Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
LDL-Receptor Related Proteins (2):
Recent article
LDL-Receptor Related Proteins
Neurobiology of Aging (32)3 2011
Abstract
We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amyloid beta (Aβ) protein and/or hyperphosphorylated microtubule-associated protein tau (MAPT): amyloid precursor protein (APP), beta-site amyloid precur...
|
PMID: 21093110
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Clinical calcium (20)10 2010
Abstract
Wnt signal has been known to play various roles in many organ from the beginning of embryogensis. Its role in bone metabolism has also been investigated and established. Lipoprotein receptor-related protein 5 (LRP5) is one of the important molecules in wnt signal pathway whose point mutations are re...
|
PMID: 20890035
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Wnt signaling system plays essential roles in development, cancer and bone metabolism. Canonical wnt signaling, which involves wnt ligands, receptor named frizzled and co-receptors LRP5/6, beta-catenin and transcription factors named LEF/TCF is well characterized and its defect causes bone abnormali...
|
PMID: 20890034
PDF is available here.
PDF is available here.
Abstract
Inhalation Toxicology (22)9 2010
Abstract
We examined how the duration and cessation of cigarette smoke exposure affects lymphocyte distribution and function in normal mice and mice predisposed to low or high bone mass due to disruption or mutation of Lrp5. We find that, independent of genotype, mice exposed to cigarette smoke for 3-12 week...
|
PMID: 20482464
PDF is available here.
PDF is available here.
Abstract
We summarize how proline-directed kinases (Gsk3, PKA, Pftk1, Grk5/6) and non-proline-directed kinases (CK1 family) act upon Lrp6, how the phosphorylation is regulated by ligand binding and mitosis, and how Lrp6 phosphorylation leads to beta-catenin stabilization....
|
PMID: 20229235
PDF is available here.
PDF is available here.
Abstract
The low-density lipoprotein receptor-related protein 5 (LRP5) has been shown to play a significant role in bone biology. This study aimed to assess the association of four common polymorphisms of the LRP5 gene with bone mineral density (BMD) and possible genexcalcium intake interactions in Greek pos...
|
PMID: 20630166
PDF is available here.
PDF is available here.
Abstract
We classified a hair follicle into four areas, hair bulb, hair bulb to bulge (lower bulge), bulge, and epidermis to bulge (upper bulge), and collected these areas from back skin sections of C57BL/6 mice by laser microdissection. Real-time RT-PCR performed on these areas revealed that Frizzled (Fzd)-...
|
PMID: 20450888
PDF is available here.
PDF is available here.
Abstract
We show that mice with a Dermo1-Cre-mediated disruption of Lrp5 in osteoblast progenitor cells have normal embryonic skeletogenesis and normal skeletal growth and development postnatally. Histomorphometric analysis of 3-month-old adult mice revealed normal osteoblast numbers, bone formation rate, an...
|
PMID: 20333369
PDF is available here.
PDF is available here.
Abstract
Abstract
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and an increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density and other determinants of fracture risk, such as ultrasound properties of...
|
PMID: 20392235
PDF is available here.
PDF is available here.
Abstract
We showed that Lrp5 actually enhances bone formation by inhibiting the expression, in duodenum, of tryptophan hydroxylase 1, the rate-limiting enzyme in the serotonin biosynthetic pathway. Accordingly, serotonin circulating levels are high in Lrp5(-/-) mice and OPPG patients but low in HBM patients,...
|
PMID: 20392224
PDF is available here.
PDF is available here.
Abstract
We found that the expression of Wnt signaling co-receptor, LRP6, is upregulated in a subset of human breast cancer tissues and cell lines. To examine whether the overexpression of LRP6 in mammary epithelial cells is sufficient to activate Wnt signaling and promote cell proliferation, we generated tr...
|
PMID: 19881541
PDF is available here.
PDF is available here.
Abstract
We have previously shown the soluble intracellular domain of the LRP6 receptor, a receptor required for activation of the Wnt pathway, can positively regulate transcriptional activity within the Wnt pathway. In the current study, we show the soluble LRP6 intracellular domain (LRP6-ICD) can also tran...
|
PMID: 20676368
PDF is available here.
PDF is available here.
Abstract
We report on the clinical and molecular findings of four unrelated Japanese patients with the syndrome. The four patients had typical skeletal and ocular phenotypes of OPS, namely severe juvenile osteoporosis and early-onset visual disturbance, with or without mental retardation. We undertook standa...
|
PMID: 20034086
PDF is available here.
PDF is available here.
Abstract
We have determined the retinal cell types that express LRP5 and investigated specific molecular and cellular functions that may be regulated by LRP5 signaling in the retina.
We characterized the development of retinal vasculature in LRP5 mutant mice using specific retinal cell makers and a GFP trans...
|
PMID: 20652025
PDF is available here.
PDF is available here.
Abstract
Our results suggest that the sFRP4 c1019G>A polymorphism may be one of the genetic factors affecting lumbar spine BMD in postmenopausal Korean women....
|
PMID: 20613673
PDF is available here.
PDF is available here.
Abstract
We have analyzed disease associated genetic variants in each of these genes for association with cerebrospinal fluid (CSF) Aβ or tau levels in 602 samples from two independent CSF series. We failed to detect association between CSF Aβ42 levels and single nucleotide polymorphisms in SORL1 despite s...
|
PMID: 20634593
PDF is available here.
PDF is available here.
Abstract
We established an animal stroke model and observed a phenomenon of spontaneous rethrombosis and thrombolysis in the cerebral vessels after vessel damage. Endogenous t-PA protected brain damage by recanalization, but the protective effect deteriorated when the occluded vessels were not reopened. On s...
|
PMID: 20595786
PDF is available here.
PDF is available here.
Molecular Cancer (9) 2010
Abstract
Our study provides a novel insight into mechanisms of myeloma associated osteolytic lesions....
|
PMID: 20846389
PDF is available here.
PDF is available here.
Science Signaling (3)142 2010
Abstract
We found that apolipoprotein E (ApoE) was present on ischemic microvessels but not contralateral controls. ApoE signaled through ApoE receptor-2 (ApoER2), which was constitutively expressed on brain microvessels, to decrease c-Jun amino-terminal kinase 1 and 2 and c-Jun activities. ApoE regulated th...
|
PMID: 20923933
PDF is available here.
PDF is available here.
Abstract
Rapid engulfment of apoptotic cells in the absence of inflammation is required for maintenance of normal tissue homeostasis. The low-density lipoprotein receptor-related protein-1 (LRP/CD91) is a receptor mediating interactions between macrophages and apoptotic cells, but recent repo...
|
PMID: 20375555
PDF is available here.
PDF is available here.
Neurobiology of Disease (35)2 2009
Abstract
Biomarkers are needed to overcome critical roadblocks in the development of disease-modifying therapeutics for neurodegenerative diseases. Evolving genome-wide expression technologies can comprehensively search for molecular biomarkers and allow fascinating insights into the expanding complexity of...
|
PMID: 19285134
PDF is available here.
PDF is available here.
Abstract
We used two systems; in vitro hematopoietic differentiation of embryonic stem (ES) cells and tissues isolated from sites specific for hematopoiesis during mouse embryogenesis. Initially genes involved in hematopoiesis were profiled and indicate differentiating ES cells undergo a wave of primitive he...
|
PMID: 18800919
PDF is available here.
PDF is available here.
médecine/sciences (25)5 2009
Abstract
Biochemical Journal (419)3 2009
Abstract
We tested the hypothesis that CETP delays the plasma clearance of TAG-rich lipoprotein by comparing human CETP expressing Tg (transgenic) and non-Tg mice. After an oral fat load, the postprandial triglyceridaemia curve was markedly increased in CETP-Tg compared with non-Tg mice (280+/-30 versus 190+...
|
PMID: 19191759
PDF is available here.
PDF is available here.
Abstract
We reveal that the Ser/Thr cluster plays an important role in the phosphorylation of the PPPSP motif. Interestingly, we observe that GSK3beta activity on the PPPSP motif requires a high ATP concentration, close to that of the physiological condition. Taken together, these data suggest that the phosp...
|
PMID: 19309792
PDF is available here.
PDF is available here.
Abstract
There is a need to develop new bone anabolic agents because current bone regeneration regimens have limitations. The Wingless-type MMTV integration site (Wnt) pathway has emerged as a regulator of bone formation and regeneration.
To review the molecular basis for Wnt pathway modulation and discuss s...
|
PMID: 19335070
PDF is available here.
PDF is available here.
Abstract
We investigated LRP5 polymorphisms in relation to treatment response in a group of 249 osteoporotic or osteopenic men who participated in a 24-month randomized double blind placebo-controlled trial of risedronate treatment. BMD and biochemical markers of bone turnover were measured at baseline and a...
|
PMID: 19148563
PDF is available here.
PDF is available here.
Abstract
The association between the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density (BMD) has been studied, but results have been mixed. Accordingly, the authors performed a meta-analysis on studies on the association between the A1330V LRP...
|
PMID: 18932002
PDF is available here.
PDF is available here.
Abstract
We review MK targeting at nucleoli in different tumor cells and its role in carcinogenesis to deepen our understanding of the mechanism of MK involved in carcinogenesis....
|
PMID: 19152444
PDF is available here.
PDF is available here.
Abstract
We show here a novel mechanism by which the adhesion molecule N-cadherin interacts with the Wnt coreceptor LRP5 and regulates canonical Wnt/beta-catenin signaling in osteoblasts. We demonstrate that N-cadherin, besides associating with beta-catenin at the membrane, forms a molecular complex with axi...
|
PMID: 19075000
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (81)9 2009
Abstract
LDLR gene mutations were detected in 50%, of APOB gene in 2.6% patients with FHHC, 70% of LDLR gene mutations have never been discovered before. Three known mutations were detected in the APOB gene: R3500Q (1.9% cases), H3543Y (0.55%), R3531C (0.15%). Incidence of coronary heart disease in untreated...
|
PMID: 19827648
PDF is available here.
PDF is available here.
Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma (80)3 2009
Abstract
The Wnt pathway is a signal-transduction cascade that mediates communication between cells; the Wnt pathway is involved in key steps during embryological development and in the maintenance of adult tissue homeostasis. Mutational dysregulation of Wnt cascade components has been observed in diverse hu...
|
PMID: 20578410
PDF is available here.
PDF is available here.
Abstract
We demonstrate that N-cadherin overexpression inhibits cell proliferation in vitro and in vivo. The negative effect of N-cadherin on cell proliferation results from decreased Wnt, ERK and PI3K/Akt signalling and is restored by N-cadherin neutralizing antibody that antagonizes N-cadherin-LRP5 interac...
|
PMID: 20011526
PDF is available here.
PDF is available here.
Abstract
We review the nature of the physical stimulus to which bone cells mount an adaptive response, including the identity of the sensor cells, their attributes and physical environment, and putative mechanoreceptors they express. Particular attention is allotted to the focal adhesion and Wnt signaling, i...
|
PMID: 19817708
PDF is available here.
PDF is available here.
Abstract
We first sequenced a 6.8-kb region surrounding FZD1 in 48 samples of African ancestry. We genotyped all common polymorphisms and performed association analysis with bone phenotypes in a larger sample. Only 3 of 35 SNPs identified were present in >or=5% of the sample and assayed further in 1084 men o...
|
PMID: 18715140
PDF is available here.
PDF is available here.
Modern Rheumatology (19)2 2009
Abstract
We attempted to determine whether the A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene is associated with a risk of self-reported incident fractures and hypercholesterolemia in Japanese patients with rheumatoid arthritis (RA). DNA samples, laboratory data, an...
|
PMID: 19023643
PDF is available here.
PDF is available here.
Biochemistry (Washington) (237)12 2008
Abstract
We demonstrate that genetic deletion of Lrp6, a bottleneck coreceptor in the canonical Wnt signaling pathway, results in ocular coloboma and neuroretinal patterning defects in mice. The expression of ventral neuroretinal patterning gene Vax2 was conserved but with dorsally shifted expression domains...
|
PMID: 18985738
PDF is available here.
PDF is available here.
Archives of Neurology (65)12 2008
Abstract
Variants of SORL1 previously associated with AD are also associated with MRI and neuropathological measures of neurodegenerative and cerebrovascular disease. These findings not only support the hypothesis that multiple areas in SORL1 are of functional importance but also raise the possibility that m...
|
PMID: 19064752
PDF is available here.
PDF is available here.
Osteoporosis International (19)12 2008
Replication of associations between LRP5 and ESRRA variants and bone density in premenopausal women.
Abstract
The association between LRP5 V667M and LS BMD is confirmed but not that between ESRRA repeats and LS BMD. This result indicates that it is imperative to validate any positive association in an independent sample....
|
PMID: 18418639
PDF is available here.
PDF is available here.
Abstract
We used a haplotype-based approach to search for common disease-associated variants in LRP5 in a cohort of 964 Spanish postmenopausal women. Twenty-four SNPs were selected, covering the LRP5 region, including the missense changes p.V667M and p.A1330V. The SNPs were genotyped and evaluated for associ...
|
PMID: 18684085
PDF is available here.
PDF is available here.
Cellular Microbiology (10)12 2008
Abstract
We show that LRP6 can indeed form a complex with ATRs, and that this interaction plays a role both in Wnt signalling and in anthrax toxin endocytosis. We found that ATRs control the levels of LRP6 in cells, and thus the Wnt signalling capacity. RNAi against ATRs indeed led to a drastic decrease in L...
|
PMID: 18717822
PDF is available here.
PDF is available here.
Abstract
Mutations in LRP5, a coreceptor for Wnt proteins, cause the disease osteoporosis pseudoglioma. A new study by Yadav et al. (2008) now challenges the view that LRP5 controls bone mass through Wnt signaling in bone and argues instead that LRP5 regulates bone mass indirectly through its effects on sero...
|
PMID: 19041744
PDF is available here.
PDF is available here.
Abstract
We show here that Lrp5 inhibits expression of Tph1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. Accordingly, decreasing serotonin blood levels normalizes bone formation and bone mass in Lrp5-deficient mice, and gut- but not osteoblast-specific Lrp5...
|
PMID: 19041748
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)48 2008
Abstract
We provide evidence that BAMBI can promote the transcriptional activity of Wnt/beta-catenin signaling. Overexpression of BAMBI enhances the expression of Wnt-responsive reporters, whereas knockdown of endogenous BAMBI attenuates them. Accordingly, BAMBI also promotes the nuclear translocation of bet...
|
PMID: 18838381
PDF is available here.
PDF is available here.
The Lancet (372)9648 2008
Abstract
Osteoarthritis and Cartilage (16)10 2008
Abstract
To examine the association of genetic variation in key players in the Wnt signaling pathway with aspects of osteoarthritis (OA) in two population-based cohort studies: the Rotterdam Study and the Chingford Study.
Radiographic OA (ROA) was defined as a Kellgren/Lawrence score (K/L) score > or = 2 for...
|
PMID: 18406176
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)38 2008
Abstract
We show that apoA-V also binds to sortilin, a receptor from the Vsp10p domain gene family that lacks LDL-A repeats. Binding of apoA-V to sortilin was competed by neurotensin, a ligand that binds specifically to the Vps10p domain. To investigate the biological fate of receptor-bound apoA-V, binding e...
|
PMID: 18603531
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)5 2008
Abstract
We identify cytoplasmic activation/proliferation-associated protein 2 (Caprin-2) as a LRP5/6-binding protein. Our data show that Caprin-2 stabilizes cytosolic beta-catenin and enhances lymphoid enhancer-binding factor 1/T cell factor-dependent reporter gene activity as well as the expression of Wnt...
|
PMID: 18762581
PDF is available here.
PDF is available here.
Abstract
We identified phosphatidylinositol 4-kinase type II alpha and phosphatidylinositol-4-phosphate 5-kinase type I (PIP5KI) as required for Wnt3a-induced LRP6 phosphorylation at Ser1490 in mammalian cells and confirmed that these kinases are important for Wnt signaling in Xenopus embryos. Wnt3a stimulat...
|
PMID: 18772438
PDF is available here.
PDF is available here.
Abstract
We previously showed a secreted, dominant-negative LRP5 receptor (DNLRP5) suppressed in vitro migration and invasion of the OS cell line SaOS-2. Therefore, we hypothesized DNLRP5 also has in vivo antitumor activity against OS. We used the 143B cell line as a model to study the effect of DNLRP5 by st...
|
PMID: 18566875
PDF is available here.
PDF is available here.
Abstract
We report that the cytosolic tail of low-density lipoprotein receptor-related protein (LRP)9 contains a bifunctional GGA and AP-1/AP-2-binding motif at its carboxy-terminus (EDEPLL). We further demonstrate that the internal EDEVLL sequence of LRP9 also binds to GGAs in addition to AP-2. Either AC-LL...
|
PMID: 18627575
PDF is available here.
PDF is available here.
Abstract
Recent studies indicate that two clusters of single nucleotide polymorphisms in the neuronal sortilin-related receptor gene (SORL1) are causally associated with late-onset Alzheimer's disease (AD). At the cellular level, SORL1 is thought to be involved in intracellular trafficking of amyloid precurs...
|
PMID: 18713574
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)34 2008
Abstract
We examined the structure of the Dkk functional domain and elucidated its interactions with LRP5/6. Using NMR spectroscopy, we determined the solution structure of the C-terminal cysteine-rich domain of mouse Dkk2 (Dkk2C). Then, guided by mutagenesis studies, we docked Dkk2C to the YWTD beta-propell...
|
PMID: 18524778
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)34 2008
Abstract
We show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6. These residues are localized at a surface that is at the opposite side of the LRP6-binding surface based on a three-dimensional structure of Dkk1 deduced from that of D...
|
PMID: 18502762
PDF is available here.
PDF is available here.
Abstract
We present here a 3 years follow-up of two brothers with OPPG carrying a novel mutation in the LRP5 gene, who were treated with intravenous pamidronate. PATIENT REPORT: We looked for a mutation in the LRP5 gene in two brothers (12 and 4 years old) with clinical features of OPPG (blindness, low BMD a...
|
PMID: 18825883
PDF is available here.
PDF is available here.
Neuropharmacology (55)2 2008
Abstract
The effects of a synthetic apoE peptide, viz., residues 133-149 (apoE[133-149]), a mimetic that comprises the apoE receptor binding domain, on N-methyl-D-aspartate (NMDA)/glycine-induced ion flow through NMDA receptor (NMDAR) channels, have been investigated. The activity of apoE[133-149] was found...
|
PMID: 18602124
PDF is available here.
PDF is available here.
Abstract
Neuroscience Letters (440)2 2008
Abstract
We examined six statistically significant single-nucleotide polymorphisms from the initial observation in a large Caucasian American case-controls cohort (1000 late-onset AD [LOAD] cases and 1000 older controls). Analysis of allele, genotype and haplotype frequencies revealed no association with LOA...
|
PMID: 18562096
PDF is available here.
PDF is available here.