Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Toll-Like Receptor 9 (0):
Recent article
Toll-Like Receptor 9
Journal of Immunotherapy (34)3 2011
Abstract
We showed that the route of administration is critical to the antitumor activity of CpG. Although intravenous (i.v.) injection of CpG was capable of inducing the activation and expansion of tumor antigen-specific T cells, most of these activated T cells failed to migrate to tumor sites. By contrast,...
|
PMID: 21389870
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated with this injury is often apoptosis, especially by death receptors. Information from experimental systems demonstrates that hepatocyte apoptosis is sufficient to cause liver hepatic fibrogenesis. The mechanis...
|
PMID: 20960379
PDF is available here.
PDF is available here.
Abstract
We isolated B cells from human blood and spleen, and showed that after a short period of ex vivo stimulation a number of these cells produced IL-10. The IL-10-producing B cells did not fall within a single clearly defined subpopulation, but were enriched in both the memory (CD27(+)) and the transiti...
|
PMID: 20809522
PDF is available here.
PDF is available here.
Abstract
We have previously shown that murine IgG2a-autoreactive AM14 B cells respond robustly to chromatin-associated IC through a mechanism dependent on both the BCR and the endosomal TLR9, despite FcγRIIB coexpression. To further evaluate the potential contribution of FcγRIIB to the regulation of autore...
|
PMID: 20809520
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
Pseudomonas aeruginosa is a prevalent opportunistic human pathogen that, like other Gram-negative pathogens, secretes outer membrane vesicles. Vesicles are complex entities composed of a subset of envelope lipid and protein components that have been observed to interact with and be internalized by h...
|
PMID: 20605984
PDF is available here.
PDF is available here.
Abstract
IMPORTANCE OF THE FIELD: Toll-like receptors (TLRs) are innate immune receptors critical in the innate immune defense against invading pathogens. Recent advances also reveal a crucial role for TLRs in shaping adaptive immune responses, conferring a potential therapeutic value to their modulation in...
|
PMID: 20560798
PDF is available here.
PDF is available here.
Abstract
These results emphasise the critical role of gut microbiota, innate immunity and TLR9 in iGvHD and highlight anti-TLR9 strategies as novel therapeutic options....
|
PMID: 20639251
PDF is available here.
PDF is available here.
Abstract
Our results reflect the capacity of TcES glyco-antigens to modulate Th1-type and inflammatory responses mediated through DC activation.
Copyright 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved....
|
PMID: 20361966
PDF is available here.
PDF is available here.
Abstract
Thirteen (13%) of the 99 hemochromatosis patients were heterozygous for a TLR4 Asp299Gly polymorphism and 86 (87%) were TLR4 wild-type-only carriers. Clinical expression of hemochromatosis was observed more frequently in carriers of the TLR4 polymorphism (100%) than in TLR4 wild-type carriers (56%,...
|
PMID: 19809335
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We measured type 1 interferon production from circulating human pDCs as a function of pDC concentration. The effects of interferon-alpha and blockade of the type 1 interferon receptor (IFNAR) on human pDC type 1 interferon and interferon-inducible transcription and protein production were measured....
|
PMID: 20346735
PDF is available here.
PDF is available here.
Abstract
We focus on an old approach with some new modifications, the so-called whole-parasite vaccination strategy against blood-stage Plasmodium falciparum, the deadliest human malarial agent. In addition, we discuss recent developments in our understanding of how the endogenous adjuvant activity in the pa...
|
PMID: 20624050
PDF is available here.
PDF is available here.
Gastroenterology (139)1 2010
Abstract
Gastroenterology (139)1 2010
Abstract
In a mouse model of NASH, TLR9 signaling induces production of IL-1beta by Kupffer cells, leading to steatosis, inflammation, and fibrosis.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
|
PMID: 20347818
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Abstract
We investigated TLR9-dependent mechanisms, triggered by the parasite Toxoplasma gondii, inducing Crp release in the lumen. Oral challenge of C57BL/6J (B6) wild-type (WT) mice with T. gondii induced TLR9 mRNA upregulation associated with a marked increase of type I IFN mRNA expression. PC secretory g...
|
PMID: 20488791
PDF is available here.
PDF is available here.
Abstract
We show that IDO-competent cells express the B-lineage commitment factor Pax5 and surface immunoglobulins. CD19 ablation abrogated IDO-dependent T-cell suppression by DCs, even though cells with phenotypic attributes matching IDO-competent cells developed normally and expressed IDO in response to in...
|
PMID: 20498068
PDF is available here.
PDF is available here.
Abstract
We demonstrate a requirement for IRF5 in the development of murine SLE via its role in B lymphocytes. We show that antinuclear autoantibodies and Ig glomerular deposits, hallmarks of SLE, are absent in Irf5(-/-) mice challenged to develop SLE by pristane injection. In particular, production of autoa...
|
PMID: 20479222
PDF is available here.
PDF is available here.
Abstract
These results suggest that signaling of TLR2, TRL3, TRL4, and TRL9 is highly redundant in the adjuvant effect needed to induce EAU and that diverse microbial infections may contribute to the pathogenesis of diseases such as uveitis....
|
PMID: 20107166
PDF is available here.
PDF is available here.
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery (45)6 2010
Abstract
To evaluate the therapeutic effect of intranasal oligodeoxynucleotides with CpG motifs (CpG ODN) in prevention of allergic rhinitis in juvenile guinea pigs.
Juvenile guinea pigs aged from 7 to 10 weeks were administrated with CpG ODN alone or combined with OVA at single dose concentration intranasal...
|
PMID: 21055324
PDF is available here.
PDF is available here.
Abstract
We hypothesized that liposome:DNA vectors also activate the cytosolic DNA-sensing pathway, which signals via interferon (IFN) regulatory factor (IRF)3. To test this, we treated dendritic cells (DCs) with liposome:DNA in vitro and found that IRF3 was phosphorylated independent of TLR9. To test the co...
|
PMID: 20145605
PDF is available here.
PDF is available here.
Abstract
We examined COX-2 expression in PC-3 cells stimulated with different doses and time courses of CpG-ODNs. The regulatory role of NF-kappaB in TLR9-mediated COX-2 expression was also investigated. CpG-ODN was found to up-regulate the expression of COX-2 in PC-3 cells in a dose- and time-dependent mann...
|
PMID: 19618291
PDF is available here.
PDF is available here.
Endocrine Journal (57)3 2010
Abstract
We aimed to clarify the pathogenesis of fulminant type 1 diabetes with special reference to insulitis and viral infection. We examined pancreatic autopsy samples from three patients who had died soon after the onset of disease and analyzed these by immunohistochemistry and in situ-hybridization. The...
|
PMID: 20009359
PDF is available here.
PDF is available here.
Journal of Immunology (184)7 2010
Abstract
Our findings lead to a model in which oxidation of carbohydrates from encapsulated microbes facilitates adaptive immune responses against microbial protein and carbohydrate Ags through promoting Ag processing for MHC II-mediated presentation as well as innate responses against released microbial DNA...
|
PMID: 20200279
PDF is available here.
PDF is available here.
Abstract
mRNA expression of mindin was upregulated 4.7 + or - 1.1 fold compared with the baseline during DSS-induced intestinal inflammation in the mice. Stimulation with CpG-ODN (a known TLR-9 ligand) induced 4.2 + or - 0.3 fold upregulation of mindin expression in RAW 264.7 cells. Full-length of mindin was...
|
PMID: 20205276
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Clinical Rheumatology (29)3 2010
Abstract
These results suggest that the involvement of TLR4 and TLR9 in immunopathogenesis of DM and PM might be connected with activation of CD4(+) T cells....
|
PMID: 19953283
PDF is available here.
PDF is available here.
Abstract
Journal of Virology (84)4 2010
Abstract
We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infectio...
|
PMID: 19939930
PDF is available here.
PDF is available here.
Abstract
I interferons (IFNs) in response to viral infection. The function of pDCs as the professional type I IFN-producing cells is linked to their selective expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the endosomal compartments. Type I IFNs produced by pDCs no...
|
PMID: 20596824
PDF is available here.
PDF is available here.
Cell Host & Microbe (7)1 2010
Abstract
We find that immunization of mice with a crude blood stage extract of the malaria parasite Plasmodium falciparum elicits parasite antigen-specific immune responses via Toll-like receptor (TLR) 9 and that the malarial heme-detoxification byproduct, hemozoin (HZ), but not malarial DNA, produces a pote...
|
PMID: 20114028
PDF is available here.
PDF is available here.
Abstract
Type 1 diabetes (T1D) is an autoimmune disease that results in the progressive loss of insulin producing cells. Studies performed in humans with T1D and animal models of the disease over the past two decades have suggested a key role for the adaptive immune system in disease mechanisms. The role of...
|
PMID: 20217515
PDF is available here.
PDF is available here.
Human Genetics (127)1 2010
Abstract
Our findings in three independent population samples indicate that variations in TLR2 and TLR9 might play important roles in determining susceptibility to TB....
|
PMID: 19771452
PDF is available here.
PDF is available here.
Abstract
Monocyte TLR2 and TLR4 and neutrophil TLR4 expressions and TLR4 activity are increased hemodialysis patients, representing another dimension of ESRD-associated inflammation.
2010 S. Karger AG, Basel....
|
PMID: 20090311
PDF is available here.
PDF is available here.
Abstract
Together, these data show that IN CpG has a therapeutic effect during established fungal asthma, which is TLR9 dependent and independent.
Copyright 2009 S. Karger AG, Basel....
|
PMID: 20016192
PDF is available here.
PDF is available here.