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POU Domain Factors (3):
Recent article
POU Domain Factors
Abstract
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Abstract
We directly investigated the effects of Brn-4 on the neuronal differentiation and development of NSCs derived from the E13 rat midbrain. We found that Brn-4 knockdown in NSCs resulted in a significant decrease of MAP-2-positive neurons with immature morphology. Overexpression of Brn-4 in NSCs marked...
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PMID: 20524937
PDF is available here.
PDF is available here.
Abstract
We implicate Drifter/Ventral veinless (Dfr/Vvl), a class III POU domain transcription factor, in tissue-specific regulation of the innate immune defense of Drosophila. We show that Dfr/Vvl is highly expressed in a range of immunocompetent tissues, including the male ejaculatory duct, where its prese...
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PMID: 20457811
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)20 2010
Abstract
We use in utero electroporation and genetic fate mapping to show that SNPs and RGCs cohabit the VZ but display different cell cycle kinetics and generate phenotypically different progeny. In addition, we find that RGC progeny undergo additional rounds of cell division as intermediate progenitor cell...
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PMID: 20484645
PDF is available here.
PDF is available here.
Abstract
We isolated and characterized mesenchymal stromal cells (MSCs) from the lungs of 1- to 2-week-old chickens. Microscopically, the cultured cells showed fibroblast-like morphology. Phenotypically these cells expressed CD44, CD90, CD105 and the transcription factor PouV, which has been shown to be crit...
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PMID: 20026347
PDF is available here.
PDF is available here.
Abstract
Neurogenesis in the hippocampus continues throughout adult life and can be regulated by the local microenvironment. To determine whether denervation stimulates neurogenesis in hippocampus, proliferation, migration, and differentiation of local neural stem cells (NSCs) in dentate gyrus was investigat...
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PMID: 20374086
PDF is available here.
PDF is available here.
Abstract
We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffic...
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PMID: 20107439
PDF is available here.
PDF is available here.
Abstract
Clear cell adenocarcinoma shows little response to standard therapy. The results of this study suggested that the transcription factor POU6F1 could be a new molecular target for treatment of this cancer....
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PMID: 20134265
PDF is available here.
PDF is available here.
Human Cell (22)4 2009
Abstract
We investigated new molecules to use when developing molecular-targeting therapy for clear cell adenocarcinoma of the ovary. RMG-I cells without invasive potential and RMG-V cells with invasive potential (derived from clear cell adenocarcinoma of the ovary) were subjected to complementary deoxyribon...
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PMID: 19874398
PDF is available here.
PDF is available here.
Abstract
Epithelial-to-mesenchymal transition (EMT) is defined as phenotypic change of epithelial cells into mesenchymal cells. EMT, allowing cellular dissociation from epithelial tissues, plays a key role in invasion and metastasis during carcinogenesis as well as in gastrulation and neurulation during embr...
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PMID: 19424592
PDF is available here.
PDF is available here.
Abstract
We found both nestin and BRN2 mRNA in almost all of 13 analyzed melanoma cell lines of different progression stages, but expression levels did not correlate. Nestin protein was detected in 11 of 13 and BRN2 protein in 7 of 13 melanoma cell lines independent of progression stage. Downregulation of BR...
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PMID: 18923447
PDF is available here.
PDF is available here.
Abstract
Transcription factors involved in pancreatic development show altered expression and subcellular localization in MEN1 nontumorous pancreas and pancreatic endocrine tumors....
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PMID: 19307926
PDF is available here.
PDF is available here.
Abstract
This report describes the first purification procedure of the human full-length N Oct-3 protein in amounts suitable for structural studies and proteomic investigations. N Oct-3 is a transcription factor member of the POU protein family. It possesses a large N-terminal transactivation domain and a DN...
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PMID: 18996486
PDF is available here.
PDF is available here.
BMC Molecular Biology (10)1 2009
Abstract
Har-POU, a new member of the POU gene family, was cloned from the suboesophageal ganglion of Helicoverpa armigera (Har), and its potential functions in the development of the central nervous system (CNS) were analyzed. Southern blot analysis suggests that a single copy of this gene is present in the...
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PMID: 19320969
PDF is available here.
PDF is available here.
Abstract
Abstract
We focus on the role of the BRN2 (POU3F2/N-Oct-3) transcription factor in the melanocytic lineage where it may co-ordinate normal developmental cues that can be re-activated in melanoma. Recent studies have shown BRN2 to be responsive to MAPK pathway activation and to modulate the levels of MITF so...
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PMID: 18983536
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)49 2008
Abstract
We show that Oct25, an Oct4 homologue in Xenopus, antagonizes the activity of nodal/activin signaling by inhibiting the transcription of its target genes, Gsc and Mix2. The inhibitory effect is achieved by forming repression complexes on the promoters of Gsc and Mix2 between Oct25 and the signal tra...
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PMID: 18922797
PDF is available here.
PDF is available here.
Development (135)17 2008
Abstract
We compared the gene expression profiles of the wild-type and Dlx5/6(-/-) mouse mandibular arch (prospective lower jaw). We identified 20 previously unrecognized Dlx5/6-downstream genes, of which 12 were downregulated and 8 upregulated in the mutant. We found a Dlx-regulated transcriptional enhancer...
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PMID: 18697905
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)31 2008
Abstract
The diversity of cell types found within the vertebrate CNS arises in part from action of complex transcriptional programs. In the retina, the programs driving diversification of various cell types have not been completely elucidated. To investigate gene regulatory networks that underlie formation a...
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PMID: 18667607
PDF is available here.
PDF is available here.
Development (135)14 2008
Abstract
We show that ems is expressed postembryonically in the progenitors of the two major olfactory PN lineages. Moreover, we show that ems has cell lineage-specific functions in postembryonic PN development. Thus, in the lateral PN lineage, transient ems expression is essential for development of the cor...
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PMID: 18550709
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)28 2008
Abstract
We have identified a new Drosophila POU gene, pdm3, that is expressed in ORNs. Genetic analysis shows that pdm3 is required for odor response in one class of ORNs. We find that pdm3 acts in odor receptor expression in this class, and that the odor response can be rescued by the receptor. Another POU...
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PMID: 18614681
PDF is available here.
PDF is available here.
Journal of Endocrinology (198)1 2008
Abstract
The proglucagon gene (gcg) encodes a number of peptide hormones that are of cell-type specifically expressed in the pancreatic islets, the distal ileum and the large intestine, as well as certain brain neuronal cells. These hormones are important in controlling blood glucose homeostasis, intestinal...
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PMID: 18577568
PDF is available here.
PDF is available here.
Neuroscience Letters (433)3 2008
Abstract
We compared the expression patterns of Sox11 and its two putative binding partners, Brn1 and Brn2 during development and following transient forebrain ischemia in the rat. The spatiotemporal expression pattern of Brn1 was similar to that of Sox11 from the late embryonic to postnatal development, and...
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PMID: 18261853
PDF is available here.
PDF is available here.
Acta Crystallographica Section F (64)Pt 3 2008
Abstract
The Brn-5 protein plays an important role in the control of cellular development and belongs to a class of transcription factors that usually contain two domains: the POU homeodomain (POU(HD)) and the POU-specific domain (POU(S)). Since high-quality crystals suitable for crystallographic studies of...
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PMID: 18323601
PDF is available here.
PDF is available here.
Abstract
We show that platypus and opossum genomes contain a Pou5f1 and pou2 homolog, pou2-related, indicating that these two genes are paralogues and arose by gene duplication in early mammalian evolution. In a complementation assay, we found that platypus or human Pou5f1, but not opossum or zebrafish pou2,...
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PMID: 19021737
PDF is available here.
PDF is available here.
Abstract
We provide the first insight into functional roles of this gene in a hemimetabolous insect species, Oncopeltus fasciatus. The analysis of its function using RNAi resulted in the altered morphology of antennae and labial tubes in the head, legs in the thorax, and, most notably, the growth of ectopic...
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PMID: 19021741
PDF is available here.
PDF is available here.
Abstract
We review the transcription factors that play important roles in the development and maintenance of IFE as evidenced by biochemical and genetic studies....
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PMID: 18197786
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (280)1-2 2008
Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL.
Abstract
PRL is mainly expressed in the pituitary and its gene expression is regulated by a variety of transcription factors including Pit-1. Brn-5 is a transcription factor that binds to Pit-1 binding elements and stimulates PRL reporter gene expression. In this study, the role of Brn-5 was examined. RNA in...
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PMID: 17933456
PDF is available here.
PDF is available here.
Developmental Biology (312)2 2007
Abstract
We generated Nkx2.2-/-;NeuroD1-/- double knockout (DKO) mice. As expected, the DKO mice fail to form beta cells, similar to the Nkx2.2-null mice, suggesting that the Nkx2.2 phenotype may be dominant over the NeuroD1 phenotype in the beta cells. Surprisingly, however, the alpha, PP and epsilon phenot...
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PMID: 17988662
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)48 2007
Abstract
We first studied the expression of Maf-B, c-Maf, and Cdx-2/3 in the developing and adult mouse pancreas. Although Maf-B was detectable in a progressively increasing number of alpha-cells throughout development and in adulthood, c-Maf and Cdx-2/3 were expressed at low and very low levels, respectivel...
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PMID: 17901057
PDF is available here.
PDF is available here.
Genes & Development (21)23 2007
Abstract
We report the identification of the ceh-30 gene as a key regulator of sex-specific apoptosis in Caenorhabditis elegans. Loss-of-function mutations in ceh-30 cause the ectopic death of male-specific CEM neurons. ceh-30 encodes a BarH homeodomain protein that acts downstream from the terminal sex dete...
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PMID: 18056429
PDF is available here.
PDF is available here.
Mammalian Genome (18)10 2007
Abstract
We located conserved, potentially regulatory sequences in the human, mouse, chicken, and fish genes by 5' RACE of brain RNA and genomic sequence comparison. A highly conserved 5' noncoding exon, exon 1c, is present in vertebrates from fish to mammals and appears to define the ancestral promoter regi...
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PMID: 17924165
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)38 2007
Abstract
We undertook a promoter analysis to identify the aqp-8 cis-regulatory elements. Using progressive 5' deletions of upstream sequence, we have mapped an essential regulatory region to roughly 300 bp upstream of the translational start site of aqp-8. Analysis of this region revealed a sequence correspo...
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PMID: 17660295
PDF is available here.
PDF is available here.
Abstract
We studied the canonical beta-catenin-mediated WNT signaling pathway in kidneys of mice bearing a beta-catenin-responsive TCF/betaGal reporter transgene. In metanephric kidney, intense canonical WNT signaling was evident in epithelia of the branching ureteric bud and in nephrogenic mesenchyme during...
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PMID: 17494089
PDF is available here.
PDF is available here.
Journal of Molecular Biology (370)4 2007
Abstract
We have previously shown that N Oct-3 can interact with the already described PORE and MORE DNA motifs, but also with a new structural element we have termed NORE. Having observed that both the PORE and NORE DNA-association modes depend on a strong anchoring of the POUh subdomain rigid arm into the...
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PMID: 17543985
PDF is available here.
PDF is available here.
EMBO Journal (26)12 2007
Abstract
We here show that the two maternal Xenopus POU-V factors, Oct-60 and Oct-25, inhibit transcription of genes activated by VegT and beta-Catenin. Maternal POU-V factors and maternal VegT show an opposite distribution along the animal/vegetal axis. Oct-25, VegT and Tcf3 interact with each other and for...
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PMID: 17541407
PDF is available here.
PDF is available here.
Developmental Biology (304)2 2007
Abstract
We investigate the existence of cell lineage restrictions along the proximal-distal (PD) axis of the wing disc. We rule out the existence of classical compartment boundaries in the hinge region, but demonstrate that there are clonal restrictions corresponding to the expression domains of two transcr...
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PMID: 17313943
PDF is available here.
PDF is available here.
Abstract
We previously reported molecular cloning and characterization of human FZD5, which showed six amino-acid substitutions with human Hfz5. FZD5, functioning as WNT5A receptor, is the key molecule in the fields of oncology, regenerative medicine, cardiology, rheumatology, diabetology, and gastroenterolo...
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PMID: 17273778
PDF is available here.
PDF is available here.
Abstract
We performed a double interaction screen in yeast to isolate Drosophila cDNAs coding for direct regulators, as well as Dif co-regulators, of the CecropinA1 gene. Three classes of positive cDNA clones corresponding to 15 Drosophila genes were isolated and further characterized. One of the Dif-indepen...
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PMID: 17296495
PDF is available here.
PDF is available here.
Abstract
We have previously indicated that Xenopus Suppressor of Hairless 2, XSu(H)2, is involved in the morphogenesis of gastrula embryos in a different manner from the XESR-1-mediated Notch signaling pathway. To address the downstream factors of XSu(H)2, we investigated the effect of XSu(H)2 on XenopusPOU-...
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PMID: 17194450
PDF is available here.
PDF is available here.
Abstract
A stapes gusher is the result of a congenital inner ear anomaly showing at tone audiometry a conductive or mixed hearing loss. The conductive part of the hearing loss could lead to the thought to explore the middle ear. The congenital origin should lead to a high resolution. CT-scanning to evaluate...
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PMID: 17245059
PDF is available here.
PDF is available here.
Abstract
We identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regu...
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PMID: 17224916
PDF is available here.
PDF is available here.
Nucleic Acids Research (35)13 2007
Abstract
We have previously shown that the neuronal POU protein N-Oct-3 linker contains a structured region. Here, we have used a combination of hydrodynamic methods, DNA footprinting experiments, molecular modeling and small angle X-ray scattering to (i) structurally interpret the N-Oct-3-binding site withi...
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PMID: 17576670
PDF is available here.
PDF is available here.
Abstract
The transcription factor Brn-1, which belongs to POU-domain family, has been shown to play critical roles in the development of the nervous system. A cDNA clone coding for a quail Brn-1 homologue, qBrn-1, was isolated. To investigate whether this gene plays a role in the development of the quail ner...
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PMID: 17266644
PDF is available here.
PDF is available here.
Mechanisms of Development (124)11-12 2007
Abstract
We present evidence that the Xenopus POU class V transcription factor XOct-25 regulates ectodermal cell fate decisions by inhibiting the competence of ectodermal cells to respond to BMP during Xenopus embryogenesis. When overexpressed in the ectoderm after the blastula stage, XOct-25 suppressed earl...
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PMID: 17950579
PDF is available here.
PDF is available here.
Abstract
We analyzed the expression of the murine homolog Pou6f2 during kidney embryogenesis and compared it to that of Wt1, the homolog of WT1, a known WT related gene involved in mesenchyme to epithelium conversion. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) performed f...
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PMID: 17164647
PDF is available here.
PDF is available here.
Abstract
Three POU domain containing transcription factors have been cloned from the urochordate Oikopleura dioica. Phylogenetic analysis showed that two of these (OctA1 and OctA2) are closely related members of the class II POU domain family, and one (OctB) is a member of the class III POU domain family. Al...
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PMID: 16989962
PDF is available here.
PDF is available here.
Experimental Cell Research (312)16 2006
Abstract
We provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developi...
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PMID: 16919269
PDF is available here.
PDF is available here.
Acta Genetica Sinica (33)10 2006
Abstract
I demonstrated polymorphism in the population, which was at Hardy-Weinberg equilibrium. Moreover, the frequencies of alleles A/B in the Nanyang population were 0.465/0.535. The association of the variations of the POU1F1 gene with the growth traits in the population was analyzed. The following param...
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PMID: 17046590
PDF is available here.
PDF is available here.
Development Genes and Evolution (216)10 2006
Abstract
POU genes play a prominent role in the nervous system differentiation of several organism models, and in particular, they are involved in the differentiation of sensory neurons in numerous invertebrate and vertebrate species. In the present report, cloning and expression profile of a class IV POU ge...
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PMID: 16773340
PDF is available here.
PDF is available here.
Genes & Development (20)18 2006
Abstract
We show that Pdm and Cas regulate late-born motor neuron identity within the NB7-1 lineage: Pdm specifies fourth-born U4 motor neuron identity, while Pdm/Cas together specify fifth-born U5 motor neuron identity. We conclude that Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act c...
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PMID: 16980589
PDF is available here.
PDF is available here.
Abstract
Two siblings, boys aged five and six years old, presented with mixed hearing loss. Computed tomography of the temporal bones showed bulbous dilatation of the internal auditory canals and incomplete separation with the basal turn of the cochlear, consistent with the diagnosis of X-linked congenital p...
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PMID: 16924369
PDF is available here.
PDF is available here.
Abstract
We now report that the loss of POU2F3 expression is tied to the hypermethylation of CpG islands in the POU2F3 promoter. Bisulfite sequencing analysis revealed that methylation of specific CpG sites (-287 to -70 bp) correlated with POU2F3 expression, which could be reactivated with a demethylating ag...
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PMID: 16607278
PDF is available here.
PDF is available here.
Mechanisms of Development (123)8 2006
Abstract
We here demonstrate that vegetal overexpression of Oct-25, Oct-60, Oct-91 or mammalian Oct-3/4 suppresses mesendoderm formation in Xenopus embryos. Oct-25 and Oct-60 are shown to inhibit activin/nodal and FGF signaling pathways. Loss of Oct-25 and Oct-60 function results in elevated transcription of...
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PMID: 16860542
PDF is available here.
PDF is available here.
Abstract
We tested this possibility to better understand how FGF-4 expression is modulated during development. Although we found that P19 EC cells express approximately 10-fold less FGF-4 mRNA than F9 EC cells, we determined that Sox2 levels do not differ markedly in F9 and P19 EC cells. We also determined t...
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PMID: 16523502
PDF is available here.
PDF is available here.
Nucleic Acids Research (34)Web Server issue 2006
Abstract
Multiple sequence alignment programs are an invaluable tool in computational biology. A-Bruijn Alignment (ABA) is a method for multiple sequence alignment that represents an alignment as a directed graph and has proved useful in aligning nucleotide and amino acid sequences that are composed of repea...
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PMID: 16845083
PDF is available here.
PDF is available here.
Laryngoscope (116)6 2006
Abstract
Multiple analysis approaches demonstrated that these disorders in the family were caused by a founder mutation in the POU3F4 gene. Our findings provided confirmatory molecular evidence to support that development of congenital profound sensorineural hearing loss in the Chinese population results fro...
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PMID: 16735904
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)19 2006
The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.
Abstract
We showed previously that the Sox2 regulatory region 2 (SRR2) drives strong expression in these cells. Here we generated transgenic mouse strains with the beta-geo reporter gene under the control of the SRR2 in order to examine the spatiotemporal function of this regulatory region. We show that the...
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PMID: 16547000
PDF is available here.
PDF is available here.
Endocrinology (147)4 2006
Abstract
We have examined Brn-4 expression in proglucagon-producing cells, isolated hamster Brn-4 cDNA, and localized its activation domain. Ectopic expression of either Cdx-2 or Brn-4 in the pancreatic B cell line In111 provoked it to express proglucagon mRNA, whereas ectopically expressing both of them fur...
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PMID: 16373422
PDF is available here.
PDF is available here.
Developmental Dynamics (235)4 2006
Abstract
We have obtained a new member of the class III POU domain genes, qBrn-1, from the cDNA library of embryonic day 5 quail and have made an extensive expression pattern analysis of qBrn-1 and qBrn-2 throughout the early embryonic development by in situ hybridization. With a specific antibody we prepare...
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PMID: 16498618
PDF is available here.
PDF is available here.