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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Arrestins (1):
Recent article
Arrestins
Abstract
We show that binding to β-arrestin1 prolongs rather than terminates the generation of cAMP by PTHR, and that cAMP generation correlates with the persistence of arrestin-receptor complexes on endosomes. PTHR signaling is instead turned off by the retromer complex, which regulates the movement of int...
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PMID: 21445058
PDF is available here.
PDF is available here.
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Abstract
Abstract
We investigated the clinical relevance of β-arrestin-1 in breast cancer and elucidated a potential link between β-arrestin-1 expression and CCND1 amplification. β-Arrestin-1 protein expression was evaluated in two breast cancer patient cohorts, comprising 179 patients (cohort I) and 500 patients...
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PMID: 21497294
PDF is available here.
PDF is available here.
Abstract
Understanding the role of G protein-coupled receptor (GPCR; also known as a 7 transmembrane receptor) heteromerization in the physiology and pathophysiology of cellular function has now become a major research focus. However, there is currently a lack of cell-based assays capable of...
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PMID: 21133678
PDF is available here.
PDF is available here.
Abstract
G protein-coupled receptors (GPCRs) are expressed throughout the nervous system where they regulate multiple physiological processes, participate in neurological diseases, and are major targets for therapy. Given that many GPCRs respond to neurotransmitters and hormones that are pres...
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PMID: 20632972
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We hypothesize that lyso-PC activation of G2A causes the increases in cytosolic Ca²(+) via release of G(α) and G(βγ) subunits, kinase activation, and the recruitment of clathrin, β-arrestin-1 and GRK6 (G-protein receptor kinase 6) to G2A for signal transduction. PMNs were isolated by standard t...
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PMID: 20799926
PDF is available here.
PDF is available here.
Molecular Pharmacology (78)2 2010
Abstract
We analyzed the effects of prolonged agonist exposure on cell surface protein levels of hMrgX1 and murine or rat MrgC in human embryonic kidney 293, Cos, F11, and ND-C cells. We observed that hMrgX1 are resistant and both MrgC are prone to agonist-promoted receptor endocytosis. In Cos cells, coexpre...
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PMID: 20424127
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We made a construct to express GPR109A fused with enhanced green fluorescent protein (EGFP) at its carboxyl-terminal end. In stable GPR109A-EGFP-expressing HEK-293 cells, GPR109A-EGFP was mainly localized at the plasma membrane and was rapidly internalized in a dose- and time-dependent manner upon a...
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PMID: 20460384
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We found that iNOS in cytokine-stimulated human lung microvascular endothelial cells (HLMVECs) is highly regulated post-translationally via activation of the B1 kinin G protein-coupled receptor (B1R). We report here that B1R-mediated iNOS activation was significantly inhibited by knockdown of beta-a...
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PMID: 20228252
PDF is available here.
PDF is available here.
Abstract
We hypothesized that a PPAR gamma agonist may exert physiologic effects via the angiotensin II type 1(A) receptor (AT1(A)R). In AT1(A)R-overexpressing HEK 293 cells, both angiotensin II (Ang II) and the PPAR gamma agonist troglitazone (Trog) enhanced AT1(A)R internalization and recruitment of endoge...
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PMID: 20460106
PDF is available here.
PDF is available here.
Abstract
We identified four FDA-approved drugs, halcinonide, fluticasone, clobetasol, and fluocinonide, as Smo agonists that activate Hedgehog signaling. These drugs demonstrated an ability to bind Smo, promote Smo internalization, activate Gli, and stimulate the proliferation of primary neuronal precursor c...
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PMID: 20439738
PDF is available here.
PDF is available here.
Abstract
Seven-transmembrane receptors (7TMRs; also known as G protein-coupled receptors) are the largest class of receptors in the human genome and are common targets for therapeutics. Originally identified as mediators of 7TMR desensitization, beta-arrestins (arrestin 2 and arrestin 3) are now recognized a...
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PMID: 20431569
PDF is available here.
PDF is available here.
Abstract
We show that the COX-2 product prostaglandin E(2) (PGE(2)) acts on cognate receptor EP4 to promote the migration of A549 lung cancer cells. Treatment with PGE(2) enhances tyrosine kinase c-Src activation, and blockade of c-Src activity represses the PGE(2)-mediated lung cancer cell migration. PGE(2)...
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PMID: 20353998
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Iubmb Life (62)2 2010
Abstract
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current revi...
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PMID: 20058265
PDF is available here.
PDF is available here.
Abstract
We demonstrate that ligand binding to the decoy receptor CXCR7 does not result in activation of signaling pathways typical of G proteins but does activate MAP kinases through beta-arrestins in transiently transfected cells. Furthermore, we observe that vascular smooth muscle cells that endogenously...
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PMID: 20018651
PDF is available here.
PDF is available here.
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (82)1 2010
Abstract
We have shown the increase of Src(Tyr416) phosphorylation in rat colonic mucosa at early stages of 6% iodoacetamide-induced ulcerative colitis (UC), while the level of Src protein expression was not changed. Pretreatment of rats with Src inhibitor PP1 (0.2 mg/100 g, subcutaneously) decreased the col...
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PMID: 20684236
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (17)14 2010
Abstract
CB1 receptors are G-protein coupled receptors (GPCRs) abundant in neurons, in which they modulate neurotransmission. The CB(1) receptor influence on memory and learning is well recognized, and disease states associated with CB(1) receptors are observed in addiction disorders, motor dysfunction, schi...
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PMID: 20166926
PDF is available here.
PDF is available here.
Abstract
G-protein coupled receptors (GPCRs) belong to the seven transmembrane protein family and mediate the transduction of extracellular signals to intracellular responses. GPCRs control diverse biological functions such as chemotaxis, intracellular calcium release, gene regulation in a li...
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PMID: 21206474
PDF is available here.
PDF is available here.
Science Signaling (3)125 2010
Abstract
We show that mechanical stretch induced beta-arrestin-biased signaling downstream of angiotensin II type I receptors (AT1Rs) in the absence of ligand or G protein activation. Mechanical stretch triggered an AT1R-mediated conformational change in beta-arrestin similar to that induced by a beta-arrest...
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PMID: 20530803
PDF is available here.
PDF is available here.
Abstract
We suggest that a clathrin-, arrestin-3, and Rab-5-dependent process mediated the internalization of CysLT(1)R. Altering the CysLT(1)R internalization process at either the clathrin or the arrestin-3 stage led to disruption of LTD(4)-induced Erk1/2 activation and up-regulation of COX-2 mRNA levels....
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PMID: 21203429
PDF is available here.
PDF is available here.
Abstract
Abstract
We review findings on the effects of antidepressants on beta-arrestins and the plethora of antidepressant effects on signal transduction elements in which beta-arrestins serve as signaling scaffold proteins, focusing on the three major groups of MAPKs: extracellular signal-regulated kinases, c-Jun N...
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PMID: 20016856
PDF is available here.
PDF is available here.
Abstract
We report highly sensitive bioluminescence resonance energy transfer (BRET) assays with optimized donor/acceptor couples. We combined the energy donors Renilla luciferase (Rluc) and the Rluc8 variant with the energy acceptors yellow fluorescent protein, the YPet variant and the Renilla green fluores...
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PMID: 19557797
PDF is available here.
PDF is available here.
Carcinogenesis (30)8 2009
Abstract
We have previously reported a novel interaction of TbetaRIII with the scaffolding protein, beta-arrestin2, which results in TbetaRIII internalization and downregulation of TGF-beta signaling. beta-arrestin2 also scaffolds interacting receptors with the mitogen-activated protein kinase and NFkappaB-s...
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PMID: 19325136
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1793)8 2009
Abstract
We show that co-treatment of human peripheral blood mononuclear cells (PBMC) with HIV-1 gp120/morphine synergistically induces apoptosis in PBMC. Co-treatment of murine splenocytes from mu opiate receptor knockout mice with gp120/morphine resulted in decreased apoptosis when compared to splenocytes...
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PMID: 19477204
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)30 2009
Abstract
We show that both the N- and C-terminal regions of arrestin2 function to inhibit basal interaction with clathrin. Truncation analysis revealed that clathrin binding increases as the C-tail of arrestin2 is shortened while site-directed mutagenesis identified Glu-404, Glu-405, and Glu-406 as being pri...
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PMID: 19555118
PDF is available here.
PDF is available here.
Molecules and Cells (28)1 2009
Abstract
We previously demonstrated that angiotensin AT(1) receptor-bound beta-arrestin 1 is cleaved after Phe(388) upon angiotensin II stimulation. The mechanism and signaling pathway of angiotensin II-induced beta-arrestin cleavage remain largely unknown. Here, we show that protein Tyr phosphatase activity...
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PMID: 19711041
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)30 2009
Abstract
We tested the hypothesis that the beta1AR and EGFR form a complex that differentially directs intracellular signaling pathways. beta1AR stimulation and EGF ligand can each induce equivalent EGFR phosphorylation, internalization, and downstream activation of ERK1/2, but only EGF ligand causes translo...
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PMID: 19509284
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)19 2009
Abstract
Compared with group NS, TFL of group M was significantly elevated after the first morphine injection (P < 0.01). But TFL of group M returned to the baseline value after chronic morphine treatment. Compared with group M, TFL increased in groups MF2 and MF3 at Days 7 and 9 (P < 0.05 or 0.01). However,...
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PMID: 19615194
PDF is available here.
PDF is available here.
Abstract
We hypothesized that altered beta-arrestin 1 phosphorylation and activation status could play a role in gliomagenesis. Using monoclonal anti-phospho-(serine 412)- and total beta-arrestin 1 antibodies, we performed immunohistochemistry on 126 human glioma samples and 7 nonneoplastic controls and West...
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PMID: 19404096
PDF is available here.
PDF is available here.
Abstract
We reported that the response of cancellous bone to intermittent PTH is reduced in beta-arrestin2(-/-) mice and suggested that beta-arrestins could influence the bone mineral balance by controlling RANKL and osteoprotegerin (OPG) gene expression. Here, we study the role of beta-arrestin2 on the in v...
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PMID: 19113915
PDF is available here.
PDF is available here.
Abstract
Bioluminescence resonance energy transfer (BRET) is a powerful and increasingly popular technique for studying protein-protein interactions in live cells and real time. In particular, there has been considerable interest in the ability to monitor interactions between G protein-coupled receptors (GPC...
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PMID: 19513659
PDF is available here.
PDF is available here.
Cell Metabolism (9)3 2009
Abstract
Insulin signaling is key to the etiology of metabolic syndrome. Recent work (Luan et al., 2009) uncovers a role for beta-arrestin, previously known to control GPCR desensitization, in insulin signaling. In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating...
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PMID: 19254565
PDF is available here.
PDF is available here.
Abstract
Using permanent and primary human bronchial epithelial (HBE) cells at air-liquid interface, we show that DEPs activate the human MMP-1 gene via RAS and subsequent activation of RAF-MEK-ERK1/2 mitogen-activated protein kinase signaling, which can be scaffolded by beta-arrestins. Short interfering RNA...
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PMID: 19337515
PDF is available here.
PDF is available here.
Abstract
We have previously reported that morphine induces apoptosis. However, the underlying molecular mechanisms remain to be elucidated. Toll-like receptor 2 (TLR2), a key immune receptor in the TLR family, modulates cell survival and cell death in various systems. Evidence indicates that beta-arrestin 2...
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PMID: 19071087
PDF is available here.
PDF is available here.
Brain Research (1248) 2009
Abstract
Tolerance to peripheral antinociception after chronic exposure to systemic morphine was assessed in mice with chronic CFA-inflammation; cross-tolerance to locally administered μ, δ and κ-opioid agonists and levels of β-arrestins in the injured paw, were also evaluated. Tolerance was induced by th...
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PMID: 19026993
PDF is available here.
PDF is available here.
Abstract
Journal of Neurochemistry (108)1 2009
Abstract
We investigated the signaling events of delta-opioid receptor (deltaOR) initiated by two ligands, DPDPE and TIPP. We found that although both ligands inhibited adenylyl cyclase (AC) and activated ERK1/2, only DPDPE induced desensitization and internalization of the deltaOR. We further found that DPD...
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PMID: 19014372
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)1 2009
Abstract
We now demonstrate that RORalpha, another member of the ROR family, regulates Opn1sw, Opn1mw, as well as Arr3 (cone arrestin) in the mouse retina. RORalpha expression is detected in cones by postnatal day 3 and maintained through adulthood. The retinas of staggerer mice, carrying a null mutation of...
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PMID: 19014374
PDF is available here.
PDF is available here.
Biochemical Journal (417)1 2009
Abstract
We report that beta-arrestin1 associates with the G-protein beta1gamma2 subunits in transfected cells, and purified beta-arrestin1 interacts with G(beta1gamma2) derived from in vitro translation. Deletion mutagenesis of beta-arrestin1 led to the identification of a region, comprising amino acids 181...
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PMID: 18729826
PDF is available here.
PDF is available here.
Cellular Signalling (21)1 2009
Abstract
We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clathrin adaptor AP-2. The phosphorylation of beta2-adaptin on tyrosine...
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PMID: 18938240
PDF is available here.
PDF is available here.
Abstract
We have shown that striatal pathogenesis may be initiated by high synaptic levels of extracellular dopamine (DA). Here we investigated in rat striatal primary neurons the mobilization of the mitogen-activated protein kinase (MAPK) signaling pathways after treatment with DA. Instead of observing an e...
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PMID: 19200235
PDF is available here.
PDF is available here.
EMBO Reports (10)1 2009
Abstract
EMBO Journal (27)23 2008
Abstract
We show that membrane stretch does not primarily gate mechanosensitive transient receptor potential (TRP) ion channels, but leads to agonist-independent activation of G(q/11)-coupled receptors, which subsequently signal to TRPC channels in a G protein- and phospholipase C-dependent manner. Mechanica...
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PMID: 18987636
PDF is available here.
PDF is available here.
EMBO Reports (9)12 2008
Abstract
We examine whether intracellular signalling components such as beta-arrestin (beta-arr) and casein kinases 1 and 2 (CK1 and CK2) can contribute to determining signalling specificity in beta-catenin-independent WNT signalling to the small GTPase RAC-1. Our findings indicate that beta-arr is sufficien...
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PMID: 18953287
PDF is available here.
PDF is available here.
Abstract
To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients....
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PMID: 19049562
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
We have investigated beta-arrestin interaction and internalization of a set of mutants of the human beta2-adrenergic receptor. Mutation of the four serine/threonine residues between residues 355 and 364 led to the loss of agonist-induced receptor-beta-arrestin2 interaction as revealed by fluorescenc...
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PMID: 18801735
PDF is available here.
PDF is available here.
Abstract
We found that β-arrestin 2, but not β-arrestin 1, is required for LPA-induced NF-κB activation and interlukin-6 expression. Mechanistically, we found that β-arrestin 2 associated with CARMA3, a scaffold protein that plays an essential role in GPCR-induced NF-κB activation, suggesting that β-ar...
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PMID: 18952848
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)45 2008
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2.
Abstract
We have investigated the internalization of the human P2Y receptors 1, 2, 4, 6, 11, and 12 and their interaction with beta-arrestin-1 and -2. Co-transfection of each individual P2Y receptor with beta-arrestin-1-GFP or beta-arrestin-2-YFP into HEK-293 cells and stimulation with the corresponding agon...
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PMID: 18703513
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanism of GR desensitization and internalization. The present study focused on the fate of internalized GR. Using both hamster hepatocytes and human embryonic kidney (HEK)-293 cells, we showed that internalized GR recycled to the plasma membrane within 30-60 min following stim...
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PMID: 18787074
PDF is available here.
PDF is available here.