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GTP-Binding Protein Regulators (3):
Recent article
GTP-Binding Protein Regulators
Abstract
We demonstrate that deletion of the filamentous protein Septin 5 imparts immature synapses with striking morphological and functional features reminiscent of mature synapses. This includes synaptic vesicles tightly localized to active zones, resistance to the slow Ca(2+) buffer EGTA and a reduced nu...
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PMID: 20624595
PDF is available here.
PDF is available here.
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Pharmacological Reviews (62)2 2010
Abstract
Heptahelical G protein-coupled receptors are the most diverse and therapeutically important family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins that transmit intracellular signals by regulating effector enzymes or ion channels. G protein signaling is terminate...
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PMID: 20427692
PDF is available here.
PDF is available here.
Abstract
We discovered that the regulator of G protein signalling (RGS) protein, EGL-10, is required for appropriate avoidance responses to noxious stimuli sensed by ASH. As it does for other behaviours in which it is also involved, egl-10 interacts genetically with the G(o)/(i)α protein GOA-1, the G(q)α p...
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PMID: 21070627
PDF is available here.
PDF is available here.
Abstract
Approximately 90% of alcoholics relapse within 4 years, in part because of an enhanced motivation to seek alcohol (EtOH). A novel G protein modulator (Gpsm1/AGS3) was up-regulated in the rat nucleus accumbens core (NAcore) but not in other limbic nuclei during abstinence from operant EtOH self-admin...
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PMID: 18719114
PDF is available here.
PDF is available here.
Animal Genetics (39)4 2008
Abstract
Abstract
We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucle...
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PMID: 18403676
PDF is available here.
PDF is available here.
Abstract
We investigated the phosphorylation of phosducin, an abundant photoreceptor-specific phosphoprotein. In mice exposed to a daily light-dark cycle, robust daily rhythms of phosducin phosphorylation and retinal dopamine metabolism were observed. Phospho-phosducin levels were low during the daytime and...
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PMID: 18547251
PDF is available here.
PDF is available here.
Abstract
We discuss the precise regulation of Ras and Rho subfamilies of GTPases by GEFs and other regulatory proteins during cardiac hypertrophy. In addition, we summarize recent published data, mainly those describing the role of small G proteins in the development of myocardial hypertrophy and we further...
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PMID: 18339399
PDF is available here.
PDF is available here.
Plant Cell Online (20)4 2008
Abstract
We studied the role of two close Phosducin-Like Protein 3 homologs from Arabidopsis thaliana (PLP3a and PLP3b) in the microtubule assembly pathway and determined the consequences of inhibiting PLP3a and PLP3b expression in the meristem. PLP3 function is essential in Arabidopsis: impairing PLP3a and...
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PMID: 18390592
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)13 2008
Abstract
We demonstrate that the knock-out of transducin gamma-subunit leads to a major downregulation of both alpha- and beta-subunit proteins, despite nearly normal levels of the corresponding transcripts, and fairly rapid photoreceptor degeneration. Significant fractions of the remaining alpha- and beta-s...
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PMID: 18367617
PDF is available here.
PDF is available here.
Abstract
RGS proteins and G alpha(i2) signaling play important roles in the control of insulin sensitivity and glucose metabolism. Identification of the specific RGS proteins involved might permit their consideration as potential therapeutic targets for obesity-related insulin resistance and type 2 diabetes....
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PMID: 17928396
PDF is available here.
PDF is available here.
Abstract
The G protein coupled oxytocin receptor (OTR) reveals some specific molecular and physiological characteristics. Ligand-receptor interaction has been analysed by photoaffinity labelling, site-directed mutagenesis, the construction of receptor chimeras and molecular modelling. Major results of these...
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PMID: 18655883
PDF is available here.
PDF is available here.
Abstract
We use approximately 3100bp of mitochondrial (ND2, ND4) and nuclear (RAG1, phosducin) DNA sequence data to recover phylogenetic relationships among 14 of the 16 recognized taxa of the lizard genus Paroedura as well as two undescribed forms. These geckos are endemic to Madagascar and the Comores and...
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PMID: 18077188
PDF is available here.
PDF is available here.
Learning & Memory (15)4 2008
Abstract
We showed previously that pairing activation of receptors that inhibit adenylate cyclase (AC) and reduce the concentration of cyclic AMP, with elevation of the concentration of cyclic GMP is sufficient to elicit a presynaptically expressed form of LTD at Schaffer collateral-CA1 synapses in the hippo...
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PMID: 18391187
PDF is available here.
PDF is available here.
Journal of Experimental Biology (210)Pt 23 2007
Abstract
We showed that this protein is bound by phosphorylated Pdc in a cell adapted to darkness. The results of this study provide additional detailed characterization of the functional properties of the ciliate Pdc. The likely functional role of Pdc in Blepharisma is discussed....
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PMID: 18025019
PDF is available here.
PDF is available here.
Cellular Signalling (19)12 2007
Abstract
Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G protein betagamma dimers (Gbetagamma) and inhibiting their ability to interact with G protein alpha subunits (Galpha) and effectors. However, recent findings have over-turned th...
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PMID: 17658730
PDF is available here.
PDF is available here.
Abstract
We review what is known about all the members of the Arf family, along with the known regulatory molecules that convert them between GDP- and GTP-bound states....
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PMID: 17506703
PDF is available here.
PDF is available here.
Abstract
We have identified complexes of the Galphao-selective RGS proteins RGS7 and RGS11, with their obligate binding partner, Gbeta5, that are localized to the dendritic tips of murine rod and cone ON-bipolar cells, along with mGluR6. Experiments using pre- and post-synaptic markers, and a dissociated bip...
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PMID: 18001285
PDF is available here.
PDF is available here.
Microbiology (61)1 2007
Abstract
Filamentous fungi are multicellular eukaryotic organisms known for nutrient recycling as well as for antibiotic and food production. This group of organisms also contains the most devastating plant pathogens and several important human pathogens. Since the first report of heterotrimeric G proteins i...
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PMID: 17506673
PDF is available here.
PDF is available here.
Abstract
We directly tested this hypothesis by characterizing the dark- and light-adapted response properties of phosducin knockout (Pd- / -) rods. Pd- / - rods were notably less sensitive to light than wild-type (WT) rods. The gain of transduction, as measured by the amplification constant using the Lamb-Pu...
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PMID: 17724163
PDF is available here.
PDF is available here.
Abstract
Recent animal studies have highlighted very promising novel therapeutic possibilities, based on the regulation of adrenergic receptor function, and novel signaling pathways are being discovered that could be relevant for future molecular approaches. SUMMARY: This review highlights some of the novel...
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PMID: 17762546
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)32 2007
Abstract
We quantitatively analyzed light dependence, time course, and subcellular localization of two principal light-regulated phosphorylation sites of phosducin, serine 54 and 71. To obtain physiologically relevant data, our experimental model exploited free-running mice and rats subjected to controlled i...
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PMID: 17569665
PDF is available here.
PDF is available here.
Abstract
Pathogenic bacteria have evolved several clever survival strategies for manipulating host cell signaling pathways to establish beneficial replicative niches within the host. Recent literature has revealed novel mechanisms adopted by bacteria to manipulate host responses. For instance, host signaling...
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PMID: 17662586
PDF is available here.
PDF is available here.
Journal of Physiology (581)Pt 1 2007
Abstract
We have proposed that Galphai3-GDP regulates GIRK gating, keeping its basal activity low but priming (predisposing) the channel for activation by agonist in intact cells, and by Gbetagamma in excised patches. Here we have further investigated GIRK priming by Galphai3 using a model in which the chann...
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PMID: 17289785
PDF is available here.
PDF is available here.
Microbiology (153)Pt 4 2007
Abstract
These results suggest that cag8 is involved in the modulation of conidiation, virulence and hydrophobin synthesis in M. anisopliae....
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PMID: 17379711
PDF is available here.
PDF is available here.
Abstract
These results altogether suggest that Jpk could be a useful cell death-triggering molecule applicable for cancer therapy as well as a useful target molecule for the treatment of certain neurodegenerative diseases caused by ER stress....
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PMID: 17404020
PDF is available here.
PDF is available here.
Journal of Physiology (581)1 2007
Abstract
We have proposed that G03B1i32013GDP regulates GIRK gating, keeping its basal activity low but priming (predisposing) the channel for activation by agonist in intact cells, and by G03B203B3 in excised patches. Here we have further investigated GIRK priming by G03B1i3 using a model in which the chann...
PDF is available here.
PDF is available here.
Abstract
We performed gene expression profiling to study the cellular response to MAGP1B using whole-genome genechips. We found that MAGP1B specifically induces the expression of genes linked to cell adhesion, motility, metabolism, gene expression, development and signal transduction. Versican, a gene produc...
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PMID: 17692555
PDF is available here.
PDF is available here.
Abstract
We isolated cDNAs encoding medaka Gbeta1 and GbetaC, which selectively expressed rods and cones. Immunohistochemical studies showed that the strong reactivity of GbetaC but not PD-C was detected in cone outer segments. In rod outer segments (ROS), PD-R reactivity was stronger in light-adapted retina...
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PMID: 16958559
PDF is available here.
PDF is available here.
Abstract
We tried to analyze the relationship between Jpk and Hoxa7 during apoptosis after confirming the regulatory effect of Jpk on the expression of Hoxa7 in F9 teratocarcinoma cells. For that purpose, an effector (pEGFP-Jpk) and reporter (pGL2-NM307) plasmid containing a luciferase gene under the 307 bp...
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PMID: 17384261
PDF is available here.
PDF is available here.
Abstract
We report a straightforward method for the fabrication of DNA-templated nickel nanostructures on surfaces. These nickel nanomaterials have potential to be applied as nanowires, as templated catalyst lines, as nanoscale magnetic domains, or in directed protein localization. Indeed, we show here that...
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PMID: 17107012
PDF is available here.
PDF is available here.
Abstract
Five of 21 H-2 Kb/Db-binding retinal protein-derived peptides were found to be immunogenic, suggesting that these peptides could function as autoantigenic epitopes in the development of inflammatory eye diseases, such as uveitis....
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PMID: 16936108
PDF is available here.
PDF is available here.
Abstract
We utilized a proximal signaling event, intracellular calcium mobilization, to determine if agonist stimulation of particular Gq-coupled receptors would result in increased sensitivity for stimulation of other Gq-coupled receptors. Platelets express three Gq-coupled receptors for thrombin, thromboxa...
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PMID: 16973501
PDF is available here.
PDF is available here.
Molecular Pharmacology (70)1 2006
Abstract
We observed similar results after activation of heterologously expressed metabotropic glutamate receptors with 100 microM L-glutamate. Neurons expressing PDC or PDCL maintained suppression of inhibition after re-exposure to agonist. Unlike other Gbetagamma sequestering proteins that abolish the shor...
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PMID: 16608918
PDF is available here.
PDF is available here.
Journal of Cell Science (119)Pt 13 2006
Abstract
Bioluminescence resonance energy transfer (BRET) and co-immunoprecipitation experiments revealed that heterotrimeric G proteins and their effectors were found in stable complexes that persisted during signal transduction. Adenylyl cyclase, Kir3.1 channel subunits and several G-protein subunits (Galp...
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PMID: 16787947
PDF is available here.
PDF is available here.
Developmental Biology (294)1 2006
Abstract
Our results indicate that MAU-8/PhLP modulates G protein signaling, stability and subcellular location to regulate various physiological functions, and they suggest that MAU-8 might not be limited to the Galphaq/Galphao network....
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PMID: 16580661
PDF is available here.
PDF is available here.
Abstract
I discuss the molecular mechanisms by which these phenomena might be explained including specific interactions between the RGS and G-protein coupled receptor, G-protein and effector....
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PMID: 16675274
PDF is available here.
PDF is available here.
Abstract
We discuss these findings and their implications for established models of GPCR signaling....
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PMID: 16647283
PDF is available here.
PDF is available here.
Abstract
Regulator of G protein signalling (RGS) proteins are vital in the adaptation of cells to stimulation via G protein-coupled receptors. Yeast have been integral in elucidating the important role that RGS proteins play within cellular processes. In addition to extensive characterisation of the endogeno...
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PMID: 16698293
PDF is available here.
PDF is available here.
Abstract
G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs. These interactions are implicated in targeting, trafficking, an...
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PMID: 16648668
PDF is available here.
PDF is available here.
Journal of Microbiology (44)2 2006
Abstract
Heterotrimeric G proteins (G proteins) are conserved in all eukaryotes and are crucial components sensing and relaying external cues into the cells to elicit appropriate physiological and biochemical responses. Basic units of the heterotrimeric G protein signaling system include a G protein-coupled...
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PMID: 16728950
PDF is available here.
PDF is available here.
Psychiatry Research (141)3 2006
Abstract
The importance of signal transduction processes beyond receptors involving receptor-G protein coupling, in both the pathophysiology and the treatment of mood disorders, is well documented. Thus, regulatory elements of G protein function may play a role in the molecular mechanisms underlying these al...
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PMID: 16510194
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)13 2006
Abstract
We report that phosducin is regulated at the posttranslational level by modification with the small ubiquitin-related modifier, SUMO. We demonstrate modification with SUMO for phosducin in vitro expressed in cells and for native phosducin purified from retina and the heart. A consensus motif for SUM...
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PMID: 16421094
PDF is available here.
PDF is available here.
Abstract
We show here that Gbetagamma subunits inhibit G protein GAP activity during receptor-stimulated, steady-state GTPase turnover. GDP/GTP exchange catalyzed by receptor requires Gbetagamma in amounts approximately equimolar to Galpha, but GAP inhibition was observed with superstoichiometric Gbetagamma....
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PMID: 16407201
PDF is available here.
PDF is available here.
Abstract
We used high resolution proteomics to compare the proteomes of the rd1 mouse retina and its congenic, wild-type counterpart at postnatal day 11 when photoreceptor death is profound. Over 3000 protein spots were consistently resolved by two-dimensional gel electrophoresis and subjected to a rigorous...
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PMID: 16253986
PDF is available here.
PDF is available here.
Abstract
Physiological changes taking place in carbon-starved, autolysing cultures of Aspergillus (Emericella) nidulans strains with mutations in the GanB/RgsA heterotrimeric G protein signalling pathway were studied and compared. Deletion of the ganB, rgsA or both genes did not alter markedly either the aut...
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PMID: 17139616
PDF is available here.
PDF is available here.
Supportive Care Cancer (13)10 2005
Abstract
The use of combinations of potent opioids is a common clinical practice. The addition of one potent opioid to another has been recommended to reduce opioid side effects, improve pain control, and limit dose escalation of the first opioid. The advantages of using combined opioids have been reported t...
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PMID: 15999263
PDF is available here.
PDF is available here.
Psychopharmacology (180)1 2005
Abstract
RGS proteins are GTPase-activating proteins (GAP) that accelerate the hydrolysis of GalphaGTP to terminate signalling at effectors. The GAP activity of RGS-R4 and RGS-Rz proteins restricts the amplitude of opioid analgesia, and the efficient deactivation of GalphazGTP subunits by RGS-Rz proteins pre...
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PMID: 15830230
PDF is available here.
PDF is available here.
Abstract
We have previously reported that motile photophobic response in ciliate Blepharisma japonicum correlates with dephosphorylation of a cytosolic 28 kDa phosphoprotein (PP28) exhibiting properties similar to those of phosducin. Here we demonstrate in in vivo phosphorylation assay that the light-elicite...
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PMID: 15878118
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (280)17 2005
Abstract
We investigated Gbetagamma dependence of the basal GIRK activity (A(GIRK,basal)) quantitatively, by titrated expression of Gbetagamma scavengers, in Xenopus oocytes expressing GIRK1/2 channels and muscarinic m2 receptors. The widely used Gbetagamma scavenger, myristoylated C terminus of beta-adrener...
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PMID: 15728579
PDF is available here.
PDF is available here.
Nature Neuroscience (8)4 2005
Abstract
We characterize direct inhibitory actions of G protein betagamma (Gbetagamma) on Ca(2+)-triggered vesicle exocytosis in permeable PC12 cells. Gbetagamma inhibition was rapid (<1 s) and was attenuated by cleavage of synaptosome-associated protein of 25 kD (SNAP25). Gbetagamma bound soluble N-ethylmal...
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PMID: 15778713
PDF is available here.
PDF is available here.
Addiction Biology (10)1 2005
Abstract
Repeated opiate administration alters gene expression in different brain regions of rodents, an effect which may contribute to plastic changes associated with addictive behaviour. There is increasing evidence that multiple transcription factors are induced in morphine tolerance, sensitization and du...
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PMID: 15849022
PDF is available here.
PDF is available here.
Acta Biochimica Polonica (52)4 2005
Abstract
Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein alpha subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstr...
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PMID: 16302027
PDF is available here.
PDF is available here.
Tsitologiia (47)4 2005
Abstract
The review summarizes current data regarding transduction mechanisms by cAMP-PKA signal pathway in unicellular eukaryotes. Conceptions of evolutionary origin of eukaryotic signal transduction systems are developed.
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PMID: 16706152
PDF is available here.
PDF is available here.
Visual Neuroscience (22)1 2005
Abstract
Phosducin (Pd) is a 28-kD phosphoprotein whose expression in retina appears limited to photoreceptor cells. Pd binds to the beta,gamma subunits of transducin (Gt). Their binding affinity is markedly diminished by Pd phosphorylation. While Pd has long been regarded as a candidate for the regulation o...
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PMID: 15842737
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (279)52 2004
Abstract
We prepared antibodies specific to the three principal phosphorylation sites (Ser-54, Ser-73, and Ser-106) and measured the kinetics of phosphorylation/dephosphorylation during light/dark adaptation and the subsequent effects on G(t)beta gamma binding. Ser-54 phosphorylation increased slowly (t((1/2...
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PMID: 15485848
PDF is available here.
PDF is available here.
Abstract
We previously identified a novel cDNA with homology to human rhotekin and in this study we cloned and characterized the coding region of this novel 12-exon gene. The ORF encodes a 609 amino-acid protein comprising a Class I Rho-binding domain and pleckstrin homology (PH) domain. Cellular cDNA expres...
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PMID: 15504364
PDF is available here.
PDF is available here.
Fungal Genetics and Biology (41)10 2004
Abstract
The aflT gene resides between the polyketide synthase gene pksA and the P450-encoding cypA gene in the aflatoxin gene cluster of Aspergillus parasiticus. It is a single copy gene in the genome of A. parasiticus SRRC 2043 and SU-1 and was also found at the same relative position in the genome of Aspe...
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PMID: 15341913
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that there are rod- and cone-specific PDs (OlPD-R and OlPD-C) in the retina of the teleost fish, medaka (Oryzias latipes) [FEBS Lett. 502 (2001) 117]. A 6x His affinity precipitation assay revealed that phosphorylation by either protein kinase A (PKA) or Ca(2+)/calmod...
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PMID: 15325255
PDF is available here.
PDF is available here.
Abstract
We use this information to make predictions about signal transduction? This problem is particularly difficult when receptors dimerize with many different species, leading to a combinatoric increase in the possible number of dimer pairs. As an example system, we focus on receptors in the G-protein co...
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PMID: 15207471
PDF is available here.
PDF is available here.