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Oncogene Protein p55(v-myc) (0):
Recent article
Oncogene Protein p55(v-myc)
Abstract
We used high-resolution array comparative genomic hybridization (array CGH) to map the minimal amplified regions. The 8p and 11q amplicons are complex and consist of at least four amplicon cores at each site. Candidate oncogenes mapping to these regions were identified by combining copy number and R...
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PMID: 19330026
PDF is available here.
PDF is available here.
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Abstract
We use ribosomal protein heterozygote mice as a genetic tool to restore increased protein synthesis in Emu-Myc/+ transgenic mice to normal levels, and show that the oncogenic potential of Myc in this context is suppressed. Our findings demonstrate that the ability of Myc to increase protein synthesi...
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PMID: 19011615
PDF is available here.
PDF is available here.
Abstract
We show that tumors induced by the cooperative actions of two oncogenes remain dependent on the activity of a single oncogene. Deinduction of either oncogene individually, or both oncogenes simultaneously, led to partial or complete tumor regression. Prolonged remission followed deinduction of Kras(...
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PMID: 18356293
PDF is available here.
PDF is available here.
Abstract
The level of Myc proteins is a critical determinant of cellular proliferation and apoptosis. Ubiquitination of Myc plays a key role in controlling protein levels by stimulating proteasomal degradation of the protein. Some experiments suggest that ubiquitination may also regulate Myc...
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PMID: 19198066
PDF is available here.
PDF is available here.
Archives of Neurology (65)1 2008
Abstract
A muscle biopsy specimen showed scattered intensely succinate dehydrogenase-positive and cytochrome-c oxidase-negative fibers. Southern blot of muscle mitochondrial DNA showed multiple deletions. The results of screening for mutations in the nuclear genes associated with PEO and multiple mitochondri...
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PMID: 18195150
PDF is available here.
PDF is available here.
Abstract
We report physical interactions between the human HAT complex STAGA (SPT3-TAF9-GCN5-acetylase) and a "core" form of the Mediator complex during transcription activation by the MYC oncoprotein. Knockdown of the STAF65gamma component of STAGA in human cells prevents the stable association of TRRAP and...
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PMID: 17967894
PDF is available here.
PDF is available here.
Abstract
We demonstrate in an in vivo transgenic model in which atorvastatin reverses and prevents the onset of MYC-induced lymphomagenesis, but fails to reverse or prevent tumorigenesis in the presence of constitutively activated K-Ras (G12D). Using phosphoprotein fluorescence-activated cell sorter (FACS) a...
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PMID: 17622571
PDF is available here.
PDF is available here.
Abstract
We show that Tip60 counteracts Myc-induced lymphomagenesis in a haplo-insufficient manner and in a time window that is restricted to a pre- or early-tumoral stage. Tip60 heterozygosity severely impaired the Myc-induced DDR but caused no general DDR defect in B cells. Myc- and p53-dependent transcrip...
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PMID: 17728759
PDF is available here.
PDF is available here.
Experimental Cell Research (313)3 2007
Abstract
We report the generation of a new, clonal NSC (hc-NSC) line, derived from human fetal cortical tissue, based on v-myc immortalization. Using immunocytochemistry, we show that these cells retain the characteristics of NSCs after more than 50 passages. Under proliferation conditions, when supplemented...
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PMID: 17156776
PDF is available here.
PDF is available here.
Stem Cells (24)12 2006
Abstract
We used normal mouse pre-B cells to determine if and how transforming growth factor (TGF)-beta1 affects these precursors to the B-cell lineage and whether transformed pre-B cells respond to TGF-beta1. We found that normal pre-B cells proliferating in the presence of interleukin (IL)-7 enter cell-cyc...
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PMID: 16945999
PDF is available here.
PDF is available here.
Molecular Cancer (4)1 2005
Abstract
We found that active forms of ERK were barely detectable in v-Myc (MC29) transformed cells. Furthermore, we could only detect reduced levels of activated ERK in c-Myc transformed cells compared to the non-transformed primary chick embryo fibroblast cells. The addition of LiCl inhibited GSK3 and succ...
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PMID: 15811177
PDF is available here.
PDF is available here.
Abstract
We have utilized a human breast cancer cell line MCF10CA1h and demonstrate that p38 MAP kinase and Rho/ROCK pathways together with Smad2 and Smad3 are necessary for TGF-beta-mediated growth inhibition of this cell line. We show that Smad2/3 are indispensable for TGF-beta-mediated growth inhibition,...
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PMID: 15520018
PDF is available here.
PDF is available here.
Nucleic Acids Research (33)16 2005
Abstract
We now show that vMyc can sustain longer deletions in the LZ domain than cMyc before complete loss in transforming activity, implicating the viral mutations in contributing to Myc:Max complex formation. We confirmed this both in vitro and in vivo, with loss of Max binding correlating with a loss in...
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PMID: 16166655
PDF is available here.
PDF is available here.
Abstract
Strong HIV-specific CD4 T cell responses are associated with efficient natural control of primary HIV-1 infection....
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PMID: 15075509
PDF is available here.
PDF is available here.
Abstract
A novel method is proposed for the detection and quantification of protein-protein interactions in solution. In this approach, one protein binding partner is tagged with a ligand binding domain, and protein-protein interaction is monitored via changes in the NMR relaxation of a reporter ligand which...
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PMID: 14871086
PDF is available here.
PDF is available here.
Abstract
We have investigated the mechanism by which expression of the v-myc oncogene interferes with the competence of primary quail myoblasts to undergo terminal differentiation. Previous studies have established that quail myoblasts transformed by myc oncogenes are severely impaired in the accumulation of...
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PMID: 12101422
PDF is available here.
PDF is available here.
Abstract
We have addressed this issue in neuroblastoma, a malignancy characterized by the near-exclusive amplification and overexpression of the N-Myc oncogene. Here, we report that N-Myc overexpression results in down-regulation of interleukin-6 (IL-6) and that IL-6 is an inhibitor of endothelial cell proli...
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PMID: 12032857
PDF is available here.
PDF is available here.
Sbornik lekarsky (103)3 2002
Abstract
Though the results were heterogeneous, certain trends were observed: most frequently monoclonality of monocytes was found (51%), granulocytes were monoclonal in 33% of cases, monoclonal T lymphocytes only in 8% of cases. There was no case with monoclonal T lymphocytes and simultaneously polyclonal m...
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PMID: 12688178
PDF is available here.
PDF is available here.
Abstract
We present evidence that v-Myc encoded by the avian retrovirus MC29 stimulates activating transcription factor 2 (ATF2)-dependent transcription. Analysis of the effect of Myc on ATF2 shows that v-Myc prolongs the half-life of ATF2 and induces the phosphorylation of N-terminal sites of ATF2 (Thr-69 a...
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PMID: 11781825
PDF is available here.
PDF is available here.
Cancer Letters (173)2 2001
Abstract
We investigated the effect of PCP on both GJIC and serum deprivation-induced apoptosis in v-myc-transfected rat liver epithelial cells. The results showed that PCP inhibited apoptosis, as measured by the TUNEL assay and DNA ladder formation. Inhibition of apoptosis was associated with a decrease in...
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PMID: 11597791
PDF is available here.
PDF is available here.
Journal of Molecular Biology (307)5 2001
Abstract
These results and CD thermal denaturation data indicate a monomeric state of the v-Myc bHLHZip domain. The (15)N relaxation data revealed backbone mobilities which corroborate the existence of a partially folded state, and suggest a "beads-on-a-string" motional behaviour of the v-Myc bHLHZip domain...
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PMID: 11292350
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1471)3 2001
Abstract
We review here our current knowledge on these transcriptional activities of Myc and their relationship to its biological function. The findings that Myc interacts with subunits of histone acetyl-transferase (HAT) complexes and of the ATP-dependent chromatin remodeling complex, SWI/SNF, suggest that...
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PMID: 11250069
PDF is available here.
PDF is available here.
Abstract
We have identified three genes of interest. Qath5, a quail basic helix-loop-helix (bHLH) gene that is closely related to the Drosophila atonal, and whose expression is found in the developing neuroretina. A Chx10-related homeobox gene also expressed in the developing neuroretina and HuD, a RNA-bindi...
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PMID: 11723821
PDF is available here.
PDF is available here.
Cancer Gene Therapy (7)11 2000
Abstract
These results show p21WAF1 expression to be affected by v-myc and a restoration of p21WAF1 expression to partially reverse myc-mediated transformation....
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PMID: 11129291
PDF is available here.
PDF is available here.
Abstract
We immortalized NCAM(+)/neurofilament(+) precursors from human embryonic spinal cord with a tetracycline repressible v-myc oncogene. Clonal NCAM(+)/neurofilament(+) cell lines differentiated exclusively into neurons within 1 week. These neurons displayed extensive processes, exhibited immunoreactivi...
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PMID: 10679769
PDF is available here.
PDF is available here.
Abstract
We focus on the Myc and Mad protein families and attempt to relate their biological functions to their transcriptional activities and gene targets. Both Myc and Mad, as well as the more recently described Mnt and Mga proteins, form heterodimers with Max, permitting binding to specific DNA sequences....
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PMID: 11031250
PDF is available here.
PDF is available here.
Abstract
We now show that the mutation at thr-61 stabilizes the v-Myc protein (turnover difference) and that this single mutation is both necessary and sufficient for the phenotype. A major involvement of the proteasome in Myc degradation was confirmed, but surprisingly, a dilysine motif adjacent to thr-61 p...
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PMID: 10602514
PDF is available here.
PDF is available here.
Abstract
We describe amplification of the MYCC oncogene in a medulloblastoma with aggressive clinical behavior. The patient was a six year old boy who underwent gross total surgical excision of a cerebellar tumor. Despite chemotherapy and total neuraxis radiation, the clinical course was one of relentless pr...
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PMID: 10643003
PDF is available here.
PDF is available here.
Abstract
We show that the expression of v-Myc oncoprotein by retroviral infection of telomerase-negative embryonal quail myoblasts and chicken neuroretina cells is sufficient for reactivating telomerase activity, earlier than telomere shortening could occur. Furthermore, the use of a conditional v-Myc-estrog...
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PMID: 10050888
PDF is available here.
PDF is available here.
Abstract
We developed a conditional cell transformation system in which expression of the MC29 v-myc allele is dependent on a doxycycline-sensitive transactivator (tTA). Clonal lines of quail embryo fibroblasts transformed by doxycycline-controlled v-myc revert to the normal phenotype and lose their ability...
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PMID: 9918878
PDF is available here.
PDF is available here.
Endothelium (6)4 1999
Abstract
We examined MCP-1 expression in human umbilical vein endothelial cells (EC) following cytokine treatment. We specifically compared the effect of TGF-beta 1 on this cytokine-induced expression, as TGF-beta has been shown to have immunosuppressive effects on EC. EC expressed MCP-1 mRNA and protein in...
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PMID: 10475092
PDF is available here.
PDF is available here.
Abstract
The immortalization of progenitor cells from embryonic murine hippocampus using oncogene-carrying retroviral vectors is described. Use of a vector encoding the oncogene v-myc results in lines of nestin-positive progenitor cells. Limited differentiation ensues if the cells are cultured in the presenc...
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PMID: 9786218
PDF is available here.
PDF is available here.
Abstract
We pointed out the carcinogenic potential of COPP and ABVD chemotherapeutical protocols in "long-term" experiments. In another follow up study we proved the connection between the early gene expression changes and the late consequences of COPP and ABVD treatment during, a one year latency period. CH...
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PMID: 9827356
PDF is available here.
PDF is available here.
Nature Biotechnology (15)6 1997
Abstract
We isolated clonal human CNS cell lines that had been immortalized with a tetracycline (Tc)-responsive v-myc oncogene; addition of Tc to the growth medium suppressed the oncoprotein rapidly and virtually completely, allowing differentiation to proceed. Two classes of bipotent precursor cells were im...
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PMID: 9181582
PDF is available here.
PDF is available here.
Journal of Cell Biology (137)4 1997
Abstract
We have investigated the possibility of synergy between CEA, v-Myc, and Bcl-2 in the transformation of cells with differentiation capacity. We find that v-Myc increases the cell division rate and maximum density of rat L6 myoblasts but also markedly stimulates both apoptosis and surprisingly, differ...
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PMID: 9151695
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (271)48 1996
Abstract
We are interested in identifying the transcriptional targets of the Myc oncoproteins. To this end, we have fused Myc of the MC29 retrovirus with the rat glucocorticoid receptor. This chimeric protein requires dexamethasone to undergo nuclear translocation and achieve an active conformation. We emplo...
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PMID: 8940053
PDF is available here.
PDF is available here.
Nucleic Acids Research (24)16 1996
Abstract
Chimaeric alleles were constructed to assay the biological functions of an N-terminal deletion and C-terminal mutations which were found in a naturally occurring mutant of feline vMyc, T17. The mutant alleles were assayed for their ability to transform chick embryo fibroblasts in vitro by a number o...
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PMID: 8774903
PDF is available here.
PDF is available here.
Abstract
We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription f...
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PMID: 8692870
PDF is available here.
PDF is available here.
Abstract
We have completed the structural characterization of the chicken c-myc gene and have begun to investigate c-myc transcription and protein expression. A comparison of c-myc structure and expression between mammals and birds presents an enigma: there are striking similarities in the pattern of gene ex...
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PMID: 8700520
PDF is available here.
PDF is available here.
Abstract
We have shown earlier that the association of v-myc and v-erbA (MAHEVA construct) is responsible for the appearance of a specific phenotype in chick embryos inoculated at E3. This phenotype comprises rapidly growing heart rhabdomyomas (induced by v-myc alone) and within these tumors secondarily appe...
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PMID: 8793620
PDF is available here.
PDF is available here.
Abstract
These results suggest that the suppression of the v-myc oncogene may be sufficient to make proliferating cells exit from cell cycles and induce terminal differentiation. The HC2S2 cells will be valuable for studying the differentiation process of neurons....
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PMID: 8643664
PDF is available here.
PDF is available here.
Abstract
We engineered a conditional MC29 mutant (GRIM) expressing v-Myc as a fusion protein with the glucocorticoid receptor and the retroviral Gag polyprotein. Only in the presence of glucocorticoids such as dexamethasone is GRIM capable of transforming embryo cells, from which six stable GRIM-lines have b...
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PMID: 7478574
PDF is available here.
PDF is available here.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research (5)6 1994
Abstract
We performed competition assays in which various regions of the v-Myc amino terminal transcription activation domain (TAD) were examined for their ability to inhibit transcription activation by v-Myc, VP16, and the myogenic regulatory factor MyoD. Overexpression of these transcriptional activators a...
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PMID: 8086335
PDF is available here.
PDF is available here.
Cancer Research (54)6 1994
Abstract
We introduced an inducible construct expressing an E2F-1 antisense RNA into the human glioblastoma T98G cell line and assessed DNA synthesis during the cell cycle. Expression of the antisense transcripts during the G1-S transition resulted in a marked delay in the completion of DNA synthesis. Band-s...
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PMID: 8137237
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Immunology Letters (39)1 1993
Abstract
We have used Balb/c 3T3 cells transfected with either H-ras (98/6), H-ras+v-myc (98/4v) or plasmid only (98/1). We found that while control and oncogene-transfected Balb/c 3T3 cells exhibit similar low sensitivity to lysis by natural killer (NK) cells, H-ras+v-myc-transfected cells could immunize sy...
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PMID: 8144187
PDF is available here.
PDF is available here.
Abstract
c-MYC was found to repress expression of the c-myc promoter in a transient assay system. Deletion constructs showed the cis-acting element(s) were common to both the P1 and P2 promoters. Further analysis involving replacement of the P2 TATA box and initiator elements with the SV40 late promoter init...
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PMID: 8352803
PDF is available here.
PDF is available here.
Abstract
We introduced several mutations into the myc gene of the avian retrovirus MC29. We observed that Gag-Myc with a mutated nuclear localization signal is confined predominantly in the cytoplasm and only about 5% of the protein could be detected in the nucleus (less than the amount of endogenous c-Myc)....
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PMID: 8497274
PDF is available here.
PDF is available here.
Anticancer Research (13)3 1993
Abstract
I within a 3'Pvu II region, a transcriptional attenuation site. Studies to explore the possibility of a point mutation in the N-ras gene were also conducted. No abnormalities were detected in either gene. Studies should be undertaken evaluating the possibility of a post-transcriptional mechanism, su...
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PMID: 8317907
PDF is available here.
PDF is available here.
Genes & Development (6)12A 1992
Abstract
We demonstrate that the Max protein is a nuclear protein in vivo and identify a carboxy-terminal region similar to nuclear localization signals whose integrity is necessary for efficient localization. Two mutants that delete amino- or carboxy-terminal consensus signals for casein kinase II (CKII) ex...
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PMID: 1459463
PDF is available here.
PDF is available here.
Abstract
We have characterized the expression of the epidermal growth factor receptor (EGFr) in H-Ras, v-Myc, and H-Ras-v-Myc transformed Balb/3T3 cells. H-Ras cells show a marked decrease in the number of EGFr molecules per cell compared to parental cells. v-Myc and H-Ras-v-Myc transformed cells express an...
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PMID: 1303308
PDF is available here.
PDF is available here.
Abstract
We have investigated the ability of the MC29 viral myc protein to activate transcription of a heterologous promoter in C3H10T1/2 cells. Overlapping portions of v-myc coding sequences were inserted 3' to the yeast GAL4 DNA-binding domain and tested for their ability to activate transcription of a chl...
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PMID: 1630816
PDF is available here.
PDF is available here.
Journal of Virology (66)5 1992
Abstract
Avian myelocytomatosis virus MC29 induces a wide variety of neoplastic diseases in infected birds and transforms cells of the macrophage lineage as well as fibroblasts and epithelial cells. A biological and biochemical analysis, carried out on a series of in-frame insertion and deletion mutations wi...
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PMID: 1313895
PDF is available here.
PDF is available here.
Toxicology Letters (60)2 1992
Abstract
The expression of ras and myc oncogene proteins was examined in formalin-fixed paraffin-embedded sections of male Sprague-Dawley rat liver at various times after liver regeneration was induced by either a necrogenic dose of CCl4 or a 2/3 partial hepatectomy. Antibody specific for these proteins and...
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PMID: 1570626
PDF is available here.
PDF is available here.
Mutation Research (281)2 1992
Abstract
We have compared cytoplasmic- and nuclear-delivered, glass needle-mediated microinjection protocols for their ability to support both transient and stable phenotypic expression of reporter gene constructs in non-immortalized human skin fibroblasts cultures. Microinjection of form I (covalently close...
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PMID: 1370978
PDF is available here.
PDF is available here.
Abstract
The histological and ultrastructural features of oncogene transformed rat liver epithelial (RLE) cells in culture and spontaneously transformed RLE cells were studied. The tumours produced in nude mice by all the transformed cells were either moderately well differentiated carcinomas or sarcomatous...
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PMID: 1576082
PDF is available here.
PDF is available here.
Abstract
We have studied the effect of other inducers utilizing signal pathways distinct from phorbol 12-myristate 13-acetate (i.e., 1 alpha, 25-dihydroxycholecalciferol and retinoic acid). We show that v-myc also inhibits differentiation associated with these inducers. However, the v-myc-associated block of...
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PMID: 1648223
PDF is available here.
PDF is available here.
Abstract
We show that a construct designated as MAHEVA, which encodes oncogenes v-myc from MH2 virus and v-erbA from AEV under the control of the LTR of MH2, induces rapidly growing heart rhabdomyosarcomas, when it is injected in E3 but not E5 chick embryos. A similar pathology has previously been observed w...
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PMID: 1676836
PDF is available here.
PDF is available here.