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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Glycoproteins (2):
Recent article
Glycoproteins
FEBS Journal (278)19 2011
Abstract
We investigated, for the first time, the alterations of the bovine milk N-glycome during early lactation (1 day, 1, 2, 3 and 4 weeks postpartum), characterizing more than 80 N-glycans. The glycomic profile of colostrum on day 1 after calving differed substantially from that in other periods during e...
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PMID: 21834831
PDF is available here.
PDF is available here.
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Abstract
We recently characterized the interaction between the intraviral domains of envelope glycoproteins (Gn and Gc) and ribonucleoprotein (RNP) of Puumala and Tula hantaviruses (genus Hantavirus, family Bunyaviridae). Herein we report a direct interaction between spike-forming glycoprotein and nucleic ac...
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PMID: 21807393
PDF is available here.
PDF is available here.
Abstract
We describe here the exosome-mediated release of small membrane vesicles containing the stem and cancer stem cell marker prominin-1 (CD133) during haematopoietic cell differentiation. Surprisingly, this contrasts with the budding mechanism underlying the release of this cholesterol-binding protein f...
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PMID: 21591261
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We show that Saccharomyces cerevisiae NMD mutants accumulate 5'-extended RNAs (CD-CUTs) of many subtelomeric genes. Using the subtelomeric ZRT1 and FIT3 genes activated in response to zinc and iron deficiency, respectively, we show that transcription of these CD-CUTs mediates repression at the bona...
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PMID: 21738494
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We have demonstrated that human antibodies with specific human N-glycan structures can be produced in glycoengineered lines of Pichia pastoris and that antibody-mediated effector functions can be optimized by generating specific glycoforms. In this chapter we provide detailed protocols for the analy...
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PMID: 19277549
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Majority of protein drugs in development today are glycoproteins e.g. recombinant antibodies expressed in various cell lines. Oligosaccharides through conformational changes can modulate therapeutic value (potency) of glycoproteins e.g. complement dependent cell cytotoxicity (CDCC) and antibody-depe...
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PMID: 18373267
PDF is available here.
PDF is available here.
Proteomics (11)8 2011
Abstract
We describe a strategy to enrich for and identify secreted plant proteins based on affinity chromatography using the lectin Concanavalin A and two-dimensional liquid chromatography, together with matrix-assisted laser desorption/ionization MS analysis. The value of this approach is illustrated throu...
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PMID: 21381198
PDF is available here.
PDF is available here.
Molecular Therapy (19)3 2011
Abstract
We have used human hematopoietic stem cells (HSCs) to generate anti-HIV gene expressing iPSCs for HIV gene therapy. HSCs were dedifferentiated into continuously growing iPSC lines with four reprogramming factors and a combination anti-HIV lentiviral vector containing a CCR5 short hairpin RNA (shRNA)...
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PMID: 21119622
PDF is available here.
PDF is available here.
Journal of Proteomics (74)3 2011
Abstract
Milk fat globule membranes (MFGM) are three-layered structures that enclose fat droplets, and are composed by an internal monolayer of endoplasmic reticulum origin, surrounded by a bilayer derived from the apical membrane of the lactating cell. In this work, an optimized protein extr...
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PMID: 21147282
PDF is available here.
PDF is available here.
Abstract
CD133(+) cells in glioblastoma (GBM) display cancer stem cell-like properties and have been considered as the culprit of tumor recurrence, justifying exploration of potential therapeutic modalities targeting CD133(+) cancer stem-like cells (CSCs). For photothermolysis studies, GBM-CD...
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PMID: 20620237
PDF is available here.
PDF is available here.
Abstract
We analyzed the incidence of BA, morphological change, morphogenesis of viral particles and viral mRNA and protein expression. The in vitro experiments showed NSP4 silencing decreased the levels of VP7 and VP4, reduced viral particles and decreased cytopathic effect. NSP4-positive cells had strongly...
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PMID: 21876759
PDF is available here.
PDF is available here.
Trends in Microbiology (19)1 2011
Abstract
We examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses. These systems are structurally and biochemically well-characterized and are simplest-case paradigms of self-assembly. Published data suggest that capsid and...
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PMID: 21163649
PDF is available here.
PDF is available here.
Abstract
Abstract
We generated vesicular stomatitis viruses pseudotyped with mutant GPs that have impaired structures of the putative receptor binding regions and thus reduced ability to infect the monkey kidney cells that are routinely used for virus propagation. We found that infectivities of viruses with the mutan...
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PMID: 21056544
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (10)11 2010
Abstract
We identified CSCs in primary GBC and in the cell line GBC-SD using the cell surface markers CD44 and CD133. The percentages of CD44+CD133+ cells were 1.76-3.05% in primary tumors and 40.29% in GBC-SD cells. These cells showed stem cell properties, including self-renewal, differentiation potential,...
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PMID: 20948317
PDF is available here.
PDF is available here.
Molecular BioSystems (6)12 2010
Abstract
The majority of molecular processes in higher organisms are performed by various proteins and are thus determined by genes that encode these proteins. However, a significant structural component of at least half of all cellular proteins is not a polypeptide encoded by a single gene,...
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PMID: 20957246
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)9 2010
Abstract
To determine the concentration of myocilin in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG) aqueous humor.
Aqueous humor was collected during surgery from patients with POAG, PEXG, and elective cataract removal (control). Volume-equivalent aqueous samples were separated on...
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PMID: 20179615
PDF is available here.
PDF is available here.
Abstract
Cartilage oligomeric matrix protein (COMP) is a potential biomarker for joint destruction associated with osteoarthritis, which is first and best investigated biomarkers to reflect osteoarthritis occurs, progress and the prognosis. In this article, multiple uses and related reports of COMP are summa...
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PMID: 21265214
PDF is available here.
PDF is available here.
Virus/Uirusu (60)2 2010
Abstract
Herpes simplex virus (HSV), the prototype of the herpesvirus family, causes a variety of diseases in human. In this review, I focus on the molecular mechanism of HSV infection including recent advance on this research field.
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PMID: 21488332
PDF is available here.
PDF is available here.
Abstract
Our recent report documented that the rice germin-like protein1 (OsGLP1), being a cell wall-associated protein involves in disease resistance in rice and possesses superoxide dismutase (SOD) activity as recognized by heterologous expression in tobacco. In the present study, the transgenic tobacco pl...
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PMID: 20971065
PDF is available here.
PDF is available here.
Abstract
We explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N→S acyl transfer....
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PMID: 20835458
PDF is available here.
PDF is available here.
Abstract
We report in this paper the first chemoenzymatic synthesis of homogeneous CD52 glycoforms carrying both N- and O-glycans. The synthetic strategy consists of two key steps: monosaccharide primers GlcNAc and GalNAc were first installed at the pre-determined N- and O-glycosylation sites by a facile sol...
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PMID: 20848033
PDF is available here.
PDF is available here.
Nature Methods (7)11 2010
Abstract
We present a flexible and highly specific targeting method for lentiviral vectors based on single-chain antibodies recognizing cell-surface antigens. We generated lentiviral vectors specific for human CD105(+) endothelial cells, human CD133(+) hematopoietic progenitors and mouse GluA-expressing neur...
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PMID: 20935652
PDF is available here.
PDF is available here.
Abstract
We used anterograde axonal tracing and immunofluorescence in organ co-cultures of the cortex and the spinal cord from 3-day-old neonatal rats. CD133(+) cells prepared from human umbilical cord blood were added to the organ co-cultures after hypoxic insult, and axonal growth, vascular damage and apop...
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PMID: 20673797
PDF is available here.
PDF is available here.
Abstract
We demonstrate that effective identification and characterization of both peptides and glycopeptides mixtures, and their constituent glycan structures, can be achieved from a single sample injection event....
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PMID: 19882125
PDF is available here.
PDF is available here.
Immunobiology (215)11 2010
Abstract
We expressed recombinant MASP-3 and generated specific monoclonal antibodies to establish biochemical characteristics and to determine the serum levels, the interactions with the LCP recognition molecules and the influence on complement activation of MASP-3.
We expressed rMASP-3 in CHO-DG44 cells an...
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PMID: 19939495
PDF is available here.
PDF is available here.
Laboratory Investigation (90)11 2010
Abstract
The two leading models that have been used to explain tumor progression in head and neck squamous cell carcinoma (HNSCC) are the stochastic clonal evolution model, in which many tumor cells are individually capable of recapitulating the entire tumor mass, and the cancer stem hierarchy model, in whic...
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PMID: 21030945
PDF is available here.
PDF is available here.
Laboratory Investigation (90)11 2010
Abstract
We conclude that the posttransplant loss of cancer cells is minimal in the xenotransplant model. Furthermore, an examination of putative cancer stem cell markers (such as CD133, CD44, SP and label retention) in HNSCC cell lines revealed no correlation between marker expression and tumorigenicity. In...
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PMID: 20661227
PDF is available here.
PDF is available here.
Abstract
We tested the feasibility of alemtuzumab dose deescalation in the context of fludarabine-melphalan conditioning and human leukocyte antigen (HLA)-identical sibling transplantation. Alemtuzumab was given 1-2 days before graft infusion, and dose reduced from 60 mg to 20 mg in 4 sequential cohorts (tot...
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PMID: 20587785
PDF is available here.
PDF is available here.
Abstract
We performed Agilent's whole human genome oligo microarray analysis and examined the differentiation potential of the bone-marrow-derived CD133+ cells after hypoxic/normoxic preconditioning of CD133+ cells. Results showed that there was no significant increase in erythroid colony forming unit (CFU-E...
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PMID: 20073989
PDF is available here.
PDF is available here.
Joint Bone Spine (77)5 2010
Abstract
We assessed the correlations between serum COMP and other variables and whether serum COMP is associated with DAS28 remission.
Serum COMP correlated with DAS28-ESR (p < 0.05, r = 0.40) at baseline. At 6 months of etanercept treatment, 10 patients entered remission (DAS28-ESR < 2.6) whereas the other...
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PMID: 20864374
PDF is available here.
PDF is available here.
Abstract
I strains from the 2000s was noteworthy (4.7-6.7%). Sequencing and phylogenetic analysis of the NSP4 genes showed almost equal distribution (45.0-55.0%) of genotypes A and B however, higher amino acid divergence within the genotype B strains (up to 9.3%) than in genotype A strains (up to 2.9%) at th...
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PMID: 20542145
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the O-GlcNAc cycling enzymes OGT and OGA, which add and remove O-GlcNAc respectively, modulate lifespan in C. elegans. Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nem...
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PMID: 20952811
PDF is available here.
PDF is available here.
Biofouling (26)7 2010
Abstract
These results indicate a high level of control over the distribution of proteins, presumably with different functions, in the byssus of this freshwater species....
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PMID: 20924840
PDF is available here.
PDF is available here.
Abstract
Bisphenol A (BPA) is one of the estrogen mimic environmental hormones and a chemical used for the wrapping foods, toy products for children, biomedical equipment, and machines. It can exert toxic effects, such as occurring allergy-related diseases. This study demonstrates that glycoprotein isolated...
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PMID: 20553123
PDF is available here.
PDF is available here.
Abstract
Bovine growth hormone (bGH) transgenic mice develop severe kidney damage. This damage may be due, at least in part, to changes in gene expression. Identification of genes with altered expression in the bGH kidney may identify mechanisms leading to damage in this system that may also be relevant to o...
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PMID: 20655258
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)10 2010
Abstract
We have employed a combination of cysteine mutagenesis and chemical crosslinking using a photoactivatable sulfhydryl reagent, benzophenone-4-maleimide, to obtain a covalent complex between human galectin-1 and a model glycoprotein ligand, asialofetuin. We previously obtained a crosslinked product wh...
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PMID: 20930491
PDF is available here.
PDF is available here.
Abstract
Glycoconjugates play pivotal and crucial roles in various biological processes, and it is thus believed that abnormal structural changes in the sugar chains of glycoconjugates are closely associated with the pathophysiology and clinical implications of many diseases. Many studies have identified and...
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PMID: 21077291
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Recently, Glockner et al. identified the methylation of TFPI2 as a frequent event in human colorectal cancer using a gene expression array-based strategy.
Methylation status of the TFPI2 gene was examined in primary carcinomas and the corresponding normal tissues derived from 38 patients with gastri...
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PMID: 21036731
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (431)2 2010
Abstract
We have shown that Xenopus laevis oocytes contain endogenous basigin, but not embigin. Co-expression of exogenous embigin was without effect on either the expression of MCT1 or its inhibition by AR-C155858. In contrast, expression of active MCT2 at the plasma membrane of oocytes was significantly en...
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PMID: 20695846
PDF is available here.
PDF is available here.
Abstract
We identified zinc-α2-glycoprotein (AZGP1, ZAG) as a tumor suppressor in pancreatic ductal adenocarcinoma whose expression is lost due to histone deacetylation. In vitro, ZAG silencing strikingly increased invasiveness of pancreatic cancer cells accompanied by the induction of a mesenchymal phenoty...
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PMID: 20581862
PDF is available here.
PDF is available here.
Journal of Proteomics (73)10 2010
Abstract
In the field of proteomics there is an apparent lack of reliable methodology for quantification of posttranslational modifications. Present study offers a novel post-digest ICPL quantification strategy directed towards characterization of phosphorylated and glycosylated proteins. The...
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PMID: 20601274
PDF is available here.
PDF is available here.
Abstract
This study aims to further the understanding of nanoscale structures relevant for cellular recognition on contact and interaction with natural-based materials. The correlation between surface characteristics and protein adsorption from unitary and complex protein systems was investigated with respec...
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PMID: 20181561
PDF is available here.
PDF is available here.
Abstract
We have used neem leaf glycoprotein (NLGP), a novel immunomodulator reported from our laboratory. NLGP upregulated CCR5 expression, as evidenced from studies on MO/Mphi of peripheral blood from HNSCC patients as well as healthy individuals. Expression of RANTES, MIP-1alpha and MIP-1beta was also upr...
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PMID: 20622890
PDF is available here.
PDF is available here.
Abstract
We describe a complete workflow for the analysis of protein N-glycans. The sample-preparation procedure, consisting of the release of the N-glycans by PNGase-F, followed by fluorescence labeling with 2-aminobenzamide and removal of excess label, was optimized to avoid alteration of the glycan sample...
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PMID: 20640408
PDF is available here.
PDF is available here.
Abstract
Recent studies have identified a new family of ammonia-specific transporters, Rh glycoproteins, which enable NH3-specific transport. The purpose of this review is to summarize recent evidence regarding the role of Rh glycoproteins in renal ammonia transport.
The Rh glycoproteins, RhAG/Rhag, RhBG/Rhb...
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PMID: 20539225
PDF is available here.
PDF is available here.
Abstract
G3BP-levels (mean+/-standard deviation) were increased during cirrhosis (22.7+/-10.1 microg/ml) compared to mild (11.3+/-6.4 microg/ml) and moderate fibrosis (13.4+/-8.3 microg/ml) (P<0.001; P=0.004, respectively). Receiver operator characteristic curves showed areas under the curve of 0.68, 0.75 an...
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PMID: 20186066
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Overexpression of P-glycoprotein (P-gp), a plasma membrane drug transporter (ABCB1, a member of the ABC transporter family), is the most prevalent cause of multidrug resistance in cancer tissues. Lectin concanavalin A (ConA) induces massive cell death of L1210 leukemia cells (S). Cell sublines of L1...
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PMID: 20944151
PDF is available here.
PDF is available here.
Abstract
The conformational space available to the flexible molecule α-D-Manp-(1-->2)-α-D-Manp-OMe, a model for the α-(1-->2)-linked mannose disaccharide in N- or O-linked glycoproteins, is determined using experimental data and molecular simulation combined with a maximum entropy approach that leads to a...
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PMID: 20574564
PDF is available here.
PDF is available here.
Abstract
We demonstrated that MAb 6B6 could inhibit the proliferation of Caco-2 cells that were derived from a human colorectal carcinoma. This functional anti-human CD133 MAb provides a valuable tool for further study of biological functions of cancer stem cell that expressed CD133....
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PMID: 20715988
PDF is available here.
PDF is available here.
Abstract
Abstract
We discuss the possibilities to use this knowledge for the rational design of plant-expressed vaccines....
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PMID: 20673008
PDF is available here.
PDF is available here.
Abstract
We propose that the reduced virulence of the pga29 mutant is a consequence of altered surface properties, resulting in altered fungal recognition.
Copyright (c) 2010 John Wiley & Sons, Ltd....
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PMID: 20533408
PDF is available here.
PDF is available here.
Abstract
We here present a first systematic analysis of the cell wall composition of the milk yeast, Kluyveromyces lactis. Electron microscopic analyses revealed that exponentially growing cells of K. lactis supplied with glucose as a carbon source have a wall thickness of 64 nm, as compared to 105 nm when g...
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PMID: 20641021
PDF is available here.
PDF is available here.
Hematology (15)4 2010
Abstract
We have shown that two downregulated genes in AML, those encoding guanine nucleotide-binding protein gamma11 (GNG11) and amphiregulin (AREG), are also downregulated in B-lineage acute lymphoblastic leukemia (B-ALL) and T-lineage acute lymphoblastic leukemia (T-ALL) patients. A second gene, that enco...
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PMID: 20670477
PDF is available here.
PDF is available here.
Abstract
We expanded formerly frozen UCB cells by treatment with SCF (stem cell factor) and GM-CSF (granulocyte-macrophage colony stimulating factor) in the presence of VPA (valproic acid). Gene expression profiles for beta cell differentiation and pluripotency (embryo stem cell phenotype) were analysed by R...
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PMID: 20397976
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
CD133 antigen has been used to identify cancer stem cells in several solid tumor types, including hepatocellular carcinomas (HCCs). The aim of this study was to investigate whether the expression and subcellular localization of CD133 correlated with the clinicopathological factors, recurrence, and s...
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PMID: 20596644
PDF is available here.
PDF is available here.
Oncology Reports (24)2 2010
Abstract
We further investigated CD133 expression in colorectal cancer following CRT using immunohistochemistry. Forty patients with primary colorectal cancers and 50 patients with rectal cancer who had received preoperative CRT followed by surgery were selected. Sections of formalin-fixed, paraffin-embedded...
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PMID: 20596619
PDF is available here.
PDF is available here.