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Proto-Oncogene Proteins c-bcl-6 (0):
Recent article
Proto-Oncogene Proteins c-bcl-6
Abstract
We employed three independent strategies that compromised interactions between CD4(+) T cells and activated B cells in vivo. Whereas the expansion of CD4(+) T cells was relatively unaffected, Tfh cell differentiation was completely blocked in all scenarios. Surprisingly, augmenting antigen presentat...
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PMID: 20691615
PDF is available here.
PDF is available here.
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Abstract
We have developed an algorithm for the prediction of dual-targeting short interfering RNAs (siRNAs) in which both strands are deliberately designed to separately target different mRNA transcripts with complete complementarity. An advantage of this approach versus the use of two separate duplexes is...
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PMID: 20410240
PDF is available here.
PDF is available here.
Abstract
We report that stimulation of DAOY with HGF resulted in the protection of these cells against etoposide-induced apoptosis, this anti-apoptotic effect being correlated with an increase in the expression of tissue factor (TF), the initiator of the extrinsic pathway of coagulation. HGF-mediated protect...
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PMID: 19921488
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
|
PMID: 20154176
PDF is available here.
PDF is available here.
Reproduction (139)5 2010
Abstract
The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation. These unique attri...
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PMID: 20154176
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (221)1-2 2010
Abstract
We investigated naïve CD4 T-cell homeostasis in relapsing-remitting multiple sclerosis (RRMS). Quantification of signal joint T-cell receptor excision circles in FACS-isolated CD31hi cells, which correspond closely to CD4 recent thymic emigrants (RTEs), indicates that young patients have reduced ge...
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PMID: 20223525
PDF is available here.
PDF is available here.
Abstract
(1) To investigate the activation of AKT/mTOR signaling transduction pathway in DLBCL and its association with the expression of bcl-6 and some other clinical pathologic factors. (2) To estimation of the signaling pathway function in diverse subtypes of DLBCL and its potential value in the targeted...
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PMID: 19489223
PDF is available here.
PDF is available here.
Respirology (13)6 2008
Abstract
Although OVA-sensitized, bleomycin-treated Bcl6 transgenic mice had markedly lower numbers of eosinophils in both BAL and lung tissue compared with OVA-sensitized, bleomycin-treated wild-type mice, the development of pulmonary fibrosis in response to bleomycin was similar in Bcl6 transgenic mice and...
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PMID: 18811877
PDF is available here.
PDF is available here.
Trends in Immunology (29)10 2008
Abstract
Interferon regulatory factor 4 (IRF4) and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical...
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PMID: 18775669
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)9 2008
Abstract
We sought to determine the clinical and immunohistopathological prognostic factors for overall survival (OS) in adult patients with post-transplant lymphoproliferative disorders (PTLDs). Eighty-four patients diagnosed with PTLDs between 1980 and 2004 at the University of Pittsburgh Medical Center we...
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PMID: 18798108
PDF is available here.
PDF is available here.
Abstract
We investigated the morphologic, phenotypic, and cytogenetic spectrum of B-NHL with such dual translocations.Dual IgH/BCL2 and BCL6 translocations were detected in follicular lymphomas (FLs) and diffuse large B-cell lymphomas (DLBCLs), representing 6.1% of 132 B-NHLs in our series, including 6 (11%)...
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PMID: 18628087
PDF is available here.
PDF is available here.
Histopathology (53)2 2008
Abstract
Analyses of MYC and Bcl-2 status, i.e. translocation and ICN, in the context of DLBCL phenotype might help predict prognosis and determine therapeutic strategies....
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PMID: 18752503
PDF is available here.
PDF is available here.
Abstract
We thus hypothesized that one function of CD40 signaling from T cells within this timeframe could be to modulate BCL6 activity. CD40 signaling rapidly disrupts the ability of BCL6 to recruit the SMRT corepressor complex by excluding it from the nucleus, leading to histone acetylation, RNA polymerase...
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PMID: 18487509
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)7 2008
Abstract
We studied 71 patients with primary nodal DLBCL at diagnosis, who received anthracycline-based therapy with or without rituximab. Immunohistochemistry was performed using anti-CD10, Bcl-6, MUM1 and Bcl-2 antibodies in order to assess the ontogenic profile of neoplastic cells and to verify its relati...
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PMID: 18604721
PDF is available here.
PDF is available here.
Abstract
The B-cell lymphoma 6 transcriptional repressor is the most commonly involved oncogene in B-cell lymphomas. Sustained expression of B-cell lymphoma 6 causes malignant transformation of germinal center B cells. Understanding the mechanism of action of B-cell lymphoma 6 is crucial for the study of how...
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PMID: 18536578
PDF is available here.
PDF is available here.
Abstract
One hundred and forty nine of 163 cases were further classified into three molecular subgroups: 40 cases of germinal center B-cell-like (GCB) type, 75 cases of activated non-germinal center B-cell-like (ABC) type, 34 cases of Type 3. Of these 149 cases, FISH for bcl-6 gene rearrangement was successf...
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PMID: 19031715
PDF is available here.
PDF is available here.
Abstract
Journal of Pathology (214)4 2008
Abstract
We describe how NFkappaB activity is increased after BCL6 silencing by shRNA in DLBCL cells, leading us to propose that BCL6 represses NFkappaB activity. We also demonstrate that this repression is brought about by a mechanism involving protein-protein interaction between BCL6 and NFkappaB members,...
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PMID: 18189332
PDF is available here.
PDF is available here.
International Immunology (20)3 2008
Abstract
B lymphocyte-induced maturation protein 1 (Blimp-1) is a key regulator for plasma cell differentiation. Prior to the terminal differentiation into plasma cells, Blimp-1 expression is suppressed in B cells by transcription repressors BTB and CNC homology 2 (Bach2) and B cell lymphoma 6 (Bcl6). Bach2...
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PMID: 18256039
PDF is available here.
PDF is available here.
Molecular Cell (29)3 2008
Abstract
We have identified a 17 residue motif from BCOR that binds directly to the BCL6 BTB domain and determined the crystal structure of the complex to a resolution of 2.6 A. Remarkably, the BCOR BCL6 binding domain (BCOR(BBD)) peptide binds in the same BCL6 binding site as the SMRT(BBD) peptide despite t...
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PMID: 18280243
PDF is available here.
PDF is available here.
Abstract
In anthracycline-treated patients, LMO2 protein expression was significantly correlated with improved overall survival (OS) and progression-free survival (PFS) in univariate analyses (OS, P = .018; PFS, P = .010) and was a significant predictor independent of the clinical International Prognostic In...
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PMID: 18086797
PDF is available here.
PDF is available here.
Immunologic Research (41)3 2008
Abstract
We focus on the role that NF-kappaB plays in the germinal center (GC) reaction. Specifically, we discuss the major NF-kappaB subunits and the IkappaB homolog, Bcl-3. Recent findings reveal that Bcl-6, an unrelated transcriptional repressor, is functionally similar to Bcl-3 as both factors may suppre...
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PMID: 18670738
PDF is available here.
PDF is available here.
Abstract
Bcl-6 expression was associated with a better prognosis in patients with PCNSL....
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PMID: 17999414
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (49)1 2008
Abstract
We explored relationships between translocations status and clinical or histological parameters at diagnosis in 182 patients stratified in four groups: BCL2-/BCL6-, BCL2+/BCL6-, BCL2-/BCL6+ and BCL2+/BCL6+. BCL2-/BCL6- and BCL2+/BCL6-. Double negative cases were ascribed to lower histological grades...
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PMID: 18203018
PDF is available here.
PDF is available here.
Abstract
We show that BCL6 can directly bind to a DNA consensus element in the CHEK1 promoter and repress its expression in normal and malignant B-cells. DLBCL cells can be killed by a specific BCL6 peptide inhibitor (BPI) that interferes with corepressor binding to the BCL6 BTB domain. BPI could reactivate...
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PMID: 18346918
PDF is available here.
PDF is available here.
Voprosy onkologii (54)2 2008
Abstract
Abstract
We found that PPAR ligands decreased sPLA2-IIA activity and inhibited mRNA accumulation under inflammatory conditions. Furthermore, interleukin-1beta-induced sPLA2-IIA promoter activity was inhibited by the three PPAR ligands and in a similar way when cells were cotransfected with PPARalpha, PPARbet...
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PMID: 17908795
PDF is available here.
PDF is available here.
Abstract
We describe here an unusual case of FL with a variant three-way translocation t(3;14;18)(q27;q32;q21). A 57-year-old man was given a diagnosis of FL, grade 2. Chromosome analysis showed 49,XY,+X,+3,t(3;14;18)(q27;q32;q21),i(6)(p10),+21. Spectral karyotyping confirmed three derivative chromosomes, de...
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PMID: 17981218
PDF is available here.
PDF is available here.
Abstract
We report that BCL6 and MTA3 are coexpressed in normal germinal center B cells and DLBCL. Depletion of MTA3 in DLBCL cells induced a differentiation-related BCL6 target gene (PRDM1), but not target genes involved in survival. Accordingly, MTA3 and PRDM1 expression are mutually exclusive in germinal...
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PMID: 17545502
PDF is available here.
PDF is available here.
Journal of Pathology (213)1 2007
Abstract
We report selective, in situ cell-type specific expression of MTA3 among lymphoid cells largely confined to the germinal centre B cell compartment. Centroblasts display greater expression than smaller, less proliferative centrocytes, with undetectable expression in quiescent plasma cells. Among B ce...
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PMID: 17573669
PDF is available here.
PDF is available here.
Leukemia Research (31)9 2007
Abstract
We evaluated the clinical characteristics and prognoses of patients with B-cell lymphoma carrying 3q27 translocations. Among the 59 patients having 3q27 translocation, 10.9% had follicular lymphoma (FL) and 23.1% had DLBCL. It is of interest that the prognostic significance was not found between FL...
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PMID: 17197022
PDF is available here.
PDF is available here.
Abstract
Tissue microarray is inappropriate for analysis of BCL6 expression in diffuse large B-cell lymphoma.
Abstract
Due to profound tissue heterogeneity, BCL6 showed a wide range of positivity, with a high number of false negative results by TMA (25% positive), compared to 53% on whole tissue sections (WTS). CD10 was more homogeneously expressed, and TMA results corresponded better to WTS. Consequently, the resul...
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PMID: 17635238
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (48)8 2007
Abstract
We used the highly standardised staining conditions of a tissue microarray to characterise co-expression of c-Myc and Bcl-6 in DLBCL. We carried out immunohistochemistry of 73 arrayed cases. The majority (62/73) did not express c-Myc, but 11 cases (15%) showed nuclear staining. 5/53 (9%) of Bcl-6 ex...
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PMID: 17701581
PDF is available here.
PDF is available here.
Histopathology (51)1 2007
Abstract
In this group of patients the risk stratification based on the new algorithm was better than that proposed by Hans et al....
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PMID: 17593082
PDF is available here.
PDF is available here.
Abstract
DLBCL of various origins show a diversified GCB and non-GCB differentiation. Nodal and extranodal DLBCL, as well as extranodal DLBCL from different primary sites, carry different biologic characteristics and prognostic implications....
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PMID: 17845761
PDF is available here.
PDF is available here.
Yonsei Medical Journal (48)3 2007
Abstract
The OME group showed greater incidence of squamous metaplasia, fewer ciliated cells, and lower expression of BCL-6 (p < 0.05 each). Deterioration of the mucosal barrier was detected in the OME group (p > 0.05). IgA secretion and adenoid size were the same for the OME and the control groups. CONCLUSI...
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PMID: 17594153
PDF is available here.
PDF is available here.
Abstract
We previously identified the human PDCD2 (programmed cell death-2) gene as a target of BCL6 repression. PDCD2 encodes a protein that is expressed in many human tissues, including lymphocytes, and is known to interact with corepressor complexes. We now show that BCL6 can bind directly to the PDCD2 pr...
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PMID: 17468402
PDF is available here.
PDF is available here.
Annals of Oncology (18)5 2007
Abstract
In 60 patients with DLBCL treated with risk-adapted therapy, immunohistochemical subcategorization of DLBCL into GC and non-GC type has little clinical value. The IPI-associated risk appears to be mitigated by intensified upfront therapy. Low HLA-DR expression is associated with poor outcome after i...
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PMID: 17395602
PDF is available here.
PDF is available here.
Abstract
We report 12 cases of lymphoma-like lesions of the cervix in patients ranging from 27-54 years of age (mean 41). The commonest clinical presentation was post-coital bleeding (8), which was followed by vaginal bleeding (2) and leukorrhagia (4). Grossly, the lesions were either polypoid (8) or ulcerat...
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PMID: 17413989
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (48)4 2007
Abstract
Diffuse Large B cell lymphoma (DLBCL) is characterized by a markedly heterogeneous clinical course and response to therapy that is not appreciated with standard histopathologic and immunophenotypic evaluations. Analysis of global gene expression using DNA microarrays has the potential to improve the...
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PMID: 17454624
PDF is available here.
PDF is available here.
Molecular Immunology (44)5 2007
Abstract
Infection of human B cells with Epstein-Barr virus (EBV) was seen to result in activation-induced cytidine deaminase (AID) and polymerase-eta (pol-eta) gene expression. AID and pol-eta are cellular gene products that play central roles in the DNA-modifying processes involved in immunoglobulin gene c...
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PMID: 16730063
PDF is available here.
PDF is available here.
Abstract
Gene expression profiling indicates that DLBCL can be subgrouped at the molecular level and can be identified by immunophenotyping. The gene expression profile of Group B lymphomas suggests that factors other than the cell-of-origin may contribute to the pathogenesis of DLBCL....
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PMID: 17493379
PDF is available here.
PDF is available here.