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Transcription Factor AP-2 (0):
Recent article
Transcription Factor AP-2
Journal of Immunotherapy (34)4 2011
Abstract
As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of...
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PMID: 21499124
PDF is available here.
PDF is available here.
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Human Immunology (71)7 2010
Abstract
CD209 (DC-SIGN) is an important C-type lectin which acts a receptor of many pathogens. The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodefic...
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PMID: 20359516
PDF is available here.
PDF is available here.
Genome Research (20)4 2010
Abstract
We used chromatin immunoprecipitation with DNA microarray hybridization (ChIP-chip) analysis to investigate targets of the TFs-TCFAP2C, EOMES, ETS2, and GATA3-and a chromatin remodeling factor, SMARCA4. We then evaluated the transcriptional states of target genes using transcriptome analysis and gen...
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PMID: 20176728
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We show that in murine mammary glands transcription factor AP-2gamma is strongly expressed in the cap cell layer and in a subset of body cells of TEBs. To decipher AP-2gamma functions during mammary development we generated AP-2gamma-deficient mice. Their mammary glands displayed impaired ductal bra...
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PMID: 20131354
PDF is available here.
PDF is available here.
Abstract
We have evaluated the clinical application of several markers of testis cancers in serum, semen and tissue samples. Immunohistochemistry detection of some of these being solid new markers in addition to the routinely used but none have been shown to be superior to the classical markers in serum and...
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PMID: 20036893
PDF is available here.
PDF is available here.
Abstract
We analyzed proteins interacting with WAFL in HEK-293 cells by immunoprecipitation and mass spectrometry. Among four proteins found to specifically interact with WAFL, both KIAA0196 and KIAA1033 bind to alpha-appendage of the adaptor protein complex 2 (AP2), which acts as an interaction hub for acce...
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PMID: 20376207
PDF is available here.
PDF is available here.
BMC Medical Genetics (11) 2010
Abstract
Modest associations were observed in CITED2, EP300, CREBBP, TFAP2A and CARM1 but not ALX1. However, these modest associations were not statistically significant after correction for multiple comparisons. Searching for potential functional variants and rare causal mutations is warranted in these gene...
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PMID: 20932315
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
This report expands the ocular phenotypic spectrum of BOFS and adds to the small number of reported TFAP2A mutations....
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PMID: 20461149
PDF is available here.
PDF is available here.
Biological Chemistry (390)9 2009
Abstract
We show that the FQQI motif is a binding site for the medium chain adaptin micro1, a subunit of the AP-1 adaptor complex that plays a role in post-Golgi/endosomal trafficking events. In order to investigate the role of AP-1 and AP-2 in GLUT4 trafficking, we generated 3T3-L1 adipocytes expressing HA-...
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PMID: 19558319
PDF is available here.
PDF is available here.
Cancer Research (69)16 2009
Abstract
We previously showed that nicotine stimulates non-small cell lung carcinoma (NSCLC) cell proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) has also been shown to induce NSCLC cell grow...
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PMID: 19654299
PDF is available here.
PDF is available here.
Journal of Antibiotics (62)6 2009
Abstract
Abstract
We present a 4-year-old girl with congenital profound sensorineural deafness associated with inner ear malformation (incomplete partition type II, enlarged vestibule, and enlarged vestibular aqueduct). The proposita also had pseudocleft lips, skin defects, auricle abnormalities, and unilateral multi...
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PMID: 19206157
PDF is available here.
PDF is available here.
Journal of Craniofacial Surgery (20 Suppl 1) 2009
Abstract
We conducted a systematic analysis of CL types in BOFS, including a retrospective cross-sectional chart and photographic review with variable longitudinal follow-up of our patients and those described in the literature. We compared data on the type of CL and palate (CL/P) and craniofacial and extrac...
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PMID: 19795528
PDF is available here.
PDF is available here.
Molecular Microbiology (71)6 2009
Abstract
We report here a Plasmodium TF (AP2-O) that activates gene expression in ookinetes, the mosquito-invasive form, and has a DNA-binding domain structurally related to that of a plant TF, Apetala2 (AP2). AP2-O mRNA is pre-synthesized by intraerythrocytic female gametocytes and translated later during o...
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PMID: 19220746
PDF is available here.
PDF is available here.
Abstract
The results from this investigation suggested that reduced expression levels of Fhit, Wwox, and nuclear AP2gamma have roles in the pathogenesis of basal-like differentiation in breast cancer. Alteration in the expression of fragile site genes occurs in most of these cancers and may contribute to def...
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PMID: 19130459
PDF is available here.
PDF is available here.
Abstract
We performed genome-wide microRNA (miRNA) expression profiling and found that several miRNA species are commonly up-regulated in melanomas. Among them was mir-221, which can directly interact with c-kit 3'UTR and inhibit cKit protein translation. Observed inverse correlation of the c-kit and mir-221...
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PMID: 19126397
PDF is available here.
PDF is available here.
Breast Cancer Research (11)6 2009
Abstract
Ku proteins in interaction with AP-2 (alpha and gamma) contribute to increased ERBB2 mRNA and protein levels in breast cancer cells....
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PMID: 19906305
PDF is available here.
PDF is available here.
Breast Cancer Research (11)6 2009
Abstract
AP-2alpha/beta and YY1 are markers of good prognosis principally due to their association with oestrogen receptor but are not independent predictors. Discordant HER2 protein/gene expression is a rare event that is not always explained by the actions of AP-2 and YY1....
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PMID: 20025767
PDF is available here.
PDF is available here.
Journal of Pathology (217)1 2009
Abstract
We present an exploratory immunohistochemical study of an archival primary breast tumour series (n = 75) with parallel clinicopathological data using a new, well-characterized antibody to AP-2gamma. Heterogeneous, exclusively nuclear expression of AP-2gamma was found in the epithelial and myoepithel...
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PMID: 18825690
PDF is available here.
PDF is available here.
Abstract
The influences exerted by the epidermal growth factor receptor (EGFR) on the skin act at multiple levels, which involve compartments that normally express EGFR. These include the basal and suprabasal layers of the epidermis, sebaceous glands, and the outer root sheath of the hair follicles. The phys...
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PMID: 19379645
PDF is available here.
PDF is available here.
Abstract
We identified 1,787 Smad2/3 binding sites in the promoter regions of over 25,500 genes by chromatin immunoprecipitation on microarray in HaCaT keratinocytes. Binding elements for the v-ets erythroblastosis virus E26 oncogene homolog (ETS) and transcription factor AP-2 (TFAP2) were significantly enri...
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PMID: 18955504
PDF is available here.
PDF is available here.
Abstract
We interrogate the NC-GRN in the lamprey, taking advantage of its slow development and basal phylogenetic position to resolve early inductive events, 1 regulatory step at the time. To establish regulatory relationships at the neural plate border, we assess relative expression of 6 neural crest netwo...
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PMID: 19104059
PDF is available here.
PDF is available here.
Abstract
PKD phosphorylates AP2alpha to negatively regulate expression of ABCA1 gene to increase HDL biogenesis. The major functional phosphorylation of AP2alpha was identified at Ser258 by PKD, in the AP2alpha basic domain highly conserved among species and all 5 subtypes of AP2. PKD/AP2 system can be a pot...
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PMID: 18845787
PDF is available here.
PDF is available here.
Developmental Dynamics (237)11 2008
Abstract
We demonstrate that a third member of the chicken AP-2 family, AP-2delta, is primarily expressed in the retina and brain, with highest levels at embryonic days 7 to 11. By in situ hybridization and immunohistochemical analysis, we show that AP-2delta RNA and protein are found in a subset of ganglion...
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PMID: 18924234
PDF is available here.
PDF is available here.
Nature Genetics (40)11 2008
Abstract
We have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6). Here, we use multispecies sequence comparisons to identify a common SNP (rs642961, G>A) in a newly identified IRF6 enhancer. The A allele is sign...
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PMID: 18836445
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)1 2008
Abstract
We unmasked functional redundancies and discovered an essential role for AP-2s in the process. In vivo and in vitro, AP-2 deficiency is accompanied by surprisingly minimal changes in basal gene expression but severely perturbed terminal differentiation and suppression of additional transcription fac...
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PMID: 18824566
PDF is available here.
PDF is available here.
Abstract
In secondary hyperparathyroidism, enhanced expression of TGF-alpha in the parathyroid leads to its own upregulation, generating a feed-forward loop for TGF-alpha activation of its receptor, EGFR receptor (EGFR), which promotes parathyroid hyperplasia. These studies examined the role of activator pro...
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PMID: 18579641
PDF is available here.
PDF is available here.
Journal of Urology (180)3 2008
Abstract
To our knowledge we report for the first time that another 5 genes (SCNN1B, SYT6, DACH1, and the tumor suppressors TFAP2A and MT1G) are hypermethylated in renal cell carcinoma. Robust computational screens and the high throughput methylation assay resulted in an enriched set of novel genes that are...
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PMID: 18639284
PDF is available here.
PDF is available here.
Journal of Virology (82)17 2008
Abstract
We have shown that Nef-induced CD4 downregulation and Ii chain upregulation are genetically distinguishable. We have identified natural nef alleles that have lost one of the two functions but not the other one. Moreover, we have characterized Nef mutant forms possessing a similar phenotype in the co...
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PMID: 18596106
PDF is available here.
PDF is available here.
Circulation Research (103)4 2008
Abstract
We found that Tfap2beta, a transcription factor associated with patent ductus arteriosus in humans, was uniquely expressed in mouse ductal smooth muscle. Endothelin-1 and the hypoxia-induced transcription factor, Hif2alpha were also highly enriched in ductal smooth muscle at embryonic day 13.5 and w...
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PMID: 18635823
PDF is available here.
PDF is available here.
FASEB Journal (22)8 2008
Abstract
We show that AP-2alpha and AP-2gamma proteins play an essential role in tumorigenesis. Down-modulation of AP-2 expression in tumor cells by RNA interference (RNAi) led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. Most of these biological mo...
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PMID: 18443366
PDF is available here.
PDF is available here.
Carcinogenesis (29)7 2008
Abstract
Human papillomavirus (HPV) infection, particularly type 16, is causally associated with cancer of the uterine cervix. The persistence or progression of cervical lesions suggests that viral antigens are not adequately presented to the immune system. This hypothesis is reinforced by the observation th...
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PMID: 18566017
PDF is available here.
PDF is available here.
Clinical Endocrinology (69)1 2008
Abstract
The G/G genotype of MAPK8 SNP-1066 did not affect T2DM susceptibility despite specific binding of AP2alpha....
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PMID: 18036196
PDF is available here.
PDF is available here.
Abstract
We assayed ApiAP2 protein-DNA interactions using protein-binding microarrays and combined these results with computational predictions of coexpressed target genes to couple these putative trans factors to corresponding cis-regulatory motifs in Plasmodium. Furthermore, we show that protein-DNA sequen...
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PMID: 18541913
PDF is available here.
PDF is available here.
Circulation Research (102)12 2008
Abstract
Hyperglycemia is an independent risk factor for development of diabetic vascular complications. The molecular mechanisms that are activated by glucose in vascular cells and could explain the development of vascular complications are still poorly understood. A putative binding site for the transcript...
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PMID: 18515748
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)24 2008
Abstract
We found that only AP-2beta is predominantly expressed in the sympathetic ganglia of developing mouse embryos, supporting its role in sympathetic development. Indeed, AP-2beta null mice expressed significantly reduced levels of both noradrenaline (NA) and NA-synthesizing dopamine beta-hydroxylase in...
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PMID: 18424435
PDF is available here.
PDF is available here.
Abstract
We performed a yeast two-hybrid screen, using Ap2delta's TAD. We identified the trithorax superfamily member, Ash2l, as a binding partner that interacts exclusively with Ap2delta. We showed that Ash2l positively mediates Ap2delta transactivation in a dose-dependent manner. Given the known role of As...
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PMID: 18495928
PDF is available here.
PDF is available here.
Abstract
We analyzed TBX20 in cardiac biopsies derived from patients with TOF, ventricular septal defects (VSDs) and normal hearts. Mutation analysis did not reveal any disease causing sequence variation, however, TBX20 is significantly upregulated in tissue samples of patients with TOF, but not VSD. In dept...
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PMID: 18275040
PDF is available here.
PDF is available here.
Abstract
We detected a 3.2 Mb deletion by 500K SNP microarray in an affected mother and son with BOFS at chromosome 6p24.3. Candidate genes in this region were selected for sequencing on the basis of their expression patterns and involvement in developmental pathways associated with the clinical findings of...
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PMID: 18423521
PDF is available here.
PDF is available here.
Developmental Biology (317)1 2008
Abstract
We show that E17.5 to E18.5 Cited2-null lungs had significantly reduced terminal sac space due to an altered differentiation of type I and type II alveolar epithelial cells. In addition, E17 Cited2-null lungs exhibited a decrease in the number of apoptotic cells, contributing to the loss in airspace...
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PMID: 18358466
PDF is available here.
PDF is available here.
Developmental Biology (317)1 2008
Abstract
These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence....
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PMID: 18353300
PDF is available here.
PDF is available here.
Inflammation Research (57)5 2008
Abstract
The results suggest that cPKCs, most likely PKC beta II, upregulate TTP expression in activated macrophages. This regulation is possibly mediated through the activation of transcription factor AP-2, and serves as an additional mechanism how PKC beta regulates the inflammatory process....
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PMID: 18594783
PDF is available here.
PDF is available here.
Glycobiology (18)5 2008
Abstract
We show, for the first time, that GM3 induces transcription factor AP-2alpha-mediated PTEN expression in colon cancer cells. The enhanced expression of PTEN by GM3 in both HCT116 and p53-null HCT116 cells has been shown to be not associated with p53 function. Thus, to further determine the mechanism...
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PMID: 18316341
PDF is available here.
PDF is available here.
Neuroscience Letters (436)1 2008
Abstract
Transcription factor AP-2beta may influence brain monoaminergic systems by regulating target genes. Several monoaminergic genes, including the serotonin transporter gene, have AP-2beta binding sites. Late auditory-evoked potentials (P1, N1/P2) and impulsiveness-related personality traits are correla...
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PMID: 18358611
PDF is available here.
PDF is available here.
Abstract
Treatment with various concentrations of doxazosin for 16 h increased the apoptotic rate and total cell death rate of the HeLa cells in a dose-dependent manner and upregulated the expression of AP-2alpha and caspase-3 in a dose-dependent manner. A dose-dependent increase was observed in the caspase-...
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PMID: 18358093
PDF is available here.
PDF is available here.
Cancer Science (99)3 2008
Abstract
We demonstrate that ErbB2 expression is enhanced by low-energy UVA (300-3000 mJ/cm(2)) irradiation in the skin tissues of both hairless mice and HaCaT keratinocytes. Luciferase reporter-gene activity using the 756-bp flanking region of the human erbB2 gene was increased by UVA irradiation. UVA irrad...
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PMID: 18177484
PDF is available here.
PDF is available here.
Endocrine-Related Cancer (15)1 2008
Abstract
We studied the effects of PPARgamma and the PPARgamma agonists thiazolidinediones (TZDs) on the insulin receptor (IR), a cell membrane tyrosine kinase receptor protein, whose role is of paramount importance in mediating the metabolic and growth-promoting effects of the peptide hormone insulin. Overe...
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PMID: 18310298
PDF is available here.
PDF is available here.
Abstract
We here show that Sp1 and AP-2alpha synergistically activate the AM gene promoter. Co-transfection of the reporter plasmid containing the AM promoter region (-103/-29) with Sp1 and AP-2alpha expression plasmids showed that Sp1 and AP-2alpha synergistically increased the promoter activity in HeLa cel...
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PMID: 17719138
PDF is available here.
PDF is available here.
Developmental Dynamics (237)3 2008
Abstract
We have created a conditional deletion of AP-2alpha in the developing mouse lens (Le-AP-2alpha mutants) to determine the cell-autonomous requirement(s) for AP-2alpha in lens development. Embryonic and adult Le-AP-2alpha mutants exhibited defects confined to lens placode derivatives, including a pers...
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PMID: 18224708
PDF is available here.
PDF is available here.
Abstract
We previously reported that cAMP-dependent protein kinase (PKA)-mediated activator protein-2 (AP-2) activation was responsible for the expression of Her-2/ErbB2 in p53-inactivated mammary epithelial cells (Yang et al., 2006). In the present study, we tested the hypothesis that PKA plays a role in th...
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PMID: 18409049
PDF is available here.
PDF is available here.
Human Pathology (39)2 2008
Abstract
Organic cation transporter 3/4 (OCT3/4) is a transcription factor of embryonic stem cells; c-kit (CD117) is a tyrosine kinase receptor implicated in seminoma carcinogenesis. Their reactivity is well characterized in testicular, but not extragonadal and metastatic, germ cell tumors. A total of 93 ger...
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PMID: 18045648
PDF is available here.
PDF is available here.
Breast Cancer Research (10)1 2008
Abstract
We observed a statistically significant correlation between ERBB2 and AP-2alpha levels in the tumors (p < 0.01). Moreover, associations were found between ERBB2 protein level and the combined high expression of AP-2alpha and YY1 (p < 0.02) as well as between the expression of AP-2alpha and YY1 (p <...
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PMID: 18218085
PDF is available here.
PDF is available here.
Tumor Biology (29)1 2008
Abstract
We evaluated the prognostic value of several serum and tissue markers in MOGCTs. Medical charts of 30 women were reviewed as regards preoperative and treatment-related factors, with a mean follow-up time of 92 months (range 2-205). Serum levels of alpha-fetoprotein, human chorionic gonadotropin and...
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PMID: 18497549
PDF is available here.
PDF is available here.
Abstract
Here, we report the generation of a stable mouse keratinocyte cell line for Tet-regulated gene expression with minimal leakiness and high degree of Tet responsivity. This mouse keratinocyte cell line was further engineered for generation of a double stable cell line, which expresses the transcriptio...
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PMID: 17964120
PDF is available here.
PDF is available here.
Abstract
We have identified an intronic enhancer within this gene that directs expression to the face and limb mesenchyme. There are two conserved sequence blocks within this intron, and the larger of these directs tissue-specific activity and is found in all vertebrate Tcfap2a genes analyzed. To assess the...
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PMID: 17984226
PDF is available here.
PDF is available here.
Abstract
We have previously shown that in response to nerve growth factor (NGF), p75(NTR) is retrogradely transported along the axons of motor neurons (MNs) in carriers shared with NGF, brain-derived neurotrophic factor and the tyrosine kinase receptor TrkB. Here, we report that NGF does not enhance the inte...
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PMID: 17897318
PDF is available here.
PDF is available here.
Abstract
One well-studied signaling center in the developing vertebrate limb, the zone of polarizing activity (ZPA), produces the morphogen sonic hedgehog that is necessary for normal growth and pattern formation. To identify additional factors expressed in the ZPA of the mouse limb bud, the Shhgfpcre allele...
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PMID: 17911046
PDF is available here.
PDF is available here.
Histopathology (51)6 2007
Abstract
AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage, possibly via modulation of an epidermal growth factor receptor....
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PMID: 18042070
PDF is available here.
PDF is available here.
Abstract
We used comparative expression profiling of PAX3/FKHR silencing in vitro and PAX3/FKHR-specific gene signatures in vivo to identify physiologically important target genes. Hereby, 51 activated genes, both novel and known, were identified. We also found repression of skeletal muscle-specific genes su...
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PMID: 17525748
PDF is available here.
PDF is available here.
Carcinogenesis (28)11 2007
Abstract
We focused our study on activator protein (AP)-2alpha transcription factor that acts as a tumour suppressor gene in several cancers. In a series of 18 human DAC, using immunohistochemistry, we confirmed that MUC4 was exclusively expressed in cancerous or preneoplastic lesions in 83% of the samples....
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PMID: 17621592
PDF is available here.
PDF is available here.