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Dental Enamel Proteins (1):
Recent article
Dental Enamel Proteins
Abstract
We obtained and characterized the messenger RNA sequences of ENAM in a frog, a lizard, and a crocodile; the genomic DNA sequences of ENAM in a frog and a lizard; and the putative sequence of chicken ENAM pseudogene. The comparison with mammalian ENAM sequences has revealed 1) the presence of an addi...
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PMID: 20403965
PDF is available here.
PDF is available here.
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Abstract
We tested the hypothesis that MMP-20 (enamelysin) catalyzes the cleavages that generate secretory-stage ameloblastin cleavage products. We isolated a 23-kDa ameloblastin cleavage product from developing enamel and determined its N-terminus sequence. Ameloblastin was stably expressed and secreted fro...
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PMID: 20400724
PDF is available here.
PDF is available here.
Abstract
Porcine enamel matrix derivative (EMD) has a clinical use in facilitating periodontal healing by enhancing the regeneration of alveolar bone, cementum, and periodontal ligament. The mechanism of clinical use has not been elucidated, but in vitro studies suggest that EMD may enhance healing, in part,...
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PMID: 20370422
PDF is available here.
PDF is available here.
Abstract
SCTGs, coronally advanced flaps alone or associated with other biomaterial, and GTR may be used as root-coverage procedures for the treatment of localized recession-type defects. In cases where root coverage and gain in keratinized tissue are expected, the use of SCTGs seems to be more adequate....
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PMID: 20367089
PDF is available here.
PDF is available here.
Abstract
Abstract
The combination of MIS and EMD yielded significant reductions in probing depths and improvements in attachment levels while producing no detectable recession. The 11-month results remained stable at 6 years....
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PMID: 20192871
PDF is available here.
PDF is available here.
Abstract
To evaluate a comparison of open-flap debridement (OFD) with or without the use of enamel matrix proteins (EMP) for the treatment of infrabony defects.
Ten volunteers (38 infrabony defects) were randomized to receive OFD+EMP (test site) and OFD (control site). Clinical outcomes included mean changes...
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PMID: 20165744
PDF is available here.
PDF is available here.
Pediatric Dentistry (32)1 2010
Abstract
The major protein components of the enamel matrix include the most abundant amelogenin proteins as well as less plentiful proteins such as enamelin and ameloblastin. The enamel defect in amelogenesis imperfecta (Al) generally results in enamel that is too thin (hypoplastic) or too soft (hypocalcific...
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PMID: 20298654
PDF is available here.
PDF is available here.
Abstract
Tissue engineering-based bone grafting has emerged as a viable alternative to biologic and synthetic grafts. The purpose of this study was to evaluate the effect of enamel matrix derivative (EMD; Emdogain gel, Biora AB, Malmö, Sweden) on bioactive glass in enhancing bone formation in rat calvarium...
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PMID: 20553173
PDF is available here.
PDF is available here.
Abstract
This study was undertaken to evaluate the topographical features of enamel surface deproteinized with sodium hypochlorite (NaOCl) and etched with phosphoric acid (H3PO4) compared to phosphoric acid alone using Scanning Electron Microscopic (SEM) Analysis.
30 enamel bl...
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PMID: 21417119
PDF is available here.
PDF is available here.
Abstract
We describe gel-based proteomic methods that enable parallel quantification, identification, and functional characterization of proteins from developing rat and mouse teeth. These refined methods are also likely to be applicable to other scarce samples....
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PMID: 20717792
PDF is available here.
PDF is available here.
Journal of Oral Science (52)1 2010
Abstract
Emdogain is a commercial product of unknown composition and is clinically used to induce periodontal regeneration. This study aims to review current knowledge of the in vitro effects of Emdogain on oral tissues and, in particular, factors related to carcinoma. A systematic approach was used to revie...
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PMID: 20339227
PDF is available here.
PDF is available here.
Journal of Oral Science (52)3 2010
Abstract
The primary aim of this randomized clinical investigation was to evaluate gingival recession defects treated by a coronally advanced flap and sub-epithelial connective tissue graft (SCTG) with or without enamel matrix derivative (EMD). Twelve patients with Miller's class III buccal recession defects...
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PMID: 20881341
PDF is available here.
PDF is available here.
Cells Tissues Organs (191)4 2010
Abstract
In a group of families in northern Sweden, a mutation in the ENAM gene (predicted to produce a highly truncated protein) results in the local hypoplastic form of autosomal dominant amelogenesis imperfecta. In this study, sections of deciduous teeth from members of 3 of these families were examined b...
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PMID: 19923784
PDF is available here.
PDF is available here.
Abstract
Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp);...
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PMID: 20066874
PDF is available here.
PDF is available here.
Abstract
The results were unexpected and may represent an aberration. However, the substantial reduction in deep probing depths and clinical attachment level gain in three of four specimens, in addition to the histologic findings of new cementum, new bone, a new periodontal ligament, and a new connective tis...
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PMID: 19722806
PDF is available here.
PDF is available here.
Abstract
Our study showed immediate effects of EMD on primary CD4+ lymphocyte migration, CD25 activation, and apoptosis. CD4+ lymphocyte apoptosis may be a further possible background for uneventful early wound healing as seen clinically as the result of EMD application....
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PMID: 19722805
PDF is available here.
PDF is available here.
Abstract
The goal of this investigation was to evaluate histologically and histometrically the healing process in dehiscence-type defects treated by enamel matrix derivative (EMD). Five adult female beagle dogs were used. Buccal osseous dehiscences were surgically created on the maxillary canines and the sec...
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PMID: 19639063
PDF is available here.
PDF is available here.
Abstract
Predictable and optimal coverage of exposed root surfaces is an important goal in periodontal plastic surgery. In this report, recession coverage was performed as laterally sliding flap technique with the adjunctive use of enamel matrix derivative (EMD). The cases of 2 female patients with gingival...
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PMID: 19587887
PDF is available here.
PDF is available here.
Matrix Biology (28)5 2009
Abstract
We unexpectedly found that this mouse is in fact a mutant that does not express the full-length protein but that produces a truncated form of AMBN. Mandibles from wild type and mutant mice were processed for morphological analyses and immunolabeling. Microdissected enamel organs and associated matri...
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PMID: 19375505
PDF is available here.
PDF is available here.
Abstract
This case cohort study was designed to evaluate the healing response of a minimally invasive surgical technique (MIST) in combination with enamel matrix derivative (EMD) in isolated deep intrabony defects. Forty deep intrabony defects were surgically accessed with the MIST This technique was designe...
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PMID: 19537465
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (25)4 2009
Abstract
The recombinant prokaryotic expression vector pET32a-Amelotin was constructed and the recombinant prorein was purified successfully. ELISA analysis showed the titer of the generated antiserum was 1:12,800. Western blot and immunohistochemistry analysis demonstrated this antibody bound specifically w...
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PMID: 19351503
PDF is available here.
PDF is available here.
Abstract
We sought to examine DPPI expression in mouse enamel organ and determine if DPPI could activate KLK4. Real-time PCR showed DPPI expression throughout amelogenesis, with highest expression at maturation, and immunohistochemical staining of mouse incisors confirmed DPPI expression by ameloblasts. We d...
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PMID: 19407151
PDF is available here.
PDF is available here.
Abstract
FAM83H gene mutations are associated with autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI), which is typically characterized by enamel having normal thickness and a markedly decreased mineral content. This study tested the hypothesis that there are phenotype and genotype association...
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PMID: 19407157
PDF is available here.
PDF is available here.
Abstract
The cellular activities stimulated by EMD are not associated with a single molecular weight species. The fact that noggin abolishes C2C12 alkaline phosphatase activity suggests that effects on osteoprogenitor cell differentiation are the result of a BMP-like protein(s), whereas effects on proliferat...
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PMID: 19335085
PDF is available here.
PDF is available here.
Abstract
We generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-/-)/Ambn(-/-) mice, not only was the ameloblast layer irregular and detached from the enamel surface, as in Ambn(-/-), but also, the enamel widt...
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PMID: 19407150
PDF is available here.
PDF is available here.
Orvosi Hetilap (150)11 2009
Abstract
Several methods are available to enhance the healing and regeneration of periodontal tissues after surgical therapy of intrabony defects. The main indications for the use of combined regenerative procedures are the extent and morphology of the osseous lesions. The six studies of the present disserta...
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PMID: 19258248
PDF is available here.
PDF is available here.
Abstract
First we confirmed the ability of apical bud to form crown-like structure ectopically. Equally important, by using the developing apical complex (DAC) conditioned medium, we found the microenvironment created by root could abrogate the "crown" features of ABCs and promote their proliferation and dif...
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PMID: 20690501
PDF is available here.
PDF is available here.
Abstract
Localized aggressive periodontitis is a distinct entity of periodontal disease and is characterized by deep vertical bony defects that typically affect the first molars and incisors of young patients. Therapy is usually aimed at reducing the pathogenic microflora through scaling and root planing and...
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PMID: 19244886
PDF is available here.
PDF is available here.
Abstract
The gain in proximal attachment after treating intrabony defects by flap surgery with BCF was significant (P = 0.004) and twice that following treatment with EMD (P = 0.056). Patient and site variables affected the clinical outcome differently....
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PMID: 19186961
PDF is available here.
PDF is available here.
Abstract
We examined developing tooth enamel in rats exposed to cadmium to test the hypothesis that cadmium exposure may cause defects in crystal formation. Electron microscopy revealed the presence of perforated crystals in developing tooth enamel, indicating that the process of crystal nucleation may have...
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PMID: 20009383
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
We identify cis- regulatory regions necessary for normal enamelin (Enam) expression. Sequence analysis of the Enam promoter 5'-noncoding region identified potentially important cis-regulatory elements located within 5.2 kb upstream of the Enam translation initiation site. DNA constructs containing 5...
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PMID: 18703866
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
The presence of LRAP leads to changes in enamel appearance compared to enamel from KO mice. Expression of a combination of amelogenin transgenes in KO mice may lead to rescue of the individual characteristics of normal enamel.
Copyright 2008 S. Karger AG, Basel....
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PMID: 18701811
PDF is available here.
PDF is available here.
Cells Tissues Organs (189)1-4 2009
Abstract
Amelogenesis imperfecta (AI) is caused by AMEL, ENAM, MMP20 and KLK4 gene mutations. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been generated. These mouse models provide tools for understanding enamel formation and AI pathogenesis. This study describes the AI phenotypes and rel...
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PMID: 18714142
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (112)51 2008
Abstract
Amelogenin is the predominant protein found during enamel development and has been shown to be essential to proper enamel formation. Leucine-rich amelogenin peptide (LRAP) is a naturally occurring splice variant that preserves the charged N- and C-termini of full length amelogenin, regions thought t...
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PMID: 19368031
PDF is available here.
PDF is available here.
Abstract
In this consecutive series, 14 patients with severe intrabony defects and pathologic tooth migration were treated with guided tissue regeneration (GTR) and subsequent orthodontic therapy in an attempt to evaluate the validity of this multidisciplinary approach. Probing pocket depths (PPD), clinical...
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PMID: 19146051
PDF is available here.
PDF is available here.
Journal of Periodontology (79)12 2008
Abstract
Analysis of soft and hard tissue measurements demonstrated a statistically significant difference from baseline within each group (P <0.001); however, there was no statistically significant difference between the groups. CONCLUSION: Both treatments were shown to be safe and effective therapy for per...
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PMID: 19053917
PDF is available here.
PDF is available here.
Journal of Periodontology (79)12 2008
Abstract
The treatment of intrabony defects in patients with chronic advanced periodontitis using GTR or EMD led to significantly improved clinical parameters. Tests of statistical significance demonstrated better results with EMD, although the absolute differences between treatment modalities was small. Fur...
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PMID: 19053918
PDF is available here.
PDF is available here.
Journal of Periodontology (79)12 2008
Abstract
The evidence reported in the literature indicates that it is advisable to treat infrabony defects > or = 3 mm by OFD, GTR, and EMD. Further studies on these topics should be encouraged. There is a need for well-conducted RCTs that report data on complications and patient opinions....
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PMID: 19053910
PDF is available here.
PDF is available here.
Abstract
We have shown that mice lacking nectin-1 exhibit defective enamel formation in their incisor teeth. Although the incisors of nectin-1-null mice were hypomineralized, the protein composition of the enamel matrix was unaltered. While strong immunostaining for nectin-1 was observed at the interface bet...
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PMID: 18703497
PDF is available here.
PDF is available here.
Abstract
I and II) and with at least 4.0 mm of clinical attachment loss were treated with a modified surgical technique for root coverage by CTG with EMD (45 recession defects) or EMD only (47 recession defects). Vertical recession depth, probing depth, clinical attachment level, dehiscence depth, width of k...
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PMID: 18991001
PDF is available here.
PDF is available here.
Journal of Periodontology (79)10 2008
Abstract
The combination of EMD with a BCP bone substitute did not interfere with the regenerative potential reported for EMD and may result in formation of new cementum with an associated periodontal ligament. However, the combination of EMD + BCP resulted in no to minimal new bone formation....
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PMID: 18834256
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (22)9 2008
Abstract
(1) The cell attachment experiment: There were significant differences in attachment cells between the control group, group A and the groups B, C and D (P < 0.05). There were no significant difference between group A and control group (P < 0.05). (2) The cell proliferation experiment: At 2 days, the...
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PMID: 18822741
PDF is available here.
PDF is available here.
Journal of Oral Science (50)3 2008
Abstract
Recent studies indicate that nanocrystalline hydroxyapatite (nano-HA) paste represents a promising class of bone graft substitute. However, the underlying molecular mechanisms of nano-HA function have not yet been determined. This study was conducted to investigate the proliferation of human periodo...
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PMID: 18818463
PDF is available here.
PDF is available here.
Abstract
Treatment with EMD yielded a mean CAL gain of 3.4+/-1.0 mm (p<0.001) and 2.9+/-1.4 mm (p<0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2+/-1.4 (p<0.001) at 1 year and 2.8+/-1.2 mm (p<0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3+/-1.1 mm (p<0.001) a...
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PMID: 18647201
PDF is available here.
PDF is available here.
Abstract
Treatment of an intrabony defect with surgery plus EMD demonstrated excellent bone fill as assessed with conventional radiographic and tomographic examinations performed over 30 months. Larger studies are needed to further assess the use of DVT imaging as an appropriate adjunctive diagnostic tool fo...
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PMID: 18771385
PDF is available here.
PDF is available here.
Abstract
We previously reported that EMD (Enamel Matrix Derivative) induces proliferation of human gingival fibroblasts via activation of Extracellular Regulated Kinase (ERK), and this study assessed the possible mediatory role of EGFR (Epidermal Growth Factor Receptor) in this effect. Treatment of gingival...
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PMID: 18719212
PDF is available here.
PDF is available here.
Abstract
Stimulation with EMD significantly (P < .01) enhanced mRNA expression of BSP up to 13.9-fold and of OPN up to 3.2-fold at day 16 compared with the 2% FCS control. The expression of mRNA for transcription factor Runx2 was not significantly changed. CONCLUSION: The beneficial effects seen in periodont...
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PMID: 18547835
PDF is available here.
PDF is available here.
Abstract
The data suggest a significant clinical benefit of supplementary application of EMD during surgical treatment of periodontitis of supra-alveolar pockets, especially in deeper pockets....
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PMID: 18631246
PDF is available here.
PDF is available here.
Abstract
This case report describes the treatment of a 55-year-old man who presented with a missing maxillary first molar and mesially inclined neighboring second molar with a severe circumferential bone defect. After bone regeneration therapy with bone grafting, the second molar was uprighted orthodonticall...
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PMID: 18717376
PDF is available here.
PDF is available here.
Abstract
Our long-term objective is to develop methods to form, in the jaw, bioengineered replacement teeth that exhibit physical properties and functions similar to those of natural teeth. Our results show that cultured rat tooth bud cells, seeded onto biodegradable scaffolds, implanted into the jaws of adu...
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PMID: 18650546
PDF is available here.
PDF is available here.
Abstract
We hypothesized that Emdogain stimulated degradation of type I collagen via osteoblasts. We showed that Emdogain enhanced cell-mediated degradation of type I collagen in an MMP-dependent manner. Although MG-63 cells spontaneously produced a zymogen form of MMP-1, treatment with Emdogain significantl...
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PMID: 18650553
PDF is available here.
PDF is available here.
Abstract
We suggest that the increase of beta-sheet conformation in the presence of Ca(2+) may allow preferable interaction of the 32 kDa enamelin with apatite crystal surfaces during enamel biomineralization. The calcium association constant (K(a)=1.55 (+/-0.13)x10(3)M(-1)) of the 32 kDa enamelin calculated...
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PMID: 18508280
PDF is available here.
PDF is available here.
Abstract
The EMD treatment significantly increased the production of IL-6 and TGF-beta1 (P < .05) at all time points. The release of OPG was also increased in mouse osteoblasts (P < .05). IGF-I and BMP-2 were not detected in both control and EMD-treated groups. CONCLUSION: This study suggests that the stimul...
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PMID: 18585627
PDF is available here.
PDF is available here.
Oral Diseases (14)5 2008
Abstract
We have documented the presence of tall secretory columnar cells, arranged in a circular configuration actively secreting enameloid-like material and believe that such an ordered arrangement of secretory cells is more likely a result of tissue induction rather than metaplasia. The origin of these se...
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PMID: 18938270
PDF is available here.
PDF is available here.
Archives of Oral Biology (53)7 2008
Abstract
Using microarrays, miRNA expression profiles have been established at selected times during development (E15.5, P0 and P5) of the murine first molar mandibular tooth germ and the right submandibular salivary gland (E15.5, P0, P5 and P25). Microarray data was validated using real-time PCR, also facil...
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PMID: 18346711
PDF is available here.
PDF is available here.
Abstract
We mechanically tested specimens in which water and organic matrix were selectively removed. Tests were performed in mid-sagittal and transverse orientations to assess the effect of the structural organization on enamel micromechanical properties. While removal of organic matrix resulted in up to a...
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PMID: 18573984
PDF is available here.
PDF is available here.
Abstract
In the negative control and EMD groups, the histologic analysis showed no bone formation within the center of the defect and limited bone repair at its margins. In the DFDBA group, granules of DFDBA were still present 8 weeks after implantation, and a limited degree of osteoinduction was seen at the...
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PMID: 18597604
PDF is available here.
PDF is available here.
Dental Traumatology (24)3 2008
Abstract
The time elapsed between a trauma and tooth replantation usually ranges from 1 to 4 h. The chances of root surface damage are higher when tooth replantation is not performed immediately or if the avulsed tooth is not stored in an adequate medium. This invariably leads to necrosis of pulp tissue, per...
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PMID: 18410388
PDF is available here.
PDF is available here.
Dental Traumatology (24)3 2008
Abstract
The purpose of the present investigation was to use an intra-individual experimental-control study design to explore if application of Emdogain prior to re-plantation after a dry extra-alveolar period of 60 min would promote a favorable healing of the periodontal ligament cells. Ten patients, for wh...
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PMID: 18410386
PDF is available here.
PDF is available here.