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Proto-Oncogene Proteins c-sis (0):
Recent article
Proto-Oncogene Proteins c-sis
Abstract
In many kidney diseases, the original insult primarily involves the glomerulus and may then pass onto the tubulointerstitium. Several hypotheses link glomerular disease to tubular injury; perhaps the foremost hypothesis involves chronic tubular hypoxia. The reported effects of hypoxi...
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PMID: 21925138
PDF is available here.
PDF is available here.
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Abstract
In many kidney diseases, the original insult primarily involves the glomerulus and may then pass onto the tubulointerstitium. Several hypotheses link glomerular disease to tubular injury; perhaps the foremost hypothesis involves chronic tubular hypoxia. The reported effects of hypoxi...
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PMID: 21925138
PDF is available here.
PDF is available here.
Abstract
In many kidney diseases, the original insult primarily involves the glomerulus and may then pass onto the tubulointerstitium. Several hypotheses link glomerular disease to tubular injury; perhaps the foremost hypothesis involves chronic tubular hypoxia. The reported effects of hypoxi...
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PMID: 21925138
PDF is available here.
PDF is available here.
Abstract
PURPOSE. Although stromal cell-derived factor (SDF)-1 contributes to angiogenesis, its effects on sprouting angiogenesis remain ill defined. The authors investigated how SDF-1 and its receptor, CXCR4, influence neovascular sprouting. METHODS. In vivo retinal vascular development was evaluated and ex...
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PMID: 20181837
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We have reinvestigated the putative benefits of doubly targeting endothelial cells and pericytes in the treatment of experimental tumors. For this purpose, we used two highly specific tools, the pericyte-deficient pdgfb(ret/ret) mouse and the recently developed specific anti-VEGF-A antibody G6-31, w...
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PMID: 20501841
PDF is available here.
PDF is available here.
Abstract
Originally identified as an oncogene activated by amplification in squamous cell carcinomas, several lines of evidence now suggest that squamous cell carcinoma-related oncogene (SCCRO; aka DCUN1D1) may play a role in the pathogenesis of a wide range of human cancers including gliomas. SCCRO's oncoge...
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PMID: 20563250
PDF is available here.
PDF is available here.
Abstract
Indeterminate fibrohistiocytic lesions of the skin share histological and immunohistochemical features of both benign fibrous histiocytoma/dermatofibroma and dermatofibrosarcoma protuberans (DFSP). Unlike dermatofibroma, DFSP harbors recurrent genetic aberrations resulting in the fusion of COL1A1 on...
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PMID: 19940748
PDF is available here.
PDF is available here.
Abstract
Abstract
This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohis...
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PMID: 19498003
PDF is available here.
PDF is available here.
Abstract
We discuss a metastatic dermatofibrosarcoma protuberans on the occiput of a 53-year-old man whose initial tumor appeared on his forehead 23 years previously. The pathology of the tumor that recurred at the initial site was fibrosarcomatous dermatofibrosarcoma protuberans, whereas the metastatic tumo...
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PMID: 19539850
PDF is available here.
PDF is available here.
Abstract
Expression of FGF2 in tumor cells is an independent negative prognostic factor, and the coexpressions of FGF2/VEGFR-3 and FGFR-1/PDGF-B are strongly associated with poor survival in NSCLC patients....
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PMID: 19318994
PDF is available here.
PDF is available here.
Abstract
We cloned cDNA fragments of Pdgf-A, Pdgf-B, and receptors PdgfR-alpha and PdgfR-beta in the snapping turtle, a reptile with temperature-dependent sex determination (TSD). We then compared gene expression profiles in gonads from embryos incubated at a male-producing temperature to those from embryos...
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PMID: 19523392
PDF is available here.
PDF is available here.
International Journal of Cancer (124)10 2009
Abstract
We describe the generation of mouse gliomas following the overexpression of PDGF-B in embryonic neural progenitors. Our histopathological, immunohistochemical and genome-wide expression analyses revealed a surprising uniformity among PDGF-B induced tumors, despite they were generated by transducing...
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PMID: 19165863
PDF is available here.
PDF is available here.
Abstract
c-fos gene has a close relationship with the osteoblasts. Mechanical signal effect on osteoblasts would change the expression level of c-fos. Authors introduce the signal pathways of four cis-response elements on the promoter of c-fos, that is, CRE (cAMP responsive element), FAP-1 (Fbs-AP-1 site), S...
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PMID: 19199340
PDF is available here.
PDF is available here.
Journal of Neurotrauma (26)2 2009
Abstract
It is well known that platelet-derived growth factor-B (PDGF-B), a member of the neurotrophic factor family, is involved in normal physiological conditions, pathological changes, and neuroregulation following lesions. But the roles of endogenous PDGF-B in neuroregulation following spinal cord injury...
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PMID: 19236168
PDF is available here.
PDF is available here.
Abstract
We will report the implication of these enzymes and the processing of their substrates in tumor progression and metastasis. Newly reported studies on the potential use of the PCs as new therapeutic targets will be also discussed....
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PMID: 19149690
PDF is available here.
PDF is available here.
Abstract
In this model, up to 3 weeks after surgery, gene expression and production of TGF-beta are high and are upregulated in this healing period. However, expression of the bFGF gene and protein is low and decreases in the healing tendon. The CTGF, VEGF, and IGF-1 genes are expressed at high or moderately...
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PMID: 19084187
PDF is available here.
PDF is available here.
Abstract
We formally demonstrated that PDGF-B-induced neoplasms undergo progression from nontumorigenic low-grade tumors toward highly malignant forms. This result, showing that PDGF-B signaling alone is insufficient to confer malignancy to cells, entails the requirement for further molecular lesions in this...
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PMID: 19048116
PDF is available here.
PDF is available here.
Endocrinology (149)12 2008
Abstract
We show that from embryonic d 18.0 (E18) and up to P5, the gonocytes express platelet-derived growth factor (PDGF) receptor {beta}-subtype (PDGFR-{beta}) and that during the same time period, the Sertoli cells express PDGF-B and PDGF-D, both ligands for PDGFR-{beta}. Inhibition of the PDGFR-{beta} t...
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PMID: 18687785
PDF is available here.
PDF is available here.
Abstract
We have studied migration of immature pre-osteoblasts and of mature osteoblasts in response to Platelet-derived growth factor (PDGF) and sphingosine-1-phosphate (S1P). PDGF is a growth factor involved in bone remodeling and fracture healing whereas S1P is a circulating sphingolipid known to control...
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PMID: 18819098
PDF is available here.
PDF is available here.
Cancer Research (68)20 2008
Abstract
We developed transgenic mice that express hPDGFB under the control of a tetracycline-responsive element (TRE/hPDGFB). These TRE/hPDGFB mice were mated with transgenic mice expressing the tetracycline transcriptional activator (tet-off), tTA, regulated by the human glial fibrillary acidic protein (GF...
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PMID: 18922925
PDF is available here.
PDF is available here.
Rinsho Ketsueki (49)10 2008
Abstract
Cardiovascular Research (79)4 2008
Abstract
S1P inhibition of PDGF-induced cell migration and Rac activation in VSMCs was abolished by the selective S1P(2) receptor antagonist JTE-013. The C-terminal peptides of Galpha subunits (Galpha-CTs) act as specific inhibitors of respective G protein-GPCR coupling. Adenovirus-mediated expression of Gal...
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PMID: 18480127
PDF is available here.
PDF is available here.
Abstract
Sustained in vitro expression of PDGF-B in HGFs by Ad-PDGF-B transduction was seen at both the mRNA and protein levels. Compared to rhPDGF-BB and Ad-PDGF-1308, Ad-PDGF-B maintained cell growth in serum-free conditions, with robust increases in DNA synthesis. Gene delivery of PDGF-B also prolonged do...
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PMID: 18823454
PDF is available here.
PDF is available here.
Experimental Cell Research (314)11-12 2008
Abstract
We investigated the role of platelet-derived growth factor-B-activated fibroblasts (PDGF-B-aFBs) in regulating recruitment, migration and differentiation of MSCs from GFP transgenic mice in an in vitro wound healing assay and a novel three-dimensional (3D) model. PDGF-B-aFBs caused significant incre...
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PMID: 18570917
PDF is available here.
PDF is available here.
Cardiovascular Research (79)1 2008
Abstract
Chronic myocarditis was induced by CVB3 infection of major histocompatibility complex (MHC) class II knockout (B6Aa(0)/Aa(0)) mice. The mice were treated with 100 mg/kg Imatinib or vehicle, respectively, twice daily for 34 days. Expression of PDGF-C and of inflammatory cytokines were analysed by sem...
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PMID: 18326555
PDF is available here.
PDF is available here.
Circulation Research (102)12 2008
Abstract
Microvascular Research (76)1 2008
Abstract
Constitutive activation of the HIF-1 alpha C-TAD, and not merely stabilization of the HIF-1 alpha molecule, is essential for optimal HIF-mediated transcriptional and angiogenic effects. This finding could have important implications for therapeutic angiogenesis using HIF-1 alpha....
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PMID: 18440561
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to examine the functional and therapeutic significance of pericytes in ovarian cancer vasculature.
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PMID: 18395047
PDF is available here.
PDF is available here.
Abstract
There is no information regarding the presence of platelet-derived growth factors (PDGFs) and their receptors in human ovaries. The expression of PDGF-A, -B and their two receptors, PDGFR-alpha and -beta, was investigated in ovarian samples from women/girls and from human fetuses, at the protein and...
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PMID: 18326546
PDF is available here.
PDF is available here.
Abstract
These data suggest that residual ethanol in the Thrombin Processing Device-produced thrombin does not affect any of the tested parameters and has similar characteristics as commercially available bovine thrombin....
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PMID: 18355586
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (15)1 2008
Abstract
We examined the T1799A BRAF mutation by direct genomic DNA sequencing in 108 primary PTC samples from a Chinese cohort and analyzed its relationship with clinicopathological, hematological, and other laboratory results as well as the levels of expression of PDGF in tumors. We found that the BRAF mut...
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PMID: 18310286
PDF is available here.
PDF is available here.
Abstract
We studied the frequency and genomic copy number of COL1A1-PDGFB in pure GCF and GCF/DFSP hybrids, and identified the molecular cytogenetic signatures in individual cells in each component. Four pure GCF and nine GCF/DFSP hybrids were studied. All tumors exhibited classical histological features and...
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PMID: 18069662
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)5 2008
Abstract
Cancer cells with overexpression of three different endogenous angiogenesis inhibitor eventually escape angiogenesis inhibition by up-regulation of various proangiogenic factors. Tsp1, endostatin, and tumstatin may be functionally redundant in this system. These endogenous angiogenesis inhibitors ar...
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PMID: 18316578
PDF is available here.
PDF is available here.
Leukemia Research (32)2 2008
Abstract
We report a case of chronic eosinophilic leukemia (CEL), demonstrating for the first time: (i) the association of CEL with the 5'KIAA1509/3'PDGFRB fusion gene as a consequence of a t(5;14)(q33;q32); (ii) the molecular detection of this rearrangement in an extramedullary site; (iii) the cloning and s...
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PMID: 17681599
PDF is available here.
PDF is available here.
Developmental Dynamics (237)2 2008
Abstract
We hypothesized that PDGF-B/PDGFR-beta-signaling is important in the cardiac contribution of epicardium-derived cells and cardiac neural crest, cell lineages crucial for heart development. We analyzed hearts of different embryonic stages of both Pdgf-b-/- and Pdgfr-beta-/- mouse embryos for structur...
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PMID: 18213589
PDF is available here.
PDF is available here.
Abstract
We hypothesized that PDGF stimulates DNA synthesis and regulates CSF-1 in these cells. We determined the effect of PDGF on CSF-1 expression using MEOE-3M ameloblasts as a model. By RT-PCR, MEOE-3M expressed PDGFRs and PDGF A- and B-chain mRNAs. PDGF-BB increased DNA synthesis and up-regulated CSF-1...
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PMID: 18096890
PDF is available here.
PDF is available here.
Abstract
Pericytes are distinctive regulators of angiogenesis and are adumbrated to provide vessel stability and control of endothelial proliferation. The present article spotlights the persona of pericytes in physiological angiogenesis, recruitment of pericytes and different mechanisms of pericyte depletion...
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PMID: 17941874
PDF is available here.
PDF is available here.
Cytotherapy (10)8 2008
Abstract
The basal migration of m-NSC was significantly reduced compared with MSC (six versus 27 out of 10,000 cells migrated within 6 h). We evaluated the effects of bone morphogenic protein 2 (BMP2), insulin-like growth factor 1 (IGF1), platelet-derived growth factor bb (PDGFbb), vascular endothelial growt...
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PMID: 19016370
PDF is available here.
PDF is available here.
Abstract
We used heterozygous Ang-2 deficient (Ang2LacZ) mice to evaluate murine retinal vascular changes and gene expression of growth factors. Vascular changes were assessed by quantitative retinal morphometry and gene expression levels of growth factors were measured by quantitative PCR. The numbers of en...
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PMID: 18209480
PDF is available here.
PDF is available here.
Abstract
These new findings suggest that GPC4 is a specific binding protein for BPI on RPE to mediate the activation of ERK1/2, Akt, and the mRNA expressions of PDGF-B and VEGF....
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PMID: 18055828
PDF is available here.
PDF is available here.
Life Sciences (81)21-22 2007
Abstract
We determined the effects of lycopene on stromal fibroblasts and their interactions with melanoma cells. We found that lycopene inhibited PDGF-BB-induced human Hs68 skin fibroblast migration on gelatin and collagen. Further analysis showed that lycopene inhibited PDGF-BB-induced signaling in human H...
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PMID: 17950366
PDF is available here.
PDF is available here.
Abstract
Trichloroacetic acid (TCA) is one of the most widely used peeling agents, and induces full necrosis of the whole epidermis, followed by reconstitution of the epidermis and the matrix of the papillary dermis. The cytotoxic effects of TCA, such as suppressing proliferation of keratinocytes and fibrobl...
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PMID: 17724602
PDF is available here.
PDF is available here.
Pediatric Research (62)5 2007
Abstract
We punctured each amniotic sac, and fetuses in the opposite uterine horn served as controls. On d 21 of gestation, the fetuses were delivered by cesarean section. Rats subjected to oligohydramnios exhibited significantly lower lung weights and lung/body weight ratios, and ATRA had no effects on the...
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PMID: 18049370
PDF is available here.
PDF is available here.
Abstract
Dermatofibrosarcoma protuberans (DFSP) represents a locally aggressive mesenchymal neoplasm of skin and subcutis with characteristic clinicopathologic, immunohistochemical, and molecular findings. In addition to typical cases, morphologic variants such as pigmented, fibrosarcomatous, myofibroblastic...
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PMID: 17890911
PDF is available here.
PDF is available here.
Abstract
We report that eliminating HSF1 protects mice from tumors induced by mutations of the RAS oncogene or a hot spot mutation in the tumor suppressor p53. In cell culture, HSF1 supports malignant transformation by orchestrating a network of core cellular functions including proliferation, survival, prot...
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PMID: 17889646
PDF is available here.
PDF is available here.
Abstract
Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety...
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PMID: 17889643
PDF is available here.
PDF is available here.
Abstract
We dissected the separate roles of Ink4a and Arf in PDGFB-induced oligodendroglioma development in mice. We found that there were differential functions of the two tumor suppressor genes. In tumors induced from astrocytes, both Ink4a-loss and Arf-loss caused a significantly increased incidence compa...
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PMID: 17438529
PDF is available here.
PDF is available here.
Abstract
The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up...
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PMID: 17694440
PDF is available here.
PDF is available here.
Cancer Research (67)15 2007
Abstract
We examined the cellular effects on tumor vasculature of a novel DNA oligonucleotide aptamer (AX102) that selectively binds PDGF-B. Treatment with AX102 led to progressive reduction of pericytes, identified by PDGF receptor beta, NG2, desmin, or alpha-smooth muscle actin immunoreactivity, in Lewis l...
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PMID: 17671206
PDF is available here.
PDF is available here.
Experimental Hematology (35)7 2007
Abstract
Mononuclear cells were shown to undergo proliferation in the presence of EGF/FGF-2. When cells were cultured in NGF/RA-containing medium, neuronal and glial marker proteins were expressed, indicating differentiation. In the presence of either growth factor combination, cells in vitro secrete interle...
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PMID: 17588481
PDF is available here.
PDF is available here.
Development (134)14 2007
Abstract
We investigate the relationship between the vasculature and muscles during limb bud development. We show that endothelial cells are detected in limb regions before muscle cells and can organize themselves in space in the absence of muscles. In chick limbs, endothelial cells are detected in the futur...
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PMID: 17553906
PDF is available here.
PDF is available here.
Journal of Neurosurgery (106)6 2007
Abstract
There is a significant association between EGFR immunoreactivity and prolonged survival in patients with atypical meningioma. Given the variable behavior of atypical meningiomas, EGFR assessment could improve existing strategies for patient stratification and treatment....
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PMID: 17564176
PDF is available here.
PDF is available here.
Journal of Endodontics (33)6 2007
Abstract
The purpose of this study was to examine the relationship between platelet-derived growth factor B chain (PDGF-B) and bone resorption in rat periapical lesions. Periapical lesions were induced in Sprague-Dawley rats by occlusal exposure of the pulp of their mandibular first molars. Animals were sacr...
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PMID: 17509411
PDF is available here.
PDF is available here.
Modern Pathology (20)6 2007
Abstract
I alpha 1 (COL1A1) gene with the platelet-derived growth factor beta chain (PDGFB) gene has been described in dermatofibrosarcoma protuberans. The abnormal fusion transcripts probably cause PDGFB and its receptor (platelet-derived growth factor receptor beta, PDGFRB) autocrine stimulation and cell p...
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PMID: 17431412
PDF is available here.
PDF is available here.
Clinical Cancer Research (13)11 2007
Abstract
Sorafenib might be a promising anticancer agent for patients carrying KIT and PDGFRbeta gatekeeper mutations....
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PMID: 17545544
PDF is available here.
PDF is available here.
Abstract
The combination of biweekly fluorouracil/leucovorin and imatinib 600 mg daily given in a week-on/week-off schedule was feasible and safe. Nausea and fluid retention represented the DLTs.
Copyright (c) 2007 American Cancer Society...
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PMID: 17377918
PDF is available here.
PDF is available here.
Abstract
Immunohistochemical reactivity for IGFs, PDGF chains, and their receptors was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors. The expression levels of IGF-II and PDGF chains were significantly higher in...
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PMID: 17391297
PDF is available here.
PDF is available here.
Transplantation (83)6 2007
Abstract
Continuous treatment with FK778 ameliorated the progression of CAN, whereas late treatment reduced proteinuria and resulted in a similar grade of CAN as compared to animals with continuous treatment. In contrast, FK778 given only during the early phase after transplantation had no effect on the prog...
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PMID: 17414707
PDF is available here.
PDF is available here.
Biology of Reproduction (76)3 2007
Abstract
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a vital role in regulating cell growth and angiogenesis. In this study, the expression of the family of PDGFs and PDGFRs in the ovarian corpus luteum were identified and characterized, and an effect of their activity on develo...
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PMID: 17108335
PDF is available here.
PDF is available here.