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Iodoproteins (1):
Recent article
Iodoproteins
Voprosy pitaniya (74)4 2005
Abstract
Iodine is an essential trace element, its deficiency leads to iodine-deficient diseases. Utilization of iodinated milk proteins in human diet seems to be one of possible decisions of the problem. The aim of the present work was to characterize iodinated milk proteins "Bioiod", produced by the origin...
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PMID: 16265907
PDF is available here.
PDF is available here.
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Abstract
We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea pig iodine allergy model and iodinated protein antigen...
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PMID: 15206582
PDF is available here.
PDF is available here.
Abstract
We hypothesize that iodine allergy is an immune response to iodinated self proteins produced in vivo from various iodine-containing chemicals. Since an antigenic determinant of experimental iodine allergy is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative an...
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PMID: 15206583
PDF is available here.
PDF is available here.
Abstract
I to cells constitutively expressing either NIS, or TPO or NIS/TPO, next to iodide accumulation due to NIS activity, organification was exclusively observed in TPO expressing/co-expressing cells. The use of specific inhibitors for TPO and NIS showed that organification is strictly dependent of TPO a...
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PMID: 15062578
PDF is available here.
PDF is available here.
Abstract
The thyroid gland is the only source of thyroid hormone production. Thyroid hormone is essential for growth and development, and is of special importance for the development of the central nervous system. It was for that reason that neonatal screening on congenital hypothyroidism was introduced and...
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PMID: 14514339
PDF is available here.
PDF is available here.
Voenno-meditsinskii zhurnal (324)5 2003
Abstract
To evaluate the efficiency of iodcasein in prophylaxis of iodine-deficient states in servicemen the following parameters were studied: iodine sufficiency determined by ioduria median; thyroid volume measured on the base of US data; functional state of hypothalamo-pituitary-thyroid system evaluated b...
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PMID: 12908402
PDF is available here.
PDF is available here.
Abstract
We report the case of a 52-year-old woman with recent diagnosis of acute myocarditis and pericarditis, admitted for fever, tachycardia, and dyspnea upon exertion. Hematochemical parameters and instrumental examinations suggested iatrogenic hyperthyroidism and secondary dilated cardiomyopathy. Althou...
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PMID: 10981492
PDF is available here.
PDF is available here.
Journal of Nuclear Medicine (40)10 1999
Abstract
The total (beta and gamma) doses to testes were 30, 33 and 43 microGy/MBq in the three subjects. CONCLUSION: These values are close to those derived from the ICRP tables (26-37 microGy/MBq 131I) for euthyroid subjects. The present data indicate that significant irradiation is delivered to the testes...
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PMID: 10520714
PDF is available here.
PDF is available here.
Clinica Chimica Acta (275)1 1998
Abstract
A method has been developed to determine plasma volume with dextran-70 without the use of a fluorescent label. The results obtained are compared to those found using the 125I-labeled albumin method, which is taken as the gold standard. The CV of the method is about 5%, compared to 3% with the gold s...
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PMID: 9706845
PDF is available here.
PDF is available here.
Abstract
Endocrinology (135)4 1994
Abstract
We examined whether polypeptides other than thyroglobulin are iodinated and hormonogenic in thyrocytes and the prerequisites for their iodination. In primary cultures of porcine thyrocytes, a substantial portion of organified radioiodine was incorporated into cellular proteins other than thyroglobul...
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PMID: 7925119
PDF is available here.
PDF is available here.
Southern Medical Journal (86)4 1993
Abstract
We have followed the case of a euthyroid patient who had a goiter diagnosed at age 15. It was originally diffuse and did not shrink during treatment, first with desiccated thyroid extract and then with triiodothyronine. After treatment was stopped, the goiter gradually became nodular and calcified w...
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PMID: 8465227
PDF is available here.
PDF is available here.
Abstract
We described sedimentation and immunologic abnormalities of thyroglobulin (Tg) in a strain of mice with inherited congenital goiter and hypothyroidism (cog/cog). The goals of the present study were to determine the extent to which thyroid gland stimulation by TSH accounts for the abnormal properties...
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PMID: 1493376
PDF is available here.
PDF is available here.
Cell and Tissue Research (265)2 1991
Abstract
This study attempts to elucidate the mechanism through which lysosomal accumulation occurs with age in the epithelial cells of the thyroid gland and especially in the "active" follicles of the aging mouse thyroid. Thyroid morphology and function in old CBA (at least 24 months of age) male mice were...
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PMID: 1934028
PDF is available here.
PDF is available here.
Endocrinology (128)6 1991
Abstract
1) blocking of all three endopeptidases reduced both iodopeptide formation in short term experiments and iodoamino acid release in long term experiments by 80-90%; 2) iodopeptide formation was reduced by 85% with Z-Phe-Ala-CHN2, by 56% with Z-Phe-Phe-CHN2, and by 26% with pepstatin; 3) iodoamino aci...
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PMID: 1903699
PDF is available here.
PDF is available here.
Abstract
1. Buffalo thyroglobulin is the major iodoprotein of buffalo thyroid with a sedimentation coefficient of 19 S and an apparent molecular mass of 685 kDa. 2. The protein is rich in iodine (1-2%) and thyroxine bound iodine (75%), unlike thyroglobulins of other mammalian species. 3. As a glycoprotein, i...
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PMID: 1799963
PDF is available here.
PDF is available here.
Abstract
I and PKA II) and calcium and phospholipid-dependent (PKC) protein kinases were studied in 2-day-old suspension cultures of porcine thyroid cells and were compared with those in freshly dissociated cells and intact glands. Thyroid cell morphology changed during the 2-day culture in the absence of sp...
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PMID: 2170212
PDF is available here.
PDF is available here.
Abstract
The RhD polypeptide and LW glycoprotein were separately immunopurified with monoclonal antibodies and compared by two-dimensional (2-D) iodopeptide mapping after digestion with alpha-chymotrypsin. These proteins have distinct 2-D maps, as seen after 125I-labeling tyrosine residues (chloramine-T proc...
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PMID: 2112034
PDF is available here.
PDF is available here.
Abstract
These results indicate that both strains inhibited protein iodination and caused a slight increase in lactoferrin release, but the virulent S. choleraesuis 38 inhibited S. aureus ingestion, cytochrome c reduction, and survived porcine PMNL killing more effectively than the avirulent S. choleraesuis...
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PMID: 2560864
PDF is available here.
PDF is available here.
Abstract
We have characterized the thyroid iodoprotein of a hagfish, Eptatretus burgeri, one of the lowest marine vertebrates. The iodoprotein was not very homogeneous in its apparent molecular mass which decreased with the increase in hormone/iodotyrosine ratio. Four subfractions with an apparent molecular...
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PMID: 2731544
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (264)12 1989
Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines.
Abstract
Monoiodinated radioligands of the homologous 36-amino acid peptides, neuropeptide Y (NPY) and peptide YY, were prepared by reverse phase high performance liquid chromatography with isocratic elution. [125I-Tyr1]- and [125I-Tyr36]monoiodoNPY bound equally well to a single class of high affinity bindi...
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PMID: 2708330
PDF is available here.
PDF is available here.
Biochemical Pharmacology (38)6 1989
Abstract
We iodinated endothelial membrane proteins of both the perfused rabbit lung and cultured rabbit lung endothelial cells. Endothelial cell protein 125I-labeling in the perfused intact lung was catalyzed by lactoperoxidase and glucose oxidase immobilized on 3-10 microns polyacrylamide beads (Enzymobead...
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PMID: 2539164
PDF is available here.
PDF is available here.
FEBS Letters (242)2 1989
Abstract
At moderate iodination levels (20 iodine atoms/mol) human thyroglobulin (hTg) produces after reduction a hormone-rich peptide of 26 kDa which contains the preferential hormonogenic 'acceptor' tyrosine (Tyr 5) of the protein. The site of cleavage of the hTg chain was demonstrated by analysis of the 2...
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PMID: 2914619
PDF is available here.
PDF is available here.
Journal of Cell Biology (107)6 Pt 1 1988
Abstract
We present here a mathematical model that accounts for the various proportions of plasma membrane constituents occurring in the lysosomal membrane of rat fibroblasts (Draye, J.-P., J. Quintart, P. J. Courtoy, and P. Baudhuin. 1987. Eur. J. Biochem. 170: 395-403; Draye, J.-P., P. J. Courtoy, J. Quint...
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PMID: 2848849
PDF is available here.
PDF is available here.
Abstract
The 32,000 molecular weight (mol wt) erythrocyte Rh D, c, and E polypeptides were separately purified from cDE/cDE erythrocytes by monoclonal immunoprecipitations and compared by two-dimensional iodopeptide mapping. Digestions of the isolated Rh polypeptides with alpha-chymotrypsin revealed a high d...
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PMID: 3139107
PDF is available here.
PDF is available here.
Abstract
A golgi-enriched subfraction was obtained from porcine thyroid glands by differential centrifugation. When incubated in a suitable medium, these vesicles were able to concentrate iodide from the medium and bind it to protein. The iodination process was inhibited by methylmercapto-imidazole and was i...
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PMID: 3409477
PDF is available here.
PDF is available here.
Abstract
Previous work from our laboratory has shown that 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-HO-A) is a potent inhibitor of iodine organification in calf thyroid slices. The present studies were performed in order to clarify the mechanism of this action. Incubation of thyroid slices with 10(-4)...
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PMID: 3131225
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (253)3 Pt 2 1987
Abstract
These results do not support the earlier notion that delay is caused by a redistribution of the labeled protein in the body to radiometrically more favorable sites. However, they are compatible with the assumption that delayed passage of a protein dose through the extracellular matrix and/or retarde...
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PMID: 3307457
PDF is available here.
PDF is available here.
Abstract
We obtained Kd values of 1.3 +/- 0.2 nM for the tyrosine-10-labeled analog and 2.0 +/- 0.2 nM for the tyrosine-13-labeled glucagon isomers confirming the higher receptor binding affinity of (Try-10)-mono-125I-glucagon. All competition curves fit the mathematical expression for a model of non-coopera...
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PMID: 3036251
PDF is available here.
PDF is available here.
Abstract
The activation-induced phosphorylation of T-cell antigen receptor (Ti)-associated proteins was investigated in order to analyse possible signal-transduction mechanisms leading to two distinct effector functions of a mouse cytolytic T-cell clone (KB5.C20): target cell killing (independent of protein...
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PMID: 2953355
PDF is available here.
PDF is available here.
Acta Radiologica (28)4 1987
Abstract
The use of radiographic contrast media is occasionally accompanied by more or less serious adverse effects, evidently of complex etiology, following intravascular administration. Some of these reactions are suspected of having an allergic basis. The in vitro and in vivo formation of iodinated serum...
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PMID: 2958066
PDF is available here.
PDF is available here.
Abstract
Soluble thyroid proteins of the human fetus were studied in parallel with the formation of the follicular structure of the gland using polyacrylamide disc electrophoresis and a radioimmunological method for measuring thyroglobulin (Tg). The study covered 24 fetuses obtained after sectio parvae perfo...
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PMID: 3549331
PDF is available here.
PDF is available here.
Endocrinology (119)6 1986
Abstract
Maternal and fetal rabbit thyroid glands were compared as to their ability to respond to excess iodide in vitro with a reduction in subsequent iodide transport activity. Preincubation of maternal thyroid tissue slices for 2 h with excess iodide (30 microM) resulted in a 31% reduction in the subseque...
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PMID: 3023017
PDF is available here.
PDF is available here.
Endocrinology (119)6 1986
Abstract
The role of protein synthesis in iodide-induced suppression of subsequent iodide transport (iodide autoregulation) was studied in cat thyroid slices. Thyroid slices were pretreated for 60-120 min in the presence or absence of either excess (30 microM) sodium iodide, inhibitors of protein synthesis,...
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PMID: 3780538
PDF is available here.
PDF is available here.
Analytical Biochemistry (158)2 1986
Abstract
These results indicate that radioiodination substantially alters the kinetics of the binding of IgG to polystyrene. In addition, the results obtained are discussed with respect to previous relevant and often apparently contradictory findings....
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PMID: 3812982
PDF is available here.
PDF is available here.
Acta Endocrinologica (112)4 1986
Abstract
In order to elucidate whether or not the 'coupling defect' observed in thyroids from diabetic rats is due to a structural defect of intrathyroidal thyroglobulin (Tg), the sedimentation pattern and the stability of the thyroidal soluble iodoproteins were studied in control (C), food restricted (FR),...
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PMID: 3529786
PDF is available here.
PDF is available here.
Abstract
Monoclonal antibodies (MA) to a thrombocytopoiesis-stimulating factor (TSF or thrombopoietin) were obtained from hybridomas derived from the fusion of P3 X 63/Ag 8 cells and spleen cells from TSF-immunized BALB/c mice. The immunizing protein was a partially purified TSF-rich preparation from the uri...
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PMID: 3703869
PDF is available here.
PDF is available here.
Abstract
Iodide organification by rat mammary glands was studied during the trimesters of pregnancy and early postpartum period. Organification was followed by measuring trichloroacetic acid (TCA) precipitation of delipidated tissue homogenates. The radiolabeled material was sensitive to proteolytic cleavage...
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PMID: 3945653
PDF is available here.
PDF is available here.
Acta Endocrinologica (111)2 1986
Abstract
Under normal conditions, a small amount of thyroglobulin (Tg) exists in peripheral blood. However, the fate of circulating Tg is unclear. In the present study, in vivo labelled rat Tg was injected iv into rats whose thyroids had been blocked with KI to determine whether circulating Tg released thyro...
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PMID: 3953233
PDF is available here.
PDF is available here.
Abstract
Human growth hormone was labelled with 125 Iodine by the stoichiometric modification of the chloramine-T method to a specific activity of 50-80 microCi/microgram, and the iodinated mixture was purified by reverse-phase high performance liquid chromatography using a C18 column (SynChropak RP-P) and a...
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PMID: 3004459
PDF is available here.
PDF is available here.
Journal of Cell Biology (101)6 1985
Abstract
We propose that this switch in cell surfaces and in secretions dependent upon cell-substratum attachments may be a common control mechanism important for embryogenesis, wound healing, and cancer....
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PMID: 2999161
PDF is available here.
PDF is available here.
Abstract
A 2 X 2 factorial arrangement with two genotypes of pigs (genetically obese and lean) and two dietary treatments (basal, a 16% protein corn-soybean meal standard grower diet, and basal +220 ppm thyroprotein as iodinated casein) was used. The 28 gilts were housed individually and fed ad libitum from...
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PMID: 4066527
PDF is available here.
PDF is available here.
Analytical Biochemistry (148)1 1985
Abstract
A rapid procedure for the separation of Escherichia coli heat-stable enterotoxin iodination products is described. A two-step procedure using reverse-phase chromatography results in the separation of native, noniodinated heat-stable enterotoxins from several distinctly iodinated species which differ...
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PMID: 4041144
PDF is available here.
PDF is available here.
Abstract
Our results confirm and extend earlier observations on a functional link between exocytosis and iodination. Redistribution of peroxidase as well as newly synthesized protein to the site of iodination might be of importance....
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PMID: 3996747
PDF is available here.
PDF is available here.
Medical Hypotheses (16)2 1985
Abstract
The signs and symptoms of hyperthyroidism are similar to those of phaeochromocytoma and adrenergic stimulation. These changes have been attributed to increased beta receptor numbers in hyperthyroidism, resulting in adrenergic supersensitivity. Beta blockers are used in treatment of hyperthyroidism a...
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PMID: 2985942
PDF is available here.
PDF is available here.
Abstract
Differential absorption spectra of alkaline solutions of monoiodotyrosine and thyroxine with 90% D2O as perturbant were measured and characterized. The obtained spectra are mainly determined by the difference of dielectric constants.
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PMID: 3986223
PDF is available here.
PDF is available here.
Abstract
125I[D-Ala2, Met5] enkephalin with high specific activity (122-185 Ci/mmol) was prepared and purified by Sep-Pak C18 reverse phase cartridge followed by high performance liquid chromatography (HPLC). HPLC at pH 3.0 resolved 125I[D-Ala2, Met5] enkephalin into two fractions, which ran as a single spot...
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PMID: 6099338
PDF is available here.
PDF is available here.
Abstract
The relationships among the content and composition of soluble iodoproteins in thyroid gland, the serum Tg concentration and the morphological structure of gland were investigated in guinea-pigs during short-term and long-term TSH administration (2 I.U. per day for 1 to 28 days). A significant decre...
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PMID: 6541146
PDF is available here.
PDF is available here.
Abstract
We characterized the abnormal thyroglobulin (TG) in the thyroid and serum of a 12-yr-old girl with a large sporadic multinodular goiter first noted at age 4 yr. She developed normally and had no clinical evidence of hypothyroidism. However, her serum T4 was less than 1.0 microgram/dl, T3 was 125 ng/...
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PMID: 6693549
PDF is available here.
PDF is available here.
Endocrine Research (10)1 1984
Abstract
Abstract
Surface membrane proteins of viable merozoites of Plasmodium chabaudi were iodinated by the Iodogen method and analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Thirteen surface membrane proteins ranging from 22 to 270 kDa were thus identified. Most of these proteins could be im...
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PMID: 6694670
PDF is available here.
PDF is available here.
Journal of Immunoassay (5)1-2 1984
Abstract
A derivative of the C-terminal nonapeptide of CCK, namely (Thr34, Nle37) - CCK31-39 was radio-iodinated by conjugation with 125I-Bolton-Hunter reagent. The labelled peptide was purified by RP-HPLC on a C-18 column. Validation of the iodinated peptide was performed by measuring its biological integri...
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PMID: 6201510
PDF is available here.
PDF is available here.
Journal of Virology (49)1 1984
Abstract
A molecular complex of simian virus 40 large tumor antigen (T-Ag) and p53 cellular protein is present on the surface of simian virus 40-transformed mouse cells. The stability of the association of the two proteins with the cell surface was characterized. Cells were either surface iodinated by the la...
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PMID: 6690721
PDF is available here.
PDF is available here.
Abstract
A procedure is described for the rapid analysis of nanogram quantities of protein resolved by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE). Proteins are first radioiodinated by the chloramine T method, acid precipitated after addition of a visible marker protein and collect...
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PMID: 6677646
PDF is available here.
PDF is available here.
Abstract
After subcutaneous injection, monoclonal antibodies directed against a tumor can enter local lymphatic vessels, pass to the draining lymph nodes, and bind to metastases there. Lymphatic delivery of antibody to early metastases is more efficient than intravenous administration, and the lymphatic rout...
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PMID: 6623082
PDF is available here.
PDF is available here.
Cell Differentiation (13)2 1983
Abstract
The protein composition of the sea urchin embryo hyaline layer has been studied by 125I surface labeling. The electrophoretic patterns of iodinated proteins indicate that the composition of the hyaline layer is species and stage-specific. Dissociation of iodinated embryos removes some labeled protei...
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PMID: 6661780
PDF is available here.
PDF is available here.
Clinica Chimica Acta (132)3 1983
Abstract
Prostatic acid phosphatase was labeled by four different iodination procedures: chloramine-T, insoluble or soluble lactoperoxidase, and Bolton-Hunter. Enzyme labeled by the chloramine-T procedure had suboptimal precipitation characteristics in immunoassays, with 36 to 67% of the tracer precipitated...
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PMID: 6616882
PDF is available here.
PDF is available here.
Abstract
Crude congenital goitres from cattle were enriched in iodoprotein content by gel chromatography. From this fraction thyroglobulin-like protein was isolated by affinity chromatography with antithyroglobulin IgG. The goitre thyroglobulin-like protein constituted only about 20% of the iodoprotein fract...
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PMID: 6879362
PDF is available here.
PDF is available here.
Abstract
Normal resting human breast tissue was obtained from immediate autopsies performed on six women who had died from head injuries sustained in accidents. Tissue samples containing epithelium were dissected asceptically and either fixed immediately or placed into culture. Samples in culture for 2 or 3...
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PMID: 6632051
PDF is available here.
PDF is available here.
Biochemistry (Washington) (22)13 1983
Abstract
Complexes were prepared containing 30S ribosomal subunits from Escherichia coli and the three initiation factors IF1, IF2, and IF3. In different experiments, each of the factors was radiolabeled with the others unlabeled. The complexes were allowed to react with 2-iminothiolane and then oxidized to...
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PMID: 6349681
PDF is available here.
PDF is available here.