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Iron-Regulatory Proteins (2):
Recent article
Iron-Regulatory Proteins
Abstract
We have compared relative gene expression of duodenal iron transporters among C282Y homozygotes [hereditary hemochromatosis (HH)] with and without iron overload. Duodenal biopsy samples were analyzed using real-time PCR for expression of DMT1, FPN1, DCYTB, and HEPH relative to GAPDH from 23 C282Y ho...
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PMID: 19892936
PDF is available here.
PDF is available here.
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Abstract
We show that IRP1 binds 5' IREs in a hierarchy extending over a ninefold range of affinities that encompasses changes in IRE binding affinity observed with human L-ferritin IRE mutants. The limits of this IRE binding hierarchy are predicted to arise due to small differences in binding energy (e.g.,...
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PMID: 19939970
PDF is available here.
PDF is available here.
Abstract
We have reported three Fe-deficiency-responsive elements (FEREs), FOX1, ATX1, and FEA1, all of which are positive regulatory elements in response to iron deficiency in Chlamydomonas reinhardtii. Here we describe FTR1, another iron regulated gene and mutational analysis of its promoter. Our results r...
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PMID: 20182641
PDF is available here.
PDF is available here.
Biochemical Journal (424)2 2009
Abstract
We demonstrated recently that HFE is expressed exclusively in the basal membrane of RPE (retinal pigment epithelium). In the present study, we used Hfe-/- mice to examine ferritin levels (an indirect readout for iron levels) and morphological changes in retina. We found increased ferritin accumulati...
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PMID: 19715555
PDF is available here.
PDF is available here.
Neurobiology of Aging (30)11 2009
Abstract
We compared young and old rodent retinas to assess iron homeostasis during normal aging and the effects of increased iron on the susceptibility of retinal neurons to degeneration. Retinal iron was significantly increased with age. Quantitative RT-PCR showed that transferrin and ferritin genes were u...
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PMID: 18308429
PDF is available here.
PDF is available here.
Biochemical Journal (421)3 2009
Abstract
We identified a single mitoferrin gene (dmfrn) in the genome of Drosophila melanogaster, which is probably an orthologue of mfrn2. Overexpression of dmfrn in the Drosophila l(2)mbn cell line (mbn-dmfrn) resulted in decreased binding between IRP-1A (iron regulatory protein 1A) and stem-loop RNA struc...
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PMID: 19453295
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (419)3 2009
Abstract
We report on the expression of HJV. Since infection of retina with CMV (cytomegalovirus) causes blindness, we also investigated the expression of HJV and other iron-regulatory proteins in retina during CMV infection. HJV (HJV gene) mRNA was expressed in RPE (retinal pigment epithelium)/eyecup and ne...
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PMID: 19191760
PDF is available here.
PDF is available here.
Abstract
Molecular Cell (32)6 2008
Abstract
We screened for and identified small molecules that selectively decrease HIF-2a translation in an mTOR-independent manner, by enhancing the binding of Iron-Regulatory Protein 1 (IRP1) to a recently reported iron-responsive element (IRE) within the 5'-untranslated region (UTR) of the HIF-2a message....
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PMID: 19111663
PDF is available here.
PDF is available here.
Neurobiology of Disease (32)2 2008
Abstract
We will provide an overview of human and animal studies investigating the contributions of iron in PD, a summary of human studies of iron-related genes in PD, a review of the literature on the genetics of iron metabolism, and some hypotheses on possible roles for iron in the pathogenic processes of...
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PMID: 18675357
PDF is available here.
PDF is available here.
Rinsho Ketsueki (49)10 2008
Abstract
Virus Genes (37)2 2008
Iron increases translation initiation directed by internal ribosome entry site of hepatitis C virus.
Abstract
We show that iron enhances the translation initiation mediated by the internal ribosome entry site (IRES) of HCV. We also demonstrate by UV cross-linking analysis that specific cellular proteins bind to HCV 5' untranslated region (5' UTR) in an iron-dependent manner. Notably, p85 and p110 are compet...
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PMID: 18566883
PDF is available here.
PDF is available here.
Abstract
Our data demonstrate that a productive BHV-1 infection in MDBK cells determines an overall decrease of IRPs RNA-binding activity without affecting their expression. As consequence of this modulation, an increased ferritin mRNA translation and a decreased TfR-1 mRNA translation were also observed. Mo...
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PMID: 17990282
PDF is available here.
PDF is available here.
Over-expressed human divalent metal transporter 1 is involved in iron accumulation in MES23.5 cells.
Abstract
These results suggested that increased DMT1+IRE expression in MES23.5 cells caused the increased intracellular iron accumulation. This resulted in the increased oxidative stress leading to ultimate cell apoptosis....
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PMID: 18082289
PDF is available here.
PDF is available here.
Abstract
We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control netw...
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PMID: 18489257
PDF is available here.
PDF is available here.
Abstract
We discuss the changing views of intracellular LI pools in relation to iron homeostasis and cellular distribution in physiological and pathological states....
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PMID: 17451993
PDF is available here.
PDF is available here.
BMC Biochemistry (9)1 2008
Abstract
We now show that pro-protein convertases (PC) are responsible for conversion of 50 kDa RGMc to a 40 kDa protein with a truncated COOH-terminus. Unlike related molecules RGMa and RGMb, RGMc encodes a conserved PC recognition and cleavage site, and JH-associated RGMc frame-shift mutants undergo COOH-t...
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PMID: 18384687
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (15)21 2008
Abstract
We propose that iron may contribute to the pathogenesis of atherosclerosis not only via changes in the body iron amount but also by its regulatory roles in redox-sensitive signaling and inflammatory immune responses of atherosclerosis....
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PMID: 18781942
PDF is available here.
PDF is available here.
Journal of Nutrition (137)12 2007
Abstract
We investigated the potential role of IRP in the regulation of iron homeostasis under conditions of vitamin A deficiency and supplementation with all-trans-retinoic acid (atRA). Rats were fed a control diet or a diet deficient in either vitamin A or iron or both micronutrients. Four parallel groups...
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PMID: 18029484
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)47 2007
Abstract
We now report that chromatin immunoprecipitated with Bach1 antiserum contains ferritin DNA sequences. In addition, overexpression of Bach1 protein in the transfected cells decreased ferritin expression, indicating insufficient endogenous Bach1 for full repression; decreasing Bach1 with antisense RNA...
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PMID: 17901053
PDF is available here.
PDF is available here.
Abstract
We suppose, based on our previous studies, that the newly discovered iron transporter divalent metal transporter 1 (DMT1) might be involved in this SN iron accumulation process. To investigate this, we first observed the cellular expression of DMT1 in rat SN, both with the iron response element (+IR...
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PMID: 17663481
PDF is available here.
PDF is available here.
Abstract
The life of aerobes is dependent on iron and oxygen for efficient bioenergetics. Due to potential risks associated with iron/oxygen chemistry, iron acquisition, concentration, storage, utilization, and efflux are tightly regulated in the cell. A central role in regulating iron/oxygen chemistry in an...
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PMID: 17849083
PDF is available here.
PDF is available here.
Abstract
Chronic iron administration elicits a unique pattern of stress protein expression. These alterations may modulate hepatic responses to iron overload, as well as other injury processes....
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PMID: 17590401
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)28 2007
Abstract
We show that exposure of cultured cells to sustained low levels of H(2)O(2) that mimic its release by inflammatory cells leads to up-regulation of transferrin receptor 1 (TfR1), the major iron uptake protein. The increase in TfR1 results in increased transferrin-mediated iron uptake and cellular acc...
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PMID: 17517884
PDF is available here.
PDF is available here.
Laboratory Investigation (87)7 2007
Abstract
In the present study, turpentine oil was injected in the hind limb muscle of the rat to stimulate an acute-phase response (APR). The changes in the gene expression of cytokines and proteins known to be involved in the iron regulatory pathway were then studied in the liver and in extra-hepatic tissue...
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PMID: 17417667
PDF is available here.
PDF is available here.
Abstract
We have studied the evolution of the IRE by considering all mRNAs previously known to be associated with this structure and by computationally examining its occurrence in a large variety of eukaryotic organisms. More than 100 novel sequences together with approximately 50 IREs that were previously r...
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PMID: 17513696
PDF is available here.
PDF is available here.
Abstract
Hypertransfusional (>8 transfusions/year) iron in liver biopsies collected immediately after transfusions in beta-thalassemia and sickle cell disease correlated with increased expression (RNA) for iron regulatory proteins 1 and 2 (3-, 9- to 11-fold) and hepcidin RNA: (5- to 8-fold) (each p <.01), wh...
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PMID: 17613866
PDF is available here.
PDF is available here.
Abstract
Iron is essential for oxygen transport because it is incorporated in the heme of the oxygen-binding proteins hemoglobin and myoglobin. An interaction between iron homeostasis and oxygen regulation is further suggested during hypoxia, in which hemoglobin and myoglobin syntheses have been reported to...
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PMID: 17311997
PDF is available here.
PDF is available here.
Journal of Bacteriology (189)11 2007
Abstract
We demonstrate that M. tuberculosis Acn is bifunctional. It is a monomeric protein that is enzymatically active in converting isocitrate to cis-aconitate at a broad pH range of 7 to 10 (optimum, pH 8). As evident from gel retardation assays, M. tuberculosis Acn also behaves like an IRP by binding to...
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PMID: 17384188
PDF is available here.
PDF is available here.
Archives of Toxicology (81)5 2007
Abstract
We studied the effect of dietary Fe on the expression of these metal transporters in peripheral tissues, and the uptake by these tissues of Cd. Mice were fed an Fe-sufficient (FeS: 120 mg Fe/kg) or Fe-deficient (FeD: 2-6 mg Fe/kg) diet for 4 weeks. The total Fe levels in the body were evaluated by m...
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PMID: 17031680
PDF is available here.
PDF is available here.
Inhalation Toxicology (19)6-7 2007
Abstract
We hypothesized that select metals (e.g., V, Al, and Mn) in each PM2.5 caused changes in alveolar macrophage (AM) Fe status that, ultimately, would lead to altered antibacterial function. To test this, iron-response protein (IRP) binding activity in a rat AM cell line was assessed after exposure to...
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PMID: 17497533
PDF is available here.
PDF is available here.
Journal of Hepatology (46)5 2007
Abstract
The S338R mutation results in a mutated ferroportin associated with iron overload and is predicted insensitive to regulation by the iron regulatory hormone hepcidin....
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PMID: 17383046
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (15)2 2007
[Expression of mitochondrial ferritin in K562 leukemic cell during TPA-induced cell differentiation]
Abstract
Mitochondrial ferritin (MtF), a new player in iron metabolism, first identified in 2001, is highly homologous to ferritin both structurally and functionally. Preliminary studies have suggested that MtF might play very important roles in the regulation of mitochondrial iron homeostasis. Leukemic cell...
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PMID: 17493330
PDF is available here.
PDF is available here.
Molecular Psychiatry (12)3 2007
Abstract
Abstract
FASEB Journal (21)2 2007
Abstract
We developed human neuroblastoma stable cell lines that express either wild-type (WT) or mutant HFE to determine the cellular consequences of the mutant forms of HFE. The presence of the C282Y mutation was associated with relatively higher labile iron pool and iron regulatory protein activity than W...
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PMID: 17194693
PDF is available here.
PDF is available here.
Trends in Cell Biology (17)2 2007
Abstract
We focus on these intriguing new molecules and the insights gained from them into cellular iron uptake and the regulation of iron metabolism....
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PMID: 17194590
PDF is available here.
PDF is available here.
Abstract
The level of serum ferritin normally parallels the concentration of storage iron within the body. In the absence of chronic diseases elevated serum ferritin levels will lead to the diagnosis congenital haemochromatosis. However, there are genetic disorders with high ferritin levels without any sign...
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PMID: 18330093
PDF is available here.
PDF is available here.
Methods in Enzymology (429) 2007
Abstract
We developed a "tethered function" assay, in which the mRNA regulatory protein is brought to the 3' UTR of an mRNA reporter through a heterologous RNA-protein interaction. In this manner, the functional activity of the protein can be studied independent of its intrinsic ability to recognize and bind...
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PMID: 17913629
PDF is available here.
PDF is available here.
Iubmb Life (59)4-5 2007
Abstract
Calcium and iron play dual roles in neuronal function: they are both essential but when present in excess they cause neuronal damage and may even induce neuronal death. Calcium signals are required for synaptic plasticity, a neuronal process that entails gene expression and which is presumably the c...
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PMID: 17505966
PDF is available here.
PDF is available here.
Abstract
We discuss how dysregulation of the IRP system can result from both iron-related and unrelated effectors and explain how this can have important pathological consequences in several human disorders....
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PMID: 18053288
PDF is available here.
PDF is available here.
Biochemistry (Washington) (45)51 2006
Abstract
We determined X-ray structures of native and SeMet forms of the PH hydroxylase (PHH) in complex with its regulatory protein (PHM) to 2.3 A resolution. PHM binds in a canyon on one side of the (alphabetagamma)2 PHH dimer, contacting alpha-subunit helices A, E, and F approximately 12 A above the diiro...
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PMID: 17176061
PDF is available here.
PDF is available here.
Journal of Parasitology (92)6 2006
Abstract
Ferritin is an intracellular protein that is involved in iron metabolism. A cDNA clone of Clonorchis sinensis (CsFtn), 565 bp long, encoded a putative polypeptide of 166 amino acids. CsFtn cDNA revealed a putative loop-stem structure similar to iron-responsive element (IRE). CsFtn polypeptide appear...
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PMID: 17304806
PDF is available here.
PDF is available here.
Abstract
IRP1 binding may not be altered in the rat model of chronic anthracycline cardiotoxicity....
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PMID: 16555089
PDF is available here.
PDF is available here.
Liver International (26)8 2006
Abstract
Taken together, the altered expressions of iron-regulatory genes in HCCs possibly reflect an increased demand for bioavailable iron and a high iron turnover in neoplastic cells....
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PMID: 16953838
PDF is available here.
PDF is available here.
Abstract
We examined the effects of MtFt overexpression on tumor iron metabolism and growth. The expression of MtFt dramatically reduced implanted tumor growth in nude mice. Mitochondrial iron deposition in MtFt-expressing tumors was directly observed by transmission electron microscopy. A cytosolic iron sta...
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PMID: 16757684
PDF is available here.
PDF is available here.
Abstract
We showed that the pattern of HFE expression mirrored the distribution of CD68+ macrophage Kupffer cells. FPN was also most strongly expressed by CD68+ Kupffer cells. These findings contribute to understanding how iron is transported and stored in the human placenta and liver....
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PMID: 16856887
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)33 2006
Abstract
We have identified several elements in the signal transduction pathway leading to the increase of AtFer1 transcript level after iron treatment. Nitric oxide quickly accumulates in the plastids after iron treatment. This compound acts downstream of iron and upstream of a PP2A-type phosphatase to prom...
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PMID: 16782706
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1763)7 2006
Abstract
Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron me...
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PMID: 16872694
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (281)27 2006
Abstract
We used purified recombinant IRP-1A and IRP-1B from Drosophila melanogaster and showed that only IRP-1A can bind to IREs, although both proteins possess aconitase activity. These results were also corroborated in whole-fly homogenates from transgenic flies that overexpress IRP-1A and IRP-1B in their...
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PMID: 16679315
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (14)3 2006
Abstract
To explore a rapid and easy method to detect labile iron of pool (LIP) in cells, HL-60 and K562 cells were cultured at a concentration 1 x 10(6)/ml in RPMI 1640 containing 10% heat-inactivated fetal bovine serum. The iron deprivation was induced by adding desferrioxamine (DFO) 10 - 100 micromol/L fo...
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PMID: 16800922
PDF is available here.
PDF is available here.
Abstract
Summary Hepcidin is an important and recently discovered regulator of iron homeostasis. There is strong evidence in support of an important role for hepcidin dysregulation in the pathogenesis of iron overload disorders, and possibly in the aetiology of the anaemia of chronic disease. Further researc...
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PMID: 16630211
PDF is available here.
PDF is available here.
Abstract
We discuss some recently identified anomalies in proteins linked with iron metabolism which signify a critical role for iron dysregulation in neurodegeneration....
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PMID: 16565471
PDF is available here.
PDF is available here.
Abstract
Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their reg...
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PMID: 16565477
PDF is available here.
PDF is available here.
Experimental Brain Research (170)3 2006
Abstract
Iron regulatory proteins (IRP1 and IRP2) bind to iron response elements (IRE) on specific mRNAs, to affect the translation of many proteins involved in iron metabolism. An increase in iron levels and divalent metal transporter-1 (DMT1) expression have been observed in the rat hippocampus after excit...
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PMID: 16328268
PDF is available here.
PDF is available here.
Iron metabolism in insect disease vectors: mining the Anopheles gambiae translated protein database.
Abstract
We have analyzed the Anopheles gambiae translated protein database for candidates that show identity to proteins involved in mammalian iron metabolism (Holt et al., 2002. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298, 129-149). Our results indicate that proteins involved...
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PMID: 16551545
PDF is available here.
PDF is available here.
Abstract
Iron regulatory protein 1 (IRP1) is a bifunctional protein with activity as an RNA-binding protein or as a cytoplasmic aconitase. Interconversion of IRP1 between these mutually exclusive states is central to cellular iron regulation and is accomplished through iron-responsive assembl...
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PMID: 16511314
PDF is available here.
PDF is available here.
Abstract
We focused on MRCKalpha. Biochemical analyses of the MRCKalpha IRE revealed that it was functional and mediated the response to iron level in the same way as transferrin receptor 1 IREs (TfR) did. Similarly to TfR mRNA, MRCKalpha mRNA is stabilized, when iron supply is low, while it is destabilized...
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PMID: 16412980
PDF is available here.
PDF is available here.
Human Mutation (27)2 2006
Abstract
We included in this study three new mutations. Thus, we analyzed 24 mutations spanning over a DNA stretch of 48 nucleotides, including four deletions 2-29 nucleotides long and 20 substitutions, seven of which were conservative transversions. With this unique experimental model we developed a microch...
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PMID: 16395671
PDF is available here.
PDF is available here.