Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Matrix Attachment Region Binding Proteins (0):
Recent article
Matrix Attachment Region Binding Proteins
Abstract
We transduced SATB2 into murine adult stem cells, and found that SATB2 significantly increased expression levels of bone matrix proteins, osteogenic transcription factors, and a potent angiogenic factor, vascular endothelial growth factor. Using an osterix (Osx) promoter-luciferase construct and cal...
|
PMID: 21385070
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Oligonucleotides (21)2 2011
Abstract
We focused on the function of special AT-rich sequence binding protein 1 (SATB1) as a target molecule for the treatment of TN breast cancers. By recruiting chromatin remodeling enzymes and transcriptional factors, SATB1 regulates the expression of >1,000 genes related to cell growth and translocatio...
|
PMID: 21500976
PDF is available here.
PDF is available here.
Abstract
Genomic DNA encompasses several levels of organization, the nuclear matrix mediates the formation of DNA loop domains that are anchored to matrix attachment regions (MARs). By means of specific interaction with MAR binding proteins (MARBPs), MAR plays an important regulation role in enhancing transg...
|
PMID: 20174991
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (336)1-2 2010
Abstract
The orchestration of the events in the cell during the progression of the cell cycle is modulated by various phenomenon which are regulated by structural modules of the cell. The nucleus is a major hub for all these regulatory units which harbour the nuclear matrix, matrix proteins and chromatin. Th...
|
PMID: 19802523
PDF is available here.
PDF is available here.
Abstract
We show that special AT-rich binding protein 1 (SATB1), the T lineage-enriched chromatin organizer and global regulator, interacts with beta-catenin and recruits it to SATB1's genomic binding sites. Gene expression profiling revealed that the genes repressed by SATB1 are upregulated upon Wnt signall...
|
PMID: 20126258
PDF is available here.
PDF is available here.
Abstract
We applied SVD to time-series gene expression datasets from the rat experimental models of stroke and seizures. We demonstrate conservation of two eigensystems, reflecting inflammation and/or apoptosis (eigensystem 2) and neuronal synaptic activity (eigensystem 3), between the stroke and seizures. W...
|
PMID: 20565733
PDF is available here.
PDF is available here.
Experimental Cell Research (315)2 2009
Abstract
We applied a proteomic approach along with a Southwestern assay to detect both differentially expressed and MAR-binding NM proteins, in persistent hepatocyte nodules (PHN) in respect with normal hepatocytes (NH). In PHN, the NM undergoes changes both in morphology and in protein composition. We dete...
|
PMID: 19000672
PDF is available here.
PDF is available here.
Journal of Immunology (182)2 2009
Abstract
We investigated the role in Th2 differentiation of the transcription regulator CCCTC-binding factor (CTCF). Chromatin immunoprecipitation analysis revealed multiple CTCF binding sites in the Th2 cytokine locus. Conditional deletion of the Ctcf gene in double-positive thymocytes allowed development o...
|
PMID: 19124743
PDF is available here.
PDF is available here.
Infection and Immunity (76)12 2008
Abstract
We recently found that mgrA mutants of strains RN6390, SH1000, and MW2 also displayed enhanced biofilm formation compared with their respective parents. The biofilms formed by mgrA mutants of RN6390 and MW2 are independent of sigB and ica loci, two genetic elements that have been previously associat...
|
PMID: 18852246
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)44 2008
Abstract
We previously reported that basal human XOR (hXOR) expression is restricted or repressed by E-box and TATA-like elements and a cluster of transcriptional proteins, including AREB6-like proteins and DNA-dependent protein kinase (DNA-PK). We now demonstrate that the cluster contains the tumor suppress...
|
PMID: 18772145
PDF is available here.
PDF is available here.
Neurosurgery (63)2 2008
Abstract
Abstract
Journal of Biological Chemistry (283)26 2008
Abstract
We performed a yeast two-hybrid screen that identified SUMO-1, Ubc9, and protein inhibitor of activated STAT (PIAS) family members as SATB1 interaction partners. These proteins, working in concert, enhanced SUMO conjugation to lysine-744 of SATB1. Overexpression of SUMO or PIAS in Jurkat cells, whic...
|
PMID: 18408014
PDF is available here.
PDF is available here.
Nature Biotechnology (26)6 2008
Abstract
Nucleic Acids Research (36)7 2008
Abstract
We have determined its optimal DNA-binding sequence by random oligonucleotide selection. The consensus SATB1-binding sequence (CSBS) comprises a palindromic sequence in which two identical AT-rich half-sites are arranged as inverted repeats flanking a central cytosine or guanine. Strikingly, the CSB...
|
PMID: 18187506
PDF is available here.
PDF is available here.
Abstract
We show that SATB1 is expressed by aggressive breast cancer cells and its expression level has high prognostic significance (P < 0.0001), independent of lymph-node status. RNA-interference-mediated knockdown of SATB1 in highly aggressive (MDA-MB-231) cancer cells altered the expression of >1,000 gen...
|
PMID: 18337816
PDF is available here.
PDF is available here.
Abstract
We analyzed mice in which the Satb2 locus was disrupted by insertion of a LacZ gene. In mutant mice, beta-galactosidase-labeled axons are absent from the corpus callosum and instead descend along the corticospinal tract. Satb2 mutant neurons acquire expression of Ctip2, a transcription factor that i...
|
PMID: 18255030
PDF is available here.
PDF is available here.
Abstract
We report that the expression of the AT-rich DNA-binding protein Satb2 defines two subclasses of UL neurons: UL1 (Satb2 positive) and UL2 (Satb2 negative). In the absence of Satb2, UL1 neurons lose their identity and activate DL- and UL2-specific genetic programs. UL1 neurons in Satb2 mutants fail t...
|
PMID: 18255031
PDF is available here.
PDF is available here.
BMC Medical Genetics (9)1 2008
Abstract
Mutation analysis in families showing linkage to the SAFB1/2 locus was performed by DNA sequencing. The complete coding sequence of the two genes SAFB1 and SAFB2 was analyzed in germline DNA from 31 affected women. No missense or frameshift mutations were detected. One polymorphism was found in SAFB...
|
PMID: 19077293
PDF is available here.
PDF is available here.
Protoplasma (233)1-2 2008
Abstract
We report here a novel MFP1-related nuclear protein of 80 kDa in A. cepa roots, with M(r) and pI values similar to those of MFP1 proteins in dicot species, and which also displays a dual location, in the nucleus and chloroplasts of leaf cells. However, this novel protein is not a nuclear matrix comp...
|
PMID: 18709475
PDF is available here.
PDF is available here.
Journal of Neuroscience (27)50 2007
Abstract
We now identify approximately 200 genes highly enriched in neonatal (postnatal day 0) mouse VMH tissue. Analyses of these VMH markers by real or virtual (Allen Brain Atlas; http://www.brain-map.org) experiments revealed distinct regional patterning within the newly formed VMH. Top neonatal markers i...
|
PMID: 18077674
PDF is available here.
PDF is available here.
Biotechnology Letters (29)12 2007
Abstract
We constructed two CMV MIE promoter-based expression plasmids for comparison to the conventional CMV MIE promoter by removing or adding UR. Addition of UR enhances transgene expression in HEK293 stable cells while removal of UR increases both transient and stably integrated expression in HeLa cells....
|
PMID: 17657408
PDF is available here.
PDF is available here.
Experimental Cell Research (313)18 2007
Abstract
We have found novel functions of scaffold attachment factor-B1 (SAFB) during apoptosis. The experiments showed that SAFB moved into the nucleolus 15 min after the induction of apoptosis and before the release of cytochrome c into the cytoplasm. Two hours later SAFB formed a peri-nucleolar ring-like...
|
PMID: 17643427
PDF is available here.
PDF is available here.
Biochemical Journal (407)3 2007
Abstract
We show that SLTM is localized to the cell nucleus, but excluded from nucleoli, and to a large extent it co-localizes with SAFB1. In the nucleus, SLTM has a punctate distribution and it does not co-localize with SR (serine/arginine) proteins. Overexpression of SAFB1 has been shown to exert a number...
|
PMID: 17630952
PDF is available here.
PDF is available here.
Abstract
Compartmentalized distribution of functional components is a hallmark of the eukaryotic nucleus. Technological advances in recent years have provided unprecedented insights into the role of chromatin organization and interactions of various structural-functional components toward gene regulation. SA...
|
PMID: 17913490
PDF is available here.
PDF is available here.
Abstract
We reported previously that pancreatic-duodenal homeobox factor-1 (PDX1) bound to a 45-bp element located within the UR [Chao, S.H., Harada, J.N., Hyndman, F., Gao, X., Nelson, C.G., Chanda, S.K., Caldwell, J.S., 2004. PDX1, a Cellular Homeoprotein, Binds to and Regulates the Activity of Human Cytom...
|
PMID: 17512569
PDF is available here.
PDF is available here.
Human Mutation (28)7 2007
Abstract
Studies of human chromosomal aberrations and knockout (KO) mice have suggested SATB2 as a candidate gene for a human malformation syndrome of craniofacial patterning and brain development. Of 59 unrelated patients with craniofacial dysmorphism, with or without mental retardation, one 36-year-old man...
|
PMID: 17377962
PDF is available here.
PDF is available here.
Journal of Virology (81)11 2007
Abstract
We show here the occurrence of Alu-like motifs in the sequences flanking the reported viral integration sites that are significantly different from those obtained from the randomly picked sequences from the human genome, suggesting that unique primary sequence features exist in the genomic regions t...
|
PMID: 17376900
PDF is available here.
PDF is available here.
Abstract
We compared gene expression in the lungs of Myf5-/-:MyoD-/- embryos to that in normal lungs at term. Nine genes were found to be up-regulated and 54 down-regulated at least 2-fold in the lungs of double-mutant embryos. Since many down-regulated genes are involved in lymphocyte function, immunohistoc...
|
PMID: 17330803
PDF is available here.
PDF is available here.
Abstract
Our results show for the first time that forced-expression of SATB1 in K562 cells triggers SPARC up-regulation by binding to a 17bp DNA sequence in the third intron....
|
PMID: 17343824
PDF is available here.
PDF is available here.
Abstract
We employed targeted homologous recombination to establish a mbr(+)/mbr(-) heterozygous Nalm-6 cell line and then compared the transcriptional activity and apoptotic effect on transcription between the wild type and targeted alleles. We found that deletion of the mbr significantly decreased the tran...
|
PMID: 17057736
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 2 2007
Abstract
We found endogenous SAFB2 protein has a different spatial distribution from SAFB1 within the nucleus where it is found in much larger nuclear complexes (up to 670 kDa in size), and a distinct pattern of expression in adult human testis. By contrast, SAFB1 protein predominantly exists either as small...
|
PMID: 17200140
PDF is available here.
PDF is available here.
BMC Genomics (8)1 2007
Abstract
Using custom software, we have mapped the occurrence of MRS across the entire C. elegans genome. We find that MRS have a distinctive chromosomal distribution, in which they appear more frequently in the gene-rich chromosome centres than in arms. Comparison to distributions of MRS estimated from chro...
|
PMID: 18005410
PDF is available here.
PDF is available here.
Abstract
We discuss the role of MARs and MARBPs in eukaryotic gene regulation, recombination, transcription and viral integration by altering the local chromatin structure and their dysregulation in disease manifestation...
|
PMID: 17484130
PDF is available here.
PDF is available here.
Nucleic Acids Research (35)15 2007
Abstract
We have revealed a five-helix structure of the N-terminal CUT domain, which is essentially the folded region in the MAR-binding domain, of human SATB1 by NMR. Here we determined crystal structure of the complex of the CUT domain and a MAR DNA, in which the third helix of the CUT domain deeply enters...
|
PMID: 17652321
PDF is available here.
PDF is available here.
Nature Genetics (38)11 2006
Abstract
We studied the role of SATB1 in regulating the coordinated expression of Il5, Il4 and Il13, located in the 200-kb T-helper 2 (T(H)2) cytokine locus on mouse chromosome 11. We show that on T(H)2 cell activation, SATB1 expression is rapidly induced to form a unique transcriptionally active chromatin s...
|
PMID: 17057718
PDF is available here.
PDF is available here.
Nature Genetics (38)11 2006
Abstract
Developmental Biology (298)1 2006
Abstract
We show that a portion of cortical projection neurons migrates tangentially over long distances. Lineage analysis revealed that these neurons are derived from Emx1+ cortical progenitors and express the transcription factor Satb2 but do not express GABA or Olig1. In vitro and in vivo analysis of reel...
|
PMID: 16901480
PDF is available here.
PDF is available here.
Abstract
We find that, similar to the way in which SATB2 is perceived to act in humans, craniofacial defects due to haploinsufficiency of Satb2, including cleft palate (in approximately 25% of cases), phenocopy those seen with 2q32-q33 deletions and translocations in humans. Full functional loss of Satb2 res...
|
PMID: 16960803
PDF is available here.
PDF is available here.
Abstract
We investigated the role of the bcl-2 mbr on reporter gene activity and the relevance of SATB1 to this function in a variety of cell lines. We found that the mbr up-regulated reporter gene expression. Deletion of the 37-bp AT-rich SATB1 binding site abolished the bcl-2 mbr regulation of reporter gen...
|
PMID: 16777355
PDF is available here.
PDF is available here.
Abstract
We show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage. Satb2-/- mice exhibit both craniofacial abnormalities that resemble those observed in humans carrying a translocation in SATB2 and defects in osteoblast differentiation and...
|
PMID: 16751105
PDF is available here.
PDF is available here.
Abstract
In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation. This work suggests a molecular mechanism that enables the integration of patt...
|
PMID: 16751095
PDF is available here.
PDF is available here.
Abstract
We have expanded the analysis of the subcellular location of MFP1 by using high-resolution confocal immunofluorescence microscopy and immunogold electron microscopy. Two different antisera raised against MFP1 from two species were used on isolated nuclei and chloroplasts from tomato, tobacco, and Ar...
|
PMID: 16331467
PDF is available here.
PDF is available here.
Molecular Cell (22)2 2006
Abstract
We show here that phosphorylation by PKC acts as a switch to determine whether SATB1 interacts with HDAC1 or PCAF. Phosphorylation and dephosphorylation of SATB1 exerted opposing effects on MAR-linked reporter activity in vivo. SATB1 interacted with both CBP/p300 and PCAF HATs; however, these intera...
|
PMID: 16630892
PDF is available here.
PDF is available here.
Abstract
We investigated the relationship of the behavior of SATB1 and the collapse of nuclear architecture in Jurkat cells with immunostaining and Western blot analysis. We demonstrated that SATB1 formed special three-dimensional network distributions during early apoptosis. The distribution change of SATB1...
|
PMID: 16377216
PDF is available here.
PDF is available here.
Abstract
We determined the solution structure of the matrix attachment region-binding domain, possessing similarity to the CUT DNA-binding domain, of human SATB1 by NMR spectroscopy. The structure consists of five alpha-helices, in which the N-terminal four are arranged similarly to the four-helix structure...
|
PMID: 16371359
PDF is available here.
PDF is available here.
Molecular Endocrinology (20)2 2006
Abstract
We asked the question whether SAFB1/2 and N-CoR could directly interact with each other, and whether this interaction results in altered repressive activities. Employing coimmunoprecipitation, cofractionation, and colocalization experiments, we have shown that SAFB1/2 interact with the nuclear recep...
|
PMID: 16195251
PDF is available here.
PDF is available here.
Abstract
Cellular differentiation, organization, proliferation and apoptosis are determined by a combination of an intrinsic genetic program, matrix/substrate interactions, and extracellular cues received from the local microenvironment. These molecular cues come in the form of soluble (e.g. cytokines) and in...
|
PMID: 16880921
PDF is available here.
PDF is available here.
Abstract
These results provide the first evidence for AcMFP1 in vivo phosphorylation, and open up further research on its nuclear functions....
|
PMID: 16291799
PDF is available here.
PDF is available here.
Abstract
We show that the LeMAF1-containing speckles are components of the Golgi apparatus. A novel tomato coiled-coil protein was identified that specifically binds to LeMAF1. Tomato WPP domain-associated protein (LeWAP) interacts in yeast and in vitro through its coiled-coil domain with several WPP-domain...
|
PMID: 16231153
PDF is available here.
PDF is available here.
Abstract
We isolated the scaffold attachment factor B1 (SAFB1/HET/HAP), which was previously shown to be a corepressor of estrogen receptor alpha. We show here that SAFB1 has a very broad tissue expression profile in human and is also expressed all along mouse embryogenesis. SAFB1 interacts in pull-down assa...
|
PMID: 16326836
PDF is available here.
PDF is available here.
Abstract
The differentiation of naïve T helper (Th) cells is induced by TCR activation and IL-12/STAT4 or IL-4/STAT6 signaling pathways, forming Th1 and Th2 cells, respectively. In this study, oligonucleotide arrays were used to identify genes regulated during the initiation of human Th1 and Th2 cell differ...
|
PMID: 16220538
PDF is available here.
PDF is available here.
Genes and Immunity (6)7 2005
Abstract
Gene expression changes in CD4 + Vbeta8+ T cells energized by in vivo exposure to staphylococcal enterotoxin B (SEB) bacterial superantigen compared to CD4 + Vbeta8+ non-energic T cells were assessed using DNA microarrays containing 5184 murine complementary DNAs. Anergy in splenic T cells of SEB-imm...
|
PMID: 16034473
PDF is available here.
PDF is available here.
Cell Cycle (4)8 2005
Abstract
We employed sequence analysis to identify phylogenetically diverse members of the SATB1 protein family, and used hidden Markov model (HMM)-based analysis to define conserved regions and motifs in this family. One of the regions conserved in SATB1- and SATB2-like proteins in mammals, fish, frog and b...
|
PMID: 15970696
PDF is available here.
PDF is available here.
Journal of Cell Science (118)Pt 15 2005
Abstract
We show that the dynein light chain rp3 is present in both the cytoplasm and the nucleus. Nuclear rp3 binds to and assembles with the transcription factor SATB1 at nuclear matrix-associated structures. Dynein intermediate chain was also detected in the nucleus, but it was dispensable for the rp3-SAT...
|
PMID: 16079286
PDF is available here.
PDF is available here.
Abstract
We have evaluated their use in various stable transfection settings to increase the production of recombinant proteins such as monoclonal antibodies from Chinese hamster ovary (CHO) cell lines. Using the green fluorescent protein coding sequence, we show that S/MAR elements mediate a dual effect on...
|
PMID: 15889435
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)26 2005
Abstract
Our studies indicate that both nuclear matrix association and DNA binding are required for optimal SATB1-mediated repression of the integrated MMTV promoter and may allow insulation from cellular regulatory elements....
|
PMID: 15851481
PDF is available here.
PDF is available here.
Journal of Immunology (174)8 2005
Abstract
Studies have suggested that binding of the SATB1 protein to L2a, a matrix association region located 4.5 kb 5' to the mouse CD8alpha gene, positively affects CD8 expression in T cells. Therefore, experiments were performed to determine the effect on T cell development of reduced expression of SATB1....
|
PMID: 15814699
PDF is available here.
PDF is available here.
Abstract
We show SATB1 family protein induction during early human adult erythroid progenitor cell differentiation concomitant with epsilon-globin expression. Erythroid differentiation of human erythroleukemia K562 cells by hemin simultaneously increases gamma-globin and down-regulates SATB1 family protein a...
|
PMID: 15618465
PDF is available here.
PDF is available here.
Abstract
We show that SATB1, a T-cell-specific global gene regulator, binds to the promoters of human IL-2 and IL-2Ralpha and recruits histone deacetylase 1 (HDAC1) in vivo. SATB1 also interacts with Tat in HIV-1-infected T cells. The functional interaction between HIV-1 Tat and SATB1 requires its PDZ-like d...
|
PMID: 15713622
PDF is available here.
PDF is available here.