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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
DNA-Binding Proteins (60):
- Tumor Suppressor Protein p53
- Retinoblastoma Protein
- Immunoglobulin J Recombination Signal Sequence-Binding Protein
- I-kappa B Proteins
- GATA Transcription Factors
- Factor For Inversion Stimulation Protein
- Early Growth Response Transcription Factors
- Trans-Activators
- NFI Transcription Factors
- NF-kappa B
- Kruppel-Like Transcription Factors
- Hepatocyte Nuclear Factors
- Telomere-Binding Proteins
- T-Box Domain Proteins
- Proto-Oncogene Proteins c-ets
- Interferon Regulatory Factors
- G-Box Binding Factors
- Transcription Factors, General
- SOX Transcription Factors
- Replication Protein C
- Replication Protein A
- Proto-Oncogene Proteins c-rel
- POU Domain Factors
- COUP Transcription Factors
- Adenovirus E2 Proteins
- Smad Proteins
- Integration Host Factors
- Paired Box Transcription Factors
- Myeloid-Lymphoid Leukemia Protein
- Winged-Helix Transcription Factors
- Proto-Oncogene Proteins c-myc
- Proto-Oncogene Proteins c-myb
- Origin Recognition Complex
- Oncogene Protein p55(v-myc)
- Heterogeneous-Nuclear Ribonucleoprotein K
- Centromere Protein B
- Butyrate Response Factor 1
- Basic-Leucine Zipper Transcription Factors
- TCF Transcription Factors
- HMGA Proteins
- Basic Helix-Loop-Helix Transcription Factors
- Tristetraprolin
- Toll-Like Receptor 9
- Rad52 DNA Repair and Recombination Protein
- Leucine-Responsive Regulatory Protein
- HMGB Proteins
- Transcription Factor AP-2
- Rad51 Recombinase
- Proto-Oncogene Proteins c-sis
- MutS Homolog 2 Protein
- MutS DNA Mismatch-Binding Protein
- Erythroid-Specific DNA-Binding Factors
- Xeroderma Pigmentosum Group A Protein
- Proto-Oncogene Proteins c-bcl-6
- Nuclear Respiratory Factors
- Methyl-CpG-Binding Protein 2
- Matrix Attachment Region Binding Proteins
- Interferon-Stimulated Gene Factor 3
- Homeodomain Proteins
- AraC Transcription Factor
Recent article
DNA-Binding Proteins
Abstract
We identified components of the RSC chromatin remodelling complex as genetic interactors with Dia2, suggesting an additional role for Dia2 in the regulation of transcription. We show that Dia2 is involved in controlling assembly of the RSC complex. RSC belongs to a group of ATP-dependent nucleosome-...
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PMID: 21701592
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Journal of Biological Chemistry (285)52 2010
Abstract
We recently identified Grainyhead-like 2 (GRHL2) as a novel transcription factor that binds to and regulates the activity of the human telomerase reverse transcriptase (hTERT) gene promoter. In this study, we investigated the biological functions of GRHL2 and the molecular mechanism underlying hTERT...
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PMID: 20938050
PDF is available here.
PDF is available here.
Abstract
We found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and p73 were induced to stabilize in association with a significant reduction of MDM2 and Itch, suggesting that, in addition to Itch, MDM2 cou...
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PMID: 21093410
PDF is available here.
PDF is available here.
Cancer Cell (18)6 2010
Abstract
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethy...
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PMID: 21130701
PDF is available here.
PDF is available here.
Abstract
We have shown previously that immunoglobulin fragment-fused GLP-1 (GLP-1/Fc) is a structurally stable GLP-1 analog. Here, we report a non-viral GLP-1/Fc gene therapy strategy utilizing a REP78-in-trans and REB-in-cis element system to achieve a site-specific genomic integration. For this purpose, th...
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PMID: 21070745
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We analysed the function of DCAFs and Cul4-linked proteins, and identified specific subsets required for progression through G1 and S phase. We discovered C6orf167/Mms22-like protein (Mms22L) as a putative human orthologue of budding yeast Mms22, which, together with cullin Rtt101, regulates genome...
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PMID: 21113133
PDF is available here.
PDF is available here.
Abstract
We show that TAp73 is expressed in neural stem cells (NSC) and its expression increases following their differentiation. NSC from p73 null mice have a reduced proliferative potential, together with reduced expression of members of the Sox-2 and Notch gene families known to be important for NSC proli...
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PMID: 20977890
PDF is available here.
PDF is available here.
Abstract
We have noted that some neoadjuvantly treated colorectal carcinomas display loss of MMR protein immunoexpression, despite a lack of underlying MSI and preserved staining in pretreatment tumor samples. The purpose of this study was to determine the frequency of this finding. We identified 51 neoadjuv...
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PMID: 21107085
PDF is available here.
PDF is available here.
European Journal of Pharmacology (647)1-3 2010
Abstract
The expression of the bradykinin B(1) receptor is strongly regulated in vascular tissue following injury, with little or no expression in healthy tissues. The present work aimed to verify whether primary human vascular cells (umbilical vein endothelial cells, umbilical artery smooth...
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PMID: 20813106
PDF is available here.
PDF is available here.
Abstract
We show that BRCA1 expression is controlled by a dynamic equilibrium between transcriptional coactivators and co-repressors that govern histone acetylation and DNA accessibility at the BRCA1 promoter. Eviction of the transcriptional co-repressor and metabolic sensor, C terminal-binding protein (CtBP...
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PMID: 21102443
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)12 2010
Abstract
Homologous recombination is the most precise way to manipulate the genome. It has been used extensively in bacteria, yeast, murine embryonic stem cells, and a few other specialized cell lines, but it has not been available in other genetic systems such as mammalian somatic cells. How...
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PMID: 21123434
PDF is available here.
PDF is available here.
Cell Cycle (9)23 2010
Abstract
We isolated a novel allele of RAD53, rad53-rep, that separates the checkpoint function of RAD53 from the DNA replication function. rad53-rep mutants display a chromosome loss phenotype that is suppressed by increased origin dosage, providing further evidence that Rad53 plays a role in the initiation...
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PMID: 21099362
PDF is available here.
PDF is available here.
Journal of Neurosurgery (113 Suppl) 2010
Abstract
Our data support the potential for downregulation of Ku70 expression in enhancing the radiosensitivity of gliomas. The findings of our study indicate that targeted gene therapy-mediated inactivation of Ku70 may represent a promising strategy in improving the radioresponsiveness of gliomas to GKT....
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PMID: 21121806
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
We searched for GLI1-interacting proteins. We report that the chromatin remodeling protein SNF5 (encoded by SMARCB1, hereafter called SNF5), which is inactivated in human malignant rhabdoid tumors (MRTs), interacts with GLI1. We show that Snf5 localizes to Gli1-regulated promoters and that loss of S...
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PMID: 21076395
PDF is available here.
PDF is available here.
Nature Medicine (16)12 2010
Abstract
Abstract
We have investigated the effect of insertion of sites of differing affinities, either upstream or within the transcribed gene, on complex binding and transcription upregulation. Insertion of four copies of the 18D11 fragment upstream or at the 3' end of a reporter gene led to strong MSL complex bind...
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PMID: 20977887
PDF is available here.
PDF is available here.
Molecular Cell (40)3 2010
Abstract
We have discovered an E3 ubiquitin ligase, called Psh1, which controls the cellular level of Cse4 via ubiquitylation and proteolysis. The activity of Psh1 is dependent on both its RING and zinc finger domains. We demonstrate the specificity of the ubiquitylation activity of Psh1 toward Cse4 in vitro...
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PMID: 21070970
PDF is available here.
PDF is available here.
A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice.
Abstract
We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1(+/0)) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of...
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PMID: 20920476
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG, and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and...
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PMID: 20826787
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We show that PhoPN, on its own, demonstrates PhoR-dependent phosphorylation. PhoPC, the truncated variant bearing the DNA binding domain, binds in vitro to the target site with affinity similar to that of the full-length protein. To complement the finding that residues spanning Met(1) to Arg(138) of...
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PMID: 20814030
PDF is available here.
PDF is available here.
Abstract
Serum response factor (SRF) is a widely expressed protein that plays a key role in the regulation of smooth muscle differentiation, proliferation, migration, and apoptosis. It is generally accepted that one mechanism by which SRF regulates these diverse functions is through pathway-specific cofactor...
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PMID: 20739623
PDF is available here.
PDF is available here.
Abstract
We use nucleosomes methylated on DNA and on histone H3 in an affinity assay, in conjunction with a SILAC-based proteomic analysis, to identify "crosstalk" between these two distinct classes of modification. Our analysis reveals proteins whose binding to nucleosomes is regulated by methylation of CpG...
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PMID: 21029866
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
While no real improvement in the long term survival has been obtained in lung cancer, during this decade a significant improvement in cancer control has been obtained by biology driven targeted therapy as with anti EGFR tyrosine kinase. Two phases can be described in the knowledge of lung cancer bio...
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PMID: 21051316
PDF is available here.
PDF is available here.
Bulletin du cancer (97)11 2010
Abstract
A complex system of molecular milestones ensures labelling of the genome, driving its organization and functions. These milestones correspond to particular marks associated to active and repressed genes, as well as to non-coding regions or those containing repetitive sequences. Most of these marks a...
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PMID: 21047719
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of acute strenuous interval exercise and circuit exercise on nesfatin and other hormones affected by metabolic stress. Fourteen provincial and national level young male-kickboxing volunteers participated [age 20.71 ± 2.6 years, height 176.6 ± 2.8 cm, body weight 67.2 ±...
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PMID: 20625762
PDF is available here.
PDF is available here.