (TIEG1) was discovered in human osteoblast (OB) cells by our laboratory. Over the past decade, a handful of laboratories have revealed a multitude of organismic, cellular, and molecular functions of this gene. TIEG1 is now classified as a member of the 3 zinc f...
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PMID: 17729309
PDF is available here.
PDF is available here.
FEBS Letters (581)20 2007
Abstract
We found that TIEG1 was significantly up-regulated during apoptosis induced by homoharringtonine or velcade. Overexpression of TIEG1 could induce apoptosis in K562 cells and promote apoptosis induced by HHT or velcade. TIEG1-induced apoptosis was shown to involve Bax and Bim up-regulation, Bcl-2 and...
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PMID: 17659279
PDF is available here.
PDF is available here.
Journal of Immunology (178)7 2007
Abstract
We describe the effect of 15d-PGJ(2) on the expression of the rankl gene in T lymphocytes. We show that 15d-PGJ(2) inhibits rankl mRNA expression, protein, and rankl promoter activity by mechanisms mediated by its chemically reactive cyclopentenone moiety. Our data also indicate that 15d-PGJ(2) repr...
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PMID: 17371958
PDF is available here.
PDF is available here.
Journal of Immunology (178)5 2007
Abstract
We examined whether other Egr transcription factors have a functionally redundant role in monocyte/macrophage differentiation. Egr1 and Egr3 expression was found to be induced in myeloid cells when they were differentiated into macrophages by treatment with M-CSF, whereas Egr2 was minimally induced...
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PMID: 17312150
PDF is available here.
PDF is available here.
Abstract
These results indicate that camostat feeding induces a spectrum of early response gene expression and AP-1 DNA binding and that these effects are mainly CCK dependent....
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PMID: 17095753
PDF is available here.
PDF is available here.
Respiration (74)4 2007
Abstract
Our results suggest that IL-10 acts as a regulatory cytokine in the inhibition of airway inflammation.
Copyright (c) 2007 S. Karger AG, Basel....
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PMID: 17377371
PDF is available here.
PDF is available here.
Journal of Neuroscience (26)52 2006
Abstract
We analyzed the KCC2 (alias Slc12a5) promoter and proximal intron-1 regions and revealed 10 candidate transcription factor binding sites that are highly conserved in mammalian KCC2 genes. Here we focus on one of these factors, early growth response 4 (Egr4), which shows a similar developmental upreg...
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PMID: 17192429
PDF is available here.
PDF is available here.
Clinical Immunology (121)3 2006
Abstract
We used endogenous viral superantigens (VSAg)-reactive T cells as a model of self-antigens in two strains of Foxp3-mutant mice. These two strains, together with wild-type mice, provided us with an advantage to simultaneously study the positively and negatively selected as well as rescued autoreactiv...
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PMID: 16945588
PDF is available here.
PDF is available here.
Abstract
We report the cloning and expression analysis of two previously uncharacterized paralogs group 2 Hox genes, striped bass hoxa2a and hoxa2b, and the developmental regulatory gene egr2. We demonstrate that both Hox genes are expressed in the rhombomeres of the developing hindbrain and the pharyngeal a...
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PMID: 16581310
PDF is available here.
PDF is available here.
Abstract
We report the crystal structure of the Siah in complex with a peptide containing the degron motif. Binding is within a groove formed in part by the zinc fingers and the first two beta strands of the TRAF-C domain of Siah. We show that residues in the degron, previously described to facilitate bindin...
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PMID: 16615911
PDF is available here.
PDF is available here.
Immunological Reviews (209) 2006
Abstract
During thymopoiesis, two major types of mature T cells are generated that can be distinguished by the clonotypic subunits contained within their T-cell receptor (TCR) complexes: alphabeta T cells and gammadelta T cells. Although there is no consensus as to the exact developmental stage where alphabe...
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PMID: 16448543
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (281)1-2 2006
Abstract
The modulation of vascular smooth muscle cells (VSMCs) from the quiescent phenotype to the proliferative and migratory phenotype is a critical event in the pathogenesis of atherosclerosis. To-date several growth factors, including platelet-derived growth factor, PDGF, have been shown to induce VSMC...
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PMID: 16328958
PDF is available here.
PDF is available here.
Behavioural Brain Research (165)2 2005
Abstract
We exposed male and female zebra finches to acoustic (song) and visual (dancing) components of courtship. Birds were played digital movies with either combined audio and video, audio only, video only, or neither audio nor video (control). We found significantly increased levels of Zenk response in t...
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PMID: 16095729
PDF is available here.
PDF is available here.
Nature Medicine (11)8 2005
Abstract
We know of numerous inducers of cardiac hypertrophy, little is known about mechanisms that limit cardiac hypertrophy. Here, we describe the transcriptional repressor NAB1 as an endogenous regulator of cardiac growth. We identified NAB1 as being upregulated in both mouse and human heart failure. Nab1...
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PMID: 16025126
PDF is available here.
PDF is available here.
Experimental Cell Research (307)2 2005
Abstract
We show that CTGF enhances the TGFbeta/Smad signaling pathway by transcriptional suppression of Smad 7 following rapid and sustained induction of the transcription factor TIEG-1. Smad 7 is a known antagonist of TGFbeta signaling and TIEG-1 is a known repressor of Smad 7 transcription. CTGF enhanced...
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PMID: 15950619
PDF is available here.
PDF is available here.
Journal of Cell Science (118)Pt 14 2005
Abstract
We characterize the basis for the T-cell-specific activity of the human zinc-finger protein early growth response factor 4 (EGR-4). A yeast two-hybrid screen showed interaction of EGR-4 with NF-kappaB p50. Using recombinant proteins, stable physical complex formation was confirmed for EGR-4 and EGR-...
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PMID: 16014385
PDF is available here.
PDF is available here.
Abstract
EGR1 expression strongly correlated with PTEN expression (P < .0001). No correlation of EGR1 with histology or stage was detected. Patients with high levels of EGR1 had better overall and disease-free survival compared with patients with low levels of EGR1 (P = .040 and P = .096, respectively). In a...
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PMID: 15774784
PDF is available here.
PDF is available here.
Abstract
We will highlight some of the recent findings that further reinforce the thesis that basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPPD) crystals can cause the degeneration of articular tissues in 2 separate pathways. In the "Direct" pathway, crystals directly induce fibro-blast...
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PMID: 15769629
PDF is available here.
PDF is available here.
Abstract
Using EGR zinc finger proteins, we measure the binding affinity of six different variants of the protein to each of six different variants of the consensus binding site. Both the protein and binding site variants include single and double mutations that allow us to assess how well additive models ca...
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PMID: 16014175
PDF is available here.
PDF is available here.
Abstract
We hypothesize that breast tumors differentially express these genes and that this expression pattern plays a role in the proliferation of breast cancer. We examined the mRNA levels of TIEG, Smad7, Smad2, and Bard1 using real-time RT/PCR in 14 normal breast, five non-invasive, 57 invasive (including...
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PMID: 15218362
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)26 2004
Abstract
We show that the -100 to -20 region of the CD11d promoter confers myeloid-specific activation of the CD11d promoter. Transforming growth factor beta-inducible early gene-1 (TIEG1) was isolated in a yeast one-hybrid screen using the -100 to -20 region of the CD11d promoter as bait. Purified GST.TIEG1...
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PMID: 15087465
PDF is available here.
PDF is available here.
Abstract
We identified Tieg3, a new member of the Tieg protein family by screening a mouse cDNA library. Tieg3 has almost all the known features of the Tieg protein family: it shares a highly conserved C(2)H(2) zinc finger DNA binding domain and is 96% identical to Tieg2 and 86% to Tieg1, respectively. In ad...
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PMID: 14697507
PDF is available here.
PDF is available here.
Abstract
We found that 15-hydroxy-eicosatetraenoic acid (15S-HETE), an endogenous ligand for PPARgamma, was significantly decreased in the serum of patients with colorectal cancer. Treatment of colon cancer cells with 15S-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an incre...
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PMID: 14566836
PDF is available here.
PDF is available here.
Abstract
We focused on the mRNA encoded by the transforming growth factor-beta- (TGF-beta-) inducible early response 1 gene (TIEG1), which plays a pivotal role in TGF-beta-regulated cell growth control and apoptosis. Northern blotting analysis demonstrated that NO upregulates TIEG1 mRNA in a dose-dependent m...
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PMID: 12788480
PDF is available here.
PDF is available here.
Animal Genetics (34)2 2003
Abstract
Genes of the early growth response (EGR) family encode transcription factors with a highly conserved DNA binding zinc finger domain, which regulate a variety of genes, e.g. late myelin genes. Here, the cloning, genomic structure and expression of the bovine orthologue of the EGR4 gene are reported....
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PMID: 12648095
PDF is available here.
PDF is available here.
DNA and Cell Biology (22)3 2003
Abstract
TGFbeta-Inducible Early Gene (TIEG) and the alternatively-transcribed Early Growth Response Gene alpha (EGRalpha) share a Cys(2)His(2) three-zinc finger region with high homology to Sp1 within its zinc finger region. Three-zinc finger transcription factors bind to GC-rich sequences, with small varia...
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PMID: 12804117
PDF is available here.
PDF is available here.
Nucleic Acids Research (31)3 2003
Abstract
We demonstrate that the zinc finger protein EGR-1 and two members of the NFAT protein family bind simultaneously to adjacent elements position -168 to -150 within the TNFalpha promoter. Both promoter sites are important for TNFalpha gene transcription as shown by transfection assays having the IL-2...
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PMID: 12560487
PDF is available here.
PDF is available here.
Abstract
Eight novel potential markers for breast cancer have been preliminarily characterized. As expected from in vitro data, their expression is able to discriminate ER- versus ER+ tumors....
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PMID: 12841681
PDF is available here.
PDF is available here.
Journal of Molecular Biology (323)4 2002
Abstract
We present a probabilistic recognition code (P-code) that assigns energies to all possible base-pair-amino acid interactions for the early growth response factor (EGR) family of zinc-finger transcription factors. The specific energy values are determined by a maximum likelihood method using examples...
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PMID: 12419259
PDF is available here.
PDF is available here.
Cancer Letters (183)2 2002
Abstract
We performed mutational screening of this gene in 22 pancreatic cancer cell lines. No sequence alterations were observed. Reverse transcription-polymerase chain reaction analysis was also performed to rule out the possibility that the expression of the gene is altered by genetic events other than mu...
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PMID: 12065093
PDF is available here.
PDF is available here.
Abstract
We studied its impact on a Smad binding element (SBE) reporter which is known to be regulated by TGFbeta through the R-Smad proteins. We demonstrate that TIEG overexpression enhances TGFbeta induction of SBE reporter activity. TIEG overexpression also enhances induction of the endogenous TGFbeta reg...
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PMID: 12173049
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (277)34 2002
Abstract
We describe the identification of an E3 ubiquitin ligase, Seven in Absentia homologue-1 (SIAH1), as a TIEG1-interacting protein. We show that TIEG1 and SIAH1 interact through an amino-terminal domain of TIEG1. Co-expression of SIAH1 results in proteasomal degradation of TIEG1 but not of the related...
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PMID: 12072443
PDF is available here.
PDF is available here.
Anticancer Research (22)6C 2002
Abstract
It is a known paradox that many TGF beta 1-producing tumor cells are resistant to this, otherwise, inhibitory cytokine. In a lymphoma of B-cell origin exogenous TGF beta 1 was able to induce apoptosis, suggesting that the apoptosis program can be switched on. The apoptosis induction was independent...
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PMID: 12553006
PDF is available here.
PDF is available here.
Abstract
We mapped a susceptibility gene for an autosomal dominant form of PD to a 10.6 cM region of chromosome 2p (PARK3; OMIM 602404). A common haplotype shared by two North American kindreds (Families B and C) genealogically traced to Southern Denmark and Northern Germany suggested a founder effect. Here...
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PMID: 11571553
PDF is available here.
PDF is available here.
Journal of Neuroscience (21)1 2001
Abstract
We have investigated their role in mediating long-term effects elicited by NGF in these cells by using the Egr zinc finger DNA-binding domain as a selective antagonist of Egr family-mediated transcription. We report that expression of this Egr inhibitor construct suppresses neurite outgrowth elicite...
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PMID: 11150318
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (275)27 2000
Abstract
Although transforming growth factor-beta (TGF-beta) is a growth factor with many known regulatory activities in many different cell types, its intracellular signaling pathway is still not fully understood. A TGF-beta-inducible early gene (TIEG) was discovered and shown by this laboratory to be a 3-z...
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PMID: 10816551
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (210)1-2 2000
Abstract
The two-hybrid system was used to isolate cDNA clones encoding polypeptides that interact with the N-terminal region (activation domains A, B and C) of the Sp1 transcription factor. Among the 65 collected clones, 43 contained cDNA fragments with open reading frames. They corresponded to 13 genes enc...
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PMID: 10976766
PDF is available here.
PDF is available here.
Abstract
We have shown that serum LH levels in male Egr1-deficient mice are adequate for maintenance of Leydig cell steroidogenesis and fertility because of partial functional redundancy with the closely related transcription factor Egr4. Egr4-Egr1 double mutant male mice had low steady-state levels of serum...
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PMID: 10866682
PDF is available here.
PDF is available here.
Abstract
Select members of the TGF-beta family of cytokines play key regulatory roles in skeletal development, structure, and turnover. This laboratory has previously reported that TGF-beta treatment of immortalized normal human fetal osteoblast (hFOB) cells results in the rapid induction of the mRNA levels...
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PMID: 10861837
PDF is available here.
PDF is available here.
Abstract
Our laboratory recently described the existence of a novel family of zinc finger transcription factors, TGF-beta-inducible early-response gene (TIEG)1 and TIEG2, from the exocrine pancreas that, similarly to Smads, participate in the TGF-beta response and inhibit epithelial cell proliferation. This...
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PMID: 10762604
PDF is available here.
PDF is available here.
Hepatology (30)6 1999
Abstract
We have previously reported that the TGF-beta(1)-inducible transcription factor, TIEG1, induces apoptosis in a pancreas-derived cell line. However, the mechanisms underlying the apoptotic effects of this transcription factor remain to be defined. In this study, using the TGF-beta(1)-sensitive Hep 3B...
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PMID: 10573529
PDF is available here.
PDF is available here.
Development (126)22 1999
Abstract
We derived Egr4 null mice through targeted mutagenesis and found that they were phenotypically normal with the exception that males, but not females, were infertile. Egr4 is expressed at low levels within male germ cells during meiosis and is critical for germ cell maturation during the early-mid pa...
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PMID: 10529423
PDF is available here.
PDF is available here.
Trends in Neurosciences (22)4 1999
Abstract
The EGR family of transcription regulatory factors, which is implicated in orchestrating the changes in gene expression that underlie neuronal plasticity, has attracted the attention of both molecular and systems neuroscientists. In this article, the advances made in both these fields of research ar...
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PMID: 10203854
PDF is available here.
PDF is available here.
Abstract
We demonstrate gender-specific effects in the proliferation of coronary artery vascular smooth muscle cells obtained from a sexually mature animal model. Vascular smooth muscle cells are an integral component of the atherosclerotic plaque, and inhibition of cell proliferation by estrogen may be one...
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PMID: 10455521
PDF is available here.
PDF is available here.
Mammalian Genome (9)10 1998
Abstract
Abstract
We examined the effects of androgens on the proliferation and differentiation of a novel human fetal osteoblastic cell line (hFOB/AR-6) that expresses a mature osteoblast phenotype and a physiological number (approximately 4,000/nucleus) of androgen receptors (AR). Treatment with 5alpha-dihydrotesto...
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PMID: 9736458
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (273)40 1998
Abstract
We and others have recently reported that the transforming growth factor (TGF)-beta-regulated gene TIEG encodes a new Sp1-like protein that inhibits cell growth in cultured cells. Here we report the identification, nuclear localization, DNA binding activity, transcriptional repression activity, and...
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PMID: 9748269
PDF is available here.
PDF is available here.
Abstract
We report that TIEG and EGRalpha are expressed from alternative promoters of the same gene. The TIEG/EGRalpha gene spans 8 kb and contains five exons. Use of alternative first exons results in TIEG having 12 unique amino acids on its N-terminus. Computer analysis of the 5' upstream regions of either...
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PMID: 9721211
PDF is available here.
PDF is available here.
Cancer Research (58)11 1998
Abstract
We sought to determine their expression in nonmalignant and malignant prostate tissues. Total RNA extracted from prostate tissues was probed with EGR-1, EGR-2, and EGR-alpha cDNA for Northern blots and digoxigenin-labeled cRNA for in situ hybridization. Both Northern blot and in situ hybridization a...
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PMID: 9622090
PDF is available here.
PDF is available here.
Endocrinology (139)3 1998
Abstract
These results support the finding that TIEG is an early responding regulatory gene for E2 in human osteoblast cells that inhibits DNA synthesis. It is speculated that TIEG may play a role in the signaling pathway for E2 in inhibiting cell proliferation....
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PMID: 9492071
PDF is available here.
PDF is available here.