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Xeroderma Pigmentosum Group A Protein (0):
Recent article
Xeroderma Pigmentosum Group A Protein
Abstract
Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix-distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and...
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PMID: 20458729
PDF is available here.
PDF is available here.
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Molecular Cell (39)2 2010
Abstract
We show that SIRT1 plays an important role in the regulation of NER pathway. Downregulation of SIRT1 significantly sensitizes cells to UV irradiation. SIRT1 interacts with XPA, and the interaction is enhanced after UV irradiation. XPA can be acetylated at lysines 63 and 67. SIRT1 deacetylates XPA bo...
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PMID: 20670893
PDF is available here.
PDF is available here.
Abstract
Among various photosensitive disorders, photosensitive genetic diseases are noticeable in that physicians play a key role in early diagnosis. Xeroderma pigmentosum (XP) and erythropoetic protoporphyria (EPP) are focused on this issue as photosensitive genetic diseases. XP is characterized by the pro...
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PMID: 20535974
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
Associations between leiomyoma with IGF2 and CDH1 polymorphism exist. Proportions of IGF2 exon 9*AA/AG/GG in and CDH1* CC/CT/TT in the groups were: group 1, 38/39.2/22.8% and 27.8/66.5/5.7%; group 2, 22.4/53.9/23.7% and 21.2/64.1/14.7. MPO, urokinase, XPA and XPD in both groups were non-significantl...
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PMID: 20651370
PDF is available here.
PDF is available here.
Abstract
The XPA R228X mutation is common in Tunisian population. This mutation is associated with a relatively moderate phenotype of the XPA. As all explored patients presented the recurrent mutation XPA R228X, a potential founder effect was searched and confirmed by haplotype analysis. Taking into account...
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PMID: 20534089
PDF is available here.
PDF is available here.
Abstract
Currently, RNA interference technology is one of the most powerful tools in molecular biology and has been widely used in genetic manipulation. In addition to chemically synthesized small interfering RNA (siRNA), vector-based methods have been developed for stable gene silencing by the expression of...
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PMID: 20217547
PDF is available here.
PDF is available here.
Abstract
We present a broad set of methods for assessing the impact of metal ions on the zinc-binding domain of xeroderma group A protein, an essential factor in nucleotide excision repair. We envisage that these methods will be useful also for other proteins....
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PMID: 20680849
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
There were significant differences in the frequency of genotypes and alleles of XRCC1 codon 194 and 399 polymorphisms between the groups. In codon 194, individuals who carried at least 1 Trp allele had a decreased risk of developing pterygium compared to those who carried the Arg/Arg wild-type genot...
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PMID: 20431719
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (128)1-3 2010
Abstract
We used bone marrow mesenchymal cells, taken from mice with the Xpa(-/-)Trp53(+/-) genotype, that were cultured and exposed to 0 and 100 muM AZT for 24 hours. Fixed and denatured cells were processed by fluorescence in situ hybridization (FISH) with whole chromosome painting probes used to identify...
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PMID: 20407220
PDF is available here.
PDF is available here.
Molecular Cell (35)5 2009
Abstract
We developed a chromatin-IP-based strategy termed eChIP and detected association of multiple FA proteins with DNA crosslinks in vivo. Interdependence analyses revealed that crosslink-specific enrichment of various FA proteins is controlled by distinct mechanisms. BRCA-related FA proteins (BRCA2, FAN...
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PMID: 19748364
PDF is available here.
PDF is available here.
DNA Repair (8)7 2009
Abstract
We have shown previously that HMGB1, a protein involved in chromatin structure, transcriptional regulation, and inflammation, can bind cooperatively to triplex-directed psoralen ICLs with RPA, and that mammalian cells lacking HMGB1 are hypersensitive to psoralen ICLs. However, whether this effect is...
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PMID: 19446504
PDF is available here.
PDF is available here.
DNA and Cell Biology (28)6 2009
Abstract
We studied the role of the antiapoptotic Bcl-x(L) protein in nucleotide excision repair (NER)-facilitated cell protection against cisplatin-induced apoptosis. Using both normal human fibroblasts (NF) and NER-defective xeroderma pigmentosum group A (XPA) and group G (XPG) fibroblasts, we demonstrated...
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PMID: 19317621
PDF is available here.
PDF is available here.
Abstract
Nucleotide excision repair (NER) is one of the most versatile DNA repair systems. It can be subdivided into several, differentially regulated, subpathways: global genome repair (GGR), transcription-coupled repair (TCR), and transcription domain-associated repair (DAR). This review begins with a brie...
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PMID: 19153657
PDF is available here.
PDF is available here.
Abstract
We show that Cep164 knockdown compromises the cell survival upon UV damage. Cep164 localizes to cyclobutane pyrimidine dimmers (CPD), one of the major DNA lesions induced by UV irradiation. Binding of Cep164 to the region of exon 4 to intron 9 within p53 gene, known as a pyrimidine-rich region as we...
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PMID: 19197159
PDF is available here.
PDF is available here.
Abstract
Journal of Chemotherapy (21)1 2009
Abstract
Cochlear lateral wall damage is a side effect of cisplatin chemotherapy. Recent studies have shown that cisplatin treatment precipitates platinated DNA adducts in the cochlear lateral wall which suggest that DNA damage may contribute to ototoxicity. Platinated adducts are high-affinity substrates fo...
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PMID: 19297277
PDF is available here.
PDF is available here.
EMBO Journal (28)4 2009
Abstract
We identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase zeta (pol zeta), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, ex...
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PMID: 19153606
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)43 2008
Abstract
We investigated the subcellular localization of RecQ4 upon treatment of cells with different DNA-damaging agents including UV irradiation, 4-nitroquinoline 1-oxide, camptothecin, etoposide, hydroxyurea, and H(2)O(2). We found that RecQ4 formed discrete nuclear foci specifically in response to UV irr...
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PMID: 18693251
PDF is available here.
PDF is available here.
Abstract
XPA A23G and XPC exon 8 Val499Ala polymorphisms may be useful markers for identifying individuals at risk of developing GCA in the high incidence region of north China....
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PMID: 18645534
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 17 2008
Abstract
We analyzed the dynamics of GFP-tagged XPC. Photobleaching experiments showed that XPC constantly associates with and dissociates from chromatin in the absence of DNA damage. DNA-damaging agents retard the mobility of XPC, and UV damage has the most pronounced effect on the mobility of XPC-GFP. XPC...
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PMID: 18682493
PDF is available here.
PDF is available here.
Abstract
We asked whether over-expression of XPA protein would alleviate the cellular sensitivity and increase the DNA repair capacity of a testis tumor cell line. Increasing XPA levels in 833K cells by 10-fold did not increase resistance to UV irradiation. XPA was localized to the cell nucleus in all cell l...
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PMID: 18240296
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)8 2008
Abstract
The interaction of nucleotide excision repair factors--xeroderma pigmentosum complementation group C protein in complex with human homolog of yeast Rad23 protein (XPC-HR23B), replication protein A (RPA), and xeroderma pigmentosum complementation group A protein (XPA)--with 48-mer DNA duplexes imitat...
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PMID: 18774935
PDF is available here.
PDF is available here.
Molecular Cell (31)1 2008
Abstract
We have followed the composition of TFIIH over time after UV irradiation of repair-proficient or -deficient human cells. We show that TFIIH changes subunit composition in response to DNA damage. The CAK is released from the core during nucleotide excision repair (NER). Using reconstituted in vitro N...
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PMID: 18614043
PDF is available here.
PDF is available here.
Abstract
We used immunohistochemistry and triple fluorescent immunostaining combined with confocal microscope scanning in brain slices of adult rat brain, including the cerebral cortex, striatum, substantia nigra compacta, ventral tegmental area, red nucleus, hippocampus, and cerebellum. Both XPA and XPB pro...
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PMID: 18543291
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (47)7 2008
Abstract
We examined the effect of trivalent inorganic and methylated arsenic metabolites on the repair of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts in normal human primary fibroblasts and their effect on repair-related protein expression. We observed that monomethylarsonous acid (MMA(III)) was the most...
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PMID: 18085531
PDF is available here.
PDF is available here.
Abstract
We inserted multiple shRNA expression sequences into a single plasmid vector. In this study, the DNA repair factor XPA was selected as a target gene since it is not essential for cell viability and it is easy to check the functional knockdown of this gene. The efficiency of knockdown was compared am...
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PMID: 18367095
PDF is available here.
PDF is available here.
Cancer Research (68)5 2008
Abstract
We believe that XPC plays a role in the removal of oxidative DNA damage and that, therefore, Xpc(-/-) mice display a significant increase in lung tumors and a significant elevation in mutant frequency in lung, and Xpc-deficient MEFs show greater sensitivity to oxygen when compared with Xpa(-/-) and...
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PMID: 18316597
PDF is available here.
PDF is available here.
Cancer Letters (260)1-2 2008
Abstract
The tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) forms DNA methylating and pyridyloxobutylating species. In this study, the involvement of nucleotide excision repair (NER) in the repair of pyridyloxobutyl adducts was assessed using an in vitro NER assay with...
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PMID: 18037231
PDF is available here.
PDF is available here.
FASEB Journal (22)2 2008
Abstract
We report that the recruitment of DSB repair factors Rad50 and Rad51 to the DSB sites, as marked by gamma-H2AX, was impaired in human HGPS and Zmpste24-deficient cells. Consistently, the progeria-associated DSBs appeared to be unrepairable although DSBs induced by camptothecin were efficiently remov...
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PMID: 17848622
PDF is available here.
PDF is available here.
Abstract
We focused on a GSNO reaction with a Cys4 zinc finger (ZF) sequence of human protein XPA, crucial to the nucleotide excision repair pathway of DNA repair. By using a corresponding synthetic 37-residue peptide acetyl-DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHK-amide (XPAzf) and combining the detection of n...
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PMID: 18171019
PDF is available here.
PDF is available here.
Lung Cancer (59)2 2008
Abstract
We examined gene-environment interactions in relation to lung cancer in 430 cases and 790 comparison persons identified within a prospective cohort of 57,053 persons. We included polymorphisms in the XPC, XPA and XPD genes involved in the nucleotide excision DNA repair pathway and analysed possible...
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PMID: 17913280
PDF is available here.
PDF is available here.
Abstract
We concluded that XPA23 polymorphism may be useful markers for identifying individuals at risk of developing ESCC. C/C genotype of XPC exon 15 may be one of the factors that affect the risk of developing ESCC in nonsmoking population in the high incidence region of China....
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PMID: 17653764
PDF is available here.
PDF is available here.
Abstract
Abstract
We propose that this indirect recognition function contributes to damage verification by probing the susceptibility of the DNA substrate to be kinked during the assembly of NER complexes....
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PMID: 19181108
PDF is available here.
PDF is available here.
Abstract
We sought to determine the involvement of Xeroderma Pigmentosum A in oxidative DNA damage-repair by treating primary fibroblasts from a patient suffering from Xeroderma Pigmentosum A with sodium arsenite and hydrogen peroxide. Our results show dose-dependent increase in genotoxicity with little chan...
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PMID: 18585952
PDF is available here.
PDF is available here.
Molecular Cancer (7)1 2008
Abstract
Either age group exhibited high frequency of overall alterations in PHF2, FANCC and PTCH1 compared to XPA. Samples with alteration (deletion/methylation) in these genes showed reduced level of mRNA expression as seen by Q-PCR. Immunohistochemical analysis of FANCC and PTCH1 also supported this obser...
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PMID: 18990233
PDF is available here.
PDF is available here.
Anticancer Research (28)5A 2008
Abstract
BACKGROUND: Cancer cells may survive cisdiamminedichloroplatinum-II (cisplatin) DNA damage through synchronous mobilization of DNA repair proteins such as xeroderma pigmentosum C and A (XPC and XPA). However, non-cancerous neuronal cells exhibit hyper-vulnerability to cisplatin which is manifest as...
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PMID: 19035288
PDF is available here.
PDF is available here.
EMBO Journal (26)22 2007
Abstract
We have investigated an essential protein-protein interaction of the NER pathway, the binding of the XPA protein to the ERCC1 subunit of the repair endonuclease ERCC1-XPF. The structure of ERCC1 in complex with an XPA peptide shows that only a small region of XPA interacts with ERCC1 to form a stabl...
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PMID: 17948053
PDF is available here.
PDF is available here.
Analytical Biochemistry (369)2 2007
Abstract
We used a synthetic 37-residue peptide acetyl-DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHK-amide (XPAzf), which corresponds to the Cys4 ZF sequence of human nucleotide excision repair protein XPA, to find out whether ESI-MS might be used quantitatively to study ZF reaction kinetics. For this purpose, we st...
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PMID: 17577569
PDF is available here.
PDF is available here.
Gynecologic Oncology (107)1 Suppl 1 2007
Abstract
This study suggests that NER gene polymorphisms may correlate with recurrence and patient survival. A larger sample size is needed to assess platinum chemotherapy response with these polymorphisms. These findings may help identify subgroups of cancer patients likely to benefit from individualized tr...
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PMID: 17825393
PDF is available here.
PDF is available here.
Human Biology (79)5 2007
Abstract
We have analyzed single nucleotide polymorphisms (SNPs) in the XPC, XPA, and XPG genes of the nucleotide excision repair (NER) pathway in the Indian population. In the XPC gene we observed nine polymorphisms in the coding region, four polymorphisms in the intronic region, and two polymorphisms in th...
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PMID: 18478970
PDF is available here.
PDF is available here.
Abstract
We recently reported an association between detectable polycyclic aromatic hydrocarbon (PAH)-DNA adducts and breast cancer risk. Using a population-based breast cancer case-control study on Long Island, New York, we examined whether polymorphisms in NER genes modified the association between PAH-DNA...
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PMID: 17932351
PDF is available here.
PDF is available here.
Journal of Virology (81)18 2007
Abstract
We amplified junctions between AAV2 DNA and AAVS1 from AAV2-infected HeLaJW cells and cells with defective Artemis or xeroderma pigmentosum group A genes. We sequenced 61 distinct junctions. The integration junction sequences show the three classical types of nonhomologous-end-joining joints: microh...
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PMID: 17626070
PDF is available here.
PDF is available here.
Journal of Neuroscience (27)35 2007
Abstract
We analyzed in a mouse model the formation and processing of the main cisplatin-induced DNA adduct (guanine-guanine intrastrand cross-link) in distinct neuronal cell types by adduct-specific monoclonal antibodies. Comparison of the adduct kinetics in cisplatin-injected mice either proficient or defi...
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PMID: 17728458
PDF is available here.
PDF is available here.
Abstract
Our findings indicate a reduced NMSC risk in relation to XPD Asp312Asn and Lys751Gln variants. Further, these data support the hypothesis that NER polymorphisms may modify the association between NMSC and arsenic....
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PMID: 17687452
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 15 2007
Abstract
We analyze and discuss the various types of DNA damage induced in cells by three different local damage induction methods: pulsed 800 nm laser irradiation, Hoechst 33342 treatment combined with 405 nm laser irradiation and UV-C (266 nm) laser irradiation. A wide variety of damage was detected with t...
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PMID: 17646676
PDF is available here.
PDF is available here.
Abstract
The Xeroderma Pigmentosum A (XPA) protein is involved in the DNA damage recognition and repair complex formation steps of nucleotide excision repair (NER), and has been shown to preferentially bind to various forms of DNA damage including bulky lesions. DNA interstrand crosslinks are of particular i...
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PMID: 17512921
PDF is available here.
PDF is available here.
Mutation Research (619)1-2 2007
Abstract
We determined the risk of colorectal cancer in association with the four polymorphisms XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn, and interactions between the polymorphisms and the environmental factors: smoking intensity, intake of alcohol, red meat, processed meat, fish and poultry,...
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PMID: 17363013
PDF is available here.
PDF is available here.
Experimental Cell Research (313)8 2007
Abstract
We provide evidence that ING1b mediates nucleotide excision repair by facilitating the access to damaged nucleosomal DNA. We demonstrate that ING1b is not recruited to UV-induced DNA lesions but enhances nucleotide excision repair only in XPC-proficient cells, implying an essential role in early ste...
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PMID: 17379210
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1770)5 2007
Abstract
Our data establish a photocrosslinking assay for the investigation of the damage recognition step in human nucleotide excision repair....
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PMID: 17320292
PDF is available here.
PDF is available here.
Abstract
We have proposed an additional role, that of a processivity factor, conferring a processive mechanism of action on XPF and XPG, the endonucleases, involved in NER. The present study was undertaken to examine the domain(s) in the XPA gene that are important for the ability of the XPA protein to funct...
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PMID: 17349973
PDF is available here.
PDF is available here.
Abstract
We examined the involvement of the nucleotide excision repair (NER) system in the removal of N2-ADPR-dG in Escherichia coli (E. coli) and human cells. The results of mobility shift gel electrophoresis assays using a 50-mer oligodeoxynucleotide containing a single N2-ADPR-dG showed that E. coli UvrAB...
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PMID: 17381135
PDF is available here.
PDF is available here.
Abstract
UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to inhibit replicon initiation. In response to stalled replication forks, ATR phosphorylates and activates the transducer kinase Chk1 through interactions with the mediator proteins TopBP1, Claspin, and Timeless (...
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PMID: 17296725
PDF is available here.
PDF is available here.
Cancer Letters (245)1-2 2007
Abstract
A single cell clonal sub-line A2780/C10B that is 18-fold resistant to oxaliplatin and approximately threefold cross-resistant to cisplatin and exhibiting a metastasis associated cellular phenotype was characterized for mechanisms of resistance. The cell line exhibited a 50% reduction in the accumula...
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PMID: 16516375
PDF is available here.
PDF is available here.
Abstract
We used transgenic mice harboring the lambda-phage-based lacZ mutational reporter gene to study the effect of Xpa null mutation (Xpa(-/-)) on damage induction, repair, and mutagenesis in mouse skin epidermis after UVB irradiation. UVB induced equal amounts of cyclobutane pyrimidine dimers (CPDs) and...
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PMID: 17163503
PDF is available here.
PDF is available here.
Abstract
We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and E...
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PMID: 17299578
PDF is available here.
PDF is available here.
Oncology (Basel) (72)5-6 2007
Abstract
Patients with XPG C/C genotype had a longer survival (p = 0.001) and TTP (p = 0.009) than patients with XPG C/T or T/T genotypes, and patients with both XPG C/C and XPA T/C or C/C genotypes had a longer survival (p = 0.0001) and TTP (p = 0.0001) than patients with other genotypes. XPG (CC) combined...
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PMID: 18204222
PDF is available here.
PDF is available here.
Abstract
The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly sugges...
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PMID: 16836470
PDF is available here.
PDF is available here.
DNA Repair (6)1 2007
Abstract
We describe the clinical, histopathologic, molecular genetic, and pathophysiological features of a 19-year-old female patient clinically diagnosed with XP as an infant. Analysis of archival material reveals a novel variation of a 13 base pair deletion in XPC exon 14 and a previously reported A>C mis...
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PMID: 17079196
PDF is available here.
PDF is available here.
Nucleic Acids Research (35)21 2007
Abstract
We present a variety of techniques to analyze this interaction in terms of selectivity and affinity. In vitro synthesized PAR was end-labeled using a carbonyl-reactive biotin analog. Binding of HPLC-fractionated PAR chains to the tumor suppressor protein p53 and to the nucleotide excision repair pro...
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PMID: 17991682
PDF is available here.
PDF is available here.