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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
HMGB Proteins (3):
Recent article
HMGB Proteins
Gene Expression Patterns (11)1-2 2011
Abstract
We characterized the HMGB family in zebrafish and report a detailed phylogenetic analysis of HMGB proteins. The B1, B2, and B3 subfamilies are present in cartilaginous fish, bony fish, and tetrapods, while jawless fish sequences emerge as basal to the gene family expansion. Two co-orthologs of each...
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PMID: 20804857
PDF is available here.
PDF is available here.
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Immunotherapy (2)5 2010
Abstract
Genes & Development (24)16 2010
Abstract
We show that a single transcription factor, Foxp1, can control the balance of cardiomyocyte proliferation during development by targeting different pathways in the endocardium and myocardium. Endocardial loss of Foxp1 results in decreased Fgf3/Fgf16/Fgf17/Fgf20 expression in the heart, leading to re...
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PMID: 20713518
PDF is available here.
PDF is available here.
Genes & Development (24)3 2010
Abstract
We show that Sox17 is a transcriptional regulator of differentiation in these pluripotent cells. ES cells deficient in Sox17 fail to differentiate into extraembryonic cell types and maintain expression of pluripotency-associated transcription factors, including Oct4, Nanog, and Sox2. In contrast, fo...
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PMID: 20123909
PDF is available here.
PDF is available here.
Developmental Cell (17)1 2009
Abstract
We show that the extrahepatobiliary system shares a common origin with the ventral pancreas and not the liver, as previously thought. These pancreatobiliary progenitor cells coexpress the transcription factors PDX1 and SOX17 at E8.5 and their segregation into a PDX1+ ventral pancreas and a SOX17+ bi...
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PMID: 19619492
PDF is available here.
PDF is available here.
Microbiology (155)Pt 4 2009
Abstract
We predicted that the ORF 19.400/19.8030 assigned as GCF1 encodes a putative mitochondrial HMG box-containing protein. In contrast to Abf2p, which contains two HMG boxes, Gcf1p contains only one C-terminal HMG box. In addition, it contains one putative coiled-coil domain with a potential role in pro...
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PMID: 19332824
PDF is available here.
PDF is available here.
Abstract
We performed yeast two-hybrid screens to identify PNUTS-interacting proteins. Here, we report that LCP1 (epidermal Langerhans cell protein 1), a novel member of the HMG-box protein family, binds tightly to PNUTS. Co-immunoprecipitation of deletion constructs revealed that the C-terminus of LCP1 is s...
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PMID: 19293638
PDF is available here.
PDF is available here.
Abstract
We used the CNP-EGFP mouse, in which oligodendrocyte lineage cells express EGFP, to study NG2(+) cells in the normal and injured spinal cord. In white matter of uninjured mice, bipolar EGFP(+)NG2(+) cells and multipolar EGFP(neg)NG2(+) cells were identified. After SCI, EGFP(+)NG2(+) cell proliferati...
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PMID: 18756526
PDF is available here.
PDF is available here.
Abstract
Ischemia/reperfusion (I/R) injury remains a major problem in solid organ transplantation, as it adversely impacts both short and long term outcomes. It has been well established that the innate immune system plays a significant role in the pathogenesis of I/R injury. In contrast, the...
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PMID: 19482628
PDF is available here.
PDF is available here.
Stem Cells (27)2 2008
Abstract
We have examined the consequences of enforced Mixl1 expression during mouse embryonic stem cell (ESC) differentiation. We show that three independently derived ESC lines constitutively expressing Mixl1 (Mixl1C ESCs) differentiate into embryoid bodies (EBs) containing a higher proportion of E-Cadheri...
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PMID: 19038793
PDF is available here.
PDF is available here.
Abstract
We focus on the mouse Nanog, Oct4 (also known as Pou5f1) and Sox2 genes and demonstrate the existence of many naturally occurring miRNA targets in their amino acid coding sequence (CDS). Some of the mouse targets analysed do not contain the miRNA seed, whereas others span exon-exon junctions or are...
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PMID: 18806776
PDF is available here.
PDF is available here.
Abstract
We show that Oct4 and Sox2 bind to a conserved promoter region of miR-302, a cluster of eight microRNAs expressed specifically in ESCs and pluripotent cells. The expression of miR-302a is dependent on Oct4/Sox2 in human ESCs (hESCs), and miR-302a is expressed at the same developmental stages and in...
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PMID: 18710938
PDF is available here.
PDF is available here.
Abstract
We report that key factors supporting pluripotency-Nanog, Oct3/4, and Sox2-bind within Xist intron 1 in undifferentiated embryonic stem (ES) cells. Whereas Nanog null ES cells display a reversible and moderate up-regulation of Xist in the absence of any apparent modification of Oct3/4 and Sox2 bindi...
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PMID: 18802003
PDF is available here.
PDF is available here.
Abstract
We use (15)N(z)-exchange transverse relaxation optimized NMR spectroscopy to characterize the mechanistic details of intermolecular hopping for the multidomain transcription factor, human Oct-1. Oct-1 is a member of the POU family of transcription factors and contains two helix-turn-helix DNA-bindin...
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PMID: 18772384
PDF is available here.
PDF is available here.
Abstract
We tested if EhHMGB1 encoded a functional HMGB protein and determined its role in control of parasite gene expression. Recombinant EhHMGB1 was able to bend DNA in vitro, a characteristic of HMGB proteins. Core conserved residues required for DNA bending activity in other HMGB proteins were demonstra...
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PMID: 18658254
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that chemical effects on cell proliferation and viability can be assessed via high-throughput methods using hNPCs. Further development of this approach as part of a strategy to screen compounds for potential effects on nervous system development is warranted....
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PMID: 18550602
PDF is available here.
PDF is available here.
Cancer Science (99)9 2008
Abstract
We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box-1 (HMGB1) (P < 0.0001) and lymph vessel densit...
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PMID: 18616526
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)15 2008
Abstract
We showed that phosphorylation of UBF by the MAP-kinase ERK regulates chromatin folding and transcription elongation, explaining the rapid response of the ribosomal RNA genes to growth factors. Here we have investigated the roles the UBF variants play in the response of these genes to ERK activity....
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PMID: 18676449
PDF is available here.
PDF is available here.
Abstract
We employed in silico analysis to search for putative HMG/POU cassettes in 50 genes reported to be co-occupied by Sox2 and Oct-3/4 in embryonic stem cells. We identified 39 genes that contain putative HMG/POU cassettes. Next, we tested the activity of seven of the putative HMG/POU cassettes in a tra...
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PMID: 18366076
PDF is available here.
PDF is available here.
FEBS Letters (582)18 2008
Abstract
We inactivated Sox2 specifically in the developing brain by using Cre-loxP system. Although mutant animals did not survive after birth, analysis of late gestation embryos revealed that loss of Sox2 causes enlargement of the lateral ventricles and a decrease in the number of neurosphere-forming cells...
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PMID: 18638478
PDF is available here.
PDF is available here.
Abstract
We show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells. These two-factor iPS cells are similar to embryonic stem cel...
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PMID: 18594515
PDF is available here.
PDF is available here.
FASEB Journal (22)8 2008
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish.
Abstract
We employed the zebrafish caudal fin regeneration model, where AHR activation blocks the regenerative process. Comparative toxicogenomic analysis revealed that both adult and larval fins respond to TCDD during regeneration with misexpression of Wnt signaling pathway members and Wnt target genes. R-S...
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PMID: 18495758
PDF is available here.
PDF is available here.
Genome Research (18)8 2008
Abstract
We introduce the GibbsModule algorithm for de novo detection of cis-regulatory motifs and modules in eukaryote genomes. GibbsModule models the coexpressed genes within one species as sharing a core cis-regulatory motif and each homologous gene group as sharing a homologous cis-regulatory module (CRM...
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PMID: 18490265
PDF is available here.
PDF is available here.
Abstract
We investigated the function of the HMG/POU cassette and LRH-1 site present in the distal enhancer (DE) and the proximal enhancer, respectively. F9 and P19 EC cells were the focus of this study because their differential utilization of Oct-3/4 enhancers parallels the use of these enhancers during di...
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PMID: 18213644
PDF is available here.
PDF is available here.
Abstract
We previously reported that the expression of activating FGF receptor mutations in osteoblasts downregulated the expression of many genes reported as targets of Wnt signaling, suggesting an antagonistic effect between Wnt signaling, which promotes osteoblast differentiation and function, and FGF sig...
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PMID: 18505824
PDF is available here.
PDF is available here.
FEBS Letters (582)17 2008
Abstract
We demonstrate that the mesoderm adjacent to intestinal heterotopic areas expresses stomach specific Barx1 while the surrounding mesoderm is Barx1 negative. We conclude that the initiation of gut histodifferentiation lies in the endodermal expression of Cdx2 and that endodermal/mesodermal cross-talk...
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PMID: 18577384
PDF is available here.
PDF is available here.
Physical Review Letters (101)3 2008
Abstract
We present a model of nonspecific cooperative binding of proteins to DNA in which the binding of isolated proteins generates local bends but binding of proteins at neighboring sites on DNA straightens the polymer. We solve the statistical mechanical problem and calculate the effective persistence le...
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PMID: 18764298
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)14 2008
Abstract
We report two novel recessive mutations in LHX3 in four patients from two unrelated pedigrees. Clinical evaluation revealed that all four patients exhibit varying degrees of bilateral sensorineural hearing loss, which has not been previously reported in association with LHX3 mutations, in addition t...
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PMID: 18407919
PDF is available here.
PDF is available here.
Biological Chemistry (389)7 2008
Abstract
We present a new expression vector system, pSESAME, that facilitates the generation of transducible proteins. Using pSESAME, both Oct4 and Sox2 were genetically fused with a TAT protein transduction domain that promotes cellular penetration. The recombinant purified Oct4 and Sox2 fusion proteins dis...
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PMID: 18681826
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)12 2008
Abstract
We are interested in sequence-nonspecific architectural DNA-binding proteins that alter the apparent flexibility of DNA by producing transient bends or kinks in DNA. The bacterial heat unstable (HU) and eukaryotic high-mobility group B (HMGB) proteins fall into this category. We have exploited a sen...
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PMID: 18515834
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)12 2008
Abstract
We present here a systematic study of predictive modeling approaches to the TF-DNA binding problem, which have been frequently shown to be more efficient than those methods only based on position-specific weight matrices (PWMs). In these approaches, a statistical relationship between genomic sequenc...
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PMID: 18556756
PDF is available here.
PDF is available here.
Abstract
We demonstrated the induction of NSC-like cells (NSCLCs) from mouse astrocytes by Bmi1 under NSC culture conditions. These NSCLCs exhibited the morphology and growth properties of NSCs, and expressed NSC marker genes, including nestin, CD133, and Sox2. In vitro differentiation of NSCLCs resulted in...
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PMID: 18439910
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)26 2008
Abstract
We report here that SOX2 promotes cell proliferation and tumorigenesis by facilitating the G(1)/S transition and through its transcription regulation of the CCND1 gene in breast cancer cells. In addition, we identified beta-catenin as the transcription partner for SOX2 and demonstrated that SOX2 and...
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PMID: 18456656
PDF is available here.
PDF is available here.
Developmental Biology (318)2 2008
Abstract
We functionally characterized five notochord enhancers, whose sequence is highly conserved, and systematically mutated two of them. Two subregions were identified to be essential for expression in the notochord of the zebrafish embryo. Synthetic enhancers containing the two essential regions in fron...
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PMID: 18455719
PDF is available here.
PDF is available here.
Abstract
We have examined DNA methylation and histone H3 acetylation at both enhancers in NT2-D1 progenitors, neurons and astrocytes, to establish the role of epigenetic mechanisms in cell-type-specific SOX2 expression. This study showed that 1) unmethylated DNA and acetylated histones at both enhancers corr...
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PMID: 18293417
PDF is available here.
PDF is available here.
Development Growth & Differentiation (50 Suppl 1) 2008
Abstract
My group has long studied transcriptional gene regulation involved in cell differentiation, employing lens cell differentiation as a model. In this article, our progress over the last quarter of a century in deciphering the principles involved in developmental gene regulation is described, outlining...
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PMID: 18430167
PDF is available here.
PDF is available here.
Development Growth & Differentiation (50 Suppl 1) 2008
Abstract
We have engaged in a number of studies in our laboratory that have focused on the molecular mechanisms underlying gut formation, with particular attention being paid to the establishment of regional differences found in the entire gut and within each digestive organ. We have found from our analyses...
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PMID: 18430165
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)11 2008
Abstract
We show that the CTE of PR contains a specific binding site for HMGB that is required for stimulation of PR-PRE binding, whereas the DNA architectural properties of HMGB are dispensable. Specific PRE DNA inhibited HMGB binding to the CTE, indicating that DNA and HMGB-CTE interactions are mutually ex...
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PMID: 18474528
PDF is available here.
PDF is available here.
Cell and Tissue Research (332)3 2008
Abstract
Sox2, which encodes an HMG box transcription factor, is known to regulate the differentiation of progenitor cells of the tongue into taste bud cells versus keratinocytes during development. To determine the neural dependence of Sox2 expression, glossopharyngeal nerves of mice were cut bilaterally. I...
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PMID: 18379823
PDF is available here.
PDF is available here.
Journal of Cell Biology (181)4 2008
Abstract
Schwann cells are remarkably plastic cells that can both form and stably maintain myelin sheaths around axons and also rapidly dedifferentiate upon injury. New findings (Parkinson, D.B., A. Bhaskaran, P. Arthur-Farraj, L.A. Noon, A. Woodhoo, A.C. Lloyd, M.L. Feltri, L. Wrabetz, A. Behrens, R. Mirsky...
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PMID: 18490509
PDF is available here.
PDF is available here.
Journal of Cell Biology (181)4 2008
Abstract
We report that c-Jun is an important regulator of this plasticity. At physiological levels, c-Jun inhibits myelin gene activation by Krox-20 or cyclic adenosine monophosphate. c-Jun also drives myelinating cells back to the immature state in transected nerves in vivo. Enforced c-Jun expression inhib...
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PMID: 18490512
PDF is available here.
PDF is available here.
Journal of Pathology (215)1 2008
Abstract
We demonstrate that SOX2 is absent in germ cells of human fetal gonads, and as expected carcinoma in situ (CIS), ie the precursor lesion of testicular germ cell tumours of adolescents and adults (TGCTs), and seminoma. Based on genome-wide expression profiling, SOX17 was found to be present, instead...
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PMID: 18348160
PDF is available here.
PDF is available here.
Biology of Reproduction (78)5 2008
Abstract
We show by RT-PCR, immunoblotting, and immunohistochemistry that human PGCs express POU5F1 and NANOG but not SOX2, with no evidence of redundancy within the group B family of human SOX genes. Although lacking SOX2, proliferative human germ cells can still be identified in situ during early developme...
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PMID: 18199879
PDF is available here.
PDF is available here.
Archives of Ophthalmology (126)5 2008
Abstract
Mutation in SOX2 is associated with typical ocular coloboma and probably other anomalies in this Chinese family. Arachnoid cyst has not been reported in individuals with the SOX2 mutation. CLINICAL RELEVANCE: The results remind us that ocular coloboma may be accompanied by arachnoid cyst and may be...
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PMID: 18474784
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)5 2008
Abstract
We have previously shown that mice lacking the TSH receptor (TSHR) exhibit osteoporosis due to enhanced osteoclast formation. The fact that this enhancement is not observed in double-null mice of TSHR and TNFalpha suggests that TNFalpha overexpression in osteoclast progenitors (macrophages) may be i...
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PMID: 18218727
PDF is available here.
PDF is available here.
Cell Research (18)5 2008
Abstract
Developmental Biology (317)1 2008
Abstract
We developed transgenic mice that express a doxycycline inducible Sox2 in the airway epithelium. Continuous expression of Sox2 hampers the branching process resulting in a severe reduction of the number of airways. In addition, the bronchioli transiently go over into enlarged, alveolar-like airspace...
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PMID: 18374910
PDF is available here.
PDF is available here.
Nature Methods (5)5 2008
Abstract
We transiently transferred multiple independent hESC lines with different growth requirements to standardized feeder-free culture, and optimized conditions for clonal growth and efficient gene transfer without loss of pluripotency. Stably transfected lines retained differentiation potential, and mos...
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PMID: 18391958
PDF is available here.
PDF is available here.
Abstract
Patients with SOX2 mutations often manifest the unusual phenotype of hypogonadotropic hypogonadism, with sparing of other pituitary hormones despite anterior pituitary hypoplasia. SOX2 expression patterns in human embryonic development support a direct involvement of the protein during development o...
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PMID: 18285410
PDF is available here.
PDF is available here.
Abstract
We analyzed the upstream signaling of Xenopus Rax (also known as Rx1) and identified the Otx2 and Sox2 proteins as direct upstream regulators of Rax. We revealed that endogenous Otx2 and Sox2 proteins bound to the conserved noncoding sequence (CNS1) located approximately 2 kb upstream of the Rax pro...
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PMID: 18385377
PDF is available here.
PDF is available here.
Abstract
We initially engineered mouse ES cells for inducible overexpression of Sox2. Using this model system, we demonstrate that small increases (twofold or less) in Sox2 protein trigger the differentiation of ES cells into cells that exhibit markers for a wide range of differentiated cell types, including...
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PMID: 18238855
PDF is available here.
PDF is available here.
Abstract
The mRNA and protein expression of HMGB1 was significantly higher in CSCC than that in normal cervical tissue (P < 0.05), correlated with stage, invasion and metastasis (P < 0.05), but not with tumor size and differentiation (P > 0.05). The levels of RAGE mRNA and HMGB1 mRNA were both significantly...
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PMID: 18788635
PDF is available here.
PDF is available here.
Abstract
We have analyzed NEDD9 mRNA expression in the mouse and identified new relevant expression sites. In addition, we have characterized NEDD9 protein expression pattern for the first time in mammals. At E9.5-E10.5, high levels of Nedd9 and the neurogenic transcription factor neurogenin-2 (Ngn2) were fo...
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PMID: 18282814
PDF is available here.
PDF is available here.
Experimental Cell Research (314)5 2008
Abstract
We introduced the Sox2 or Nanog gene into the cells. Sox2 and Nanog are not only essential for pluripotency and self-renewal of embryonic stem cells, but also expressed in somatic stem cells that have superior expansion and differentiation potentials. We found that Sox2-expressing MSCs showed consis...
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PMID: 18187129
PDF is available here.
PDF is available here.
Abstract
We investigated the possible role of SOX2 in MUC5AC transcription and in the development of mucinous cancers. We observed good correlation between SOX2 and MUC5AC message levels in most colon cancer cell lines. SOX2 expression significantly transactivated MUC5AC promoter/reporter constructs in 3 of...
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PMID: 18027866
PDF is available here.
PDF is available here.
Genes & Development (22)6 2008
Abstract
We report here that a terminal component of the canonical Wnt pathway in ES cells, the transcription factor T-cell factor-3 (Tcf3), co-occupies promoters throughout the genome in association with the pluripotency regulators Oct4 and Nanog. Thus, Tcf3 is an integral component of the core regulatory c...
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PMID: 18347094
PDF is available here.
PDF is available here.
Neuroreport (19)4 2008
Abstract
We found a dramatic decrease in the number of Sox2+ neural progenitor cells in the subventricular zone of E18.5 Pax6(-/-) mice. We confirmed that Pax6 could bind to the Sox2 promoter by chromatin immunoprecipitation assay and activate Sox2 expression by a luciferase reporter gene assay. Moreover, ne...
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PMID: 18287938
PDF is available here.
PDF is available here.
Abstract
We previously reported that the SOX2 protein is expressed in normal gastric mucosae but downregulated in some human gastric carcinomas. To clarify the roles of SOX2 in gastric carcinogenesis, we carried out functional characterisation of SOX2 in gastric epithelial cell lines. Exogenous expression of...
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PMID: 18268498
PDF is available here.
PDF is available here.
Abstract
Development (135)3 2008
Abstract
We performed in vitro differentiation studies on neural stem cells cultured from embryonic and adult brains of 'knockdown' mutants. Sox2 expression is high in undifferentiated cells, and declines with differentiation, but remains visible in at least some of the mature neurons. In mutant cells, neuro...
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PMID: 18171687
PDF is available here.
PDF is available here.