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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Hepatocyte Nuclear Factors (6):
Recent article
Hepatocyte Nuclear Factors
Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide variety of physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer partners. The Class II NRs are involved in a broad...
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PMID: 21554208
PDF is available here.
PDF is available here.
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Abstract
We used hepatocytes from an aneuploid mouse strain carrying human chromosome 21 to determine, on a chromosomal scale, whether interspecies differences in transcriptional regulation are primarily directed by human genetic sequence or mouse nuclear environment. Virtually all transcription factor-bindi...
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PMID: 18787134
PDF is available here.
PDF is available here.
Differentiation (76)5 2008
Abstract
We show that expression of R522K-Shb results in up-regulation of FGFR1 and FGF2 in EBs. Addition of activin A to the cultures enhances the expression of endodermal genes primarily in EBs expressing mutant Shb. Inhibition of FGF signaling by the addition of the FGFR1 inhibitor SU5402 completely count...
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PMID: 18093225
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)5 2008
Abstract
We suppose that tissue-specific factors that underlie the key steps in differentiation programs of certain tissues and are able to receive or modulate signals from the cell environment might be considered as promising candidates for the role of tumor suppressors in the tissue types where they normal...
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PMID: 18605982
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)1 2008
Abstract
We have used data from the literature concerning gene expression in mouse liver (high content of FOXA proteins) and kidney (FOXA expression is absent) obtained by hybridization on microchips. A search for FOXA binding sites in regulatory regions of forty differentially expressing genes involved in p...
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PMID: 18294132
PDF is available here.
PDF is available here.
Toxicology In Vitro (21)7 2007
Abstract
We studied the effects of a proliferative response triggered by EGF on the albumin secretion and urea production, and on cytochrome P450 (CYP) 1A1 and CYP2B1 expression and their corresponding 7-ethoxyresorufin-O-deethylase (EROD) and 7-pentoxyresorufin-O-dealkylase (PROD) activities. It was found t...
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PMID: 17560764
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)31 2007
Abstract
We studied and deciphered the molecular mechanisms responsible for MUC4 transcriptional regulation by these TFs. Experiments using small interfering RNA, cell co-transfection, and site-directed mutagenesis indicated that MUC4 is regulated at the transcriptional level by CDX-1 and -2, HNF-1 alpha and...
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PMID: 17553805
PDF is available here.
PDF is available here.
Abstract
Alpha-fetoprotein (AFP)-producing gastric cancer (AFP-GC) is a highly malignant variant of adenocarcinoma with aberrant hepatocellular phenotype. A detailed understanding of the regulation of its liver phenotype is lacking. Liver-enriched nuclear factors (LENFs) are implicated in the transcriptional...
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PMID: 16904665
PDF is available here.
PDF is available here.
Diabetes Care (30)6 2007
Abstract
Abstract
We found that a previously undescribed helioxanthin analogue, 8-1, exhibited potent anti-hepatitis B virus (HBV) activity with little cytotoxicity. 8-1 suppressed both HBV RNA and protein expression, as well as DNA replication of both wild-type and 3TC-resistant virus. Time-course analyses revealed...
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PMID: 17488817
PDF is available here.
PDF is available here.
Abstract
We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes....
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PMID: 17425917
PDF is available here.
PDF is available here.
Abstract
We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes....
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PMID: 17425917
PDF is available here.
PDF is available here.
Abstract
I biotransformation capacity, whereas the activity of phase II glutathione S-transferases (GST) was not affected. Western blot and qRT-PCR analysis of CYP1A1, CYP2B1 and CYP3A11 protein and mRNA levels, respectively, further revealed that TSA acts at the transcriptional level. In addition, protein e...
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PMID: 17125810
PDF is available here.
PDF is available here.
Developmental Biology (294)2 2006
Abstract
We report here the identification of 129 genuine liver-enriched genes in adult zebrafish and show that, through in situ hybridization, 69 of these genes are also enriched in the embryonic liver. External embryogenesis coupled with the well-established morpholino-mediated gene knock-down technique in...
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PMID: 16631158
PDF is available here.
PDF is available here.
Abstract
We wonder whether differences in the distribution of anion transporters (ntcp [M77479], besp [NM_031760], mrp2 [NM_012833], oatp1 [NM_017111], oatp2 [NM_131906]) cause the differences in bile acid excretion. Therefore, we analyzed the distribution of these anion transporters in periportal and perice...
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PMID: 16614971
PDF is available here.
PDF is available here.
Journal of Hepatology (44)2 2006
Abstract
Early hepatic differentiation genes were induced in bone marrow in response to hepatectomy, especially when regeneration of the remnant liver was suppressed. Circulating signals generated in the AAF/PHx liver might activate this differentiation....
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PMID: 16226826
PDF is available here.
PDF is available here.
Frontiers in Bioscience (11)1 2006
Abstract
Stem cells responsible for maintenance and repair of tissues are found in a number of organs. The liver's remarkable capacity to regenerate after hepatectomy or chemical-induced injury does not involve proliferation of stem cells. However, recent studies suggest that liver stem cells exist in both e...
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PMID: 16368517
PDF is available here.
PDF is available here.
Clinical laboratory (52)11-12 2006
Abstract
Maturity-onset diabetes of the young (MODY) is a dominantly inherited form of non-ketotic diabetes. It usually develops in childhood, adolescence or young adulthood. The disease is heterogenous regarding the genetic and clinical features. Until now, 6 causal genes have been identified. According to...
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PMID: 17175890
PDF is available here.
PDF is available here.
Abstract
We have used E-cadherin-positive and -negative expressing cells to find out the possible up- or down regulating transcription factors in human E-cadherin regulatory sequences. Functional analysis of human E-cadherin regulatory sequences constructs indicated that AML1, Sp1, and p300 may play importan...
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PMID: 16116478
PDF is available here.
PDF is available here.
Hereditas (Beijing) (27)1 2005
Abstract
The union of the two complementary disciplines, developmental biology and evolutionary biology resulted in a new division of evolutionary developmental biology, namely "Evo-Devo". Recently, the research on this field has been fruitful in understanding the origin and development of vertebrates. The c...
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PMID: 15730974
PDF is available here.
PDF is available here.
Developmental Biology (183)1 1997
Abstract
Firstly, that the role of the dorsal lip/Hensen's node, notochord, and floor plate as organisers of the vertebrate body plan evolved prior to the separation of the vertebrate and cephalochordate lineages, at least 520 million years ago. Secondly, that the role of HNF-3 genes in these structures pred...
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PMID: 9119116
PDF is available here.
PDF is available here.