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Smad Proteins (3):
Recent article
Smad Proteins
Biochemical Pharmacology (82)11 2011
Abstract
We analyzed the effects of IFN-α2b and TGF-β1 treatments on Wnt/β-catenin pathway, Smads proteins levels, β-catenin/TCF4/Smads interaction and proliferation and apoptotic death in HepG2/C3A and Huh7 cell lines. IFN-α2b and TGF-β1 attenuated Wnt/β-catenin signal by decreasing β-catenin and Fr...
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PMID: 21843516
PDF is available here.
PDF is available here.
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Abstract
We report that sustained inhibition of the transforming growth factor beta type I receptor (also termed activin receptor-like kinase or ALK) using a chemical inhibitor selective for ALK4/5/7 (ALKi) leads to the cardiac differentiation of hESCs under feeder-free and serum-free conditions. Treatment w...
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PMID: 21208046
PDF is available here.
PDF is available here.
Abstract
Our aim was to investigate the role of tranilast in transforming growth factor (TGF) β/Smad pathways using a rat model of chronic cyclosporine (CsA) nephrotoxicity.
Thirty Sprague-Dawley (SD) rats were equally randomized in to 5 groups for gavage treatments daily for 4 weeks: normal...
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PMID: 21693312
PDF is available here.
PDF is available here.
Abstract
Our aim was to investigate the role of tranilast in transforming growth factor (TGF) β/Smad pathways using a rat model of chronic cyclosporine (CsA) nephrotoxicity.
Thirty Sprague-Dawley (SD) rats were equally randomized in to 5 groups for gavage treatments daily for 4 weeks: normal...
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PMID: 21693312
PDF is available here.
PDF is available here.
Abstract
Our aim was to investigate the role of tranilast in transforming growth factor (TGF) β/Smad pathways using a rat model of chronic cyclosporine (CsA) nephrotoxicity.
Thirty Sprague-Dawley (SD) rats were equally randomized in to 5 groups for gavage treatments daily for 4 weeks: normal...
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PMID: 21693312
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Cancer Cell (19)2 2011
Abstract
We report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jag...
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PMID: 21295524
PDF is available here.
PDF is available here.
Abstract
We have established a tethering system, in which the Gal4 DNA binding domain (DBD) of the Flag:Gal4 DBD:Ote▵LEM fusion protein physically interacts with the Gal4 binding sites upstream of bamP-gfp to artificially recruit the reporter gene gfp to the nuclear membrane. Our data demonstrated that the...
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PMID: 21356524
PDF is available here.
PDF is available here.
Abstract
We evaluated the effects of exogenous apoA-I expression on cardiac differentiation of ESCs and maturation of ESC-derived cardiomyocytes. We stably over-expressed full-length human apoA-I cDNA with lentivirus (LV)-mediated gene transfer in undifferentiated mouse ESCs and human induced pluripotent ste...
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PMID: 21589943
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Immunohistochemical investigation demonstrated increased expression of SMAD2, -3 and -4, and decreased expression of SMURF2. TGF-β1 antisense therapy significantly down-regulated SMAD2 and SMAD4, up-regulated SMURF2 and showed no effect on SMAD3 and SMAD6. CONCLUSION: TGF-β1 led to elevated levels...
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PMID: 20944123
PDF is available here.
PDF is available here.
Abstract
We expand the number of TGFbeta/BMP-regulated miRNAs (T/B-miRs) to 20. Of interest, a majority of T/B-miRs contain a consensus sequence (R-SBE) within the stem region of the primary transcripts of T/B-miRs (pri-T/B-miRs). Here, we demonstrate that Smads directly bind the R-SBE. Mutation of the R-SBE...
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PMID: 20705240
PDF is available here.
PDF is available here.
Abstract
These results suggest that Id genes are one of the potential targets of BMP signaling in the differentiation of RPCs....
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PMID: 20130285
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
We also observed a decrease in the expression of CTGF in discs from Smad3-null mice as compared with those from wild-type mice. Analysis of human nucleus pulposus samples indicated a trend toward increasing CTGF and TGFbeta expression in the degenerated state.
TGFbeta, through Smad3...
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PMID: 20222112
PDF is available here.
PDF is available here.
Abstract
We sought to investigate whether budesonide, a widely used glucocorticoid in clinical practice, could attenuate TGF-beta1 (transforming growth factor-beta1)-induced VEGF production by HFL-1 (human lung fibroblasts). HFL-1 fibroblasts were treated with various concentrations of budesonide (10(-11) M,...
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PMID: 20359293
PDF is available here.
PDF is available here.
Abstract
We found that Nrf2/Smad3/Smad4 formed an immunoprecipitable nuclear complex. Thus, loss of Nrf2 increased R-Smad phosphorylation and R-Smad signaling, supporting the hypothesis that loss of Nrf2 in an oncogenic context-dependent manner can enhance cellular plasticity and motility, in part by using t...
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PMID: 20440267
PDF is available here.
PDF is available here.
Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.
Abstract
The balance between anabolic and catabolic signaling pathways is critical in maintaining cartilage homeostasis and its disturbance contributes to joint diseases such as osteoarthritis (OA). A unique mechanism that modulates the activity of cell signaling pathways is controlled by extracellular hepar...
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PMID: 20479257
PDF is available here.
PDF is available here.
Abstract
We show that grade IV human glioma cell lines expressed different levels of Nodal, paralleled to the potential for cell invasiveness. Treatment of glioma cell lines with recombinant Nodal (rNodal) increased matrix metalloproteinase 2 (MMP-2) secretion and cell invasiveness. The ectopic expression of...
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PMID: 20383200
PDF is available here.
PDF is available here.
Abstract
We provide evidence that neogenin plays a critical role in iron homeostasis by regulation of HJV secretion and bone morphogenetic protein (BMP) signaling. Livers of neogenin mutant mice exhibit iron overload, low levels of hepcidin, and reduced BMP signaling. Mutant hepatocytes in vitro show impaire...
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PMID: 20065295
PDF is available here.
PDF is available here.
Abstract
We tested the effects of pharmacological PI3K/AKT/mTOR inhibitors on their potential to induce osteogenic differentiation of hESCs. Under feeder-free culture conditions, rapamycin (an mTOR inhibitor) potently inhibited the activities of mTOR and p70S6K in undifferentiated hESCs; however, LY294002 (a...
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PMID: 19642865
PDF is available here.
PDF is available here.
Abstract
We focus on the genetic mouse models for Smad pathways, which have provided functional evidence regarding the complex circuitry in angiogenesis and hematopoiesis during development. In the early stages of vascular development, TGF-beta signaling is a contributing factor in angiogenesis and vascular...
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PMID: 20596915
PDF is available here.
PDF is available here.
Abstract
Smad signalling in osteosarcoma is partially operative. The high p21/WAF1 expression in osteosarcoma is significantly correlated with tumour extension. Our results suggest that overexpression of p21/WAF1 in osteosarcoma might be one of the poor prognostic factors....
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PMID: 20350217
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
|
PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
|
PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
|
PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
|
PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
|
PMID: 20157054
PDF is available here.
PDF is available here.
Hypertension (55)4 2010
Abstract
I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). The enhancement in cardiac remodeling in mice that express human CRP was associated with further upregulation of the Ang II type I receptor and transforming growth factor-beta1 and overacti...
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PMID: 20157054
PDF is available here.
PDF is available here.
Matrix Biology (29)3 2010
Abstract
We have previously characterized a 3kb human alpha11 promoter region in vitro. In the current study we generated promoter-LacZ reporter transgenic mice to examine the ability of the 3kb alpha11 promoter to drive tissue-specific expression also in vivo. Our data show that the 3 kb alpha11 promoter co...
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PMID: 19913614
PDF is available here.
PDF is available here.
Abstract
We revealed that MIA/CD-RAP can modulate bone morphogenetic protein (BMP)2-induced osteogenic differentiation into a chondrogenic direction. In the current study we aimed to find the molecular details of this MIA/CD-RAP function. Direct influence of MIA on BMP2 by protein-protein-interaction or modu...
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PMID: 20164682
PDF is available here.
PDF is available here.
Abstract
We report the phenotype of mice with a conditional deletion of TGF-beta-activated kinase 1 (TAK1), a MAP3K family member, in cartilage using the collagen 2alpha promoter. These mice display chondrodysplasia characterized by neonatal-onset runting, delayed formation of secondary ossification centers,...
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PMID: 20392264
PDF is available here.
PDF is available here.
Laboratory Investigation (90)3 2010
Abstract
We investigated if paclitaxel can attenuate tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction (UUO). Rats in groups of six were subjected to UUO and received low-dose intraperitoneal injection of paclitaxel (0.3 mg/kg) twice a week. They were killed at day 7 and 14 after...
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PMID: 20142807
PDF is available here.
PDF is available here.
Nutrition Research (30)3 2010
Abstract
I collagen genes were up-regulated. After simvastatin treatment, both the RasGRF1 and phospho-RasGRF1 in the cytoplasm decreased significantly, whereas those on the plasma membrane increased. A marked increase in membranous GAP-associated protein (P190) and the activated form of both phospho-extrace...
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PMID: 20417880
PDF is available here.
PDF is available here.
Molecular Medicine (16)3-4 2010
Abstract
We analyzed components of TGFbeta signaling pathway in biopsies from 10 patients with nonhealing venous ulcers (VUs). Using comparative genomics of transcriptional profiles of VUs and TGFbeta-treated keratinocytes, we found deregulation of TGFbeta target genes in VUs. Using quantitative polymerase c...
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PMID: 20069132
PDF is available here.
PDF is available here.
Abstract
We highlight the effects of proteasomal inhibition in various animal models of tissue fibrosis and mechanisms by which it may regulate TGF-beta1 expression and signaling. At present, there are no effective therapies for fibroproliferative acute respiratory distress syndrome or IPF, and proteasomal i...
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PMID: 20160152
PDF is available here.
PDF is available here.
Abstract
Compound Astragalus and Salvia miltiorrhiza extract (CASE) is made up of astragalosides, astragalus polysaccharide and salvianolic acids extracted from Astragalus membranaceus Bunge (Leguminosae) and Salvia miltiorhiza Bunge (Lamiaceae) with a standard ratio. Previous reports showed...
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PMID: 19793165
PDF is available here.
PDF is available here.
Molecular Cell (37)1 2010
Abstract
We show that TMEPAI, a direct target gene of TGF-beta signaling, antagonizes TGF-beta signaling by interfering with TGF-beta type I receptor (TbetaRI)-induced R-Smad phosphorylation. TMEPAI can directly interact with R-Smads via a Smad interaction motif. TMEPAI competes with Smad anchor for receptor...
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PMID: 20129061
PDF is available here.
PDF is available here.
Abstract
The identification of mutations in the bone morphogenetic protein (BMP) type II receptor in the majority of cases of familial pulmonary arterial hypertension (PAH) has provided a focus for researchers studying the complex pathobiology of this condition. Mutations are also found in a proportion of id...
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PMID: 20204735
PDF is available here.
PDF is available here.
Abstract
We thus hypothesize that BMPR2 mutation thus leads to an impaired ability to terminate the injury repair process, leading to strong predisposition to PAH....
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PMID: 20204736
PDF is available here.
PDF is available here.
Localization of phosphorylated SMAD proteins in granulosa cells, oocytes and oviduct of female mice.
Abstract
We also observed substantial staining for pSMADs in intact fully-grown oocytes from antral follicles. In granulosa cells, immunostaining for both pSMAD2/3 and pSMAD1/5/9 was apparent in preantral granulosa cells from primordial to secondary follicles. In antral follicles, immunostaining for pSMADs b...
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PMID: 20176141
PDF is available here.
PDF is available here.
Abstract
We have explored this concept using an approach that represents a template for the testing of agents with prospective orthopaedic applications.
The effects of BMP-2, TGF-beta1, and the TGF-beta receptor (ALK-4/5/7) inhibitor SB431542 on osteogenic differentiation were tested in the MC3T3-E1 murine p...
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PMID: 20509926
PDF is available here.
PDF is available here.
Respiratory Research (11) 2010
Abstract
These results suggest that chronic cigarette smoke exposure can increase chymase activity and expression in hamster lungs. The capability of activated chymase to induce Ang II formation and TGF-beta1 signaling may be part of the mechanism for smoking-induced pulmonary vascular remodeling. Thus, our...
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PMID: 20356378
PDF is available here.
PDF is available here.
Abstract
Curcumin blocks the profibrotic actions of TGF-beta on HK-2 cells through the down-regulation of the Smad signaling pathway, and curcumin may have some similar effect as serine/threonine protein phosphatases. Our findings suggest curcumin as a potential candidate for treatment of tubulointerstitial...
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PMID: 20160437
PDF is available here.
PDF is available here.
BioFactors (36)1 2010
Abstract
Since the discovery by this laboratory of the zinc finger transcription factor, KLF10, a member of the Krüppel-like family of transcription factors, there have been multiple publications regarding its functions and its immediate family members, in numerous cell types. KLF10 has been shown to be rap...
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PMID: 20087894
PDF is available here.
PDF is available here.
BioFactors (36)1 2010
Abstract
In recent years, much progress has been made in understanding the factors that regulate the gene expression program that underlies the induction, proliferation, differentiation, and maturation of osteoblasts. A large and growing number of transcription factors make important contributions to the pre...
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PMID: 20087883
PDF is available here.
PDF is available here.
Abstract
Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by vari...
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PMID: 20890584
PDF is available here.
PDF is available here.
Abstract
We report here that the c-Rel transcription factor controlled development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB. Although Smad and CREB first bound to Foxp3 enhancers, they later moved to the promoter t...
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PMID: 20064450
PDF is available here.
PDF is available here.
Cell Cycle (8)24 2009
Abstract
We provide evidence that BMP4 and IL-7 interplay is important in the maintenance of the human thymic progenitor population. Intrathymic CD34(+) cells express BMP receptors (BMPRIA, BMPRIB, ActRIA, BMPRII), signal transduction molecules (Smad1, 5, 8 and 4), and produce BMP4. Neutralization of endogen...
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PMID: 19923894
PDF is available here.
PDF is available here.
Abstract
These results suggest that beta1-integrin impairs the TGF-beta1-mediated signals through the altered phosphorylation of the R-Smads....
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PMID: 19885568
PDF is available here.
PDF is available here.
Abstract
IFN-gamma can down-regulate the expression of Smad 3 while up-regulate the expression of Smad 7 in a time- and dose-dependent manner, and reduce the expression level of CTGF and alpha-SMA in the basic state or induced by TGF-beta(1), which shows a significant inhibitory effect on the TGF-beta/Smad s...
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PMID: 20193171
PDF is available here.
PDF is available here.
Abstract
I to III meningiomas were analyzed by Western blot for BMP-2/4, BMPR IA, and BMPR II, and activation of downstream p-Smad1, p38 mitogen-activated protein kinase (MAPK), and p44/42 MAPK signaling molecules. Sections from 20 normal leptomeninges, 2 arachnoid cysts, and 51 meningiomas were analyzed for...
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PMID: 19816200
PDF is available here.
PDF is available here.
Abstract
We used transient transfection assays of a SMAD luciferase reporter to investigate whether beta-cryptoxanthin regulates SMAD activation in MC3T3 pre-osteoblastic cells. Beta-cryptoxanthin did not stimulate basal SMAD activity but amplified transforming growth factor (TGF)-beta1-induced SMAD activati...
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PMID: 19787201
PDF is available here.
PDF is available here.
Abstract
We construct a two-compartment model for Smad complex formation in TGF-beta signal transduction. A simplified one-way oligomerization model, which ignores dissociation and well appropriate the full model under high expression levels of R- and Co-Smad, is constructed to analytically investigate the e...
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PMID: 19358856
PDF is available here.
PDF is available here.
Abstract
In thalassemia and other iron loading anemias, ineffective erythropoiesis and erythroid signaling molecules are thought to cause inappropriate suppression of a small peptide produced by hepatocytes named hepcidin. Previously, it was reported that the erythrokine GDF15 is expressed at very high level...
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PMID: 19414861
PDF is available here.
PDF is available here.
Abstract
Disruption of hyaluronan-CD44 interactions has little effect on the TGF-beta responses; however, re-establishing CD44-hyaluronan ligation promotes a robust cellular response to BMP-7 by articular chondrocytes. Thus, changes in cell-hyaluronan interactions may serve as a mechanism to modulate cellula...
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PMID: 19195913
PDF is available here.
PDF is available here.
Abstract
Our results indicated that recombinant BMP6 induced ALP activity in a dose-dependent and time-course-dependent manner. Treatment with TGF-beta1 reduced both the cell proliferation and the expression of E-cadherin, induced a morphological transformation, decreased the expression and activity of MMP-2...
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PMID: 19543302
PDF is available here.
PDF is available here.