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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Telomere-Binding Proteins (3):
Recent article
Telomere-Binding Proteins
Abstract
We developed a regression approach to correct for variability in fluorescence intensity due to differences in cell size and granularity without discarding any of the cells, which gating ipso facto does. This approach enables quantitative studies of cellular heterogeneity and transcriptional noise in...
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PMID: 21952134
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We purified the recombinant Stn1p in Escherichia coli and found that the purified protein could specifically interact with single-stranded telomeric DNA in vitro. Co-fractionation of co-overexpressed Stn1p and Ten1p in insect cells revealed their stable association. A Stn1p/Ten1p binary complex was...
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PMID: 20576529
PDF is available here.
PDF is available here.
Genes & Development (24)15 2010
Abstract
We show that Verrocchio (Ver), an oligonucleotide/oligosaccharide-binding (OB) fold-containing protein related to Rpa2/Stn1, interacts physically with HOAP and Moi, is enriched only at telomeres, and prevents telomere fusion. These results indicate that Ver is a new terminin component; we speculate...
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PMID: 20679394
PDF is available here.
PDF is available here.
Nature Cell Biology (12)8 2010
Abstract
We show that Rap1 deficiency is dispensable for telomere capping but leads to increased telomere recombination and fragility. We generated cells and mice deleted for Rap1; mice with Rap1 deletion in stratified epithelia were viable but had shorter telomeres and developed skin hyperpigmentation in ad...
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PMID: 20622869
PDF is available here.
PDF is available here.
Nature Cell Biology (12)8 2010
Abstract
Nature Cell Biology (12)8 2010
Abstract
We describe a genome-wide gain-of-function screen for regulators of NF-kappaB, and identify Rap1 (Trf2IP), as an essential modulator of NF-kappaB-mediated pathways. NF-kappaB is induced by ectopic expression of Rap1, whereas its activity is inhibited by Rap1 depletion. In addition to localizing on t...
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PMID: 20622870
PDF is available here.
PDF is available here.
Abstract
To determine mRNA expression of telomeric binding proteins in inflammatory bowel disease (IBD), and to note any effects of pharmacotherapy on telomere binding protein expression.
Peripheral blood mononuclear cells (PBMC) obtained from 31 IBD patients and 13 controls w...
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PMID: 20061197
PDF is available here.
PDF is available here.
Molecular Cell (38)6 2010
Cdc13 and telomerase bind through different mechanisms at the lagging- and leading-strand telomeres.
Abstract
We developed a method allowing us to distinguish which of the two daughter telomeres chromosome end-binding proteins bind to at the end of S phase. The single-stranded DNA-binding protein Cdc13 and the telomerase subunits Est1 and Est2 can bind to the two daughter telomeres, but only their binding t...
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PMID: 20620955
PDF is available here.
PDF is available here.
Abstract
We used cryo-electron microscopy to determine the architecture of nucleoprotein complexes composed of TFIID, TFIIA, the transcriptional activator Rap1 and yeast enhancer-promoter DNA. These structures revealed the mode of binding of Rap1 and TFIIA to TFIID, as well as a reorganization of TFIIA induc...
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PMID: 20559389
PDF is available here.
PDF is available here.
Abstract
We report results of a genome-wide association study of LTL in a consortium of four observational studies (n = 3,417 participants with LTL and genome-wide genotyping). SNPs in the regions of the oligonucleotide/oligosaccharide-binding folds containing one gene (OBFC1; rs4387287; P = 3.9 x 10(-9)) an...
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PMID: 20421499
PDF is available here.
PDF is available here.
Abstract
We report on the role of the TRF2-interacting factor Rap1, a conserved shelterin subunit of unknown function. We removed Rap1 from mouse telomeres either through gene deletion or by replacing TRF2 with a mutant that does not bind Rap1. Rap1 was dispensable for the essential functions of TRF2--repres...
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PMID: 20339076
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
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PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
Nesprins are a family of nuclear transmembrane proteins anchored via Sun proteins to the nuclear membrane. Analysis of nesprins during human muscle development revealed an increase in nesprin-1-giant during early myogenesis in vitro. During the transition from immature to mature musc...
|
PMID: 20108321
PDF is available here.
PDF is available here.
Developmental Cell (18)2 2010
Abstract
We report the crystal structure of the Fbx4-TRF1 complex at 2.4 A resolution. Fbx4 contains an unusual substrate-binding domain that adopts a small GTPase fold. Strikingly, this atypical GTPase domain of Fbx4 binds to a globular domain of TRF1 through an intermolecular beta sheet, instead of recogni...
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PMID: 20159592
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed RNAi-mediated knockdown of Dock180 in SKOV3 cells using small interfering RNA expression vector. In Dock180 knockdown cells, we found that Elmo1 expression and Rac1 activity were decreased simultaneously. By contrast, the expressions of both another Crk-combining molecule C3G and Rap1 a...
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PMID: 20237902
PDF is available here.
PDF is available here.
Cell Transplantation (19)1 2010
Abstract
While advances in regenerative medicine and vascular tissue engineering have been substantial in recent years, important stumbling blocks remain. In particular, the limited life span of differentiated cells that are harvested from elderly human donors is an important limitation in many areas of rege...
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PMID: 19878625
PDF is available here.
PDF is available here.
Abstract
We report the crystal structures of the C-terminal domain of the Saccharomyces cerevisiae Stn1 and the Schizosaccharomyces pombe Ten1 proteins. These structures reveal striking similarities to corresponding subunits in the replication protein A complex, further supporting an evolutionary link betwee...
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PMID: 19884503
PDF is available here.
PDF is available here.
Cell Cycle (8)22 2009
Abstract
Abstract
We will summarize recent advances in our understanding of proteins involved in the protection and replication of telomeres, and the way these factors are dynamically recruited to telomeres during the cell cycle. We will focus mainly on recent results from fission yeast Schizosaccharomyces pombe, and...
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PMID: 19898524
PDF is available here.
PDF is available here.
Abstract
We show that the histone 3/lysine 4 (H3/K4) HMT and the transcriptional regulator MLL associate with telomeres and contribute to their H3/K4 methylation and transcription in a telomere length-dependent manner. In human diploid fibroblasts, RNA interference-mediated MLL depletion affects telomere chr...
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PMID: 19528237
PDF is available here.
PDF is available here.
Molecular Cell (34)6 2009
Abstract
We used a genome-wide approach to identify 96 sites of very high DNA polymerase binding in wild-type cells. Most of these binding sites were not previously identified pause sites. Rather, the most highly represented genomic category among high DNA polymerase binding sites was the open reading frames...
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PMID: 19560424
PDF is available here.
PDF is available here.
Oncology Reports (21)6 2009
Abstract
These results manifest that radioresistant Hep-2R cell lines showed certain changes in gene expression and bionomical profiles that are different from the profile changes of the more-sensitive Hep-2 cell lines, and that evaluation of telomere-associated genes may be a prognostic marker for response...
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PMID: 19424630
PDF is available here.
PDF is available here.
Archives of Toxicology (83)5 2009
Abstract
We summarize some of the apparent difficulties encountered by the DNA replication machinery when it approaches the chromosome ends. Eukaryotic cells have evolved diverse mechanisms to overcome these problems, underlining the importance of telomere maintenance for a number of aspects of chromosome fu...
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PMID: 19337721
PDF is available here.
PDF is available here.
Abstract
We present evidence for a TIN2 isoform (TIN2L) that differs from the originally described TIN2 isoform (TIN2S) in two ways: TIN2L contains an additional 97 amino acids, and TIN2L associates strongly with the nuclear matrix. Stringent salt and detergent conditions failed to extract TIN2L from the nuc...
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PMID: 19229133
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We identified the C-terminal 110-amino acid region (RTBP1(506-615)) as the minimal telomeric DNA binding domain, suggesting that the Myb extension is required for binding plant telomeric DNA. Like other telomeric proteins such as human TRF1 and yeast Rap1, RTBP1 induced a DNA bending in the telomeri...
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PMID: 19152316
PDF is available here.
PDF is available here.
Abstract
We show that Cdk1-dependent phosphorylation of Cdc13 is essential for efficient recruitment of the yeast telomerase complex to telomeres by favoring the interaction of Cdc13 with Est1 rather than the competing Stn1-Ten1 complex. These results provide a direct mechanistic link between coordination of...
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PMID: 19135888
PDF is available here.
PDF is available here.
Abstract
We report here, POT1a and POT1b do not differ in their ability to repress telomere recombination. By swapping domains, we show that the DNA binding domain of POT1a specifies its ability to repress the DNA damage response. However, no differences were detected in the in vitro DNA binding features of...
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PMID: 18955498
PDF is available here.
PDF is available here.
Biological Research (42)2 2009
Abstract
We have previously reported the TRFl expression levels were down-regulation in non-small cell lung cancer (NSCLC). The regulation of TRFl localization is proposed to be important for the function and expression. The nuclear localization signal (NLS) and nuclear export signal (NES) are often importan...
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PMID: 19746267
PDF is available here.
PDF is available here.
Abstract
Telomeres, repeat sequences at the ends of chromosomes, are protective chromosomal structures highly conserved from primitive organisms to humans. Telomeres inevitably shorten with every cell cycle, and telomere attrition has been hypothesized to be fundamental to normal senescence of cells, tissues...
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PMID: 20008219
PDF is available here.
PDF is available here.
Abstract
The rapid evolution of telomere proteins has hindered identification of orthologs from diverse species and created the impression that certain groups of eukaryotes have largely non-overlapping sets of telomere proteins. However, the recent identification of additional telomere proteins from various...
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PMID: 19839711
PDF is available here.
PDF is available here.
Abstract