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TCF Transcription Factors (2):
Recent article
TCF Transcription Factors
Clinical calcium (20)10 2010
Abstract
Wnt signaling system plays essential roles in development, cancer and bone metabolism. Canonical wnt signaling, which involves wnt ligands, receptor named frizzled and co-receptors LRP5/6, beta-catenin and transcription factors named LEF/TCF is well characterized and its defect causes bone abnormali...
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PMID: 20890034
PDF is available here.
PDF is available here.
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Oncology Reports (24)2 2010
Abstract
Our research results showed that CPP caused a dose- and time-dependent inhibition of cell growth as assessed by MTT assay and an induction in apoptosis as measured by flow cytometry and transmission electron microscopy. Furthermore, the CPP- treated cells were characterized by a decreased expression...
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PMID: 20596624
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)8 2010
Abstract
We examined polymorphic markers of genes rs12255372 [NT_03359.12:g33557428G --> T] of 7CF7L2 gene and rs13266634 [NP_776250.2:p.R325W] of SLC30A8 in groups of Russians with type 2 diabetes (T2D) (n = 588) and healthy normoglycemic controles (n = 597). Significant association of allele T(rs12255372)...
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PMID: 20873210
PDF is available here.
PDF is available here.
Abstract
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Ris...
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PMID: 20578204
PDF is available here.
PDF is available here.
Growth Factors (28)3 2010
Abstract
We have previously demonstrated that in vivo interferon-alpha2b (IFN-alpha2b) administration induces apoptosis in preneoplastic livers, a mechanism mediated by reactive oxygen species (ROS) and transforming growth factor-beta(1) (TGF-beta(1)). This study was aimed to assess the status of the Wnt/bet...
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PMID: 20109105
PDF is available here.
PDF is available here.
Cancer Research (70)9 2010
Abstract
Id proteins (Id1 to Id4) are helix-loop-helix transcription factors that promote metastasis. It was found that Semaphorin 3F (SEMA3F), a potent inhibitor of metastasis, was repressed by Id2. High metastatic human tumor cell lines had relatively high amounts of Id2 and low SEMA3F levels compared with...
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PMID: 20388805
PDF is available here.
PDF is available here.
Abstract
The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D).
Several studies reported that dietary factors related to carbohydrate quality and quantity, such as whole grains and gly...
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PMID: 19915463
PDF is available here.
PDF is available here.
Abstract
The Wnt signaling pathway is critically important not only for stem cell amplification, differentiation, and migration, but also is important for organogenesis and the development of the body plan. Beta-catenin/TCF7L2-dependent Wnt signaling (the canonical pathway) is involved in pancreas developmen...
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PMID: 20217507
PDF is available here.
PDF is available here.
Abstract
We showed that the downstream MYC enhancer (MYC 3' WRE) cooperated with the upstream enhancer (MYC 5' WRE) to activate expression of a heterologous reporter gene in response to Wnt/beta-catenin and mitogen signaling. Here we use chromatin conformation capture (3C) to show that the MYC 5' and 3' WREs...
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PMID: 19966299
PDF is available here.
PDF is available here.
Abstract
We show that e2f1 expression is regulated through the Wnt/Tcf-pathway: e2f1 promoter activity is inhibited by sodium butyrate (NaB) and by overexpression of beta-catenin/Tcf. The e2f1 promoter was found to contain two putative Tcf-binding elements: the proximal one competes well with canonical Tcf e...
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PMID: 19900401
PDF is available here.
PDF is available here.
Abstract
We investigated the potential role of URG11 in hypoxia-induced renal tubular epithelial-to-mesenchymal (EMT). Overexpression of URG11 in a human proximal tubule cell line (HK2) promoted a mesenchymal phenotype accompanied by reduced expression of the epithelial marker E-cadherin and increased expres...
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PMID: 19900406
PDF is available here.
PDF is available here.
Abstract
We have placed six copies of a TCF/Lef responsive element and an hsp68 minimal promoter in front of a fluorescent protein fusion comprising human histone H2B to GFP and used it to generate a strain of mice that would report Wnt/β-catenin signaling activity. Characterization of developmental and adu...
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PMID: 21176145
PDF is available here.
PDF is available here.
Molecular Cancer (9)1 2010
Abstract
We assessed promoter activity of the intergenic region in both orientations in cancer cell lines derived from breast (AU565, SKBR3), colon (HCT-15, KM12), and stomach (AGS) cancers, as well as in embryonic human kidney (HEK293T) cells. The intergenic segment was active in both orientations in all of...
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PMID: 20459822
PDF is available here.
PDF is available here.
Diabetologia (53)1 2010
Abstract
Endogenous canonical WNT signalling was absent in the adult endocrine pancreas in both wild-type and obese mice. We identified WNT4 as an abundant WNT signalling molecule in adult pancreatic islets that is induced in two different insulin-resistant mouse models. Increased expression of WNT4 inhibite...
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PMID: 19898815
PDF is available here.
PDF is available here.
Nature Genetics (41)10 2009
Abstract
We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin...
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PMID: 19718027
PDF is available here.
PDF is available here.
Nature Neuroscience (12)9 2009
Abstract
Genetics in Medicine (11)8 2009
Abstract
The actual prevalence of type 2 diabetes in the study population was 20%. Predicted risks were below average for carriers of the TCF7L2 CC genotype (predicted risk 17.6%) and above average for the CT and TT genotypes (20.8% and 28.0%). Adding the other 17 polymorphisms caused 34% of participants to...
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PMID: 19636253
PDF is available here.
PDF is available here.
Abstract
Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (...
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PMID: 19608393
PDF is available here.
PDF is available here.
Abstract
Fibroblast growth factor receptor 3 (FGFR-3) is expressed in the lower crypt epithelium, where stem cells of the intestine reside. The role of FGFR-3 signaling in regulating features of intestinal morphogenesis was examined in FGFR-3-null (FGFR-3(-/-)) mice. FGFR-3(-/-) mice had only about half the...
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PMID: 19407216
PDF is available here.
PDF is available here.
Carcinogenesis (30)7 2009
Abstract
These results tie together the previously observed misregulation of Id2 with a novel mechanism for tumorigenesis....
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PMID: 19451188
PDF is available here.
PDF is available here.
Human Molecular Genetics (18)13 2009
Abstract
We have shown that TCF7L2 expression in the beta-cells is correlated with function and survival of the insulin-producing pancreatic beta-cell. In order to understand how variations in TCF7L2 influence diabetes progression, we investigated its mechanism of action in the beta-cell. We show robust diff...
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PMID: 19386626
PDF is available here.
PDF is available here.
Abstract
We have observed evidence of association with two independent TCF7L2 loci in a PCOS cohort: 1) association between the proinsulin:insulin molar ratio and the T2D locus; and 2) association with reproductive PCOS phenotype and a novel locus. This study suggests that variation in different regions of a...
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PMID: 19351735
PDF is available here.
PDF is available here.
Diabetologia (52)5 2009
Abstract
The mapping of TCF7L2 splice variants shows a specific pattern in pancreatic islets, with four predominant transcripts and high usage of the variable exons 4 and 15. The overall concentration of TCF7L2 mRNA is highest in islets and fat and lower in blood and muscle. No significant difference in over...
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PMID: 19247628
PDF is available here.
PDF is available here.
Diabetologia (52)5 2009
Abstract
Low birthweight was associated with type 2 diabetes (p = 0.008) and impaired insulin secretion (p = 0.04). Of the tested variants, the risk variant in HHEX showed a trend towards a low birthweight (p = 0.09) and the risk variant in the CDKN2A/2B locus was associated with high birthweight (p = 0.01)....
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PMID: 19225753
PDF is available here.
PDF is available here.
Surgical Endoscopy (23)4 2009
Abstract
The cause of diabetes is multifactorial but the data from our pilot study documents the relationship of TCF7L2 with type 2 diabetes in morbidly obese patients....
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PMID: 18806947
PDF is available here.
PDF is available here.
Diabetologia (52)4 2009
Abstract
As expected, the T risk allele of rs7903146 was associated with higher fasting plasma glucose (p = 0.01). T/T homozygotes had a 23.5% increase in the proinsulin/insulin ratio (p = 1 x 10(-7)) compared with C/C homozygotes. There was no association of HapA with BMI (p = 0.98), waist circumference (p...
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PMID: 19183934
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the balance between E-protein transcription factors and their inhibitors, Id proteins, is important for the myeloid-versus-lymphoid fate choice. Using Id1-GFP knockin mice, we show that transcription of the Id1 gene begins to be up-regulated at the granulocyte-macrophage progenit...
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PMID: 18927439
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)3 2009
Abstract
We established the culture system of adult rat dentate gyrus-derived neural precursor cells (ADPs) and examined the effects of dexamethasone (DEX), an agonist of glucocorticoids receptor, and Li on ADP proliferation. It is possible for ADP to be a type 2a cell, which corresponds to the second stage...
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PMID: 19005466
PDF is available here.
PDF is available here.
Hepatology (49)2 2009
Abstract
We tested if TCF7L2 polymorphism is a risk factor for nonalcoholic fatty liver disease (NAFLD) and if it modulates liver injury, glucose homeostasis, lipoprotein, and adipokine profiles in NASH. TCF7L2 genotype and dietary habits of 78 nondiabetic normolipidemic NAFLD subjects and 156 age-, body mas...
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PMID: 19105201
PDF is available here.
PDF is available here.
British Journal of Nutrition (101)4 2009
Abstract
We employed a case-cohort study of 2318 randomised individuals and 724 incident type 2 diabetes cases from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. Multivariate Cox regression was used to estimate relative risks of diabetes including product terms testi...
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PMID: 19149908
PDF is available here.
PDF is available here.
Abstract
We assessed the mechanisms of action of WIF1 by either restoring WIF1 expression in invasive bladder cancer cell lines (T24 and TSU-PR1) or using a recombinant protein containing functional WIF1 domain. Both ectopic expression of WIF1 and treatment with WIF1 domain protein resulted in cell growth in...
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PMID: 19174556
PDF is available here.
PDF is available here.
Mutation Research (660)1-2 2009
Abstract
We examine genetic variants in insulin, inflammation, estrogen, metabolizing enzymes, and energy homeostasis genes to explore associations with microsatellite instability (MSI), CpG Island methylator phenotype (CIMP), mutations of p53 in exons 5 through 8, and mutations in codons 12 and 13 of Ki-ras...
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PMID: 18992263
PDF is available here.
PDF is available here.
Human Pathology (40)1 2009
Abstract
We analyzed human AXIN2 exon 8 and TCF7L2 exon 14 in 32 gastric carcinomas with high MSI, 13 gastric carcinomas with low MSI, and 47 gastric carcinomas without MSI by a single-strand conformation polymorphism analysis. Overall, we detected 9 AXIN2 and 6 TCF7L2 frameshift mutations in the mononucleot...
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PMID: 18755497
PDF is available here.
PDF is available here.
Abstract
We report the effects of lef1 loss of function on early development in X. tropicalis. Depletion of lef1 affects gene expression already during gastrulation and results in abnormal differentiation of cells derived from ectoderm and mesoderm. At tail bud stages, the epidermis was devoid of ciliated ce...
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PMID: 19123129
PDF is available here.
PDF is available here.
Abstract
Experimental Cell Research (315)1 2009
Abstract
We provide mechanistic basis of changes in beta-catenin/APC/CKIepsilon leading to progression and/or regression of hyperplasia in vivo. In response to CR-induced TMCH, crypt lengths increased significantly between days 6-27 post-infection, followed by a steep decline by day 34. beta-Cat(45)/total be...
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PMID: 18996369
PDF is available here.
PDF is available here.
Abstract
Reduced insulin sensitivity plays a role in the early pathogenesis of type 2 diabetes, and defects in insulin secretion by pancreatic beta-cells are instrumental in hyperglycemic progression. There is strong evidence that genetic factors play an important role in both of these components. Several of...
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PMID: 19203201
PDF is available here.
PDF is available here.
BMC Medical Genetics (10)1 2009
Abstract
Minor allele frequency did not differ significantly (p = 0.47) between Generation R (T-allele: 28.7%) and the SGA cohort (T-allele: 29.8%). No differences at birth were found in gestational age or size (head circumference, length, weight) between the genotypes in either cohort. TCF7L2 genotype was a...
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PMID: 19615048
PDF is available here.
PDF is available here.
BMC Medical Genetics (10)1 2009
Abstract
TCF7L2-rs7903146 T allele increased susceptibility to T2D (OR = 1.25 [1.06-1.47], P = 0.006) in our study population. This risk was 56% higher among subjects carrying the TT genotype in comparison to those carrying the CC genotype (OR = 1.56 [1.13-2.16], P = 0.002). No allelic or genotypic associati...
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PMID: 19368707
PDF is available here.
PDF is available here.
BMC Medical Genetics (10)1 2009
Abstract
The studies included 35,843 cases of T2DM and 39,123 controls, using mainly primary data. For T2DM and IVS3C>T polymorphism, the Bayesian OR for TT homozygotes and TC heterozygotes versus CC homozygote was 1.968 (95% credible interval (CrI): 1.790, 2.157), 1.406 (95% CrI: 1.341, 1.476), respectively...
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PMID: 19228405
PDF is available here.
PDF is available here.
Abstract
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of s...
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PMID: 18931037
PDF is available here.
PDF is available here.
Abstract
We examined the effect of celecoxib on the expression of T-cell factors (TCFs) to clarify the mechanism by which celecoxib suppress beta-catenin/TCF-dependent transcriptional activity without reducing the level of beta-catenin protein, using HCT-116 cells. Celecoxib suppressed the expression of TCF-...
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PMID: 18983819
PDF is available here.
PDF is available here.
Abstract
Journal of Pathology (216)4 2008
Abstract
We show that transcription factor early growth response 1 (Egr1) acts as an initial mediator through up-regulating the expression of TCF4 and p300. In an endometrial carcinoma cell line with abundant oestrogen receptor alpha, Egr1 expression at both mRNA and protein levels was significantly increase...
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PMID: 18798221
PDF is available here.
PDF is available here.
Nature Neuroscience (11)12 2008
Abstract
We found that beta-catenin-mediated Wnt signaling critically maintained progenitor proliferation in the subcortical (pallidal) telencephalon. Targeted deletion of beta-catenin in mice severely impaired proliferation in the medial ganglionic eminence without grossly altering differentiated fate. Seve...
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PMID: 18997789
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of PPARgamma inhibition and its mechanism on intestinal tumorigenesis using a selective antagonist, T0070907. We treated Apc(Min/+) mice and carcinogen-induced colon cancer model C57BL/6 mice with T0070907 and counted the number of spontaneous polyps and aberrant crypt foc...
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PMID: 19075513
PDF is available here.
PDF is available here.
Abstract
We demonstrate that FGF2 signaling through phosphatidylinositol 3 kinase activation inactivates glycogen synthase kinase 3beta (GSK3beta) and leads to the accumulation of beta-catenin in a manner different from that in the Wnt canonical pathway. The nuclear accumulated beta-catenin leads to cell pro...
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PMID: 18852283
PDF is available here.
PDF is available here.
Abstract
We report that a more robust beta-catenin binding region localizes 1.4 kb downstream from the c-Myc transcriptional stop site. This site was discovered using a genome-wide method for identifying transcription factor binding sites termed serial analysis of chromatin occupancy. Chromatin immunoprecipi...
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PMID: 18852287
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (295)1-2 2008
Abstract
We show that a specific E-box in the mouse GnRHR promoter binds two group A basic-helix-loop-helix (bHLH) transcription factors. Mutation of this E-box decreases expression in mouse gonadotrope-derived alphaT3-1 and LbetaT2 cell lines. Microarray and western blots show that the bHLH transcription fa...
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PMID: 18760324
PDF is available here.
PDF is available here.
Nature Neuroscience (11)12 2008
Abstract
We found that beta-catenin–mediated Wnt signaling critically maintained progenitor proliferation in the subcortical (pallidal) telencephalon. Targeted deletion of beta-catenin in mice severely impaired proliferation in the medial ganglionic eminence without grossly altering differentiated fate. Se...
PDF is available here.
PDF is available here.
Abstract
Journal of Immunology (181)9 2008
Abstract
We show that multipotent LSKs (lineage(-)Sca(high)c-kit(+)) from E47-deficient mice exhibit a striking hyperproliferation associated with a loss of cell cycle quiescence and increased susceptibility to in vivo challenge with a mitotoxic drug. Total LSKs contain long-term self-renewing hematopoietic...
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PMID: 18941177
PDF is available here.
PDF is available here.
Abstract
The assay described here is a suitable strategy for the TCF7/L2 rs7903146 (C/T) genotyping also allowing rapid and reliable identification....
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PMID: 19169495
PDF is available here.
PDF is available here.
FASEB Journal (22)11 2008
Abstract
We identified FHL2, a member of the LIM-only subclass of the LIM protein superfamily, that is up-regulated during early osteoblast differentiation induced by dexamethasone in murine and human MSCs. Gain-of-function studies showed that FHL2 promotes the expression of the osteoblast transcription fact...
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PMID: 18653765
PDF is available here.
PDF is available here.
Molecular Endocrinology (22)11 2008
Abstract
We still do not know mechanistically how the polymorphisms within the intron regions of TCF7L2 affect the risk of type 2 diabetes, this transcriptional regulator was shown to be involved in stimulating the proliferation of pancreatic beta-cells and the production of the incretin hormone glucagon-lik...
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PMID: 18599616
PDF is available here.
PDF is available here.
Human Mutation (29)11 2008
Abstract
We selected for this study 30 unrelated patients whose phenotype overlapped PHS but which had been initially addressed for Angelman, Mowat-Wilson, or Rett syndromes. In 10 patients we identified nine novel mutations (four large cryptic deletions, including one in mosaic, and five small deletions), a...
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PMID: 18781613
PDF is available here.
PDF is available here.
Abstract
We show that Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription. Subsequent transforming growth factor (TGF)-beta3 signaling increases LEF-1 gene expression causing formation of...
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PMID: 18799618
PDF is available here.
PDF is available here.
Cancer Causes & Control (19)9 2008
Abstract
We evaluated the association of a polymorphism in TCF7L2 (RS12255372) in the WNT signaling pathway, which previously has been strongly associated with risk of Type II Diabetes, with colorectal cancer (CRC) and adenoma in the prospective Nurses' Health Study (NHS) and Health Professionals Follow-up S...
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PMID: 18478343
PDF is available here.
PDF is available here.
Diabetologia (51)11 2008
Abstract
The minor allele frequency of rs7901695, rs7903146 and rs12255372 was significantly higher in diabetic patients compared with that in non-diabetic individuals. The T (minor) allele of the variant rs7903146 was significantly associated with a greater OR for type 2 diabetes adjusted for age, sex and B...
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PMID: 18712344
PDF is available here.
PDF is available here.
Diabetologia (51)11 2008
Abstract
The diabetes-risk alleles for CDKAL1, HHEX/IDE and TCF7L2 showed an additive model of association with measures of beta cell function. Beta cell glucose sensitivity was decreased by 39% in those individuals with five or more risk alleles compared with those individuals with no risk alleles (geometri...
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PMID: 18719881
PDF is available here.
PDF is available here.