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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Heat-Shock Proteins (6):
Recent article
Heat-Shock Proteins
Journal of Neuroscience (31)33 2011
Abstract
We observed that small heat shock proteins (sHsps) are associated with Aβ deposits in AD. In this study the molecular chaperones Hsp20, HspB8 and HspB2B3 were found to colocalize with CAA and capCAA in AD brains. In addition, Hsp20, HspB8 and HspB2B3 colocalized with intercellular adhesion molecule...
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PMID: 21849559
PDF is available here.
PDF is available here.
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Cell Metabolism (13)6 2011
Abstract
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect. Disruption of the HSPB1 gene in embryonic fibroblasts with wild-type HMGB1 recapitulates the mitochondrial fragmentation, deficits in mitochondrial respiration, and adenosine triphosphate (ATP) synthes...
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PMID: 21641551
PDF is available here.
PDF is available here.
Abstract
We will address how protein homeostasis (proteostasis) is achieved at the level of the cell and organism, and how the threshold of the stress response is set to detect and combat protein misfolding. For metazoans, the requirement for coordinated function and growth imposes additional constraints on...
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PMID: 21536706
PDF is available here.
PDF is available here.
Abstract
We performed comparative proteome analysis of lung tissue from patients with sporadic IPF (n = 14) and human donor lungs (controls, n = 10) using two-dimensional gel electrophoresis and MALDI-TOF-MS. Eighty-nine differentially expressed proteins were identified, from which 51 were up-regulated and 3...
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PMID: 21319792
PDF is available here.
PDF is available here.
Neuroscience Bulletin (27)2 2011
Abstract
To perform the modulation of an assay system for the sensory integration of 2 sensory stimuli that inhibit each other.
The assay system for assessing the integrative response to 2 reciprocally-inhibitory sensory stimuli was modulated by changing the metal ion barrier....
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PMID: 21441968
PDF is available here.
PDF is available here.
Liver Transplantation (17)2 2011
Abstract
We investigated ER stress signaling and blockade in the mediation of CIR injury in severely steatotic rodent allografts. Steatotic allografts from genetically leptin-resistant rodents had increased ER stress responses and increased markers of hepatocellular injury after liver transplantation into st...
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PMID: 21280192
PDF is available here.
PDF is available here.
Abstract
I in Dulbecco's modified Eagle's medium containing 5.5 mM glucose. For cocultures, pericytes and endothelial cells were seeded together on rat tail collagen type I-coated cell culture plates. After 24 h of initial culture, the medium was replaced with serum-free medium containing 0-100 mM g...
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PMID: 21091050
PDF is available here.
PDF is available here.
Nutrition and Cancer (63)3 2011
Abstract
We investigated the effect of the tomato lycopene complex against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Male Wistar rats (n = 28, 8 wk old, between 200-215 g) were divided into 4 groups: (a) control, (b) tomato lycopene complex (6 mg/kg, daily; consisting of 6% lycopene, 1...
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PMID: 21391123
PDF is available here.
PDF is available here.
Nutrition and Cancer (63)3 2011
Abstract
We investigated the effect of the tomato lycopene complex against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Male Wistar rats (n = 28, 8 wk old, between 200-215 g) were divided into 4 groups: (a) control, (b) tomato lycopene complex (6 mg/kg, daily; consisting of 6% lycopene, 1...
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PMID: 21391123
PDF is available here.
PDF is available here.
Nutrition and Cancer (63)3 2011
Abstract
We investigated the effect of the tomato lycopene complex against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Male Wistar rats (n = 28, 8 wk old, between 200-215 g) were divided into 4 groups: (a) control, (b) tomato lycopene complex (6 mg/kg, daily; consisting of 6% lycopene, 1...
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PMID: 21391123
PDF is available here.
PDF is available here.
Abstract
We used the two months tail suspension model to simulate microgravity and investigated the simulated microgravity on the renal morphological damages and related molecular mechanisms. The microscopic examination of tissue structure and ultrastructure was carried out for histopathological changes of r...
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PMID: 21625440
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (132)1-2 2011
Abstract
We analyzed the effect of B-chromosome presence on expression level of heat shock protein 70 (Hsp70) in cerebral ganglion and gonad in both males and females of the grasshopper Eyprepocnemis plorans. Two natural Spanish populations, Salobreña (Granada) and Torrox (Málaga) were assayed, the former...
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PMID: 20798487
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We provide evidence that CtsR activity during heat stress is mediated by intrinsic heat sensing through a glycine-rich loop, probably in all Gram-positive species. Moreover, a function for the recently identified arginine kinase McsB is confirmed, however, not for initial inactivation and dissociati...
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PMID: 20852588
PDF is available here.
PDF is available here.
Abstract
We have summarized recent findings related to gastroduodenal mucosal defense as well as factors contributing to defensive failure, highlighting findings that illuminate new pathophysiological mechanisms.
Gastroduodenal bicarbonate secretion is mediated by prostaglandin E receptors and stimulated by...
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PMID: 20948371
PDF is available here.
PDF is available here.
Circulation (122)17 2010
Abstract
Biochemical Journal (432)1 2010
Abstract
We have investigated the possible effects on hA misfolding of the chaperones HSP (heat-shock protein) 70, GRP78/BiP (glucose-regulated protein of 78 kDa/immunoglobulin heavy-chain-binding protein) and HSP40/DnaJ. We demonstrate that hA underwent spontaneous time-dependent β-sheet formation and aggr...
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PMID: 20735358
PDF is available here.
PDF is available here.
Abstract
We looked for two potential interacting partners of Mdy2, investigated the function of Mdy2 in nuclear movement, determined the increased heat sensitivity defects of mdy2Δ mutants, and inspected localization of Mdy2. Coprecipitation studies show that Mdy2 associates with α-tubulin and with the mic...
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PMID: 20722039
PDF is available here.
PDF is available here.
Abstract
Sestrins (Sesns) are a family of highly conserved stress-responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from oxidative stress. However, their major biochemical and physiological function do...
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PMID: 20878915
PDF is available here.
PDF is available here.
Abstract
The review highlights recent findings regarding the functions of mitochondria in adipocytes, providing an understanding of their central roles in regulating substrate metabolism, energy expenditure, disposal of reactive oxygen species (ROS), and in the pathophysiology of obesity and...
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PMID: 20585248
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the O-GlcNAc cycling enzymes OGT and OGA, which add and remove O-GlcNAc respectively, modulate lifespan in C. elegans. Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nem...
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PMID: 20952811
PDF is available here.
PDF is available here.
Abstract
The Modern Challenges in Therapeutic Protein Production conference hosted 44 delegates from the UK and Germany and was organized by EuroSciCon. The aim of the meeting was to look at the challenges that currently face the production of therapeutic proteins and to attempt to demystify some of the nove...
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PMID: 20973635
PDF is available here.
PDF is available here.
Current Drug Targets (11)10 2010
Abstract
Mitochondrial dysfunction is a common hallmark of ageing-related diseases involving neurodegeneration. Huntington's disease (HD) is one of the most common monogenetic forms of neurodegenerative disorders and shares many salient features with the major sporadic disease of neurodegeneration, such as a...
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PMID: 20840068
PDF is available here.
PDF is available here.
Journal of Molecular Biology (402)1 2010
Abstract
We demonstrate that the M-domain is essential for protein disaggregation, but dispensable for Hsp104 ATPase- and substrate-translocating activities. Remarkably, replacing the Hsp104 M-domain with that of bacterial ClpB, and vice versa, switches species specificity so that our chimeras now cooperate...
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PMID: 20654624
PDF is available here.
PDF is available here.
Cell Metabolism (12)3 2010
Abstract
We demonstrate that increased intrinsic thermotolerance, due to lower ILS, is not dependent on stress-induced transcriptional responses but instead requires active protein translation. Translation profiling experiments reveal genes that are posttranscriptionally regulated in response to altered ILS...
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PMID: 20816092
PDF is available here.
PDF is available here.
Abstract
We observed changes in cell morphology under stress conditions. Surprisingly, in the cell, Hsp12 exists both as a soluble cytosolic protein and associated to the plasma membrane. The in vitro analysis revealed that Hsp12, unlike all other Hsps studied so far, is completely unfolded; however, in the...
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PMID: 20797624
PDF is available here.
PDF is available here.
Proteomics (10)17 2010
Abstract
We studied the physiological and proteomic changes of C. spinarum in response to 42 degrees C heat stress treatment in combination with drought stress. Dynamic changes in the leaf proteome were analyzed at four time points during the stress treatment and recovery stages. Approximately, 650 protein s...
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PMID: 20661954
PDF is available here.
PDF is available here.
Abstract
We designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer. HITS is an 18-kDa nuclear protein expressed in a variety of tissues including stomach, colon, lung and lymphoid organs. In human gastric and colorectal cancers and...
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PMID: 20664927
PDF is available here.
PDF is available here.
Abstract
We identified poly(ADP-ribose) polymerase-1 (PARP-1) as a novel negative transcriptional regulator of the AT2R. However, the complex interactions between ethanol, PARP-1, and the AT2R are largely unknown. In this in vitro study, we aimed to clarify whether acute ethanol treatment modifies AT2R promo...
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PMID: 20693103
PDF is available here.
PDF is available here.
Reproductive Toxicology (30)2 2010
Abstract
We investigated whether embryonic stem cell (ESC) differentiation and its modulation by toxic exposure could be monitored by proteome profiling. We compared the proteomes of mouse ESC, differentiating ESC (DIF) and differentiating ESC exposed to the embryotoxicant monobutyl phthalate (MBP). Experime...
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PMID: 20553848
PDF is available here.
PDF is available here.
Abstract
Expression of glucose regulated protein 78 was shown in 100% of the HCC samples with 66% showing strong staining. In-vitro UPR activation was achieved with glucose deprivation. UPR activation induced significant resistance to doxorubicin: 34% survival under standard culture conditions versus 58% and...
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PMID: 20177386
PDF is available here.
PDF is available here.
Abstract
Our study provides proof of principle for the application of an 8-plex iTRAQ approach to uncover clinically relevant candidate biomarkers for prostate cancer progression.
(c) 2010 Wiley-Liss, Inc....
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PMID: 20623638
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
We show that statins, a class of drug widely employed in the clinical management of hypercholesterolemia, reduces lipid-induced macrophage endoplasmic reticulum stress in an isolated cell system and in LDL receptor knockout mice. Given the importance of endoplasmic reticulum stress as an inducer of...
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PMID: 20537647
PDF is available here.
PDF is available here.
Molecular Cell (39)3 2010
Abstract
I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20705236
PDF is available here.
PDF is available here.
Abstract
A proteomic approach was used to investigate the dynamic cellular host cell response induced by influenza virus infection in two different vaccine production cell lines, MDCK and Vero. For identification of proteins possibly involved in global host cell response mechanisms and virus-host cell intera...
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PMID: 20435171
PDF is available here.
PDF is available here.
Abstract
We measured the effects of various mutations introduced to the L2 loop's region (residues 228-238) on the stability of HtrA molecule and its proteolytic activity. We demonstrated that most mutations affected the activity of HtrA. In the case of the following substitutions: L229N, N235I, I238N, the p...
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PMID: 20515644
PDF is available here.
PDF is available here.
Abstract
We show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex....
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PMID: 20639883
PDF is available here.
PDF is available here.
Journal of Medical Microbiology (59)Pt 8 2010
Abstract
We previously engineered the food-grade bacterium Lactococcus lactis to express LLO and demonstrated an LLO-specific CD8(+) response upon immunization of mice with the engineered L. lactis vaccine strains. In the present work, we examined the immune response and protective efficacy of an L. lactis s...
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PMID: 20488938
PDF is available here.
PDF is available here.
Abstract
GRP78 and GRP94 expression might play important roles in the pathogenesis and progression of pediatric HB....
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PMID: 20704797
PDF is available here.
PDF is available here.
Abstract
We tested the effects of the irreversible arginase inhibitor (+)-S-2-amino-6-iodoacetamidohexanoic acid (AIHA) on L-arginine-induced acute pancreatitis.
The inhibitory effect of AIHA on arginase activity was tested on rat liver homogenate and purified bovine arginase. Male Wistar rats were administe...
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PMID: 20697209
PDF is available here.
PDF is available here.
Abstract
We highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time...
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PMID: 20420569
PDF is available here.
PDF is available here.
Abstract
We identified 28 transcripts significantly involved in the resistance phenotype across all genotypes. The most significant of these were annotated as blue copper-binding protein, heat-stress transcription factor, pathogen-induced WIR1A protein, and ent-kaurene synthase transcripts. Unique transcript...
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PMID: 19937262
PDF is available here.
PDF is available here.
Abstract
Abstract
Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and l...
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PMID: 20628411
PDF is available here.
PDF is available here.
Abstract
The relative intensity of brief intermittent exercise is of major importance for the exercise-induced increase of several mRNA, including PGC-1alpha....
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PMID: 20139785
PDF is available here.
PDF is available here.
Outbreak of pneumonia associated with emergent human adenovirus serotype 14--Southeast Alaska, 2008.
Abstract
During a community outbreak in Alaska, HAdV-14 appeared to have spread mostly among close contacts and not widely in the community. Demographic characteristics and illness patterns among the case patients were similar to those observed in other recent outbreaks of HAdV-14 infection in the United Sta...
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PMID: 20533881
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We have mapped an antioxidant response element (ARE) in the p62 promoter that is responsible for its induction by oxidative stress via NRF2. Chromatin immunoprecipitation and gel mobility-shift assays verified that NRF2 binds to this cis-element in vivo and in vitro. Also, p62 docks directly onto th...
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PMID: 20452972
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We introduced mutations into the ER-lumenal Hsp70, BiP/Kar2p, and found that an R217A substitution in the J domain-interacting surface of BiP compromised the physical and functional interaction with Sec63p, an Hsp40 required for ER translocation. In contrast, interaction with Jem1p, an Hsp40 require...
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PMID: 20430885
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)28 2010
Abstract
We describe that cpSRP43 alone prevents aggregation of LHCP by formation of a complex with nanomolar affinity, whereas cpSRP54 is not required for this chaperone activity. Other stromal chaperones like trigger factor cannot replace cpSRP43, which implies that LHCPs require a specific chaperone. Alth...
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PMID: 20498370
PDF is available here.
PDF is available here.
Abstract
Development of two species of necrophagous flies, Sarcophaga bullata Parker (Sarcophagidae) and Protophormia terraenovae (Robineau-Desvoidy) (Calliphoridae), was examined in different size maggot masses generated under laboratory conditions. Larvae from both species induced elevated mass temperature...
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PMID: 20695285
PDF is available here.
PDF is available here.
Abstract
We investigated the contribution of ROS in mitochondrial signaling pathways, death-receptor-initiated signaling pathway, and endoplasmic reticulum stress in butyric-acid-induced T-cell apoptosis. N-acetyl-L-Cysteine (NAC) abrogated mitochondrial injury, cytochrome c, AIF, and Smac release, and Bcl-2...
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PMID: 20439934
PDF is available here.
PDF is available here.
Abstract
We hypothesized that lifelong overexpression of the mitochondrial heat shock protein (HSP) HSP10 in muscle of mice would protect against development of these deficits. P(o) generation by extensor digitorum longus muscles of adult and old wild-type and HSP10-overexpressing mice was determined in situ...
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PMID: 20410481
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)1 2010
Abstract
CO treatment before CPB was associated with evidence of renoprotection, demonstrated by fewer histological injuries and decreased cystatin C concentrations. The findings that the antiinflammatory and antiapoptotic effects of CO were accompanied by activation of HSP-70, which in turn were reversed by...
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PMID: 20519418
PDF is available here.
PDF is available here.
Abstract
We surmised that gestational vitamin D deficiency is a risk factor for MS. To test this hypothesis, a vitamin D deficiency was induced in C57BL/6 female mice 6 weeks prior to conception and prolonged until offspring birth. Contrary to our prediction, we show here that adult offspring exposed to deve...
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PMID: 20214984
PDF is available here.
PDF is available here.
Journal of Plant Physiology (167)10 2010
Abstract
We report the cloning and characterization of heat shock-induced genes in grapevine (Vitis vinifera L.). Using the cDNA subtraction method, four heat shock-induced genes were identified in heat shock-treated Pinot noir grapevine. The four genes were immediately induced and upregulated in leaves and...
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PMID: 20096476
PDF is available here.
PDF is available here.
Abstract
We confirm this link by finding that deletion of STI1 both suppresses Ssa1-21 impairment of [PSI(+)] and blocks Hsp104 curing of [PSI(+)]. Hsp104's tetratricopeptide repeat (TPR) interaction motif was dispensable for curing; however, cells expressing Sti1 defective in Hsp70 or Hsp90 interaction cure...
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PMID: 20479121
PDF is available here.
PDF is available here.
Abstract
We present the 2.1A crystal structure of the PSP protein from Pseudomonas syringae pv. tomato str. DC3000 (PSPTO-PSP), in complex with D-glucose. The quaternary structure of PSPTO-PSP is a homologous trimer. Glucose is located in the cavity between each two monomers. Comparison of the hydrogen bonds...
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PMID: 20478270
PDF is available here.
PDF is available here.
Biotechnology Letters (32)6 2010
Abstract
Gene expression system Hsh is developed to increase enzyme production and to decrease the cost in the induction of gene expression in Escherichia coli. The vectors of Hsh system were constructed by combining a synthesized heat-shock promoter with a synthesized terminator and an origin of replication...
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PMID: 20155484
PDF is available here.
PDF is available here.
Abstract
The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity and protein in relationship to peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial content were determined in human skeletal muscle. Six wee...
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PMID: 20555380
PDF is available here.
PDF is available here.
Abstract
We previously established that redox sensitive transcription factor Nrf2 up-regulates SQSTM1 expression in response to atherogenic stimuli or laminar shear stress in vascular cells, and here examine the role of SQSTM1 in neointimal hyperplasia and vascular remodelling in vivo following carotid arter...
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PMID: 19780870
PDF is available here.
PDF is available here.
Neuromolecular Medicine (12)2 2010
Abstract
Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes extensively to neurologic injury. With more recent focus on innate immune processes, it appears that necrotic...
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PMID: 19830599
PDF is available here.
PDF is available here.