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Intracellular Signaling Peptides and Proteins (44):
- Ribosomal Protein S6 Kinases
- rho-Associated Kinases
- Mitogen-Activated Protein Kinases
- Intracellular Calcium-Sensing Proteins
- I-kappa B Proteins
- Guanylate Cyclase
- Calcium-Calmodulin-Dependent Protein Kinases
- Adenylate Cyclase
- Cyclic Nucleotide-Regulated Protein Kinases
- Apoptosis Regulatory Proteins
- AMP-Activated Protein Kinases
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- Phosphoinositide Phospholipase C
- Phosphatidylethanolamine Binding Protein
- Heterotrimeric GTP-Binding Proteins
- Protein Phosphatase 2
- Mucin-4
- GTP-Binding Protein Regulators
- eIF-2 Kinase
- 3',5'-Cyclic-AMP Phosphodiesterases
- Olfactory Marker Protein
- MAP Kinase Kinase Kinases
- Interleukin-1 Receptor-Associated Kinases
- Receptor-Like Protein Tyrosine Phosphatases
- Protein Tyrosine Phosphatases, Non-Receptor
- p21-Activated Kinases
- Mitogen-Activated Protein Kinase Phosphatases
- Focal Adhesion Protein-Tyrosine Kinases
- Lim Kinases
- Cyclin-Dependent Kinases
- Phospholipase C gamma
- Mitogen-Activated Protein Kinase Kinases
- Dual-Specificity Phosphatases
- Calcineurin
- Monomeric GTP-Binding Proteins
- Activating Transcription Factor 6
- I-kappa B Kinase
- Cyclins
- 3',5'-Cyclic-GMP Phosphodiesterases
- Glycogen Synthase Kinases
- G-Protein-Coupled Receptor Kinases
- Cyclin-Dependent Kinase Inhibitor Proteins
- Casein Kinases
- Adaptor Proteins, Signal Transducing
Recent article
Intracellular Signaling Peptides and Proteins
Abstract
We show an innovative procedure of perfusion and fixation of brain tissue, that allows, by applying Golgi-Cox impregnation and immunofluorescence in the same histological section, to obtain high-quality histological material, with a very simple and inexpensive method. This procedure is based on thre...
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PMID: 21461741
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We found that KIF1A, an axonal transporter of synaptic vesicles, interacts with the domain encoded by the HSN2 exon. In parallel to this screen, we performed genome-wide homozygosity mapping in a consanguineous Afghan family affected by HSANII and identified a unique region of homozygosity located o...
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PMID: 21820098
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
Heritable causes of proteinuria are rare and account for a relatively small proportion of all cases of proteinuria affecting children and adults. Yet, significant contributions to understanding the mechanistic basis for proteinuria have been made through genetic and molecular analyse...
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PMID: 21782134
PDF is available here.
PDF is available here.
Abstract
Abstract
We present a clinical and molecular characterization of a patient with Noonan-like syndrome with loose anagen hair phenotype and additional features including mild psychomotor developmental delay, osteoporosis, gingival hyperplasia, spinal neuroblastoma, intrathoracic extramedullary hematopoiesis, a...
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PMID: 21548061
PDF is available here.
PDF is available here.
Abstract
We investigated whether variants in major candidate genes for food intake and body weight regulation contribute to obesity-related traits under a multilocus perspective. We studied 375 Brazilian subjects from partially isolated African-derived populations (quilombos). Seven variants displaying confl...
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PMID: 21233811
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
We investigated in vivo the effects of sirolimus on nephrin, podocin, CD2ap, and actin protein expression. Slit diaphragm (SD)-associated protein expressions were evaluated in T0 and T2 biopsies. The same analysis was performed in cultured human podocytes treated with different doses of sirolimus (5...
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PMID: 21364499
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
We investigated in vivo the effects of sirolimus on nephrin, podocin, CD2ap, and actin protein expression. Slit diaphragm (SD)-associated protein expressions were evaluated in T0 and T2 biopsies. The same analysis was performed in cultured human podocytes treated with different doses of sirolimus (5...
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PMID: 21364499
PDF is available here.
PDF is available here.
Abstract
We use and build on in adult life. Key to persistent modifications of neuronal connectivity and plasticity of the neocortex are molecular changes occurring at the synapse. Here we used isobaric tag for relative and absolute quantification to measure levels of 467 synaptic proteins in a well-establis...
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PMID: 21398567
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)4 2011
Abstract
As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of...
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PMID: 21499124
PDF is available here.
PDF is available here.
Cell Cycle (10)8 2011
Abstract
We show that RNF8 and RNF168 are recruited to DNA damage foci in late mitosis, presumably to prime sites for 53BP1 recruitment in early G1. Interestingly, we show that, although RNF8, RNF168 and 53BP1 are excluded from DSB sites during most of mitosis, they associate with mitotic structures such as...
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PMID: 21412056
PDF is available here.
PDF is available here.
Abstract
We have identified 6 different mutations in coenzyme Q10 biosynthesis monooxygenase 6 (COQ6) in 13 individuals from 7 families by homozygosity mapping. Each mutation was linked to early-onset SRNS with sensorineural deafness. The deleterious effects of these human COQ6 mutations were validated by th...
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PMID: 21540551
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)4 2011
Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.
Abstract
We test our hypothesis that the Hypocretin system is regulated by TNF-α. Prepro-Hypocretin and Hypocretin receptor 2 (HcrtR2) can be detected at a very low level in rat B35 neuroblastoma cells. In response to TNF-α, Prepro-Hypocretin mRNA and protein levels are down-regulated, and also HcrtR2 prot...
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PMID: 21094253
PDF is available here.
PDF is available here.
Abstract
The neuropeptides hypocretin-1 and -2 (orexin A and B) are critical in the regulation of arousal and maintenance of wakefulness. Understanding the role of the hypocretin system in sleep/wake regulation has come from narcolepsy-cataplexy research. Deficiency of hypocretin results in l...
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PMID: 21170610
PDF is available here.
PDF is available here.
Abstract
Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lo...
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PMID: 21375490
PDF is available here.
PDF is available here.
Abstract
We show that although MSCs effectively engraft in AMI tissue, this engraftment leads to downregulation of CP expression in the implanted MSCs. We also found that pretransplantation cardiac specification of MSCs by exposure of the cells to transforming growth factor beta 1 (TGF-β1) led to sustained...
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PMID: 20666606
PDF is available here.
PDF is available here.
Abstract
In patients with active rheumatoid arthritis despite therapy with DMARDS, treatment with a spleen tyrosine kinase inhibitor has achieved similar response rates to those achieved in clinical trials of other drugs, including biologic agents. Where might these agents fit in the current...
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PMID: 21304505
PDF is available here.
PDF is available here.
Cell Cycle (10)4 2011
Abstract
We will discuss the effects of NO in tumor biology and disease progression with an emphasis on breast cancer, and will examine the mechanisms that link increased NO to a basal-like transcription pattern in human breast tumors and poor disease outcome....
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PMID: 21293193
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (63)2 2011
Abstract
Our findings indicate that there were no differences in the primary end point between the R788 and placebo groups. Differences were observed between the R788 and placebo groups in secondary end points, particularly in those patients who entered the study with an elevated CRP level.
C...
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PMID: 21279990
PDF is available here.
PDF is available here.
Biomedical Materials (6)1 2011
Abstract
Stem cell-based tissue engineering has provided an alternative strategy to treat cartilage lesions, and synovium-derived mesenchymal stem cells (SMSCs) are considered as a promising cell source for cartilage repair. In this study, the SMSCs were isolated from rat synovium, and CD105-...
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PMID: 21205995
PDF is available here.
PDF is available here.
Abstract
We extracted DNA from the patient's teeth and identified a germline mutation in the aryl hydrocarbon-interacting protein gene (AIP). Four contemporary Northern Irish families who presented with gigantism, acromegaly, or prolactinoma have the same mutation and haplotype associated with the mutated ge...
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PMID: 21208107
PDF is available here.
PDF is available here.
Nippon Jinzo Gakkai shi (53)2 2011
Abstract
Abstract
We show that SDF-1 and VEGF, which are produced by tumors, increase Dll4 expression on recruited BM-VPC. Mechanistically, BM-VPC activated, in a Dll4-dependent manner, a transcriptional program on mature EC suggestive of EC activation and stabilization. BM-VPC induced ICAM-2 and Fibronectin expressi...
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PMID: 21483741
PDF is available here.
PDF is available here.
Abstract
Four and a half LIM domains protein 1 (FHL1) and FHL2, as the name suggests, contain four and a half LIM domain binding proteins. Proteins in this family capable of interacting with many types of proteins, including structural proteins, kinases, and several classes of transcription f...
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PMID: 21539754
PDF is available here.
PDF is available here.
Abstract
We have determined the sensitivity of VRK1 and VRK2 to kinase inhibitors, currently used in biological assays or in preclinical studies, in order to discriminate between the two proteins as well as with respect to the vaccinia virus B1R kinase. Both VRK proteins and vaccinia B1R are poorly inhibited...
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PMID: 21829721
PDF is available here.
PDF is available here.
Abstract
We describe the case of a 22-month-old boy with LCH associated with X-linked lymphoproliferative disease (XLP). Sequence analysis of SH2D1A for mutations that cause T-cell dysfunction revealed a CT substitution at nucleotide 462. This is the first case that hints at an association between XLP and LC...
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PMID: 21094704
PDF is available here.
PDF is available here.
Cytometry Part B (80)1 2011
Abstract
We previously generated an antihuman SAP monoclonal antibody (KST-3) for a flow cytometric assay and described the activation of T cells to be necessary for the flow cytometric assessment of the SAP expression using an FITC-conjugated secondary antibody.
Between 2005 and 2008, we rec...
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PMID: 20632414
PDF is available here.
PDF is available here.
Abstract
The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parki...
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PMID: 21482412
PDF is available here.
PDF is available here.
Abstract
We show that Rtt107 is recruited to DSBs induced by the HO endonuclease. Rtt107 phosphorylation by Mec1 and its interaction with the Smc5-Smc6 complex are both required for Rtt107 loading to breaks, while Rtt107 regulators Slx4 and Rtt101 are not. We demonstrate that Rtt107 has an effect on the effi...
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PMID: 21647453
PDF is available here.
PDF is available here.
DNA and Cell Biology (30)3 2010
Abstract
We aimed at investigating the role of spleen tyrosine kinase (Syk) in the proliferation and phenotypes in rat pulmonary arterial VSMCs. Our results demonstrate that PDGF-BB or Syk-adenovirus led to a substantial increase of proliferation of VSMCs and cytoskeleton rearrangement in rat VSMCs. Consiste...
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PMID: 21189061
PDF is available here.
PDF is available here.
Abstract
We performed chromatin immunoprecipitation (ChIP) analysis, double-immunostaining, a luciferase reporter assay, and an in utero electroporation study. ChIP analysis showed that endogenous NR6A1 binds to a putative NR6A1-binding site. Double-immunostaining indicated almost all hypocretin neurons were...
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PMID: 21056546
PDF is available here.
PDF is available here.
Abstract
We report that orexin-A induces invivo neovascularization in a mouse Matrigel plug and ex vivo sprouting of endothelial cells in rat aortic rings. We also show that orexin-A increases migration and tube formation in human umbilical vein endothelial cells (HUVECs), and this effect is mediated by orex...
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PMID: 21040705
PDF is available here.
PDF is available here.
Abstract
Nature Medicine (16)12 2010
Abstract
Nature Medicine (16)12 2010
Abstract
We show that cerebral ischemia induces the interaction of nNOS with postsynaptic density protein-95 (PSD-95). Disrupting nNOS-PSD-95 interaction via overexpressing the N-terminal amino acid residues 1-133 of nNOS (nNOS-N(1-133)) prevented glutamate-induced excitotoxicity and cerebral ischemic damage...
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PMID: 21102461
PDF is available here.
PDF is available here.
Abstract
Traumatic brain injury (TBI) induces significant neurological damage, including deficits in learning and memory, which contribute to a poor clinical prognosis. Treatment options to limit cognitive decline and promote neurological recovery are lacking, in part due to a poor understanding of the second...
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PMID: 20397893
PDF is available here.
PDF is available here.
Abstract
Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms...
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PMID: 20446769
PDF is available here.
PDF is available here.
Abstract
Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental and endogenous stresses and serves to render animals resistant to chemical carcinogenesis and other forms of toxicity, whereas disruption of the pathway exacerbates these outcomes. This pathway, w...
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PMID: 20367496
PDF is available here.
PDF is available here.
Abstract
We will discuss the regulation of each CRL using the Cul3-Keap1-E3 ligase complex as the primary focus. The substrates of CRLs are involved in many signaling pathways. Therefore, deregulation of CRLs affects several cellular processes, including cell cycle arrest, DNA repair, cell proliferation, sen...
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PMID: 20486766
PDF is available here.
PDF is available here.
Cell Cycle (9)23 2010
Abstract
We used budding yeast as a tool to explore Cdk2 function. We showed that hCdk2 promoted S phase in cells carrying a temperature-sensitive mutation in yCDK1, albeit, only when expressed at low or moderate levels. Overexpression of hCdk2 resulted in a defect in the G1 to S transition and a reduction i...
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PMID: 21099355
PDF is available here.
PDF is available here.
Abstract
We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monocl...
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PMID: 21088136
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (10)9 2010
Abstract
In recent years, oncologists have begun to conclude that chemotherapy has reached a plateau of efficacy as a primary treatment modality, even if toxicity can be effectively controlled. Emerging specific inhibitors of signaling and metabolic pathways (i.e., targeted agents) contrast w...
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PMID: 20935499
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We found that MitoQ is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible inhibition of clonogenic growth of breast cancer cells through a combination of autophagy and apoptotic cell death mechanisms. Relatively limited cytotoxicity was s...
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PMID: 20805228
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We tested whether chromatin modifications affected the requirement for Rtt107 and Slx4 during DNA damage repair. Here, we report that the sensitivity to DNA-damaging agents of rtt107Δ and slx4Δ mutants was rescued by inactivation of the chromatin regulatory pathway leading to H3 K79 trimethylation...
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PMID: 20810656
PDF is available here.
PDF is available here.
Abstract
We identified an FDA-approved drug, pyrvinium, as a potent inhibitor of Wnt signaling (EC(50) of ∼10 nM). We show pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. CK1α...
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PMID: 20890287
PDF is available here.
PDF is available here.
Abstract
To investigate the role of spleen tyrosine kinase (Syk) in rat pulmonary vascular smooth muscle cells (PVSMCs) proliferation induced by platelet-derived growth factor-BB (PDGF-BB).
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PMID: 21083985
PDF is available here.
PDF is available here.
Abstract
We report that mammalian target of rapamycin (mTOR) inhibitor rapamycin impaired Flt3L-driven DC development in vitro, with the pDCs and CD8(+)-like cDCs most profoundly affected. Conversely, deletion of the phosphoinositide 3-kinase (PI3K)-mTOR negative regulator Pten facilitated Flt3L-driven DC de...
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PMID: 20933441
PDF is available here.
PDF is available here.
Abstract
The rs5029939 G allele was found to be significantly associated with SSc susceptibility (pooled OR=2.08 (95% CI 1.59 to 2.72); p=1.16×10⁻⁷), whereas the rs10499194 and rs6920220 variants displayed no association. Only one of the predicted haplotypes investigated in the French sample was signifi...
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PMID: 20511617
PDF is available here.
PDF is available here.
Abstract
We suggest that the prevalence of WW domain-mediated complexes in the Hippo pathway should facilitate its molecular analysis and aid prediction of new pathway components.
Copyright © 2010 Elsevier Ltd. All rights reserved....
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PMID: 20598891
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but only in the G1-phase of the cell cycle. Recruitment of TopBP1 to sites of DNA replication stress was dependent on BRCT domains 1-2 and 7-8, whereas recruitment to sites of DNA DSBs was dependent on BRCT...
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PMID: 20871591
PDF is available here.
PDF is available here.
Molecular Therapy (18)11 2010
Abstract
We present a novel method to achieve this by adhering nanoparticles containing different small-interfering RNAs (siRNAs) into nanostructured scaffolds. This allows spatial retention of the RNAs within nanopores until their cellular delivery. The released siRNAs were capable of gene silencing BCL2L2...
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PMID: 20808289
PDF is available here.
PDF is available here.
Abstract
We show that serine 197 (S197) in the cytoplasmic tail of Ig-α is phosphorylated upon B-cell antigen receptor activation, and that this modification inhibits the signal output of the B-cell antigen receptor. Surprisingly, we found that the well-known protein tyrosine kinase Syk (spleen tyrosine kin...
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PMID: 20940318
PDF is available here.
PDF is available here.
EMBO Journal (29)20 2010
Abstract
We demonstrate with in vitro vesicle fusion experiments that αS has an inhibitory function on membrane fusion. Upon increased expression in cultured cells and in Caenorhabditis elegans, αS binds to mitochondria and leads to mitochondrial fragmentation. In C. elegans age-dependent fragmentation of...
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PMID: 20842103
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
In this phase 2 study, a Syk inhibitor reduced disease activity in patients with rheumatoid arthritis; adverse events included diarrhea, hypertension, and neutropenia. Additional studies will be needed to further assess the safety and efficacy of Syk-inhibition therapy in patients with rheumatoid ar...
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PMID: 20879879
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)14 2010
Abstract
Abstract
We describe the design and construction of an optimized expression and purification system for the full-length, human Cullin3-RINGBox 1 (Rbx1) protein complex from Escherichia coli. The dual-expression system is comprised of codon-optimized Cullin3 and Rbx1 genes co-expressed from a single pET-Duet-...
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PMID: 20735986
PDF is available here.
PDF is available here.
Neuroscience Letters (482)3 2010
Abstract
We have determined whether general anesthesia would affect plasma orexin A (OXA) and norepinephrine concentrations. Twelve patients scheduled for elective ophthalmic surgery under general anesthesia with sevoflurane, fentanyl and vecuronium were studied. Arterial blood was collected before and 1 and...
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PMID: 20655366
PDF is available here.
PDF is available here.
Abstract
Our experiment suggested that the swine MAPKAPK3 gene might play an important role in the growth and development differences between mini-type Diannan small-ear pigs and large-type Diannan small-ear pigs....
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PMID: 19921547
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Tocotrienols belong to the vitamin E family of chemicals known to have potent anti-proliferative and apoptotic activities against a variety of cancer cells with little to no comparable influence on the normal cells. Whether tocotrienols control the expression of phase II antioxidant enzymes in the c...
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PMID: 21036737
PDF is available here.
PDF is available here.