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NFI Transcription Factors (0):
Recent article
NFI Transcription Factors
Abstract
The NFI and NFY repressors contribute differentially to organ-specific regulation of the VWF promoter, and the organ-specific action of NFI may reflect its organ-specific isoform distribution. In addition, the lung-specific enhancer region of the endogenous VWF gene may inhibit NFI repressor functio...
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PMID: 20431063
PDF is available here.
PDF is available here.
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Journal of Neuroscience (30)27 2010
Abstract
We demonstrate that, in addition to activating the expression of astrocyte-specific genes, Nfia also downregulates the activity of the Notch signaling pathway via repression of the key Notch effector Hes1. These data provide a significant conceptual advance in our understanding of neural progenitor...
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PMID: 20610746
PDF is available here.
PDF is available here.
Abstract
Abstract
We report another case of a microdeletion with involvement of the NFIA gene in the short arm of chromosome 1 (del(1)(p31.3p32.2)) with, amongst other features, hypoplasia of the corpus callosum, ventriculomegaly, and dysmorphic features. A microdeletion 1p31.3p32.2 which includes the NFIA gene is as...
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PMID: 19763616
PDF is available here.
PDF is available here.
BMC Medical Genetics (11) 2010
Abstract
Our results suggest that rs17373080 in LXRβ is associated with T2DM and obesity, maybe via altered LXRβ expression....
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PMID: 20939869
PDF is available here.
PDF is available here.
Abstract
I (NFI) is a transcription factor playing wide role in signal transduction pathways and developmental processes in higher eukaryotes. In order to produce recombinant NFI proteins for functional and structural studies, full length cDNAs of individual isoforms were subcloned into pETM30 vector and exp...
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PMID: 20097955
PDF is available here.
PDF is available here.
Eukaryotic Cell (8)10 2009
Abstract
We have investigated the regulatory network governing alternative carbon metabolism in this organism through characterization of transcriptional regulators identified based on the model fungi, Saccharomyces cerevisiae and Aspergillus nidulans. C. albicans has homologs of the ScCAT8/AnFacB and ScADR1...
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PMID: 19700635
PDF is available here.
PDF is available here.
Molecular Neurobiology (39)1 2009
Abstract
We discuss the importance and role of NFI in these processes in the context of several CNS systems including the neocortex, hippocampus, cerebellum, and spinal cord at both cellular and molecular levels....
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PMID: 19058033
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1789)2 2009
Abstract
We report evidence for a functional Nuclear Factor I (NFI) cis element that mediates activation or repression of IGFBP5 transcription by the NFI gene family. All four NFI genes were expressed in human osteoblast cultures and osteosarcoma cell lines. Co-transfection with human IGFBP5 promoter lucifer...
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PMID: 18809517
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
We analyzed the NFI-C gene structure, identifying 2 potential alternative promoters driving expression of selective mRNA transcripts. Our studies show the expression of 3 NFI-C transcripts with the overall splicing pattern conserved between dental and nondental cells tested. Furthermore, by quantita...
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PMID: 18765927
PDF is available here.
PDF is available here.
Abstract
We identified a full binding site for nuclear factor I (NFI) transcription factors in the regulatory region of the mouse L1 gene. Electrophoretic mobility shift assay (EMSA) showed binding of nuclear factor I-A (NFI-A) to this site. Moreover, for a brain-specific isoform of NFI-A (NFI-A bs), we conf...
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PMID: 20003413
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)47 2008
Abstract
We find that in Nuclear Factor I b (Nfib)-deficient mice, a subpopulation of glia from the ammonic neuroepithelium of the hippocampus fail to develop. This results in severe morphological defects, including a failure of the hippocampal fissure, and subsequently the dentate gyrus, to form. As in wild...
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PMID: 19020026
PDF is available here.
PDF is available here.
Abstract
Journal of Lipid Research (49)10 2008
Abstract
Change in phosphoethanolamine pool size in tumor tissues is an important indicator of tumor prognosis and drug therapy efficacy. Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de novo biosynthesis of phosphatidylethanolamine (P...
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PMID: 18583706
PDF is available here.
PDF is available here.
Abstract
Repression of alpha6 expression therefore contributes to the final steps of corneal wound healing by both reducing proliferation and allowing attachment of the epithelium to the basal membrane....
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PMID: 18421093
PDF is available here.
PDF is available here.
Developmental Dynamics (237)8 2008
Abstract
We showed previously that loss of nfi-1 in worms results in multiple behavioral defects; slower pharyngeal pumping rate, impaired egg laying, defective motility, and a shortened life span. Here, we generated cell-type specific transgenic worms to determine the cells in which nfi-1 must be expressed...
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PMID: 18651662
PDF is available here.
PDF is available here.
Journal of General Virology (89)Pt 6 2008
Abstract
We show that downregulation of NF-1A expression in JCV-non-susceptible progenitor and HeLa cells results in a reversion to susceptibility for JCV multiplication. These data demonstrate that a higher level of NF-1A protein in JCV-non-permissive cell types, compared with the level of NF-1X, may be act...
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PMID: 18474555
PDF is available here.
PDF is available here.
Abstract
We detail the protein expression of NFIA and NFIB during embryonic and postnatal mouse forebrain development. We find that both NFIA and NFIB are expressed in the deep cortical layers and subplate prenatally and display dynamic expression patterns postnatally. Both genes are also highly expressed in...
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PMID: 18335562
PDF is available here.
PDF is available here.
Journal of Molecular Biology (378)3 2008
Abstract
We analyzed the structure of the miR-21 gene by determining its promoter and primary transcripts. We show that activation protein 1 (AP-1) activates the miR-21 transcription in conjugation with the SWI/SNF complex, after PMA stimulation, through the conserved AP-1 and PU.1 binding sites in the promo...
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PMID: 18384814
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)13 2008
Abstract
We detected a protein, distinct from MTF-1, specifically binding to the MREc region. DNA binding competition experiments using synthetic oligonucleotides and specific anti-NF1 antibodies showed that this protein binds to an NF1 site overlapping the MREc element as well as to a second site upstream o...
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PMID: 18230604
PDF is available here.
PDF is available here.
Abstract
Site-specific transcription factors of the nuclear factor 1 (NF1) family are ubiquitous, are encoded by four genes in mammals, and play a role in regulating transcription of approximately 100 cell and viral genes. The NF1 proteins are characterized by the ability to act as both transcription factors...
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PMID: 18702298
PDF is available here.
PDF is available here.
Abstract
Here we show that disruption of Nfix by Cre-recombinase mediated excision of the 2nd exon results in defects in brain development that differ from those seen in Nfia and Nfib KO mice. In particular, complete callosal agenesis is not seen in Nfix-/- mice but rather there appears to be an overabundanc...
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PMID: 18477394
PDF is available here.
PDF is available here.
Anticancer Research (28)1B 2008
Abstract
There were 23 cases (22.5%) expressing HMGA2/LPP, 2 cases (1.9%) expressing HMGA2/RDC1 and no cases of HMGA2/NFIB expression (0%). There were no significant intergroup differences in age, gender, body mass index, tumor size or location. The magnetic resonance images and pathological features were al...
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PMID: 18383898
PDF is available here.
PDF is available here.
Abstract
We describe a pathway by which the master transcription factor PU.1 regulates human monocyte/macrophage differentiation. This includes miR-424 and the transcriptional factor NFI-A. We show that PU.1 and these two components are interlinked in a finely tuned temporal and regulatory circuitry: PU.1 ac...
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PMID: 18056638
PDF is available here.
PDF is available here.
Abstract
We have applied a comparative phylogenomic analysis to study the evolutionary relationships between GC content, CpG-dinucleotide content (CpGs), potential nuclear factor I (NFI) binding sites, and potential Z-DNA forming regions (ZDRs) as representative structural and functional GC-rich genomic elem...
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PMID: 17925442
PDF is available here.
PDF is available here.
Abstract
No differences were detected between group A and B in any of the SF-36 domains. There was an association between the question on self-perception of QOL and the SF-36 domains, emotional aspects excepted. As regards sexuality, there was difference in the quality of sex life between the groups, which w...
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PMID: 17992381
PDF is available here.
PDF is available here.
Abstract
The loss of Nfic did not interfere with the formation of HERS, but it caused disrupted odontoblast differentiation, which resulted in the formation of short and abnormal roots, and decreased cementum. This finding suggests that root dentin is required for normal cementum formation. Therefore, Nfic m...
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PMID: 17760551
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)35 2007
Abstract
We cloned the 5'-flanking region with 3,979 bp of the rat LO gene. LO transcription started at multiple sites clustered at the region from -78 to -51 upstream of ATG. The downstream core promoter element functionally independent of the initiator predominantly activated the TATA-less LO gene. 5' Dele...
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PMID: 17597074
PDF is available here.
PDF is available here.
Abstract
We used an in vivo transgenic approach to investigate the mechanisms regulating Pitx2 transcription. We identified a 7-kb fragment that directs LacZ expression in oral ectoderm and in many of its derivatives. Deletion analysis of transgenic embryos reduced this fragment to a 520-bp region that direc...
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PMID: 17562863
PDF is available here.
PDF is available here.
Abstract
We analyzed the transactivation regions of two NFI isoforms by making chimeric proteins between the NFI-A and B isoforms. Though, their DNA-binding specificities were not altered as compared to the corresponding wild-type transcription factors, the C-terminal region of the NFI-B isoform was shown to...
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PMID: 17511965
PDF is available here.
PDF is available here.
Journal of Neuroscience (27)23 2007
Abstract
We show that the nuclear factor I (NFI) family of transcriptional regulators is expressed and functions throughout the postmitotic development of cerebellar granule neurons (CGNs). Expression of an NFI dominant repressor in CGN cultures blocked axon outgrowth and dendrite formation and decreased CGN...
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PMID: 17553984
PDF is available here.
PDF is available here.
Abstract
We found that both H(2)O(2) and B[a]P exposure activated nuclear transcription factor I (NFI) in NIH-3T3 cells, which specifically bound to the CCAAT element in the JWA proximal promoter (-58/-28 bp) and thereby induced JWA expression. Consistently siRNA mediated a knockdown of NFI, which prevented...
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PMID: 17462538
PDF is available here.
PDF is available here.
Abstract
We report the knockout analysis of the fourth and last member of this gene family, Nfix. Loss of NFIX is postnatally lethal and leads to hydrocephalus and to a partial agenesis of the corpus callosum. Furthermore, NFIX-deficient mice develop a deformation of the spine, which is due to a delay in oss...
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PMID: 17353270
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)11 2007
Abstract
We demonstrate cooperativity between two transcription factors, the glucocorticoid receptor (GR) and nuclear factor 1 (NF1) to bind the mouse mammary tumor virus promoter organized as regular chromatin in vivo. This cooperativity is not observed when the promoter is introduced transiently into cells...
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PMID: 17186943
PDF is available here.
PDF is available here.
Journal of Biochemistry (141)3 2007
Abstract
Continuous endoplasmic reticulum (ER) stress, such as the accumulation of unfolded proteins, results in cell death and relates to the pathogenesis of some neurodegenerative diseases. Treatment of brefeldin A, an inhibitor of transport between the ER and Golgi complex, induced cell death during 24 h,...
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PMID: 17301078
PDF is available here.
PDF is available here.
Abstract
We provide evidence that Emx1 and Emx2 regulate different developmental processes during corpus callosum formation and review how both genes function in cellular migration and the formation of cortical axon projections. The Nfi gene family is made up of four members, Nfia, Nfib, Nfic and Nfix. Expre...
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PMID: 18494262
PDF is available here.
PDF is available here.
Abstract
Hematopoiesis is highly controlled by lineage-specific transcription factors that, by interacting with specific DNA sequences, directly activate or repress specific gene expression. These transcription factors have been found mutated or altered by chromosomal translocations associated with leukemias...
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PMID: 17217039
PDF is available here.
PDF is available here.
Genome Biology (8)5 2007
Abstract
To identify potential NFI-A target genes involved in the observed tissue malformations, we analyzed gene expression in brains from Nfia-/- and Nfia+/+ littermate mice at the mRNA level using oligonucleotide microarrays. In young postnatal animals (postnatal day 16), 356 genes were identified as bein...
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PMID: 17475010
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1769)11-12 2007
Abstract
We test the hypothesis that the bHLH factors counteract negative regulation exerted through a repressor E box (-90/-85) by recruiting positive-acting transcription factors to the nucleotides (-135/-57) surrounding the repressor E box. We used electrophoretic mobility shift assays to identify candida...
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PMID: 17936922
PDF is available here.
PDF is available here.
Abstract
We identified a family of transcription factors, called NFI genes, which are induced throughout the spinal cord ventricular zone (VZ) concomitantly with the induction of GLAST, an early marker of gliogenesis. NFIA is both necessary and sufficient for GLAST induction in the VZ. Unexpectedly, NFIA is...
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PMID: 17178400
PDF is available here.
PDF is available here.
Abstract
The human testicular receptor 2 (TR2), a member of the nuclear hormone receptor superfamily, has no identified ligand yet. Previous evidence demonstrated that a 63bp DNA fragment, named the promoter activating cis-element (PACE), has been identified as a positive regulatory region in the 5' promoter...
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PMID: 17010934
PDF is available here.
PDF is available here.
Biochemical Pharmacology (72)9 2006
Abstract
We will therefore discuss in this review the multilayered interplay of NF-kappaB signaling and epigenome dynamics, in achieving appropriate gene expression responses and transcriptional activity....
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PMID: 16934762
PDF is available here.
PDF is available here.
Journal of Virology (80)21 2006
Abstract
We identified an NF-1 class member, NF-1X, as a critical transcription factor affecting the JCV cellular host range. Within variant JCV promoters, as well as other viral and cellular promoters, adjacently located NF-1 and AP-1 consensus sites are often found. The close proximity of these two binding...
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PMID: 16928756
PDF is available here.
PDF is available here.
Abstract
Nuclear factor I-A1 (NF1-A1) can bind to the TTGGC motif in the rat regucalcin gene promoter region. This study was undertaken to determine whether NF1-A1 is involved in the enhancement of the rat regucalcin gene promoter activity using the -710/+18 LUC construct (wild-type) or -710/+18 LUC construc...
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PMID: 16964421
PDF is available here.
PDF is available here.
Abstract
Nuclear factor I-A1 (NF1-A1) can bind to the TTGGC motif in the rat regucalcin gene promoter region. This study was undertaken to determine whether NF1-A1 is involved in the enhancement of the rat regucalcin gene promoter activity using the -710/+18 LUC construct (wild-type) or -710/...
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PMID: 16964421
PDF is available here.
PDF is available here.
Abstract
Nuclear factor I-A1 (NF1-A1) can bind to the TTGGC motif in the rat regucalcin gene promoter region. This study was undertaken to determine whether NF1-A1 is involved in the enhancement of the rat regucalcin gene promoter activity using the -710/+18 LUC construct (wild-type) or -710/...
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PMID: 16964421
PDF is available here.
PDF is available here.
Abstract
Nuclear factor I-A1 (NF1-A1) can bind to the TTGGC motif in the rat regucalcin gene promoter region. This study was undertaken to determine whether NF1-A1 is involved in the enhancement of the rat regucalcin gene promoter activity using the -710/+18 LUC construct (wild-type) or -710/...
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PMID: 16964421
PDF is available here.
PDF is available here.
Abstract
Nuclear factor I-A1 (NF1-A1) can bind to the TTGGC motif in the rat regucalcin gene promoter region. This study was undertaken to determine whether NF1-A1 is involved in the enhancement of the rat regucalcin gene promoter activity using the -710/+18 LUC construct (wild-type) or -710/...
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PMID: 16964421
PDF is available here.
PDF is available here.
Genes & Development (20)18 2006
Abstract
We show that estradiol (E2) stimulation of CCND1 expression in BCC depends on a novel cell-type-specific enhancer downstream from the CCND1 coding region, which is the primary ERalpha recruitment site in estrogen-responsive cells. The pioneer factor FoxA1 is specifically required for the active chro...
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PMID: 16980581
PDF is available here.
PDF is available here.
Abstract
We describe an alternative pathway through which prolactin via Jak2 localized in the nucleus activates the transcription factor nuclear factor 1-C2 (NF1-C2). Previous reports have demonstrated a nuclear localization of Jak2, but the physiologic importance of nuclear Jak2 has not been clear. We demon...
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PMID: 16847321
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)19 2006
Abstract
We identify a new regulatory element, located within the -13-kb enhancer of the ACT gene, that binds nuclear factor-1 (NFI) and is indispensable for the full basal transcriptional activity of the ACT gene. Furthermore, down-regulation of NFI expression by siRNA abolishes basal ACT expression in glio...
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PMID: 16565071
PDF is available here.
PDF is available here.
Abstract
We investigated regulatory elements located in a proximal region of the GFAP promoter, important for expression in cortical precursor cells differentiating into astrocytes. One of these elements recognizes transcription factors of the nuclear factor-I family (NFI). We found that, in primary cultures...
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PMID: 16606365
PDF is available here.
PDF is available here.
Journal of Virology (80)10 2006
Abstract
We have previously shown that p32 regulates RNA splicing by binding and inhibiting the essential SR protein ASF/SF2. To determine whether p32 also functions as a regulator of splicing in virus-infected cells, we constructed a recombinant adenovirus expressing p32 under the transcriptional control of...
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PMID: 16641292
PDF is available here.
PDF is available here.
Physical Biology (3)1 2006
Abstract
We address what is a suitable experimental and computational procedure to infer parameters of transcription factor-DNA interaction from SELEX experiments. To answer this, we use a biophysical model of transcription factor-DNA interactions to quantitatively model SELEX. We show that a standard proced...
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PMID: 16582458
PDF is available here.
PDF is available here.
Molecular Endocrinology (20)3 2006
Abstract
We reported a P sequence element (263P) capable of repressing placental CS-A promoter activity in transfected pituitary (GC) cells, and our data indicated a possible role for nuclear factor-1 (NF-1) and regulatory factor X1 in this repression. In this study we show the formation of two independent p...
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PMID: 16239259
PDF is available here.
PDF is available here.
Endocrinology (147)1 2006
Abstract
We conclude that dual promoters allow regulated production of two hLHX3 mRNAs....
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PMID: 16179410
PDF is available here.
PDF is available here.
Abstract
We recently showed that human fetal brain-derived progenitor cells are susceptible to HIV-1 and JC virus infection, and that differentiation toward an astrocyte phenotype increased virus production from these cells. In the current study, we found that in the absence of infection, progenitors produce...
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PMID: 16206198
PDF is available here.
PDF is available here.
Nucleic Acids Research (34)22 2006
Abstract
We identified a functional target site for the transcription factor, nuclear factor I (NFI), in the basal promoter from the p21 gene. Transfection of recombinant constructs bearing mutations in the p21 NFI site demonstrated that NFI acts as a repressor of p21 gene expression in various types of cult...
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PMID: 17130157
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)49 2005
Abstract
Depletion of peroxisome proliferator-activated receptor gamma (PPARgamma) represents one of the key molecular changes that underlie transdifferentiation (activation) of hepatic stellate cells in the genesis of liver fibrosis (Miyahara, T., Schrum, L., Rippe, R., Xiong, S., Yee, H. F., Jr., Motomura,...
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PMID: 16216869
PDF is available here.
PDF is available here.
Abstract
We show that human granulocytic differentiation is controlled by a regulatory circuitry involving miR-223 and two transcriptional factors, NFI-A and C/EBPalpha. The two factors compete for binding to the miR-223 promoter: NFI-A maintains miR-223 at low levels, whereas its replacement by C/EBPalpha,...
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PMID: 16325577
PDF is available here.
PDF is available here.