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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Lectins (9):
Recent article
Lectins
Journal of Biological Chemistry (286)40 2011
Abstract
We analyzed early activation of murine CD4+ and CD8+ T-lymphocytes at 24 h. We observed a striking and selective up-regulation in the binding of a recombinant soluble form of siglec-E, an inhibitory siglec, which is expressed on several myeloid cell types including antigen-presenting dendritic cells...
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PMID: 21835922
PDF is available here.
PDF is available here.
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Abstract
In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (T(reg)) cells. Several factors may influence the 'decision' of DCs...
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PMID: 21296197
PDF is available here.
PDF is available here.
Abstract
We investigated an ER-associated degradation-related protein in adipocytes, namely osteosarcoma amplified 9 (OS-9), a protein that is reported to have lectin activity and to be involved in ER quality control. We found that OS-9 is expressed at high levels in both types of fat tissues - brown and wh...
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PMID: 21523322
PDF is available here.
PDF is available here.
Abstract
We show that GRFT, unlike CV-N, binds the surface of human epithelial and peripheral blood mononuclear cells (PBMC) through an exclusively oligosaccharide-dependent interaction. In contrast to several other antiviral lectins however, GRFT treatment induces only minimal changes in secretion of inflam...
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PMID: 21829638
PDF is available here.
PDF is available here.
Abstract
We have witnessed critical advances in genomics and proteomics which contributed to delineate the "tumor progression signature". This includes the altered expression of genes and proteins not only in tumor cells, but also in tumor-associated stromal, endothelial, and immune cells. Adding more comple...
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PMID: 20941621
PDF is available here.
PDF is available here.
Abstract
We investigated whether or not the ligation of tumor-produced mucins with Siglec-9 expressed on immature DCs is related to escape from immunosurveillance in the tumor-bearing state. Expression of Siglec-9 was up-regulated on the development of monocytes into immature DCs and was decreased in mature...
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PMID: 20971061
PDF is available here.
PDF is available here.
Proteomics Clinical Applications (4)10-11 2010
Abstract
dialysis-induced inflammatory response including leukocyte and complement activation is considered a significant cofactor of chronic morbidity in long-term hemodialysis (HD) patients. The aim of this study was to provide better insight into its molecular background.
i...
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PMID: 21137026
PDF is available here.
PDF is available here.
Immunobiology (215)11 2010
Abstract
We expressed recombinant MASP-3 and generated specific monoclonal antibodies to establish biochemical characteristics and to determine the serum levels, the interactions with the LCP recognition molecules and the influence on complement activation of MASP-3.
We expressed rMASP-3 in CHO-DG44 cells an...
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PMID: 19939495
PDF is available here.
PDF is available here.
Abstract
We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation and are tumor specific. Unexpectedly, added glycans terminate at high mannose, suggesting a potentially important interaction of F...
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PMID: 20937880
PDF is available here.
PDF is available here.
Histology and histopathology (25)10 2010
Abstract
We confirm the species variation on the ultrastructure and lectin histochemistry of AMG in rats and gerbils, and speculate that these variations may be due to the different living environment....
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PMID: 20712015
PDF is available here.
PDF is available here.
Abstract
We described the isolation and characterization of pearl oyster Pinctada fucata LGBP (designated as poLGBP). The poLGBP cDNA was 2,075 bp long and consisted of a 5'-untranslated region (UTR) of 18 bp, a 3'-UTR of 299 bp with one cytokine RNA instability motifs (ATTTA), and an open reading frame (ORF...
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PMID: 19888673
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
Mantle cell lymphoma (MCL) is a chemoresistant lymphoma overexpressing the class pi glutathione-S-transferase (GST-pi). The nuclear localisation of GST-pi is induced by chemotherapy and is correlated to cell resistance. In this study, the effect of the Agaricus bisporus lectin (ABL), a GST-pi nuclea...
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PMID: 21036708
PDF is available here.
PDF is available here.
Abstract
The influence of Enteromyxum spp. infections on the carbohydrate patterns of the digestive tract of gilthead sea bream (GSB) Sparus aurata L. and turbot (TB) Psetta maxima (L.) has been studied. Histochemical stainings to differentiate the types of mucins and lectin-binding assays to detect terminal...
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PMID: 20601108
PDF is available here.
PDF is available here.
Abstract
Ethanol ingestion is well known to induce morphological and biochemical changes in intestine and is responsible for intestinal dysfunctions. Luminal surface of enterocytes is rich in glycolipids, but the effects of ethanol ingestion on membrane glycolipids are not well characterized. In the present...
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PMID: 20708369
PDF is available here.
PDF is available here.
Abstract
These results suggest that special sugars are expressed on the most luminal portions of mucosae as exclusive epithelial cell-shedding sites, and that sugar expression differs among the various segments of the alimentary tract. These site differences might reflect differences in resident bacterial sp...
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PMID: 20379083
PDF is available here.
PDF is available here.
Abstract
We purified the sialic acid-specific lectin(s) from the pupal hemolymph using formaldehyde-fixed HRBC and determined the sequence of the amino-terminal 19 amino acid residues. A polyclonal antibody produced against this N-terminal peptide clearly inhibited the hemolytic activity of the hemolymph in...
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PMID: 20193690
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
We constructed an unmarked, in-frame H. ducreyi cpxA deletion mutant, 35000HPDeltacpxA. In human inoculation experiments, 35000HPDeltacpxA formed papules at a rate and size that were significantly less than its parent and was unable to form pustules compared to the parent. CpxA usually has kinase an...
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PMID: 20605985
PDF is available here.
PDF is available here.
Abstract
Recombinant antigen production in plants is a safe and economically sound strategy for vaccine development, particularly for oral/mucosal vaccination, but subunit vaccines usually suffer from weak immunogenicity and require adjuvants that escort the antigens, target them to relevant sites and/or act...
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PMID: 20673009
PDF is available here.
PDF is available here.
Glycobiology (20)8 2010
Abstract
We recently determined the structure of its conserved domain and found a highly selective binding to Glc(2)Man(9)GlcNAc(2), an intermediate of N-glycosylation. In our quest for putative ligands during the initial characterization of the protein, we noticed that the malectin domain is highly specific...
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PMID: 20466650
PDF is available here.
PDF is available here.
Phytomedicine (17)10 2010
Abstract
To date only a ribonuclease and a protein with anti-HIV-1 reverse transcriptase activity have been isolated from mushrooms of the genus Russula. In this study a novel lectin, with a molecular weight of 32 kDa, and a unique N-terminal sequence different from other lectins, was isolated from the mushr...
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PMID: 20378319
PDF is available here.
PDF is available here.
Abstract
We report that deletion of the N-terminal dirigent domain in the above lectins dramatically changes their sugar-specificities. Deletions in the N-terminal region of the dirigent domain of BGAF abolished binding to galactose/lactose, but binding to mannose was unaffected. Glucose, which was a poor in...
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PMID: 20462765
PDF is available here.
PDF is available here.
Journal of Molecular Biology (400)3 2010
Abstract
I (DiscI) and discoidin II (DiscII) are N-acetylgalactosamine (GalNAc)-binding proteins from Dictyostelium discoideum. They consist of two domains: an N-terminal discoidin domain and a C-terminal H-type lectin domain. They were cloned and expressed in high yield in recombinant form in Escherichia co...
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PMID: 20580724
PDF is available here.
PDF is available here.
Abstract
We sought to identify the molecular mechanism responsible for the membrane association of Ficolin-1 to monocytes and granulocytes. We demonstrate that expression of Ficolin-1 on the cell surface is restricted to monocytes and granulocytes. Ficolin-1 is tethered to the cell surface of these cells thr...
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PMID: 20400674
PDF is available here.
PDF is available here.
Abstract
Antigen uptake has been shown to occur in the teleost intestine, but so far, limited information is available on the distribution and nature of cells involved in the process, and M cells, known for their antigen-sampling abilities in mammals, have not been identified. Here, different intestinal segm...
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PMID: 20178814
PDF is available here.
PDF is available here.
Abstract
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (28)3 2010
Abstract
To express the genes of adenosine deaminase (ADA), C-lectin and serpin (serine protease inhibitor) in the salivary gland of Aedes albopictus.
Total RNA was extracted respectively from salivary glands of unfed (group SG) and engorged adult female Ae. albopictus mosquitoes (group BSG), female carcasse...
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PMID: 20806502
PDF is available here.
PDF is available here.
Abstract
The disc immunohistochemistry showed evidence of sensory nerve fibers lying in the outermost layer of the anulus fibrosus. FluoroGold labeled DRG neurons mainly derived from S1 to S3 DRGs, especially S2 and S3. No labeled neurons were observed in the S4 DRG. The histochemistry of the DRGs showed a p...
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PMID: 20354476
PDF is available here.
PDF is available here.
Abstract
YKL-40 is detected in the early nineties not only a glycoprotein secreted by cancer cells, but also of neutrophils, chondrocytes and endothelial cells. Biological function of YKL-40 are not exactly known, it is suggested that this protein participates in many physiological and pathological processes...
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PMID: 20642115
PDF is available here.
PDF is available here.
Abstract
We show the development of a cell model for investigating the direct role of a cell-surface lectin in homologous cell-cell adhesion. Parenchymal cells were isolated from caprine liver using a perfusion buffer, and dispersed in a chemically defined modified Ringer's solution. These cells undergo auto...
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PMID: 20336407
PDF is available here.
PDF is available here.
Abstract
The Ssp1 development-specific protein is the most abundant soluble protein in sclerotia and apothecia of Sclerotinia sclerotiorum. Although closely associated with these developmental stages, the functions of the Ssp1 protein and its paralog, Ssp2, are not known. In this study, protein structure pre...
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PMID: 20350614
PDF is available here.
PDF is available here.
Inflammation Research (59)6 2010
Abstract
After a maximum of two ablations, 19 patients (41%) had SR without recurrence of AF after 12 months. The patients with no recurrence of AF had significantly lower baseline plasma levels of YKL-40 prior to ablation compared to patients with recurrence of AF (31 vs. 62 microg/l, P = 0.029). Plasma YKL...
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PMID: 20012147
PDF is available here.
PDF is available here.
Abstract
We have detected glycochains by lectin histochemistry. We have also identified Types II and III by immunohistochemistry. Then, we combined lectin histochemistry and immunohistochemistry to determine which types of cells have which glycochains. In addition, we have compared these reactions in differe...
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PMID: 20145374
PDF is available here.
PDF is available here.
Nanotechnology (21)21 2010
Abstract
We proposed a facile, efficient, and cost-effective method whereby diverse carbohydrate types are modified in a single step and directly immobilized onto a glass surface, with retention of functional orientation. We modified various types of carbohydrates by reductive amination, in which reducing su...
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PMID: 20431189
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)6 2010
Abstract
Recognition and elimination of misfolded proteins are essential cellular processes. More than thirty percent of the cellular proteins are proteins of the secretory pathway. They fold in the lumen or membrane of the endoplasmic reticulum from where they are sorted to their site of action. The folding...
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PMID: 20219571
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)6 2010
Abstract
Eukaryotic secretory pathway cargo fold to their native structures within the confines of the endoplasmic reticulum (ER). To ensure a high degree of folding fidelity, a multitude of covalent and noncovalent constraints are imparted upon nascent proteins. These constraints come in the form of topologi...
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PMID: 19891995
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)12 2010
Abstract
We investigated here the role of AlgU in the formation of nonmucoid biofilms. The algU mutant of P. aeruginosa PAO1 (PAOU) showed a dramatic impairment in biofilm formation under dynamic conditions. PAOU was defective both in cell attachment to glass and in development of robust, shear-resistant bio...
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PMID: 20348252
PDF is available here.
PDF is available here.
Analytica Chimica Acta (668)1 2010
Abstract
A study of biospecific interactions between lectins and glycoproteins using a quartz crystal microbalance biosensor with dissipation monitoring (QCM-D) was reported. Four lectins were covalently immobilised on the thiol-modified gold electrode of the QCM chips in order to obtain sensing surfaces. Th...
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PMID: 20457306
PDF is available here.
PDF is available here.
Journal of Chromatography A (1217)19 2010
Abstract
We describe the development of a proteomics approach to identify breast cancer related changes in either concentration and/or the carbohydrate structures of glycoprotein(s) present in blood samples. Diseased and healthy serum samples were processed by an optimized sample preparation protocol using m...
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PMID: 19782370
PDF is available here.
PDF is available here.
Theriogenology (73)8 2010
Abstract
I staining). The tail of sperm from semen collected during the breeding and non-breeding periods showed a lectin binding pattern similar to the post-acrosomal region, except for the absence of HPA staining in sperm collected during the winter season. These results indicate that the surface of stalli...
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PMID: 20172596
PDF is available here.
PDF is available here.
Abstract
A versatile synthetic procedure to construct series of high- and low-density homo- and heteroglycoclusters is reported. The binding properties of these synthetic multivalent glycoconjugates to concanavalin A (Con A), a model lectin, have been assessed by using a range of competitive and non-competit...
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PMID: 20449489
PDF is available here.
PDF is available here.
Chemical Communications (46)14 2010
Abstract
We describe multivalent biorecognition of adsorbed lectin layers by biomimetic sensing nanoplatforms based on dynamic glycovesicles in a continuous flow QCM setup.
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PMID: 20379552
PDF is available here.
PDF is available here.
Abstract
While certain cases showed a discrepancy in fucosylated haptoglobin concentrations between the lectin-antibody ELISA and conventional lectin blotting, this novel type of lectin-antibody ELISA might be useful for a tumor marker for PC....
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PMID: 20128732
PDF is available here.
PDF is available here.
Abstract
Taenia saginata metacestode antigens have been constituted a useful alternative antigen for neurocysticercosis (NC) serodiagnosis, particularly due to an increasing difficulty to obtain Taenia solium homologous antigen. Cross-reactivity with Echinococcus granulosus infection occurs i...
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PMID: 20130125
PDF is available here.
PDF is available here.
Abstract
We postulate that the observed release profiles support the previously suggested concept that lectins have the ability to function as protection agents for living marine algae....
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PMID: 20433081
PDF is available here.
PDF is available here.
Abstract
Baseline plasma YKL-40 was increased (median 92 microg/L) compared to healthy subjects (median 34 microg/L, p <0.001). In the placebo group hs-CRP and YKL-40 correlated at baseline (p = 0.04) and day 3 (p = 0.01), but not at day 7 and 30. Moreover, YKL-40 correlated negatively to LVEF recovery (p =...
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PMID: 20102300
PDF is available here.
PDF is available here.
Parasitology (137)4 2010
Abstract
We have previously discovered a unique mechanism of epigenetic transcriptional gene silencing in the Entamoeba histolytica trophozoites of strain HM-1:IMSS that resulted in the persistent downregulation of the amoebapore A (ap-a) gene, and that could be successfully applied to silence other virulenc...
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PMID: 19849886
PDF is available here.
PDF is available here.
Molecular Immunology (47)7-8 2010
Abstract
We used mice deficient of heparanase (Hpse(-/-)) to study the impact of heparanase on airway leukocytes. Normal numbers of macrophages and lymphocytes were present in bronchoalveolar lavage fluid of Hpse(-/-) mice, indicating that heparanase is not essential for proper homing of leukocytes to airway...
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PMID: 20226534
PDF is available here.
PDF is available here.
Abstract
The present study reports on the characterization of two cDNAs coding beta-glucan binding proteins (betaGBPs), designated as Cg-betaGBP-1 and Cg-betaGBP-2, from the Pacific oyster, Crassostrea gigas. Cg-betaGBP-1 consists of 555 amino acid residues and possesses two possible integrin recognition sit...
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PMID: 19995575
PDF is available here.
PDF is available here.
Hypertension Research (33)4 2010
Abstract
Moxonidine is a selective imidazoline receptor agonist with comparable blood pressure-lowering efficacy to first-line antihypertensives and favorable metabolic effects. YKL-40 (chitinase-3-1-protein) has been proposed as a new marker of inflammation, atherosclerosis and endothelial dysfunction in ne...
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PMID: 20139920
PDF is available here.
PDF is available here.
Methods in Molecular Biology (627)627 2010
Abstract
We obtained best and reproducible results when the lectin was immobilized and its ligands were used as soluble analytes. With heterogeneous glycoconjugates such as neoglycoproteins (which are heterogeneous in terms of nature, number, and position of sugar residues) or a mixture of oligosaccharides,...
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PMID: 20217620
PDF is available here.
PDF is available here.
Abstract
We used a potent plant toxin (viscumin) and lactosides synthetically modified at the C6/C6' positions and the reducing end aglycan. Changes in the saturation transfer difference (STD) in NMR spectroscopy, applied in inhibition assays, yielded evidence for ligand activity and affinity differences. In...
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PMID: 20094999
PDF is available here.
PDF is available here.
Abstract
I and II, respectively.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20004743
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
We used a potent plant toxin (viscumin) and lactosides synthetically modified at the C6/C6' positions and the reducing end aglycan. Changes in the saturation transfer difference (STD) in NMR spectroscopy, applied in inhibition assays, yielded evidence for ligand activity and affinity differences. In...
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PMID: 20094999
PDF is available here.
PDF is available here.
Chemmedchem (5)3 2010
Abstract
We used a potent plant toxin (viscumin) and lactosides synthetically modified at the C6/C6' positions and the reducing end aglycan. Changes in the saturation transfer difference (STD) in NMR spectroscopy, applied in inhibition assays, yielded evidence for ligand activity and affinity differences. In...
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PMID: 20094999
PDF is available here.
PDF is available here.
Abstract
The hemagglutination activities of midgut (MG) fractions of red palm weevil, Rhynchophorus ferrugineus against mammalian erythrocytes (RBC) from man (ABO), rabbit, horse and sheep were studied. The highest titers were seen with rabbit RBC (p < 0.05) followed by human group B, human group O, horse, h...
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PMID: 20464944
PDF is available here.
PDF is available here.
Acta Histochemica (112)2 2010
Abstract
The localization of sialic acids and antimicrobial substances in the foot pads of the cat was examined by lectin histochemical and immunohistochemical methods. The lectin binding patterns of the eccrine glands were suggestive of the existence of large concentrations of sialoglycoconjugates that term...
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PMID: 19095295
PDF is available here.
PDF is available here.
Abstract
Clinical Chemistry (56)2 2010
Abstract
We survey clinical tests that target carbohydrate modifications for diagnosing and treating cancer. We present the biological relevance of glycosylation to disease progression by highlighting the role these structures play in adhesion, signaling, and metastasis and then address current methodologica...
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PMID: 19959616
PDF is available here.
PDF is available here.
Journal of Cell Biology (188)2 2010
Abstract
We show that disposal of soluble (nontransmembrane) polypeptides with luminal lesions (ERAD-L(S) substrates) is strictly dependent on the E3 ubiquitin ligase HRD1, the associated cargo receptor SEL1L, and two interchangeable ERAD lectins, OS-9 and XTP3-B. These ERAD factors become dispensable for de...
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PMID: 20100910
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)3 2010
Abstract
We report that AP-3 and BLOC-1 differentially regulate the composition of presynaptic terminals in the striatum and dentate gyrus of the hippocampus. Quantitative immunoelectron microscopy demonstrated that the majority of AP-3 immunoreactivity in both wild-type striatum and hippocampus localizes to...
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PMID: 20089890
PDF is available here.
PDF is available here.