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Lithostathine (0):
Recent article
Lithostathine
Abstract
These data demonstrate that in acinar cells, reg I overexpression is linked to acinar cell differentiation, whereas inhibition of reg I leads to beta cell and possibly ductal phenotype. Reg I expression in acinar cells is important in maintaining pancreatic cell lineage, and when decreased, cells ca...
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PMID: 19557902
PDF is available here.
PDF is available here.
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Critical Care Medicine (37)5 2009
Abstract
We conclude that PSP/reg is up-regulated in blood after trauma, and the PSP/reg level is related to the severity of inflammation. Furthermore, PSP/reg binds to and activates neutrophils. Therefore, PSP/reg might be an acute-phase protein that could serve as a marker for posttraumatic complications....
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PMID: 19325491
PDF is available here.
PDF is available here.
Abstract
We here demonstrated that PPARgamma-agonist thiazolidinediones (TZDs) inhibited cell proliferation and REG Ialpha protein/mRNA expression in gastrointestinal cancer cells. TZDs inhibited the REG Ialpha gene promoter activity, via its cis-acting element which lacked PPAR response element and could no...
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PMID: 19118520
PDF is available here.
PDF is available here.
Abstract
We investigated REG Ialpha expression in the MSG of patients with primary Sjögren's syndrome (SS) and assessed its role in ductal epithelial cell proliferation in such tissues. Lip biopsy specimens were obtained from 40 patients with primary SS and examined using immunohistochemistry for REG Ialpha...
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PMID: 19016805
PDF is available here.
PDF is available here.
Cancer Science (99)12 2008
Abstract
We used MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays to compare the chemo- and radiosensitivities of untransfected TE-5 and TE-9 cells with those of cells stably transfected with REG Ialpha and Ibeta. We then used flow cytometry to determine whether REG I expression alte...
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PMID: 19032369
PDF is available here.
PDF is available here.
Abstract
Depletion of the acinar product reg I is associated with the pathogenesis of impaired glucose tolerance of pancreatitis-associated diabetes and aging, and replacement therapy could be useful in these patients. Reg I is an acinar cell product, which affects islet function....
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PMID: 18953250
PDF is available here.
PDF is available here.
Histology and histopathology (23)10 2008
Abstract
We analyzed the expression of Reg I in normal rodent and human testes where germ cells normally proliferate and differentiate into spermatozoa, and in seminoma testis, the most common cancer of young men. Western blot analyses demonstrated the presence of a specific band at 19 kDa in human and roden...
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PMID: 18712671
PDF is available here.
PDF is available here.
Neuroscience (155)4 2008
Abstract
We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat model of monoarthritis, Reg-2 immunoreactivity was detected in DRG neurons at 1 day, peaked at 3 days (in 11.6% of DRG neurons), and was still present at 10 days (in 5%). Expres...
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PMID: 18652880
PDF is available here.
PDF is available here.
Abstract
We performed a comparative proteomic analysis of pancreatic tissue extracts from rats with AP and healthy rodent controls in order to identify changes in protein expression related to the pathobiological processes of this disease. Pancreatic extracts from diseased and controls rats were analyzed by...
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PMID: 18686302
PDF is available here.
PDF is available here.
Abstract
We found regenerating islet-derived 1 alpha (REG1A) to be upregulated in patients with an unfavorable clinical outcome. For validation, REG1A expression was quantified in another colorectal cancer (CRC) patient cohort by Taqman PCR. Aside from tumor and normal tissue from 63 nonpretreated CRC patien...
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PMID: 18452172
PDF is available here.
PDF is available here.
Abstract
We aimed to develop a pathologically relevant model to study obesity-associated severe AP. Lean WT and obese leptin-deficient ob/ob mice received two injections of IL-12 plus IL-18. Survival, pancreatic inflammation, and biochemical markers of AP were measured. Dosing with IL-12 plus IL-18 induced 1...
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PMID: 18515422
PDF is available here.
PDF is available here.
Cancer Research (68)9 2008
Abstract
We investigated the efficacy of H. pylori eradication in preventing the progression of gastritis to gastric cancer in H. pylori-infected transgenic INS-GAS mice. H. pylori infection induced severe dysplasia and gastric cancer classified as high-grade and low-grade gastrointestinal intraepithelial ne...
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PMID: 18441088
PDF is available here.
PDF is available here.
Lung Cancer (60)1 2008
Abstract
Within samples of tumor tissue, the cytosol of tumor cells was stained with anti-REG1A antibody. Cells from normal tissue were not stained. The 5-year over-all survival rate among patients expressing lower levels of REG1A was significantly better than among those expressing higher levels of REG1A (P...
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PMID: 17964685
PDF is available here.
PDF is available here.
Abstract
The present study is the first to show REG expression in Barrett's esophagus. Expression of REG Ialpha was more frequently observed in patients who showed squamous re-epithelialization of Barrett's esophagus at biopsy sites....
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PMID: 18289358
PDF is available here.
PDF is available here.
Journal of Surgical Research (144)1 2008
Abstract
Reg I, MLCK, and MYH11 in tumors of MSS HNPCC showed significant differences in gene expression pattern compared with the adjacent pathologically normal tissues (P = 0.028, P = 0.002, and P = 0.001, respectively). Similar differences in expression patterns for the same set of genes were seen between...
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PMID: 17950328
PDF is available here.
PDF is available here.
Carcinogenesis (29)1 2008
Abstract
We investigated the involvement of IL-6/STAT3 signaling in REG Ialpha protein expression and examined whether REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. The effects of IL-6/STAT3 signaling on REG Ialpha protein expression were examined using a ST...
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PMID: 18024479
PDF is available here.
PDF is available here.
Abstract
We found 8 reported and 2 novel polymo-rphisms including an insertion-deletion polymorphism in the promoter region of reg1alpha. None of the 5'UTR variants altered any known transcription factor binding sites, neither did any show a statistically significant association with TCP. No association with...
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PMID: 17990360
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the effect of Astragalus polysaccharide (APS) on pancreatic beta cell mass in type 1 diabetic mice. METHOD: Diabetic mice induced by multiple low dose streptozotocin (MLD-STZ) were administered either APS (100, 200, 400 mg x kg(-1) body weight) or saline intraperitoneally daily,...
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PMID: 18306755
PDF is available here.
PDF is available here.
Abstract
We performed proteomic analysis of protein plugs to elucidate formation mechanism. Protein plugs were obtained from three pediatric patients with choledochal cyst. Proteins were separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Gel bands common to the samples were excised fo...
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PMID: 17415647
PDF is available here.
PDF is available here.
Abstract
PAP/HIP(-/-) mice showed the normal phenotype at birth and normal postnatal development. Caerulein-induced pancreatic necrosis was, however, less severe in PAP/HIP(-/-) mice than in wild-type mice, as judged by lower amylasemia and lipasemia levels and smaller areas of necrosis. On the contrary, pan...
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PMID: 17409121
PDF is available here.
PDF is available here.
Abstract
We now describe how Helicobacter and gastrin stimulate the expression of a putative growth factor, Reg1, in primary gastric epithelial cells. RT-PCR and Western immunoblotting of human gastric corpus and antrum showed significantly increased Reg1alpha in H. pylori-infected patients. Similarly, Reg1...
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PMID: 17463184
PDF is available here.
PDF is available here.
Abstract
As compared with controls, non-inflamed colonic mucosal cells contain two up-regulated genes related to the innate immune system. Up-regulation of these genes, known to be induced by microorganisms, suggests either increased microflora antigenicity or an altered function in mucosal barrier defence....
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PMID: 17454855
PDF is available here.
PDF is available here.
Abstract
I (regenerating gene product I) is a growth factor that plays a central role in the generation and regeneration of the gastric mucosal architecture. On the other hand, mouse Reg I mRNA is expressed at the highest levels in the small intestine among the gastrointestinal tissues. In the current study,...
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PMID: 16909126
PDF is available here.
PDF is available here.
Bratislavske lekarske listy (108)3 2007
Abstract
Our study, for the first time, indicates that serum Reg-1alpha is not useful for the diagnosis of metabolic syndrome (Tab. 3, Ref. 7)....
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PMID: 17682540
PDF is available here.
PDF is available here.
Annals of Surgical Oncology (13)12 2006
Abstract
Evaluation of REG I expression in untreated endoscopic biopsy specimens may provide a basis for new treatments of locally advanced thoracic squamous cell esophageal cancers....
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PMID: 17009160
PDF is available here.
PDF is available here.
Biomedical Papers (150)2 2006
Abstract
High diagnostic efficacy of detectable MLC-1 was shown for the diagnosis of latent myocardial ischemia. Measurement of serum Clusterin or Reg-Ialpha did not sufficient for the diagnosis of latent myocardial ischemia....
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PMID: 17426785
PDF is available here.
PDF is available here.
Diabetologia (49)10 2006
Abstract
Reg2 was upregulated in islets from the NOD RIP-HuIFNbeta mice at the onset of the autoimmune attack. IFNbeta upregulates Reg1 and Reg2 genes in NIT-1 cells. The expression of Il6 was increased in islets from transgenic mice and in NIT-1 cells exposed to HuIFNbeta. Moreover, islets from transgenic m...
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PMID: 16900387
PDF is available here.
PDF is available here.
Abstract
Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum reg I concentrations from controls. However, Western blot demonstrated increased tissue levels of reg I at 24 and 36 h. This increase was localiz...
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PMID: 16874863
PDF is available here.
PDF is available here.
Biomedical Papers (150)1 2006
Abstract
Our findings did not support the hypothesis that measurement of Reg-Ia maybe the useful marker of myocardial stress....
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PMID: 16936908
PDF is available here.
PDF is available here.
Abstract
We have recently reported that Pdx1-Cre-mediated whole pancreas inactivation of IGF-I gene [in pancreatic-specific IGF-I gene-deficient (PID) mice] results in increased beta-cell mass and significant protection against both type 1 and type 2 diabetes. Because the phenotype is unlikely a direct conse...
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PMID: 16449294
PDF is available here.
PDF is available here.
Journal of Surgical Research (133)2 2006
Abstract
In this review we discuss the debate on the localization and functional roles of PSP/reg and PAP/regIII. Therefore, we have summarized hypotheses and experimental results supporting such hypotheses....
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PMID: 16360171
PDF is available here.
PDF is available here.
Abstract
We used endotoxin [lipopolysaccharide (LPS)] as a tool to induce cellular injury in the alcoholic pancreas. Single, increasing doses of endotoxin were injected in rats fed an alcohol or control diet and killed 24 h after the injection. We examined the mechanism by which LPS exacerbates pancreatic in...
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PMID: 15976389
PDF is available here.
PDF is available here.
Abstract
We tried to identify the genes involved in carcinogenesis and progression of HCC with beta-catenin mutations. We used PCR-based subtractive hybridization to compare gene expression between malignant and benign components of a human HCC occurring in pre-existing adenoma activated for beta-catenin. Tw...
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PMID: 16314847
PDF is available here.
PDF is available here.
FEBS Letters (580)2 2006
Abstract
We found that Reg increased phospho-ATF-2, which binds to -57 to -52 of the cyclin D1 gene to activate the promoter. The Reg/ATF-2-induced cyclin D1 promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin. In Reg knockout mouse islets, the levels of phospho-ATF-2, cyc...
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PMID: 16405968
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 11) 2005
Abstract
Abstract
Reg expression was found localized in the deeper part of gastric fundic glands and clearly shown in chromogranin A-positive cells in the gastric corpus. Semiquantitative immunohistochemistry and Western blotting results for Reg expression were significantly associated with polymorphonuclear neutroph...
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PMID: 16181363
PDF is available here.
PDF is available here.
Abstract
The REG Ialpha gene is inducible by cytokines and its gene product may function as a mitogenic and/or an antiapoptotic factor in the UC-colitic cancer sequence....
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PMID: 15914572
PDF is available here.
PDF is available here.
Abstract
We examined the hepatic transcriptome after injury in search of transcriptional programs that are sensitive to the Plg/fibrinogen system. To this end, we generated biotinylated cRNA pools from livers of Plg(o) mice and controls before and after a single dose of the hepatotoxin carbon tetrachloride a...
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PMID: 16006527
PDF is available here.
PDF is available here.
Abstract
We first found REG-1 protein expression in human hearts obtained from autopsied patients who died of myocardial infarction. REG protein was immunohistochemically stained in a fine granular pattern in the cytoplasm of cardiomyocytes. To demonstrate the activation profiles of Reg gene expression in th...
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PMID: 15778284
PDF is available here.
PDF is available here.
Abstract
Abstract
Almost all pancreatic stents had clogging material, predominantly located at the duodenal flap, which contained plant material, mucopolysaccharides, and crystals, as well as visible calcium carbonate calculi. Albumin and lithostathine may play an important role in the development of stent occlusion....
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PMID: 15933688
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1723)1-3 2005
Abstract
PSP/Lithostathine/PTP/regI, PAP/p23/HIP, reg1L, regIV and "similar to PAP" are the members of a multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide. The expression of this group of proteins is controlled by complex mechanisms, some...
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PMID: 15715980
PDF is available here.
PDF is available here.
Clinical Cancer Research (11)7 2005
Abstract
These data suggest that PAP expression designate a subset of low-grade, low-stage HCC with frequent beta-catenin mutation and hence more favorable prognosis, whereas further genetic or epigenetic alterations, such as p53 mutation and REG1A expression, lead to more advanced HCCs....
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PMID: 15814635
PDF is available here.
PDF is available here.
Gastroenterology (128)3 2005
Abstract
REG Ialpha gene is inducible by cytokine stimulation and its gene product may function as a mitogenic and/or an antiapoptotic factor in the development of early gastric cancer....
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PMID: 15765400
PDF is available here.
PDF is available here.
Abstract
Anti-REG autoantibodies were found in 24.9% of Type 1, 14.9% of Type 2 and 2.7% of control subjects (P = 0.0004). There were significant differences between the autoantibody positive and negative groups in the duration of disease in the Type 1 subjects (P = 0.0035), and the age of onset in the Type...
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PMID: 15530148
PDF is available here.
PDF is available here.
Journal of Endocrinology (182)1 2004
Abstract
The pancreatic ductal stem cells are known to differentiate into islets of Langerhans; however, their yield is limited and the islet population is not defined. Therefore, the aims of the present study were to improvise a methodology for obtaining large numbers of islets in vitro and to characterize t...
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PMID: 15225135
PDF is available here.
PDF is available here.
Abstract
We aimed to evaluate whether the Reg I protein might be involved in this dedifferentiation process in the human pancreas. We studied duct-like structures in fixed human pathologic pancreatic tissues and human cells with a ductal phenotype obtained by culturing human exocrine preparations. Immunocyto...
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PMID: 15211106
PDF is available here.
PDF is available here.
Abstract
Alzheimer-associated neuronal thread protein, AD7c-NTP, accumulates in cortical neurons and co-localizes with phospho-tau-containing cytoskeletal lesions in brains with AD. Over-expression of AD7c-NTP results in increased neuronal death mediated by apoptosis and mitochondrial dysfunction. Empirical...
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PMID: 15201478
PDF is available here.
PDF is available here.
Journal of Surgical Research (118)2 2004
Abstract
There is a tight spatial and temporal association between pre-inflammatory changes or inflammation and SSP-expression. These results support our concept that PSP/reg and PAP are coordinately regulated SSP....
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PMID: 15100001
PDF is available here.
PDF is available here.
Abstract
Reg (regenerating gene product) was originally identified as a growth factor involved in pancreatic regeneration. During the healing course of gastric erosion, Reg expression is highly increased in the enterochromaffin-like (ECL) cells surrounding the ulcer crater, suggesting its role as a regulator...
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PMID: 15116092
PDF is available here.
PDF is available here.
Abstract
Determination of REG expression may help to identify aggressive gastric tumors and to tailor appropriate therapy for patients with REG-positive tumors.
Copyright 2004 American Cancer Society....
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PMID: 15022278
PDF is available here.
PDF is available here.
Digestive Diseases and Sciences (49)11-12 2004
Abstract
Symptoms of pancreaticobiliary maljunction/choledochal cysts are caused by the obstruction of bile and pancreatic ducts due to protein plugs compacted in the common channel. However, the mechanism of protein plug formation remains unknown. Pancreatic stone protein (PSP) is reported to be a key prote...
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PMID: 15628732
PDF is available here.
PDF is available here.
Abstract
Twenty-three (37.7%) of the 61 gastric cancer tissues samples were positive for Reg I alpha protein. The Reg I alpha expression was significantly related to the presence of lymphatic invasion but not to tumor size, tumor stage, Lauren's classification, presence of venous invasion, lymph node metasta...
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PMID: 15166487
PDF is available here.
PDF is available here.
Hepato-gastroenterology (51)55 2004
Abstract
The current study revealed that acinoductular cells characterized by dual expression of REG I and cytokeratin 19 also express insulin, chromogranin A and trypsin and therefore supports the hypothesis that transdifferentiation of fully differentiated (acinar) cells may be the main source of islet neo...
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PMID: 15011837
PDF is available here.
PDF is available here.
Gastroenterology (126)1 2004
Abstract
gp130(757F/F) Mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I. Tumor development occurs in a hypogastrinemic environment. Balanced IL-6 signaling is required...
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PMID: 14699500
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (278)51 2003
Abstract
We show that such fibrils also occur in Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker diseases, where they form protease-K-resistant deposits and co-localize with amyloid plaques formed from prion protein. Lithostathine does not appear to change its native-like, globular structure during f...
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PMID: 13129929
PDF is available here.
PDF is available here.
Abstract
We characterized its expression and regulation in human SH-Sy5y neuronal cells. Quantitative real-time reverse transcription-polymerase chain reactin and Western blot analysis demonstrated prominent insulin, moderate insulin-like growth factor, type 1 (IGF-1) and minimal nerve growth factor stimulat...
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PMID: 14685691
PDF is available here.
PDF is available here.
Laboratory Investigation (83)12 2003
Abstract
We have recently shown that both gastrin and gastric mucosal inflammation enhance Reg gene expression in the fundic mucosa in rats. This study was designed to clarify whether Reg protein is involved in Helicobacter pylori-induced gastritis and whether Reg gene expression is linked to serum gastrin l...
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PMID: 14691296
PDF is available here.
PDF is available here.
Laboratory Investigation (83)10 2003
Abstract
We hypothesized that mediators of adaptation might be the regenerating protein (RegI) and the trefoil peptides TFF1 and TFF2, because these proteins play pivotal roles in gastric mucosal protection and repair. The gene expression and the protein levels of these proteins were measured and compared in...
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PMID: 14563943
PDF is available here.
PDF is available here.
Abstract
The results of the current study suggest that the expression of the REG gene is closely related to the infiltrating property of gastric carcinoma, and may be a prognostic indicator of differentiated adenocarcinoma of the stomach.
Copyright 2003 American Cancer Society.DOI 10.1002/cncr.11658...
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PMID: 14508825
PDF is available here.
PDF is available here.