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Ankyrins (0):
Recent article
Ankyrins
Abstract
We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Netwo...
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PMID: 21468319
PDF is available here.
PDF is available here.
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Journal of Biological Chemistry (285)28 2010
Abstract
We describe that cpSRP43 alone prevents aggregation of LHCP by formation of a complex with nanomolar affinity, whereas cpSRP54 is not required for this chaperone activity. Other stromal chaperones like trigger factor cannot replace cpSRP43, which implies that LHCPs require a specific chaperone. Alth...
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PMID: 20498370
PDF is available here.
PDF is available here.
Abstract
We previously identified a dinucleotide deletion in the human ankyrin-1 gene (ANK-1) promoter that underlies ankyrin-deficient hereditary spherocytosis. The presence of the deletion was associated with a decrease in promoter function both in vitro and in vivo establishing it as a causative hereditar...
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PMID: 20479128
PDF is available here.
PDF is available here.
Abstract
We demonstrate that allelic diversity at a single locus, ACCELERATED CELL DEATH 6 (ACD6), underpins marked pleiotropic differences in both vegetative growth and resistance to microbial infection and herbivory among natural Arabidopsis thaliana strains. A hyperactive ACD6 allele, compared to the refe...
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PMID: 20520716
PDF is available here.
PDF is available here.
Bipolar Disorders (12)4 2010
Abstract
We investigated whether, instead of affecting protein function, these risk variants might impact on gene regulation affecting expression.
We have done this by testing for allelic expression imbalance (AEI) to identify cis-acting regulatory polymorphisms.
We identified evidence of cis-acting variatio...
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PMID: 20636642
PDF is available here.
PDF is available here.
Neurochemical Research (35)5 2010
Abstract
We aimed to examine the involvement of TRPV1 and TRPA1 in the stress-induced visceral hyperalgesia. Rats were exposed to 1-h water avoidance stress (WAS) daily for 10 consecutive days. The abdominal withdrawal reflex (AWR) to colorectal distension was assessed at the end of the 10-day period. Wester...
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PMID: 20182791
PDF is available here.
PDF is available here.
Abstract
We mapped the major immunodeterminants of the E. chaffeensis 200-kDa ankyrin protein (Ank200) and the minor immunodeterminants in the N- and C-terminal regions of E. chaffeensis TRP47. Major antibody epitopes of Ank200 were localized to four polypeptide regions (18-mer, 20-mer, 20-mer, and 21-mer, r...
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PMID: 19955322
PDF is available here.
PDF is available here.
Abstract
We found that ankyrin-B-deficient islets displayed impaired potentiation of insulin secretion by the muscarinic agonist carbachol, blunted carbachol-mediated intracellular Ca2+ release, and reduced the abundance of IP3R. Ankyrin-B-haploinsufficient mice exhibited hyperglycemia after oral ingestion b...
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PMID: 20234002
PDF is available here.
PDF is available here.
Abstract
K(ATP) channels play critical roles in many cellular functions by coupling cell metabolic status to electrical activity. First discovered in cardiomyocytes,(1) K(ATP) channels (comprised of Kir6.x and SUR subunits) have since been found in many other tissues, including pancreatic beta cells, skeleta...
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PMID: 19901534
PDF is available here.
PDF is available here.
Abstract
Our results suggest that the largest conformational changes occur for Frag1 bound to PC : PE (2 : 3) liposomes what is consistent with previous studies on monolayers. They are also in good agreement with those obtained previously for native erythroid and nonerythroid spectrin molecules....
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PMID: 20037194
PDF is available here.
PDF is available here.
Abstract
The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and force-transducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization,...
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PMID: 19636256
PDF is available here.
PDF is available here.
Biochemical Society transactions (37)Pt 4 2009
Abstract
I review recent findings on the origins and adaptations in this system. (i) The genome of the choanoflagellate Monosiga brevicollis encodes alpha-, beta- and beta(Heavy)-spectrin, indicating that spectrins evolved in the immediate unicellular precursors of animals. (ii) Ankyrin and 4.1 are not encod...
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PMID: 19614597
PDF is available here.
PDF is available here.
Abstract
Ankyrins are critical components of ion channel and transporter signaling complexes in the cardiovascular system. Over the past 5 years, ankyrin dysfunction has been linked with abnormal ion channel and transporter membrane organization and fatal human arrhythmias. Loss-of-function variants in the a...
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PMID: 19394342
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)9 2009
Abstract
We determined the density, laminar distribution, and length of AIS immunoreactive (IR) for ankryin-G and betaIV spectrin, two proteins involved in the regulation of synapse structure and ion channel clustering at AIS, in dlPFC area 46 from 14 matched triads of subjects with schizophrenia or major de...
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PMID: 19322171
PDF is available here.
PDF is available here.
Journal of Cell Science (122)Pt 15 2009
Abstract
We investigate the importance of obscurin for SR architecture and organization. Lack of obscurin in cross-striated muscles leads to changes in longitudinal SR architecture and disruption of small ankyrin-1.5 (sAnk1.5) expression and localization. Changes in SR architecture in obscurin knockout mice...
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PMID: 19584095
PDF is available here.
PDF is available here.
Microbiology (155)7 2009
Abstract
Using microarray-based comparative genome hybridization (mCGH), the genomic content of Wolbachia pipientis wMel from Drosophila melanogaster was compared to the closely related Wolbachia from D. innubila (wInn), D. santomea (wSan), and three strains from D. simulans (wAu, wRi, wSim). A large number...
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PMID: 19389774
PDF is available here.
PDF is available here.
Pharmacogenomics (10)6 2009
Abstract
The pattern of variation we report is an important step towards incorporating common variation across the rhythmonome in studies of arrhythmia susceptibility....
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PMID: 19530973
PDF is available here.
PDF is available here.
Molecular Psychiatry (14)5 2009
Abstract
We first reported association between BD and the ANK3 marker rs9804190 in a genome-wide association study (GWAS) of two independent samples (Baum et al., 2008). Subsequently, a meta-analysis of GWAS data based on samples from the US and the UK reported association with a different ANK3 marker, rs109...
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PMID: 19088739
PDF is available here.
PDF is available here.
Biochemical Journal (419)3 2009
Abstract
The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytopla...
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PMID: 19356150
PDF is available here.
PDF is available here.
Abstract
Camelpox is a contagious viral skin disease that is mostly seen in young camels. The disease is caused by the Camelpox virus (CMLV). In the present study, a polymerase chain reaction (PCR) assay based on the C18L gene (encoding ankyrin repeat protein) and a duplex PCR based on the C18L and DNA polym...
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PMID: 19286503
PDF is available here.
PDF is available here.
Biophysical Journal (96)3 2009
Abstract
We calculate the influence of a flexible network of long-chain proteins, which is anchored to a fluid membrane, on protein diffusion in this membrane. This is a model for the cortical cytoskeleton and the lipid bilayer of the red blood cell, which we apply to predict the influence of the cytoskeleto...
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PMID: 19186123
PDF is available here.
PDF is available here.
Abstract
We propose that ankyrin-binding to L1-type CAMs provides a master switch. The interaction with ankyrins directs L1-type adhesive proteins into different functional contexts, either ankyrin-independent functions, such as neurite outgrowth and axonal pathfinding or into ankyrin-dependent functions, su...
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PMID: 18839070
PDF is available here.
PDF is available here.
Archives of Virology (154)8 2009
Abstract
Twenty-four genomic segments of Cotesia plutellae bracovirus (CpBV) were completely sequenced, and their genomic structures were analyzed. The aggregated genome size is 351,299 bp long and exhibits an average GC content of approximately 34.6%. Average coding density is about 32.3%, and 125 putative...
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PMID: 19618256
PDF is available here.
PDF is available here.
Abstract
We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Dystrophin binds ankyrin-B and ankyrin-G, while beta-DG binds ankyrin-G. Dystrophin and beta-DG require ankyrin-G for retention at costameres but not delivery to the sarcolemma. Dystrophin and...
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PMID: 19109891
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)6 2008
Abstract
Neurons have high densities of voltage-gated Na(+) channels that are restricted to axon initial segments and nodes of Ranvier, where they are responsible for initiating and propagating action potentials. New findings (Bréchet, A., M.-P. Fache, A. Brachet, G. Ferracci, A. Baude, M. Irondelle, S. Per...
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PMID: 19075107
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)6 2008
Abstract
We found that the ankyrin-binding motif of Na(v)1.2 that determines channel concentration at the AIS depends on a glutamate residue (E1111), but also on several serine residues (S1112, S1124, and S1126). We showed that phosphorylation of these residues by protein kinase CK2 (CK2) regulates Na(v) cha...
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PMID: 19064667
PDF is available here.
PDF is available here.
Abstract
We identify seven new exons associated with the ANK2 gene including an alternative first exon located approximately 145 kb upstream of the previously-identified first exon. In addition, we identify over thirty alternative splicing events associated with ANK2 mRNA transcripts. Using real-time PCR and...
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PMID: 18790697
PDF is available here.
PDF is available here.
Abstract
Journal of Physiology (586)Pt 23 2008
Abstract
The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na(+) (Na(v)) channels that drive autonomous firing. In order to determine the principles underlying the initiation and propagation of action potentials in STN neurons, 2-p...
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PMID: 18832425
PDF is available here.
PDF is available here.
Journal of Virology (82)23 2008
Abstract
We examined the interplay between Tax and the potent proto-oncogene B-cell chronic leukemia protein 3 (Bcl3). Bcl3 is a critical regulator of cell survival and proliferation and is overexpressed in HTLV-1-infected cells. We found that Tax induced Bcl3 expression through stimulation of the NF-kappaB...
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PMID: 18815299
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
We report that alternative splicing regulates ankyrin-B localization and function in cardiomyocytes. Specifically, we identify a novel exon (exon 43') in the ankyrin-B regulatory domain that mediates interaction with the Rho-GEF obscurin. Ankyrin-B transcripts harboring exon 43' represent the primar...
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PMID: 18782775
PDF is available here.
PDF is available here.
ChemBioChem (9)16 2008
Abstract
We here describe the formation of an actin-based cytoskeleton within giant unilamellar vesicles (GUVs) made from porcine brain lipid extracts. We demonstrate that the actin filaments are localised and anchored to the interior walls of the GUVs through the spectrin/ankyrin proteins, and produce tight...
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PMID: 18830993
PDF is available here.
PDF is available here.
Neuroscience Research (62)3 2008
Abstract
We showed that most parvalbumin positive cells in the external plexiform layer (EPL) of the mouse main olfactory bulb (MOB) were anaxonic but displayed some patch-like betaIV-spectrin and sodium channel cluster positive segments on their dendrites. In this study we further characterized those partic...
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PMID: 18786578
PDF is available here.
PDF is available here.
Abstract
We found in Madin-Darby canine kidney cells and in other cultured cells that the 25-residue ankyrin-binding sequence of alpha(1)-Na(+)-K(+)-ATPase facilitates the entry of alpha(1),beta(1)-Na(+)-K(+)-ATPase into the secretory pathway and that replacement of the cytoplasmic domain of vesicular stomat...
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PMID: 18768923
PDF is available here.
PDF is available here.
Molecular Microbiology (70)4 2008
Abstract
We have recently shown that L. pneumophila strain AA100/130b harbours 11 genes encoding eukaryotic-like ankyrin (Ank) proteins, a family of proteins involved in various essential eukaryotic cellular processes. In contrast to most Dot/Icm-exported substrates, which have little or no detectable role i...
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PMID: 18811729
PDF is available here.
PDF is available here.
Abstract
We report a genetic and molecular mechanism for human SND. We mapped two families with highly penetrant and severe SND to the human ANK2 (ankyrin-B/AnkB) locus. Mice heterozygous for AnkB phenocopy human SND displayed severe bradycardia and rate variability. AnkB is essential for normal membrane org...
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PMID: 18832177
PDF is available here.
PDF is available here.
Abstract
We demonstrate for the first time that in the adult CNS Nav1.1 is expressed in nodes of Ranvier throughout the mouse spinal cord and in many brain regions. We identified three populations of nodes: expressing Nav1.1, Nav1.6 or both. We also found Nav1.1 expression concentrated in a proximal AIS subc...
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PMID: 18621130
PDF is available here.
PDF is available here.
Abstract
We screened the ankyrin gene of the proband of a large, three generation African-American kindred with ankyrin-deficient HS. DHPLC yielded an abnormal chromatogram for exon 1. Examination of the corresponding exon 1 sequence in genomic DNA from the proband revealed heterozygosity for a mutation of t...
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PMID: 18704959
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)39 2008
Abstract
We showed here that triple alanine substitution of the (419)FLD(421) sequence, which links the cytoplasmic C-terminal domain of RhBG to ankyrin-G, not only disrupted the interaction of RhBG with the spectrin-based skeleton but also delayed its cell surface expression, decreased its plasma membrane s...
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PMID: 18635543
PDF is available here.
PDF is available here.
Abstract
The Notch pathway is a short-range signaling mechanism between neighboring cells that results in changes in gene expression. Extracellular interactions between Notch receptors and ligands trigger proteolytic cleavage of the receptor Notch. Following cleavage, the freed intracellular domain of Notch...
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PMID: 18758478
PDF is available here.
PDF is available here.
Neuroscience Letters (440)3 2008
Abstract
Transient receptor potential ankyrin-1 (TRPA1) is an important receptor that contributes to inflammatory pain. However, previous studies were mainly concerned with its function in somatic hyperalgesia while few referred to visceral, especially colonic inflammatory hyperalgesia. The present study was...
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PMID: 18583045
PDF is available here.
PDF is available here.
Drug Discovery Today (13)15-16 2008
Abstract
DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the potential to overcome limitations of monoclonal antibodies, hence allowing novel therapeutic approaches. DARPins are small, single domain proteins (14 kDa) which can be selected to bind any given target protei...
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PMID: 18621567
PDF is available here.
PDF is available here.
Abstract
We report on the cloning and purification of AnkSBD and describe the results of binding experiments, in which we showed high-affinity interactions between the AnkSBD construct and isolated erythrocyte or non-erythroid spectrins. pEGFP-AnkSBD-transfected cells co-localised with non-erythroid spectrin...
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PMID: 18495489
PDF is available here.
PDF is available here.
Abstract
We use site-directed mutagenesis to investigate the kinetic unfolding mechanism of D34, a 426-residue, 12-ankyrin repeat fragment of the protein ankyrinR. The data are consistent with a model in which the N-terminal half of the protein unfolds first by unraveling progressively from the start of the...
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PMID: 18632570
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (283)30 2008
Abstract
We report the 2.0A structure of the BARD1 ankyrin repeat domain. The structure includes four ankyrin repeats with a non-canonical C-terminal capping ankyrin repeat and a well ordered extended loop preceding the first repeat. Conserved surface features show an acidic patch and an acidic pocket along...
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PMID: 18480049
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)28 2008
Abstract
These results were confirmed by analytical ultracentrifugation to sedimentation equilibrium by which a 1:1 complex was obtained if and only if Zu5 was mixed with beta-spectrin constructs containing repeats 14 and 15 in tandem. Surface plasmon resonance yielded a K D of 15.2 nM for binding of beta-sp...
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PMID: 18563915
PDF is available here.
PDF is available here.
Biochemical Journal (413)2 2008
Abstract
We provide new evidence to suggest further that ANCO-1 and ANCO-2 also interact with the co-activator ADA3 (alteration/deficiency in activation 3). The interaction occurs between the conserved C-terminal domain of ANCO-1 and the N-terminal transactivation domain of ADA3. Several subunits of the P/CA...
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PMID: 18377363
PDF is available here.
PDF is available here.
Abstract
We describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin) technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome display. Selected pool members interacted specifically wit...
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PMID: 18654624
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)1 2008
Abstract
We took a comparative approach to studying mossy fiber action potential initiation and propagation in hippocampal slices from juvenile rats. Dentate granule neurons exhibited axonal action potential initiation significantly more proximal than CA3 pyramidal neurons. This conclusion was suggested by p...
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PMID: 18480368
PDF is available here.
PDF is available here.
Abstract
We use two methods to revisit the requirements on InsP(3) receptor for ankyrin binding. We demonstrate that ankyrin-B interacts with the cytoplasmic N-terminal domain of InsP(3) receptor. In summary, our findings demonstrate that the ankyrin-binding site is located on the cytoplasmic face of the Ins...
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PMID: 18275062
PDF is available here.
PDF is available here.
Abstract
We hypothesized that 2 alpha,beta-unsaturated aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ion channel coexpressed with TRPV1 on capsaicin-sensitive nociceptors. We found that CS aqueous extract (CSE), crotonaldehyde, and ac...
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PMID: 18568077
PDF is available here.
PDF is available here.
Neuroscience (154)3 2008
Abstract
These results demonstrate that TRPA1 is expressed on peripheral nociceptors, and they are up-regulated on intact Adelta-fibers following nerve injury, contributing to cold hypersensitivity....
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PMID: 18514429
PDF is available here.
PDF is available here.
Brain Research (1215) 2008
Abstract
Our data suggests that icilin modulates the mechanosensitivity of dorsal horn neurones. The differing effects of ice and icilin on dorsal horn neurones indicate different mechanisms of action....
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PMID: 18479674
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)25 2008
Abstract
We investigated HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell transcription factor) in both human breast tumor cells (MCF-7 cells) and human ovarian tumor cells (SK-OV-3.ipl cells). Using a specific primer pair to amplify Nanog by reverse transcriptase-PCR, we...
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PMID: 18441325
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)24 2008
Abstract
We report that IQCJ-SCHIP-1, a recently identified isoform of schwannomin-interacting protein-1 (SCHIP-1), is a novel component of both AISs and NRs in the central and peripheral nervous systems. We show that IQCJ-SCHIP-1 binds calmodulin in the absence of Ca(2+) and is highly enriched at AISs and N...
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PMID: 18550753
PDF is available here.
PDF is available here.
Abstract
We show that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of hippocampal CA1 pyramids, independently of alterations in synaptic activity. This action was primarily because of modulation of action potential threshold and resting membrane pot...
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PMID: 18515424
PDF is available here.
PDF is available here.
Abstract
We have constructed isogenic mutants of L. pneumophila in ten of the ank genes. Among the mutants, the DeltaankH and DeltaankJ mutants exhibit significant defects in robust intracellular replication within A. polyphaga, Hartmanella vermiformis and Tetrahymena pyriformis. A similar defect is also exh...
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PMID: 18279343
PDF is available here.
PDF is available here.
Abstract
We cloned the full sequence of gene CvBV-ank2, encoding an IkappaB-like protein in C. vestalis polydnavirus (CvBV). The full sequence of CvBV-ank2 is 955 bp, encoding 162 amino acids with a calculated molecular mass of 18,355 Da. CvBV-ank2 shares high similarity with the exon I and exon II of CvBV-a...
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PMID: 18454492
PDF is available here.
PDF is available here.
Abstract
We performed a yeast-two-hybrid screen with 68k-ank to find interacting proteins. From a human and a murine cDNA library, 99% of the interaction partners were S-phase kinase-associated protein 1a (Skp1a), a part of the SCF ubiquitin ligase complex. 68k-ank co-immunoprecipitated with components of th...
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PMID: 18353424
PDF is available here.
PDF is available here.