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Chemokine CX3CL1 (0):
Recent article
Chemokine CX3CL1
Hypertension Research (34)6 2011
Abstract
I collagen in Mallory-Azan staining, concomitant with the downregulation of transforming growth factor (TGF)-β(1) and type I procollagen mRNA expression in damaged kidneys. The CX3CR1 blockade also decreased the number of infiltrating F4/80-positive macrophages in damaged kidneys. These results sug...
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PMID: 21451526
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Hypertension Research (34)6 2011
Abstract
I collagen in Mallory-Azan staining, concomitant with the downregulation of transforming growth factor (TGF)-β(1) and type I procollagen mRNA expression in damaged kidneys. The CX3CR1 blockade also decreased the number of infiltrating F4/80-positive macrophages in damaged kidneys. These results sug...
|
PMID: 21451526
PDF is available here.
PDF is available here.
Hypertension Research (34)6 2011
Abstract
I collagen in Mallory-Azan staining, concomitant with the downregulation of transforming growth factor (TGF)-β(1) and type I procollagen mRNA expression in damaged kidneys. The CX3CR1 blockade also decreased the number of infiltrating F4/80-positive macrophages in damaged kidneys. These results sug...
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PMID: 21451526
PDF is available here.
PDF is available here.
Abstract
We presently lack a thorough knowledge of the cell type(s) involved in its induction and maintenance in the inflamed intestinal mucosa. This study aimed to determine whether platelet (PLT) adhesion to inflamed intestinal endothelial cells of human origin may favour angiogenesis. Unstimulated or thro...
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PMID: 20158572
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
TNF-alpha-stimulated fractalkine expression is suppressed by aspirin in a dose-dependent manner through the nuclear factor-kappa B p65 pathway....
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PMID: 19493461
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
Our study aimed at elucidating the role of the cytokine fractalkine in the process of HCC carcinogenesis. Expression of fractalkine in hepatocellular carcinoma cell line HepG2 was knocked-down by RNAi. Conditioned media (CMs) from HepG2 was used in angiogenesis assays both in vitro and in vivo. Comp...
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PMID: 20664972
PDF is available here.
PDF is available here.
Abstract
Soluble fractalkine is increased in the liver during times of injury; however the effect of pro-inflammatory cytokines in this process is currently unknown. The aim of this study was to determine whether pro-inflammatory cytokines elevated in patients with hepatocellular carcinoma in...
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PMID: 20922190
PDF is available here.
PDF is available here.
Biomarkers (15)5 2010
Abstract
Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.
To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.
In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI...
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PMID: 20482449
PDF is available here.
PDF is available here.
Abstract
We summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression.
Copyright Thieme Medical Publishers....
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PMID: 20665374
PDF is available here.
PDF is available here.
Abstract
We examined Fkn expression and CD16(+) Mo accumulation induced in experimental C.B-17/Inc-scid/scid (SCID) lupus model mice by injection of IgG(3)-producing hybridoma clones obtained from MRL/lpr mice. Glomerular Fkn expression and accumulation of CD16(+) Mos were semiquantitatively evaluated using...
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PMID: 20410215
PDF is available here.
PDF is available here.
Abstract
Ingestion of DSS solution can induce in rodents acute colitis with a massive infiltration of neutrophils and macropahges, mimicking pathological changes observed in the acute phase of UC patients. Concomitantly, DSS ingestion enhanced the expression of a potent macrophage-tropic chemokine, CX3CL1/fr...
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PMID: 20335311
PDF is available here.
PDF is available here.
Circulation Journal (74)2 2010
Abstract
Increases in the FKN level and the number of CX3CR1-expressing mononuclear cells might contribute to coronary plaque rupture....
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PMID: 20019415
PDF is available here.
PDF is available here.
Abstract
We demonstrate that Fkn induces significant alterations in cytoskeletal structure and specifically activates the MAP kinases, JNK and Erk 1/2, both of which appear necessary for endothelial cell migration. Our results suggest that the endogenous Fkn present in the RA joint may induce angiogenesis th...
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PMID: 20185962
PDF is available here.
PDF is available here.
Abstract
We have investigated CX(3)CR1 expression and function in human naïve, germinal centre and memory B cells isolated from tonsil or peripheral blood.
We demonstrate unambiguously that highly purified human B cells from tonsil and peripheral blood expressed CX(3)CR1 at mRNA and protein...
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PMID: 20041188
PDF is available here.
PDF is available here.
Abstract
Based on these results, it may be that fractalkine contributes to the development of SS, especially in lymphocyte migration to exocrine glands, and that it accelerates the disease in association with other molecules....
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PMID: 19407023
PDF is available here.
PDF is available here.
Abstract
We investigated the potential shedding activities involved in the release of the soluble chemotactic peptides from CX3CL1 in the injured liver. We showed an increased expression of the sheddases ADAM10 and ADAM17 in patients with chronic liver diseases that was associated with the severity of liver...
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PMID: 19432809
PDF is available here.
PDF is available here.
Abstract
We demonstrated for the first time that Cx3cl1 was upregulated in osteogenic-induced rat bone marrow mesenchymal stem cells (BMSCs). To analyze the gene expression profiling of Cx3cl1 in osteogenic-induced rat BMSCs at different times, real-time quantitative polymerase chain reaction (real-time PCR)...
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PMID: 19422292
PDF is available here.
PDF is available here.
Pediatric Research (65)5 Pt 2 2009
Abstract
We summarize available data on the impact of host genetics on MTCT and disease progression of HIV-infected children....
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PMID: 19190524
PDF is available here.
PDF is available here.
Abstract
Although chemokines, as chemotactic factors, were already known in 70's of the past century, it was only the progress in molecular biology, genetics and immunology which occurred in the past few years that opened the way to discover new molecules, their chemical structure and biological functions. F...
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PMID: 19388544
PDF is available here.
PDF is available here.
Abstract
Amalgam, a multi-domain member of the immunoglobulin superfamily, possesses homophilic and heterophilic cell adhesion properties. It is required for axon guidance during Drosophila development in which it interacts with the extracellular domain of the transmembrane protein, neurotactin, to promote a...
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PMID: 18938249
PDF is available here.
PDF is available here.
Cancer Letters (273)1 2009
Abstract
We asked if CX3CR1 is involved in the TEM of neuroblastoma cells. We demonstrated that biologically functional CX3CR1 is expressed by several neuroblastoma cell lines. Most importantly, CX3CR1-expressing neuroblastoma cells were stimulated by CX3CL1 to transmigrate through human bone-marrow endothel...
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PMID: 18778890
PDF is available here.
PDF is available here.
Abstract
We compared serum fractalkine concentrations of 46 patients with coronary heart disease (CHD) and 47 insulin-dependent diabetic patients (IDDM) following rehabilitation with those of 50 control subjects. Following rehabilitation serum fractalkine levels (477 + or - 225 pg/mL) in CHD patients were si...
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PMID: 19851523
PDF is available here.
PDF is available here.
Cell Transplantation (18)3 2009
Abstract
We sought to understand if cytokine-induced NF-kappaB activity and downstream effects depend on substrate adherence of endothelial cells (EC). We compared the upstream phosphorylation cascade, activation of NF-kappaB, and expression/secretion of downstream effects of EC grown on tissue culture polys...
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PMID: 19558775
PDF is available here.
PDF is available here.
Molecular Medicine (15)9-10 2009
Abstract
We intratracheally injected MSCs expressing CX3CL1 (MSC/RGDFKN) into the lung of lung tumor-bearing mice with multiple metastases of C26 or Lewis lung carcinoma (LLC). Antitumor effects were evaluated by counting the number of lung metastases and survival. We demonstrated the tropism of mouse MSCs t...
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PMID: 19603106
PDF is available here.
PDF is available here.
Abstract
We found that FTK levels were elevated in plasma 24 h after CLP. Reverse transcription-polymerase chain reaction results showed that FTK messenger RNA levels were upregulated, whereas CX3CR1 messenger RNA levels were downregulated in lungs after CLP procedure. To study the role of FTK in lung injury...
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PMID: 18497708
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of EGCG on fractalkine expression in TNF-alpha-induced human umbilical vein endothelial cells (HUVECs). EGCG decreased TNF-alpha-induced fractalkine mRNA and protein expression in HUVECs in a time-dependent manner. EGCG suppressed the TNF-alpha-induced phosphorylation and...
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PMID: 19910690
PDF is available here.
PDF is available here.
Abstract
By real-time RT-PCR, glomerular preferential expression of FKN/CX3CL1 was confirmed, whereas CX3CR1 was detected in glomeruli and cortices. The localization of FKN/CX3CL1 gene and protein were demonstrated in glomerular cells including podocytes. In nephrotic puromycin aminonucleoside (PAN) nephrosi...
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PMID: 19590241
PDF is available here.
PDF is available here.
Abstract
We presumed FKN/CX3CL1 might play some roles in glomerular physiology. The purpose of this study is to examine the expression and localization of FKN/CX3CL1 in normal and proteinuric glomeruli.
Normal and proteinuric rat kidneys were studied. The gene and protein expressions of FKN/C...
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PMID: 19590241
PDF is available here.
PDF is available here.
Abstract
We presumed FKN/CX3CL1 might play some roles in glomerular physiology. The purpose of this study is to examine the expression and localization of FKN/CX3CL1 in normal and proteinuric glomeruli.
Normal and proteinuric rat kidneys were studied. The gene and protein expressions of FKN/C...
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PMID: 19590241
PDF is available here.
PDF is available here.
Abstract
We presumed FKN/CX3CL1 might play some roles in glomerular physiology. The purpose of this study is to examine the expression and localization of FKN/CX3CL1 in normal and proteinuric glomeruli.
Normal and proteinuric rat kidneys were studied. The gene and protein expressions of FKN/C...
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PMID: 19590241
PDF is available here.
PDF is available here.
Abstract
We show that CX3CL1/fractalkine, a chemokine and intercellular adhesion molecule, is released rapidly from apoptotic lymphocytes, via caspase- and Bcl-2-regulated mechanisms, to attract macrophages. Effective chemotaxis of macrophages to apoptotic lymphocytes is dependent on macrophage fractalkine r...
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PMID: 18799722
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (100)6 2008
Abstract
We investigated the effect of diabetes-associated high glucose (HG) on these chemokines and signalling mechanisms involved in human aortic smooth muscle cells (SMC). Exposure of SMC to HG resulted in an increase of fractalkine and MCP-1 expression and the activated mitogen-activated protein kinase (...
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PMID: 19132243
PDF is available here.
PDF is available here.
Abstract
We constructed two baculovirus transfer vectors that incorporate several mammalian transcriptional regulatory elements necessary for high-level protein expression in mammalian cells. Using these vectors, we show that the BacMam system in combination with the 293 GnTI(-) cell line can be used for pro...
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PMID: 18782620
PDF is available here.
PDF is available here.
Clinical Cancer Research (14)23 2008
Abstract
Each of the three chemokines can serve as independent predictors of biochemical recurrence. However, the combination of chemokine biomarkers plus clinicopathologic variables discriminated prostatectomy subjects for the probability of biochemical recurrence significantly better than clinicopathologic...
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PMID: 19047106
PDF is available here.
PDF is available here.
Abstract
Patients with CP showed significant higher levels of serum TGF-beta1 and s-fractalkine, but not MCP-1, compared to the controls. Serum TGF-beta1 in the severe stage and s-fractalkine in the mild and the severe stage of CP significantly increased compared to those of controls. However, it was observe...
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PMID: 19030200
PDF is available here.
PDF is available here.
Abstract
Vascular remodeling stands for structural changes of the vessel wall in response to various noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal narrowing because of neointima formation and constrictive remodeling leading to hypoperfusion is the most relevant cli...
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PMID: 18818421
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)44 2008
Abstract
We investigated the role of molecular aggregation in the CX3CL1 adhesiveness. Assays of bioluminescence resonance energy transfer (BRET) and homogeneous time-resolved fluorescence (HTRF) in transfected cell lines and in primary cells showed specific signals indicative of CX3CL1 clustering. Truncatio...
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PMID: 18725411
PDF is available here.
PDF is available here.
Abstract
We show that mice chronically exposed to cigarette smoke up-regulate CX3CL1 gene expression, which is associated with an influx of CX3CR1+ cells in the lungs. The increase in CX3CR1+ cells is primarily comprised of macrophages and T lymphocytes and is associated with the development of emphysema. In...
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PMID: 18772344
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (198)1-2 2008
Abstract
Human glioblastoma multiforme (GBM) is the most malignant form of human brain tumors. A characteristic of GBM is the marked presence of tumor infiltrated microglia/macrophages and lymphocytes. The goal of this study was directed toward understanding the role of the chemokine system CX3CL1 and its re...
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PMID: 18508133
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (198)1-2 2008
Abstract
We review the critical role of fractalkine in neuron-to-glial communication after peripheral nerve injury and inflammation and explore anti-inflammatory cytokines like interleukin-10 as a novel and effective approach for clinical pain control....
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PMID: 18547654
PDF is available here.
PDF is available here.
Growth Factors (26)4 2008
Abstract
CTGF enhanced the mRNA expressions and protein release of fractalkine, MCP-1 and RANTES, and the expressions of phosphorylated ERK1/2, PI3-K and PKB, and activities of NF-KB. Blockade of ERK1/2 inhibited the CTGF-induced expression ofphosphorylated ERK1/2 and NF-kappaB, and partially decreased the e...
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PMID: 19378419
PDF is available here.
PDF is available here.
Abstract
We have examined alterations in gene expression during HF progression by microarray technology in non-infarcted left ventricular (LV) murine tissue at various time points after myocardial infarction (MI). The highest number of regulated genes was found five days after MI. In total, we identified 14...
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PMID: 18585734
PDF is available here.
PDF is available here.
Abstract
We studied the role that various signaling chemokine receptors play during ligand homeostasis in vivo. We examined the levels of ligands in serum and CNS tissue in mice lacking chemokine receptors. Compared with receptor-sufficient controls, Cx3cr1(-/-) mice exhibited augmented levels of CX3CL1 both...
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PMID: 18347198
PDF is available here.
PDF is available here.
Journal of Immunology (181)2 2008
Abstract
We show that Stx2 triggered expression of fractalkine (FKN), a CX3C transmembrane chemokine, acting as both adhesion counterreceptor on endothelial cells and soluble chemoattractant. Stx2 caused in HUVEC expression of FKN mRNA and protein, which promoted leukocyte capture, ablated by Abs to either e...
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PMID: 18606701
PDF is available here.
PDF is available here.
Abstract
We studied the effect of the serine protease thrombin on endothelial CX3CL1 induction and its putative relevance for monocyte function. In HUVEC, thrombin triggered a time- and concentration-dependent expression of CX3CL1 at the mRNA and the protein level as shown by RT-PCR, Western immunoblotting,...
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PMID: 18436581
PDF is available here.
PDF is available here.
Biology of Reproduction (79)1 2008
Abstract
We have previously shown that the chemokines CX3CL1 and CCL14 are abundant in endometrial vasculature, epithelial, and decidual cells at this time, and that their receptors, CX3CR1 and CCR1, are present on invading human trophoblasts. CX3CL1 and CCL14 promote trophoblast migration. We hypothesized t...
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PMID: 18367676
PDF is available here.
PDF is available here.
Journal of Neurochemistry (106)2 2008
Abstract
We demonstrate that levels of CX3CR1 (the receptor for the chemokine fractalkine) mRNA in lumbar dorsal root ganglia (DRG) increase 5.8-fold 7 days after sciatic nerve axotomy, and 1.7- and 2.9-fold, 3 and 7 days respectively, after the spared nerve injury (SNI) model of neuropathic pain. In contras...
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PMID: 18410510
PDF is available here.
PDF is available here.
Abstract
CX3CR1+ cells were detected in 19/28 AAA tissue samples and predominately localised in the adventitia. PBMCs from patients with AAA demonstrated higher percentages of CX3CR1+ NK cells (60.0-88.6%) and T cells (7.5-39.4%) compared with healthy controls. Furthermore, the frequency of CX3CR1+ NK cells...
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PMID: 18296082
PDF is available here.
PDF is available here.
Journal of Immunology (180)12 2008
Abstract
TCR engagement on adherent human effector memory CD4(+) T cells by TNF-treated HUVECs under flow induces formation of a transendothelial protrusion (TEP) by the T cell but fails to induce transendothelial migration (TEM). In contrast, TCR engagement of the same T cell populations by TNF-treated huma...
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PMID: 18523306
PDF is available here.
PDF is available here.
Neurochemical Research (33)6 2008
Abstract
We examined the expression of chemokines, fractalkine, interferon-inducible protein-10 (IP-10) and macrophage inflammatory protein-1alpha (MIP-1alpha) by immunohistochemistry in the brain of transgenic mice APP SWE (Tg2576) at ages of 9, 11, and 17 months, which over-express a mutated form of human...
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PMID: 18095157
PDF is available here.
PDF is available here.
FASEB Journal (22)6 2008
Abstract
We show, in lung A549 epithelial cells, that the tumor necrosis factor-alpha (TNF-alpha) and IFNgamma synergistically induced protein release and mRNA expression of CX(3)CL1 is inhibited by dexamethasone, without interfering with cytokine-induced nuclear translocation of NF-kappaB, and by an inhibit...
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PMID: 18230685
PDF is available here.
PDF is available here.
Neuroscience Letters (437)2 2008
Abstract
We show that in rat experimental autoimmune neuritis (EAN) mechanical allodynia developed up to 9 days before the onset of detectable neurological deficits. Allodynia was associated with an increase in the number of microglial cells in the dorsal horn of the spinal cord. The expression of the chemok...
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PMID: 18448252
PDF is available here.
PDF is available here.
Endocrinology (149)6 2008
Abstract
We found a major increase in the transcript levels of a chemokine fractalkine after human chorionic gonadotropin (hCG) treatment during the preovulatory period in gonadotropin-primed immature mice and rats. Although CX3CR1, the seven-transmembrane receptor for fractalkine, was also found in murine o...
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PMID: 18292196
PDF is available here.
PDF is available here.
Journal of Immunology (180)11 2008
Abstract
We report that these same effects are mimicked by exposing neurons to a medium conditioned with CX(3)CL1-treated mouse microglial cell line BV2 (BV2-st medium). Furthermore, CX(3)CL1-induced neuroprotection from Glu toxicity is mediated through the adenosine receptor 1 (AR(1)), being blocked by neur...
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PMID: 18490761
PDF is available here.
PDF is available here.
Abstract
These data suggest that the expression of Fractalkine by tumor cells enhances the recruitment of CD8+ T cells and NK cells and induces both innate and adaptive immunity, thereby yielding a better prognosis in gastric adenocarcinoma. Fractalkine is a new independent predictor of the prognosis and can...
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PMID: 18363071
PDF is available here.
PDF is available here.
Neuroscience Letters (436)2 2008
Abstract
We evaluated the levels of plasma soluble fractalkine in patients with mild cognitive impairment (MCI), patients with AD and healthy controls. We also investigated the changes in the levels of plasma soluble fractalkine in patients with AD. A total of 102 patients with cognitive impairment, includin...
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PMID: 18378084
PDF is available here.
PDF is available here.
Abstract
These data extend our previous findings and suggest that deleterious autoimmunity to brain antigens can be prevented by prophylactically inducing regulatory T-cell responses to those antigens....
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PMID: 18323496
PDF is available here.
PDF is available here.
Journal of Immunology (180)9 2008
Abstract
We recently observed, in a microarray study, an altered circulating leukocyte CX3CR1 mRNA expression associated with patients' mortality. As monocytes play a central role in septic shock pathophysiology and express high levels of CX3CR1, we therefore further investigated the alteration of CX3CR1 exp...
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PMID: 18424766
PDF is available here.
PDF is available here.
Circulation (117)13 2008
Abstract
These data provide the first in vivo evidence for independent roles for CCR2 and CX3CL1 in macrophage accumulation and atherosclerotic lesion formation and suggest that successful therapeutic strategies may need to target multiple chemokines or chemokine receptors....
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PMID: 18165355
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)13 2008
Abstract
We performed yeast two-hybrid analysis. Nine candidate interactors were identified, including GPS2 (G-protein pathway suppressor 2). Indirect immunofluorescence demonstrated that GPS2 and RFX4_v3 co-localized to the nucleus. Both GPS2 and RFX4_v3 mRNAs were also present in most portions of the adult...
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PMID: 18218630
PDF is available here.
PDF is available here.